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The map label for this gene is ggt [H]

Identifier: 74317428

GI number: 74317428

Start: 1494890

End: 1496695

Strand: Direct

Name: ggt [H]

Synonym: Tbd_1410

Alternate gene names: 74317428

Gene position: 1494890-1496695 (Clockwise)

Preceding gene: 74317427

Following gene: 74317437

Centisome position: 51.37

GC content: 70.65

Gene sequence:

>1806_bases
ATGCCCATGAACCGCTTTTTGCTCTGGCTGCTCCTCAGCCTCGTCGCGTCCCCGCTGCGCGCCGCGCCTGACGGGGTCGT
CGCCGTTTCCCATCCGGCCGCGGCCGCCGCCGGCGCGCGCATGCTCGCCACGGGCGGCAACGCCGTCGACGCCGCCGCGG
CGGTGCAGTTCGCGTTGAACGTGGTCGAGCCGCAGTCGTCCGGCATCGGCGGCGGCGGCTTCATGCTGATTCATCTCGCC
AAGACCGGCGAGACCGTCATCGTCGACTCGCGCGAGCGCGCACCGGCTGCGTCCCGCGCCGACATGTTCGCGCCCGGCGG
CGCGCCGATGGCGTTTCCGCTCGCCTCGACGAGCGGGCTTGCGGTCGGCGTGCCGGGTACCGTGCGCGGCGTCGACACGG
CGCTGCGCCGTTGGGGCACGATGGCGCTCGCCGACACGCTCGCCCCCGCGATCGAACTCGCCGCGGGCGGCTTTCGCGTC
AACCGCTTTCTCGCTGCCGACATCGCCGACGACGGCGGGCGGACAGCCATCCATCCGGAAACCGCTGCGATCTTTCGGCC
CGGCGGCGTGCCGTTGGCCGAGGGCGACTGGCTGGTGCAGCCCGATCTTGCGCGCACGCTCAGACTCATTGCGACAGGTG
GGCCAAAGGTTTTTTACGAGGGTCCGCTCGCGCGCGCGATCGTCGAAGCCCAGCAACGGACACGCGGCGAGTTGGGCGAG
CCCGGCCGCGGACGCATGGCAATCGCCGACCTGCGCGACTACACGGCCGCGATCCGGCGTCCGCTCACGGGGCAGTACCG
CGGCTGGACCGTGGCGAGCATGCCACCCCCGTCCTCGGGCGGCCTGACGTTGCTGCAGACGCTGGGCCTGCTCGAGCGCT
TTCCGCTCGGCGATACGACACAGGGTTACGGCTTCGGCAGCGCGAAAACGGTGCACCTCATGATCGAAGCGATGCGCCTC
GCCTTCGCCGACCGCGCCGTCTGGATCGGCGACGACGACGCACGCGCCCTGCCCCAGGCCGCGCTGCTGCATCCGCAGTA
CCAGGCCGCACGCGCCGCGCTCATCGATCCGGCGCGACGCATCGAACAGGCAAGCGCCGGCGACCCGACACGCTGGGCCC
CCGCGGCAACCAAGGCGCCGCAACGCATCCGTAGCAGGGCGGAAAGTCCGCAGACGACCCATTTCTCGATCGTCGACCGC
TGGGGCAACGTCGTGAGCTATACGAGCACGATCGAATACACCTGGGGCGCGGGCATCACCGTGCCGGGCTACGGCTTTCT
GCTCAACAACGAACTGACCGATTTCAATTTCGTGCCGAGCGCCGACAGCGCGACCGGCAATCCCGGCGCCAACGACGTCG
CGCCCGGCAGACGTCCGCGATCGAGCATGGCACCGACGCTGCTTCTGAAAAACGGGCGTCCGGTCGCGGCCTACGGCTCG
CCGGGCGGCGCGACGATCATCAACTCGGTGCTCAACATGACGCTCAATCTCGTCGACCACGGCATGACGCCGGGTCAGGC
GATCGCCGCGCCGCGCGTCTCGGTCACGAGCGCTGCAGGCAAAGTCGCCTGCGAGGGCGGCGAGGATTTCATGCAGCCGC
GCCTGAGCATCGCGGTGCAGGACCGCCTTCGCGCGCTCGGACACGTCGGACTGGGAGAAGCCGGGACGGACGGCTGTCAG
GGGAGGATCGGTTCGGTGCAGGCGGTCGTCGTCGACCTGACCAGTGGCGCGCAGTACGGCGCCGCCGATCCGCGCCGCGA
AGGTACGGTGATCCGGGTAGGTCCCGGCGCGCCCCTCGCGCCCTGA

