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The map label for this gene is envZ [H]

Identifier: 74317306

GI number: 74317306

Start: 1355978

End: 1357276

Strand: Direct

Name: envZ [H]

Synonym: Tbd_1288

Alternate gene names: 74317306

Gene position: 1355978-1357276 (Clockwise)

Preceding gene: 74317305

Following gene: 74317307

Centisome position: 46.6

GC content: 67.21

Gene sequence:

>1299_bases
GTGAAGCTGCTGCCAGGCAGTTTTTACTATCGAACCGCGGCGGCGCTGTTCATCGCCACGCTGGCGAGTTCGGTCCTGCT
CGTCGGCATCGGCTGGCTGCTGGTCGGCAAACCGATGGTCAAGCACCAGGCGATGACCTTCGCCAGGCAGATCCAGAACG
CCGCCGACACCTATCGCATCGTCGCCGGGCCCCGACGCGCCGAATTTCTTGCGCACCTCGAGCGCGACCAGGCCCTGACG
CTCGAGCCGGGGGCGACATCGGCGCTGAGCGGCGAACGTCCGCGCCTGCCGTATTTCGGCCATCTCGAAGCGGCGGTCTC
GCAACTCGCCGGCAGGCCGGTCCCGCTGCTGCGGCGCGGTGAGGTGTATTCCTTCGATTTTCCGCTCGGCGACACGCGGC
TGCGTTTTCATTTCAACGAAAACAGGACCGGTGCGGCGCCGGTCCTCGCGCTCTCGGCGATGACCGTGTTCGCGGTCCTC
TCGAGCCTGCTGGCGGCCGTGCTCGTCGGCAAGTACACGGCGCGCCCGATCGAGACGATCGCCCACCGCACCGAGGCCCG
GCACGAAAGCGGGCTGCGCGGGCCGATTCCCGAGGAGGGGCCGCGCGAGCTGCGCGAAATCGTCCGCAACTTCAACCAGA
TCAGTTCGCAGAACCGCGACCTGATCAACAGCAGTTCGATCATGCTCGCCGGCATCTCGCACGACCTGCGCGCGCCGATC
ACGCGTGCGCGCATGGCCCTCGAACTCGCGCGCGCAAGCATGGACGAGAGCCTGGCGCTGCGCATCGAGCGCGCGCTGAT
CCAGATGGAAACGCTGATCGCGCAATATCTCGACTTCACCGGCGGCAGCATCAAGGAGGGCGCCTCACCGCTCAACATCT
CCGCGCTGCTCAGGGAGGTGATGCAGACCCACAAGCATTCCGAAATCCATCTCGACGTGTCGTGCGAGGAGGTCGCCTAC
CTGCCGTCGCGCGCGTTCATCCGCTGCGCACAGAACCTGATCGACAACGCGGTCAAGCACGGCCGTGGCGCGCCGATCGA
CGTCTCGTTCCGCAAGAGCGCGTCGATCTGGACGCTCGAAATCGCCGACCGGGGCCCGGGCATCCCCGACGCCCAGCTCG
AGCGCGTCTTTCAACCCTTCCTGCGCCTCGACAACGCGCGCACTCAGACCGGAAGCGGACTCGGGCTCTCGATCGTCCAG
GAAATCTGCCGCACCCAGGGCTGGTTCATCACGCTGCTGCCGCGCCCCGGCGGCGGCCTGATCGCGCGCCTGGCCCTGCC
GGTCGCGGTGCAGAGTTGA

Upstream 100 bases:

>100_bases
GGCTGCGCCGCAAGATCGAGGACGACCCGGCGCAGCCGCGCTACATCCGCACCGTGCGCGGCAGCGGCTACCTGTTCGTG
CCCGACGGTGGCGACGAGCG

Downstream 100 bases:

>100_bases
GCAGGCCGCAAACGCTTCGCAGGGATGGCGGCCCGCGGCGCTGCCGGCACGTCGGGCGCCGCGCCCGGGTCCGCGCGCAC
GATCCGACCCGCAGACGCGC

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MKLLPGSFYYRTAAALFIATLASSVLLVGIGWLLVGKPMVKHQAMTFARQIQNAADTYRIVAGPRRAEFLAHLERDQALT
LEPGATSALSGERPRLPYFGHLEAAVSQLAGRPVPLLRRGEVYSFDFPLGDTRLRFHFNENRTGAAPVLALSAMTVFAVL
SSLLAAVLVGKYTARPIETIAHRTEARHESGLRGPIPEEGPRELREIVRNFNQISSQNRDLINSSSIMLAGISHDLRAPI
TRARMALELARASMDESLALRIERALIQMETLIAQYLDFTGGSIKEGASPLNISALLREVMQTHKHSEIHLDVSCEEVAY
LPSRAFIRCAQNLIDNAVKHGRGAPIDVSFRKSASIWTLEIADRGPGIPDAQLERVFQPFLRLDNARTQTGSGLGLSIVQ
EICRTQGWFITLLPRPGGGLIARLALPVAVQS

