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The map label for this gene is yciR [C]

Identifier: 74317384

GI number: 74317384

Start: 1446133

End: 1448349

Strand: Direct

Name: yciR [C]

Synonym: Tbd_1366

Alternate gene names: 74317384

Gene position: 1446133-1448349 (Clockwise)

Preceding gene: 74317383

Following gene: 74317385

Centisome position: 49.7

GC content: 62.92

Gene sequence:

>2217_bases
ATGTGTCTACCGCTCAAGAAGCGGTGCCAGGTGCCGAATACGCAAGAAGGAGACAAATCCTCGGTCGACAACGAACGGGA
AAAATACAATGACAAACATCGCAAACCCTTACGGCCATCCGCCGGCCGGCCGCTCCGCCCGCTGGGCTGGCGGCTCTCAC
TGCCCACGCTCCGAGTCGAGACACGTCTAGCTGTTGCGATGTCGCATCAGTCCCCGATTCTGAGCACGCGCCCGGCTCCG
CCCCGCGACGCTGCGACCGCGTGCGCCAGGTCGAACTACGTCGAGCCGACGATACGGAGCATCGCCGGTGCCTTCATCCT
CGCGTGCGGGATCCTGGTCTTGATCAAGCCGGAATGGTCCGTGCTGTGGGCCGCGACCCTGTGCTTTGTCGGCTTCAACC
TGTTCCAGTCCGGCTTCACGCAGTTCTGCGTGATGGAAAAGCTGCTGAAGAAGCTGCGCTTCAAAAGCGAACTCGACGAA
ATCCGTACCCTGAGCCGATCGCACGCGGAAGCCGAGGCACGGGCCGCGTTCTACGACACGCTCGGGCTCCTCAACGAAGT
CGTCGTCGAACTGTCGCGCGAGGGCGAACTCGCGTTCCTATCCGAACACTGGACCAAGCTGCTCGCGGCCGACGGGCGGC
GCAACGCCGATTTTCTCGGGCTCGCCTTCCTCTCCTTCGTCAAACAACACGACCGCGACACCCTCGAACAGCGTCTGAGC
GCTTTGCTCAAGGGCGAGAGCGACATCGTGACGCTGCGCTTCCGCATGCAGCGCGAGGACAGACTCGAGCACTGGGTGGA
AGGGAAGTTCGCCCGCCATCACAAGCACGGGCAGGTGCACGGCATTCGCGGCGTGCTGCGCGACGTGACCGAAGCCTACA
TGCAGGAAAAGCGCATCAGCCACATGGCGATGCACGACGCCTTGACCGGGCTTCCGAACCGCACCTATCTCGACGCACGC
ATCAACGAAGCGATCGAACAATCGCGCAGCAGCGCGACGAAATTCGCCCTGCTCTTCATCGATCTCGACAACTTCAAACG
TATCAACGACCTCTACGGTCACAAGGCGGGCGATCAGTTGCTCGTCAGCGTCGGCGAACTCCTGCGCGCCAGCCTGCGGG
CGACCGACGTGCTCGCGCGCTGGGGCGGCGACGAGTTTGTCGTGCTGCTGCCCTTCCCCGGGGAGATCGACATGGTGCGC
AGAATCGCGAGCGAGCTGCTGGACGGCCTGCGAAACGATCTGGAGAAGCAGTGTCGCGACACCTTCGTCACCGTGAGTAT
CGGTGTCGCGATCTACCCCGACGATGCGGAATCGGCCGAGACGCTCCTCGTTCAGGCGGACAAGGCCTTGTTTTACGCCA
AGTCGCAGGGGCGCAACAACATCCAGCTGTACGCGGATCTGCAGACCCGCGCACCCGGCTTCGAGGACGCCGAAATGACC
GCTCGCTTCGTCGCCGCGGTCAAACAGAACCTGCTCGAAGTCCACTACCAGCCGGTCATGGACGCGGCGAATCCACGGTG
CCCGGTAAGCGTCGAAGCCCTTGCGCGCTGGCACGACGACAAGTACGGCTGGGTCAATCCGGCCGACTTCATTCCGCTCG
CCGAGAATATGGGGCTCATCCACGAGGTCGGACGGCAGGTTCTGGAACAGGCGCTCGACCACTTCAGCAAGCGCAACAAC
ACCTGCGACGCACTCAAGCTCGCCGTGAACGTATCGAAACGTCAGTTGATGTCGCCCGATTTCTACCCGACGCTGCTTGC
GACCGTCGAGCGCTTTGGCGTGCATCCCCGCCAGATCAAACTCGAGATCACCGAAAGCATCGCGCTCGAGGGCATCGAGC
GGGCGCGTGCGCTTCTGCAGCGGCTCTCCGACGCGGGATTCACGCTTTCGCTCGATGATTTCGGCACGGGGTTTTCCTCG
CTCTCGCACGTCCACGAGTTGCCGTTCGACGAAATCAAGATCGACATCTCGTTCGTTCGCCGCATCAAGACGCCCGAAGG
ACGCGTCCTCGTCAAGACCATCGTCGACATGGGGCACGCCATGCGCCTCGCGCTTGTCGCCGAGGGCGTCGAGGACAGCG
AAACCGCGGCGATCCTGCAGGGCATGGGCGTCGAAATGCTGCAGGGCTACCATTTCAGCCGGCCCATGCCGAAAGAGGTA
TGTGCCGATTTCATCGCCAGACTGCAAGCGCCTCCGGCCGCCGCGGCCGCCGCCTGA