Upstream 100 bases:

>100_bases
CTGCTGCGCCCCCGCGTCGACGGCAAGCCGGGCTGAACCCGCCGCGCATTTGACGCGCCGGCGGCAACCGGTGCACGCTC
GGGCTTCTGCCTCGCCGCCG

Downstream 100 bases:

>100_bases
CGCTCAGGCGACGCGCACAGCGGGCGCGGTGTCTTCCTCGTAGAACTTGACCTGATGGCGGCCCGCCGACTTGGCGCGGT
ACATCGCCTGATCGGCGCGG

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 601; Mature: 600

Protein sequence:

>601_residues
MPMNRFLLWLLLSLVASPLRAAPDGVVAVSHPAAAAAGARMLATGGNAVDAAAAVQFALNVVEPQSSGIGGGGFMLIHLA
KTGETVIVDSRERAPAASRADMFAPGGAPMAFPLASTSGLAVGVPGTVRGVDTALRRWGTMALADTLAPAIELAAGGFRV
NRFLAADIADDGGRTAIHPETAAIFRPGGVPLAEGDWLVQPDLARTLRLIATGGPKVFYEGPLARAIVEAQQRTRGELGE
PGRGRMAIADLRDYTAAIRRPLTGQYRGWTVASMPPPSSGGLTLLQTLGLLERFPLGDTTQGYGFGSAKTVHLMIEAMRL
AFADRAVWIGDDDARALPQAALLHPQYQAARAALIDPARRIEQASAGDPTRWAPAATKAPQRIRSRAESPQTTHFSIVDR
WGNVVSYTSTIEYTWGAGITVPGYGFLLNNELTDFNFVPSADSATGNPGANDVAPGRRPRSSMAPTLLLKNGRPVAAYGS
PGGATIINSVLNMTLNLVDHGMTPGQAIAAPRVSVTSAAGKVACEGGEDFMQPRLSIAVQDRLRALGHVGLGEAGTDGCQ
GRIGSVQAVVVDLTSGAQYGAADPRREGTVIRVGPGAPLAP

Sequences:

>Translated_601_residues
MPMNRFLLWLLLSLVASPLRAAPDGVVAVSHPAAAAAGARMLATGGNAVDAAAAVQFALNVVEPQSSGIGGGGFMLIHLA
KTGETVIVDSRERAPAASRADMFAPGGAPMAFPLASTSGLAVGVPGTVRGVDTALRRWGTMALADTLAPAIELAAGGFRV
NRFLAADIADDGGRTAIHPETAAIFRPGGVPLAEGDWLVQPDLARTLRLIATGGPKVFYEGPLARAIVEAQQRTRGELGE
PGRGRMAIADLRDYTAAIRRPLTGQYRGWTVASMPPPSSGGLTLLQTLGLLERFPLGDTTQGYGFGSAKTVHLMIEAMRL
AFADRAVWIGDDDARALPQAALLHPQYQAARAALIDPARRIEQASAGDPTRWAPAATKAPQRIRSRAESPQTTHFSIVDR
WGNVVSYTSTIEYTWGAGITVPGYGFLLNNELTDFNFVPSADSATGNPGANDVAPGRRPRSSMAPTLLLKNGRPVAAYGS
PGGATIINSVLNMTLNLVDHGMTPGQAIAAPRVSVTSAAGKVACEGGEDFMQPRLSIAVQDRLRALGHVGLGEAGTDGCQ
GRIGSVQAVVVDLTSGAQYGAADPRREGTVIRVGPGAPLAP
>Mature_600_residues
PMNRFLLWLLLSLVASPLRAAPDGVVAVSHPAAAAAGARMLATGGNAVDAAAAVQFALNVVEPQSSGIGGGGFMLIHLAK
TGETVIVDSRERAPAASRADMFAPGGAPMAFPLASTSGLAVGVPGTVRGVDTALRRWGTMALADTLAPAIELAAGGFRVN
RFLAADIADDGGRTAIHPETAAIFRPGGVPLAEGDWLVQPDLARTLRLIATGGPKVFYEGPLARAIVEAQQRTRGELGEP
GRGRMAIADLRDYTAAIRRPLTGQYRGWTVASMPPPSSGGLTLLQTLGLLERFPLGDTTQGYGFGSAKTVHLMIEAMRLA
FADRAVWIGDDDARALPQAALLHPQYQAARAALIDPARRIEQASAGDPTRWAPAATKAPQRIRSRAESPQTTHFSIVDRW
GNVVSYTSTIEYTWGAGITVPGYGFLLNNELTDFNFVPSADSATGNPGANDVAPGRRPRSSMAPTLLLKNGRPVAAYGSP
GGATIINSVLNMTLNLVDHGMTPGQAIAAPRVSVTSAAGKVACEGGEDFMQPRLSIAVQDRLRALGHVGLGEAGTDGCQG
RIGSVQAVVVDLTSGAQYGAADPRREGTVIRVGPGAPLAP