Sequences:

>Translated_432_residues
MKLLPGSFYYRTAAALFIATLASSVLLVGIGWLLVGKPMVKHQAMTFARQIQNAADTYRIVAGPRRAEFLAHLERDQALT
LEPGATSALSGERPRLPYFGHLEAAVSQLAGRPVPLLRRGEVYSFDFPLGDTRLRFHFNENRTGAAPVLALSAMTVFAVL
SSLLAAVLVGKYTARPIETIAHRTEARHESGLRGPIPEEGPRELREIVRNFNQISSQNRDLINSSSIMLAGISHDLRAPI
TRARMALELARASMDESLALRIERALIQMETLIAQYLDFTGGSIKEGASPLNISALLREVMQTHKHSEIHLDVSCEEVAY
LPSRAFIRCAQNLIDNAVKHGRGAPIDVSFRKSASIWTLEIADRGPGIPDAQLERVFQPFLRLDNARTQTGSGLGLSIVQ
EICRTQGWFITLLPRPGGGLIARLALPVAVQS
>Mature_432_residues
MKLLPGSFYYRTAAALFIATLASSVLLVGIGWLLVGKPMVKHQAMTFARQIQNAADTYRIVAGPRRAEFLAHLERDQALT
LEPGATSALSGERPRLPYFGHLEAAVSQLAGRPVPLLRRGEVYSFDFPLGDTRLRFHFNENRTGAAPVLALSAMTVFAVL
SSLLAAVLVGKYTARPIETIAHRTEARHESGLRGPIPEEGPRELREIVRNFNQISSQNRDLINSSSIMLAGISHDLRAPI
TRARMALELARASMDESLALRIERALIQMETLIAQYLDFTGGSIKEGASPLNISALLREVMQTHKHSEIHLDVSCEEVAY
LPSRAFIRCAQNLIDNAVKHGRGAPIDVSFRKSASIWTLEIADRGPGIPDAQLERVFQPFLRLDNARTQTGSGLGLSIVQ
EICRTQGWFITLLPRPGGGLIARLALPVAVQS

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=282, Percent_Identity=31.9148936170213, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI1787894, Length=208, Percent_Identity=31.7307692307692, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790346, Length=252, Percent_Identity=29.3650793650794, Blast_Score=82, Evalue=8e-17,
Organism=Escherichia coli, GI1790861, Length=246, Percent_Identity=26.8292682926829, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787374, Length=246, Percent_Identity=27.2357723577236, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786912, Length=216, Percent_Identity=30.5555555555556, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789149, Length=219, Percent_Identity=29.2237442922374, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1789403, Length=454, Percent_Identity=24.4493392070485, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47390; Mature: 47390

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLPGSFYYRTAAALFIATLASSVLLVGIGWLLVGKPMVKHQAMTFARQIQNAADTYRI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCEEE
VAGPRRAEFLAHLERDQALTLEPGATSALSGERPRLPYFGHLEAAVSQLAGRPVPLLRRG
ECCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEECC
EVYSFDFPLGDTRLRFHFNENRTGAAPVLALSAMTVFAVLSSLLAAVLVGKYTARPIETI
CEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AHRTEARHESGLRGPIPEEGPRELREIVRNFNQISSQNRDLINSSSIMLAGISHDLRAPI
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHH
TRARMALELARASMDESLALRIERALIQMETLIAQYLDFTGGSIKEGASPLNISALLREV
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHH
MQTHKHSEIHLDVSCEEVAYLPSRAFIRCAQNLIDNAVKHGRGAPIDVSFRKSASIWTLE
HHHCCCCEEEEEECHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEE
IADRGPGIPDAQLERVFQPFLRLDNARTQTGSGLGLSIVQEICRTQGWFITLLPRPGGGL
ECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCH
IARLALPVAVQS
HHHHHHHHHCCC
>Mature Secondary Structure
MKLLPGSFYYRTAAALFIATLASSVLLVGIGWLLVGKPMVKHQAMTFARQIQNAADTYRI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCEEE
VAGPRRAEFLAHLERDQALTLEPGATSALSGERPRLPYFGHLEAAVSQLAGRPVPLLRRG
ECCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEECC
EVYSFDFPLGDTRLRFHFNENRTGAAPVLALSAMTVFAVLSSLLAAVLVGKYTARPIETI
CEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AHRTEARHESGLRGPIPEEGPRELREIVRNFNQISSQNRDLINSSSIMLAGISHDLRAPI
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHH
TRARMALELARASMDESLALRIERALIQMETLIAQYLDFTGGSIKEGASPLNISALLREV
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCHHHHHHHH
MQTHKHSEIHLDVSCEEVAYLPSRAFIRCAQNLIDNAVKHGRGAPIDVSFRKSASIWTLE
HHHCCCCEEEEEECHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEE
IADRGPGIPDAQLERVFQPFLRLDNARTQTGSGLGLSIVQEICRTQGWFITLLPRPGGGL
ECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCH
IARLALPVAVQS
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]