Upstream 100 bases:

>100_bases
CCCGCGACGTTGCACAGACGACCCGCGACCCTCTCGGTGTTGCCCGCAGCCATGAGCGCGGGGCACCCCCGAAGCGGATT
CGCGCCCCCGAGGCCATAGC

Downstream 100 bases:

>100_bases
GCGATTCACCCCCGCTCCAGGGCCTGCTGGCCACGCCGGCGCGTGTGCTATGTTGACCTTGGAGGTGTCGCTGATGAAAA
ACGGAAACGCTGTTCTCAAA

Product: diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 738; Mature: 738

Protein sequence:

>738_residues
MCLPLKKRCQVPNTQEGDKSSVDNEREKYNDKHRKPLRPSAGRPLRPLGWRLSLPTLRVETRLAVAMSHQSPILSTRPAP
PRDAATACARSNYVEPTIRSIAGAFILACGILVLIKPEWSVLWAATLCFVGFNLFQSGFTQFCVMEKLLKKLRFKSELDE
IRTLSRSHAEAEARAAFYDTLGLLNEVVVELSREGELAFLSEHWTKLLAADGRRNADFLGLAFLSFVKQHDRDTLEQRLS
ALLKGESDIVTLRFRMQREDRLEHWVEGKFARHHKHGQVHGIRGVLRDVTEAYMQEKRISHMAMHDALTGLPNRTYLDAR
INEAIEQSRSSATKFALLFIDLDNFKRINDLYGHKAGDQLLVSVGELLRASLRATDVLARWGGDEFVVLLPFPGEIDMVR
RIASELLDGLRNDLEKQCRDTFVTVSIGVAIYPDDAESAETLLVQADKALFYAKSQGRNNIQLYADLQTRAPGFEDAEMT
ARFVAAVKQNLLEVHYQPVMDAANPRCPVSVEALARWHDDKYGWVNPADFIPLAENMGLIHEVGRQVLEQALDHFSKRNN
TCDALKLAVNVSKRQLMSPDFYPTLLATVERFGVHPRQIKLEITESIALEGIERARALLQRLSDAGFTLSLDDFGTGFSS
LSHVHELPFDEIKIDISFVRRIKTPEGRVLVKTIVDMGHAMRLALVAEGVEDSETAAILQGMGVEMLQGYHFSRPMPKEV
CADFIARLQAPPAAAAAA

Sequences:

>Translated_738_residues
MCLPLKKRCQVPNTQEGDKSSVDNEREKYNDKHRKPLRPSAGRPLRPLGWRLSLPTLRVETRLAVAMSHQSPILSTRPAP
PRDAATACARSNYVEPTIRSIAGAFILACGILVLIKPEWSVLWAATLCFVGFNLFQSGFTQFCVMEKLLKKLRFKSELDE
IRTLSRSHAEAEARAAFYDTLGLLNEVVVELSREGELAFLSEHWTKLLAADGRRNADFLGLAFLSFVKQHDRDTLEQRLS
ALLKGESDIVTLRFRMQREDRLEHWVEGKFARHHKHGQVHGIRGVLRDVTEAYMQEKRISHMAMHDALTGLPNRTYLDAR
INEAIEQSRSSATKFALLFIDLDNFKRINDLYGHKAGDQLLVSVGELLRASLRATDVLARWGGDEFVVLLPFPGEIDMVR
RIASELLDGLRNDLEKQCRDTFVTVSIGVAIYPDDAESAETLLVQADKALFYAKSQGRNNIQLYADLQTRAPGFEDAEMT
ARFVAAVKQNLLEVHYQPVMDAANPRCPVSVEALARWHDDKYGWVNPADFIPLAENMGLIHEVGRQVLEQALDHFSKRNN
TCDALKLAVNVSKRQLMSPDFYPTLLATVERFGVHPRQIKLEITESIALEGIERARALLQRLSDAGFTLSLDDFGTGFSS
LSHVHELPFDEIKIDISFVRRIKTPEGRVLVKTIVDMGHAMRLALVAEGVEDSETAAILQGMGVEMLQGYHFSRPMPKEV
CADFIARLQAPPAAAAAA
>Mature_738_residues
MCLPLKKRCQVPNTQEGDKSSVDNEREKYNDKHRKPLRPSAGRPLRPLGWRLSLPTLRVETRLAVAMSHQSPILSTRPAP
PRDAATACARSNYVEPTIRSIAGAFILACGILVLIKPEWSVLWAATLCFVGFNLFQSGFTQFCVMEKLLKKLRFKSELDE
IRTLSRSHAEAEARAAFYDTLGLLNEVVVELSREGELAFLSEHWTKLLAADGRRNADFLGLAFLSFVKQHDRDTLEQRLS
ALLKGESDIVTLRFRMQREDRLEHWVEGKFARHHKHGQVHGIRGVLRDVTEAYMQEKRISHMAMHDALTGLPNRTYLDAR
INEAIEQSRSSATKFALLFIDLDNFKRINDLYGHKAGDQLLVSVGELLRASLRATDVLARWGGDEFVVLLPFPGEIDMVR
RIASELLDGLRNDLEKQCRDTFVTVSIGVAIYPDDAESAETLLVQADKALFYAKSQGRNNIQLYADLQTRAPGFEDAEMT
ARFVAAVKQNLLEVHYQPVMDAANPRCPVSVEALARWHDDKYGWVNPADFIPLAENMGLIHEVGRQVLEQALDHFSKRNN
TCDALKLAVNVSKRQLMSPDFYPTLLATVERFGVHPRQIKLEITESIALEGIERARALLQRLSDAGFTLSLDDFGTGFSS
LSHVHELPFDEIKIDISFVRRIKTPEGRVLVKTIVDMGHAMRLALVAEGVEDSETAAILQGMGVEMLQGYHFSRPMPKEV
CADFIARLQAPPAAAAAA

Specific function: Unknown

COG id: COG5001

COG function: function code T; Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MHYT domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=433, Percent_Identity=35.5658198614319, Blast_Score=251, Evalue=1e-67,
Organism=Escherichia coli, GI87081921, Length=434, Percent_Identity=33.1797235023041, Blast_Score=204, Evalue=2e-53,
Organism=Escherichia coli, GI226510982, Length=428, Percent_Identity=29.6728971962617, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1787055, Length=225, Percent_Identity=35.1111111111111, Blast_Score=142, Evalue=8e-35,
Organism=Escherichia coli, GI1790496, Length=246, Percent_Identity=30.4878048780488, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1788381, Length=449, Percent_Identity=27.8396436525612, Blast_Score=132, Evalue=1e-31,
Organism=Escherichia coli, GI87081743, Length=244, Percent_Identity=33.1967213114754, Blast_Score=132, Evalue=1e-31,
Organism=Escherichia coli, GI87081845, Length=226, Percent_Identity=34.5132743362832, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1786507, Length=223, Percent_Identity=35.4260089686099, Blast_Score=125, Evalue=9e-30,
Organism=Escherichia coli, GI87081980, Length=253, Percent_Identity=33.201581027668, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI87081881, Length=179, Percent_Identity=38.5474860335196, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI87082096, Length=429, Percent_Identity=25.4079254079254, Blast_Score=108, Evalue=2e-24,
Organism=Escherichia coli, GI1788502, Length=250, Percent_Identity=31.2, Blast_Score=107, Evalue=3e-24,
Organism=Escherichia coli, GI1788849, Length=244, Percent_Identity=27.0491803278689, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI145693134, Length=173, Percent_Identity=33.5260115606936, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1786584, Length=174, Percent_Identity=33.3333333333333, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1787262, Length=173, Percent_Identity=36.4161849710983, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1788085, Length=172, Percent_Identity=33.7209302325581, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI87082007, Length=184, Percent_Identity=31.5217391304348, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1788956, Length=156, Percent_Identity=39.1025641025641, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI87081977, Length=158, Percent_Identity=32.2784810126582, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1787816, Length=158, Percent_Identity=29.746835443038, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1787802, Length=169, Percent_Identity=30.1775147928994, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI87081974, Length=110, Percent_Identity=31.8181818181818, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR005330 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF03707 MHYT [H]

EC number: NA

Molecular weight: Translated: 82837; Mature: 82837

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCLPLKKRCQVPNTQEGDKSSVDNEREKYNDKHRKPLRPSAGRPLRPLGWRLSLPTLRVE
CCCCCHHHCCCCCCCCCCCCCCCHHHHHHCHHCCCCCCCCCCCCCCCCCCEECCCCEEHH
TRLAVAMSHQSPILSTRPAPPRDAATACARSNYVEPTIRSIAGAFILACGILVLIKPEWS
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEECCCHH
VLWAATLCFVGFNLFQSGFTQFCVMEKLLKKLRFKSELDEIRTLSRSHAEAEARAAFYDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLLNEVVVELSREGELAFLSEHWTKLLAADGRRNADFLGLAFLSFVKQHDRDTLEQRLS
HHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHH
ALLKGESDIVTLRFRMQREDRLEHWVEGKFARHHKHGQVHGIRGVLRDVTEAYMQEKRIS
HHHCCCCCEEEEEEECCHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
HMAMHDALTGLPNRTYLDARINEAIEQSRSSATKFALLFIDLDNFKRINDLYGHKAGDQL
HHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHCCCCCHHH
LVSVGELLRASLRATDVLARWGGDEFVVLLPFPGEIDMVRRIASELLDGLRNDLEKQCRD
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TFVTVSIGVAIYPDDAESAETLLVQADKALFYAKSQGRNNIQLYADLQTRAPGFEDAEMT
CEEEEEEEEEECCCCCCCHHHHHEEECHHHEEECCCCCCCEEEEEEEHHCCCCCCCHHHH
ARFVAAVKQNLLEVHYQPVMDAANPRCPVSVEALARWHDDKYGWVNPADFIPLAENMGLI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCHHCCCCHHCCCHH
HEVGRQVLEQALDHFSKRNNTCDALKLAVNVSKRQLMSPDFYPTLLATVERFGVHPRQIK
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEE
LEITESIALEGIERARALLQRLSDAGFTLSLDDFGTGFSSLSHVHELPFDEIKIDISFVR
EEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHCCCHHHHHHHHHCCHHHHEEHHHHHH
RIKTPEGRVLVKTIVDMGHAMRLALVAEGVEDSETAAILQGMGVEMLQGYHFSRPMPKEV
HHCCCCCCCHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHCCCCCCCCCCHHH
CADFIARLQAPPAAAAAA
HHHHHHHHCCCCCHHCCC
>Mature Secondary Structure
MCLPLKKRCQVPNTQEGDKSSVDNEREKYNDKHRKPLRPSAGRPLRPLGWRLSLPTLRVE
CCCCCHHHCCCCCCCCCCCCCCCHHHHHHCHHCCCCCCCCCCCCCCCCCCEECCCCEEHH
TRLAVAMSHQSPILSTRPAPPRDAATACARSNYVEPTIRSIAGAFILACGILVLIKPEWS
HHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEECCCHH
VLWAATLCFVGFNLFQSGFTQFCVMEKLLKKLRFKSELDEIRTLSRSHAEAEARAAFYDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLLNEVVVELSREGELAFLSEHWTKLLAADGRRNADFLGLAFLSFVKQHDRDTLEQRLS
HHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHH
ALLKGESDIVTLRFRMQREDRLEHWVEGKFARHHKHGQVHGIRGVLRDVTEAYMQEKRIS
HHHCCCCCEEEEEEECCHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
HMAMHDALTGLPNRTYLDARINEAIEQSRSSATKFALLFIDLDNFKRINDLYGHKAGDQL
HHHHHHHHHCCCCCEEHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHCCCCCHHH
LVSVGELLRASLRATDVLARWGGDEFVVLLPFPGEIDMVRRIASELLDGLRNDLEKQCRD
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TFVTVSIGVAIYPDDAESAETLLVQADKALFYAKSQGRNNIQLYADLQTRAPGFEDAEMT
CEEEEEEEEEECCCCCCCHHHHHEEECHHHEEECCCCCCCEEEEEEEHHCCCCCCCHHHH
ARFVAAVKQNLLEVHYQPVMDAANPRCPVSVEALARWHDDKYGWVNPADFIPLAENMGLI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCHHCCCCHHCCCHH
HEVGRQVLEQALDHFSKRNNTCDALKLAVNVSKRQLMSPDFYPTLLATVERFGVHPRQIK
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEE
LEITESIALEGIERARALLQRLSDAGFTLSLDDFGTGFSSLSHVHELPFDEIKIDISFVR
EEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHCCCHHHHHHHHHCCHHHHEEHHHHHH
RIKTPEGRVLVKTIVDMGHAMRLALVAEGVEDSETAAILQGMGVEMLQGYHFSRPMPKEV
HHCCCCCCCHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHCCCCCCCCCCHHH
CADFIARLQAPPAAAAAA
HHHHHHHHCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]