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=497, Percent_Identity=30.784708249497, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI73915090, Length=497, Percent_Identity=30.784708249497, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI73915096, Length=497, Percent_Identity=30.784708249497, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI73915094, Length=497, Percent_Identity=30.784708249497, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI153266885, Length=522, Percent_Identity=29.3103448275862, Blast_Score=149, Evalue=9e-36,
Organism=Homo sapiens, GI153266901, Length=523, Percent_Identity=29.6367112810707, Blast_Score=147, Evalue=4e-35,
Organism=Homo sapiens, GI113429324, Length=482, Percent_Identity=29.045643153527, Blast_Score=145, Evalue=2e-34,
Organism=Homo sapiens, GI109148539, Length=491, Percent_Identity=29.1242362525458, Blast_Score=143, Evalue=6e-34,
Organism=Homo sapiens, GI113429326, Length=489, Percent_Identity=29.4478527607362, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI153266907, Length=522, Percent_Identity=27.9693486590038, Blast_Score=125, Evalue=1e-28,
Organism=Escherichia coli, GI1789856, Length=575, Percent_Identity=40.1739130434783, Blast_Score=353, Evalue=1e-98,
Organism=Caenorhabditis elegans, GI212646519, Length=499, Percent_Identity=30.4609218436874, Blast_Score=173, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI72000294, Length=499, Percent_Identity=30.4609218436874, Blast_Score=172, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17506189, Length=521, Percent_Identity=29.1746641074856, Blast_Score=169, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17542894, Length=554, Percent_Identity=29.0613718411552, Blast_Score=167, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI193208245, Length=525, Percent_Identity=29.5238095238095, Blast_Score=148, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI193208247, Length=525, Percent_Identity=29.5238095238095, Blast_Score=148, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI72001497, Length=266, Percent_Identity=25.5639097744361, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI72001495, Length=266, Percent_Identity=25.5639097744361, Blast_Score=82, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323330, Length=531, Percent_Identity=26.3653483992467, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI18859893, Length=538, Percent_Identity=28.996282527881, Blast_Score=160, Evalue=3e-39,
Organism=Drosophila melanogaster, GI161077878, Length=513, Percent_Identity=29.2397660818713, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI161077880, Length=513, Percent_Identity=29.2397660818713, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24642670, Length=513, Percent_Identity=29.2397660818713, Blast_Score=150, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24642666, Length=513, Percent_Identity=29.2397660818713, Blast_Score=150, Evalue=4e-36,
Organism=Drosophila melanogaster, GI45551474, Length=513, Percent_Identity=29.2397660818713, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI161077496, Length=498, Percent_Identity=29.3172690763052, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI18859741, Length=512, Percent_Identity=27.5390625, Blast_Score=135, Evalue=8e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 62391; Mature: 62260

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMNRFLLWLLLSLVASPLRAAPDGVVAVSHPAAAAAGARMLATGGNAVDAAAAVQFALN
CCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHCCCEEEECCCCHHHHHHHHHHHHH
VVEPQSSGIGGGGFMLIHLAKTGETVIVDSRERAPAASRADMFAPGGAPMAFPLASTSGL
EECCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCE
AVGVPGTVRGVDTALRRWGTMALADTLAPAIELAAGGFRVNRFLAADIADDGGRTAIHPE
EEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCEEECCC
TAAIFRPGGVPLAEGDWLVQPDLARTLRLIATGGPKVFYEGPLARAIVEAQQRTRGELGE
CEEEECCCCCCCCCCCEEECCHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCCCC
PGRGRMAIADLRDYTAAIRRPLTGQYRGWTVASMPPPSSGGLTLLQTLGLLERFPLGDTT
CCCCCEEEHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCC
QGYGFGSAKTVHLMIEAMRLAFADRAVWIGDDDARALPQAALLHPQYQAARAALIDPARR
CCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCHHHHCCHHHHCCCHHHHHHHHHHCHHHH
IEQASAGDPTRWAPAATKAPQRIRSRAESPQTTHFSIVDRWGNVVSYTSTIEYTWGAGIT
HHHCCCCCCCCCCCCHHCCHHHHHHHCCCCCCEEEHHHHHCCCEEEEEEEEEEECCCCCC
VPGYGFLLNNELTDFNFVPSADSATGNPGANDVAPGRRPRSSMAPTLLLKNGRPVAAYGS
CCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEECC
PGGATIINSVLNMTLNLVDHGMTPGQAIAAPRVSVTSAAGKVACEGGEDFMQPRLSIAVQ
CCHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCEEEECCCCCEEECCCHHHHHHHHHHHHH
DRLRALGHVGLGEAGTDGCQGRIGSVQAVVVDLTSGAQYGAADPRREGTVIRVGPGAPLA
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCC
P
C
>Mature Secondary Structure 
PMNRFLLWLLLSLVASPLRAAPDGVVAVSHPAAAAAGARMLATGGNAVDAAAAVQFALN
CHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHCCCEEEECCCCHHHHHHHHHHHHH
VVEPQSSGIGGGGFMLIHLAKTGETVIVDSRERAPAASRADMFAPGGAPMAFPLASTSGL
EECCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCE
AVGVPGTVRGVDTALRRWGTMALADTLAPAIELAAGGFRVNRFLAADIADDGGRTAIHPE
EEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCCEEECCC
TAAIFRPGGVPLAEGDWLVQPDLARTLRLIATGGPKVFYEGPLARAIVEAQQRTRGELGE
CEEEECCCCCCCCCCCEEECCHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHCCCCCC
PGRGRMAIADLRDYTAAIRRPLTGQYRGWTVASMPPPSSGGLTLLQTLGLLERFPLGDTT
CCCCCEEEHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCC
QGYGFGSAKTVHLMIEAMRLAFADRAVWIGDDDARALPQAALLHPQYQAARAALIDPARR
CCCCCCCCHHHHHHHHHHHHHHHCCEEEECCCHHHHCCHHHHCCCHHHHHHHHHHCHHHH
IEQASAGDPTRWAPAATKAPQRIRSRAESPQTTHFSIVDRWGNVVSYTSTIEYTWGAGIT
HHHCCCCCCCCCCCCHHCCHHHHHHHCCCCCCEEEHHHHHCCCEEEEEEEEEEECCCCCC
VPGYGFLLNNELTDFNFVPSADSATGNPGANDVAPGRRPRSSMAPTLLLKNGRPVAAYGS
CCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEECC
PGGATIINSVLNMTLNLVDHGMTPGQAIAAPRVSVTSAAGKVACEGGEDFMQPRLSIAVQ
CCHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCEEEECCCCCEEECCCHHHHHHHHHHHHH
DRLRALGHVGLGEAGTDGCQGRIGSVQAVVVDLTSGAQYGAADPRREGTVIRVGPGAPLA
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA