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The map label for this gene is lon2 [H]

Identifier: 74317270

GI number: 74317270

Start: 1314391

End: 1316784

Strand: Direct

Name: lon2 [H]

Synonym: Tbd_1252

Alternate gene names: 74317270

Gene position: 1314391-1316784 (Clockwise)

Preceding gene: 74317269

Following gene: 74317274

Centisome position: 45.17

GC content: 64.83

Gene sequence:

>2394_bases
ATGGCCAATGATTTCAGCGACGCGACGCTCGAAGGCGAAGTCATTCCCGACGACCGAAGCCTGCCGGCGGCGCCCGTCCT
GCCGCCCGAGCTCTATCTGCTGCCGCTGACCGAGAAGCCGTTCTTTCCGGCGCAGACGCTGCCGCTCCTGATGAACGAGG
CGCCCTGGCTGTCGACCGTCGAAGCGATCGGCGAAACGCCGCAGCACATGGTCGGACTGGTCGTGGTCAAGCCGGACAAC
ACCGACGACGTCAAACGCGGCGACTTCCAGACGGTCGGCACCGCGGTGCGTATCCATCATCCGGTGCGCGCCGACGGCAA
GATGCAATTCATCGCCGAGGGCGTGCGCCGCTTTCGAGTGGTCGAGTGGCTGTCGGACACGGCGCCGTACCGCGTCCGCG
TCGACTATCCGAACGAGACCGGCAAGCCGGAGTCCGAGGAAATCCGCGCGTACTCGATCGCGATCATCAATACGATCAAG
GAGTTGCTGCCGCTCAATCCGCTGTACTCGGAGGAGCTCAAGTTCTTTCTCAATCGCTTCGGCCCGAACGAACCCTCGCA
GCTGACCGATTTTGCCGCGAGCCTCACGACCGCGTCCAAGCTCGAACTGCAGGATGTGCTCGAGGCGTTCAGCCTGAAGA
AGCGCATGGAGAAGGTGCTCGTGCTGCTGAAGAAGGAGCTCGACGTCGCCCGGCTGCAGTCGCAGATCCGCGAGCGGGTC
GACGAGAAGATGAGCGAGCAGCAGCGCGAATTCTTCCTGCGCCAGCAGTTGAAGGCGATCCAGAAGGAACTGGGCATCGC
GAAGGACGACAAGACCGCCGAGCTCGACACCTTCCGTGAGCGGATCGCCAAACTCGCACTGCCCGAGCAGGCGAAAAAGC
GCATCGACGAGGAAATGCACAAGCTCTCGATGCTCGAAACGGGCTCGGCCGAATACACGGTGACGCGCAACTATCTCGAC
TGGCTGACCGTGCTGCCCTGGGGCGTCCATACCCAGGACAAGATCGACCTCGAACGCGCGCGACGCATCCTCGACCGCGA
CCACGACGGGCTCGACGACGTCAAGGATCGCATCATCGAATTCCTCGCCGTCGGCGCGATGCGCGGCGAGATGGCAGGCT
CGATCCTGCTGCTGATAGGCCCGCCCGGCGTCGGCAAGACGTCGATCGGCAAGTCGGTCGCCGAGGCGCTCGGGCGCAAG
TTCTTCCGCTTCTCGGTCGGCGGCATGCGCGACGAGGCCGAGATCAAGGGCCATCGCCGCACCTATATCGGCGCGATGCC
GGGCAAGTTCGTGCAGGCGCTGAAGGAGGCCGGCTCGGCCAACCCGGTCATCATGCTCGACGAGGTCGACAAGATCGGCG
CGAGCTACCAGGGCGACCCGGCGTCGGCGCTGCTCGAGGTGCTCGATCCCGAACAGAACGCCGACTTCCTCGACCACTAT
CTCGACGTGCGTTTCGACTTATCCAAGGCGCTTTTCATCTGCACGGCGAACGATTTTTCGATTCCCTCGGCGCTGCTCGA
CCGCATGGAGGTCATCCGCCTTTCGGGCTACATCACGGCGGAAAAGATCGACATCGCGAAGCACCATCTGTGGCCGCGCG
TGCTCGAACGGGCGGGGCTCAAGAAGAACCAGCTGACGATCACCGAAAGCGCGCTGCGGCACGTGATCGAAGGCTATGCC
CGCGAGGCCGGCGTGCGTAACCTCGAAAAACAACTCGGCCGGGTCGCGCGCAAGGCGGTCGTCAAGATTCTCGGCGGCGC
CGACACGCCGATCAAGATCGGCGTGCGCGAGATCGAGGCCTATCTCGACAAGCCGGTGTTCCTGCGCGAACGGCCGCTGT
CGGGGATCGGCGTGGTGACCGGCCTCGCCTGGACCTCGATGGGCGGCGCGACGCTTCCGGTCGAGGCGACACGCGTCCAC
ACGCTCAACCGCGGCTTCAAGCTCACGGGCAAGCTCGGCGAAGTCATGCGCGAATCGGCCGAGATCGCATACAGCTACGT
CGCCTCGCATCTCAAGGACTACGGCGCCGACCGCAGCTTCTTCGACACGAGCTTCGTCCACCTGCACGTGCCCGAAGGCG
CGACGCCGAAGGACGGCCCGAGCGCCGGCGTCACCATGGCGAGCGCGCTGCTGTCGCTGGCCAAGAACACCAAGATCGCG
CGGCCCCTCGCGATGACCGGTGAACTCACGCTGACCGGGCAGGTGCTGCCGGTAGGCGGCATACGCGAGAAGGTCATCGC
AGCGCGTCGCGTCGGCATCGGCGAACTGATCCTGCCCGAAGCCAACCGCCGCGATTTCGACAAGCTGCCCGAGCACATCC
GTGCGGGACTGACCGTGCATTTCGCCAAGCGTTATCGCGACGTCGCCGACGTCATCTTCGGGCCGCGTGCCTGA

Upstream 100 bases:

>100_bases
CCGACACGGTCGACGAAATCCCCGTACCCGCCGCGCCTTGAAAAGCCGGGGATAGCCCCGATACTTCCAGTTCCGCTTGT
CGAACTGAGAAGGATCCCGT

Downstream 100 bases:

>100_bases
GACGGCGCGGCCCGGCAAACCGGCCGCGGCCGGGTTCAGATGAAGAGGTTGACGTCCGACTTCTGCGCGATCGACAGGAA
ACTCGCCGCGCCGATCCAGC

Product: PIM1 peptidase

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 797; Mature: 796

Protein sequence:

>797_residues
MANDFSDATLEGEVIPDDRSLPAAPVLPPELYLLPLTEKPFFPAQTLPLLMNEAPWLSTVEAIGETPQHMVGLVVVKPDN
TDDVKRGDFQTVGTAVRIHHPVRADGKMQFIAEGVRRFRVVEWLSDTAPYRVRVDYPNETGKPESEEIRAYSIAIINTIK
ELLPLNPLYSEELKFFLNRFGPNEPSQLTDFAASLTTASKLELQDVLEAFSLKKRMEKVLVLLKKELDVARLQSQIRERV
DEKMSEQQREFFLRQQLKAIQKELGIAKDDKTAELDTFRERIAKLALPEQAKKRIDEEMHKLSMLETGSAEYTVTRNYLD
WLTVLPWGVHTQDKIDLERARRILDRDHDGLDDVKDRIIEFLAVGAMRGEMAGSILLLIGPPGVGKTSIGKSVAEALGRK
FFRFSVGGMRDEAEIKGHRRTYIGAMPGKFVQALKEAGSANPVIMLDEVDKIGASYQGDPASALLEVLDPEQNADFLDHY
LDVRFDLSKALFICTANDFSIPSALLDRMEVIRLSGYITAEKIDIAKHHLWPRVLERAGLKKNQLTITESALRHVIEGYA
REAGVRNLEKQLGRVARKAVVKILGGADTPIKIGVREIEAYLDKPVFLRERPLSGIGVVTGLAWTSMGGATLPVEATRVH
TLNRGFKLTGKLGEVMRESAEIAYSYVASHLKDYGADRSFFDTSFVHLHVPEGATPKDGPSAGVTMASALLSLAKNTKIA
RPLAMTGELTLTGQVLPVGGIREKVIAARRVGIGELILPEANRRDFDKLPEHIRAGLTVHFAKRYRDVADVIFGPRA

Sequences:

>Translated_797_residues
MANDFSDATLEGEVIPDDRSLPAAPVLPPELYLLPLTEKPFFPAQTLPLLMNEAPWLSTVEAIGETPQHMVGLVVVKPDN
TDDVKRGDFQTVGTAVRIHHPVRADGKMQFIAEGVRRFRVVEWLSDTAPYRVRVDYPNETGKPESEEIRAYSIAIINTIK
ELLPLNPLYSEELKFFLNRFGPNEPSQLTDFAASLTTASKLELQDVLEAFSLKKRMEKVLVLLKKELDVARLQSQIRERV
DEKMSEQQREFFLRQQLKAIQKELGIAKDDKTAELDTFRERIAKLALPEQAKKRIDEEMHKLSMLETGSAEYTVTRNYLD
WLTVLPWGVHTQDKIDLERARRILDRDHDGLDDVKDRIIEFLAVGAMRGEMAGSILLLIGPPGVGKTSIGKSVAEALGRK
FFRFSVGGMRDEAEIKGHRRTYIGAMPGKFVQALKEAGSANPVIMLDEVDKIGASYQGDPASALLEVLDPEQNADFLDHY
LDVRFDLSKALFICTANDFSIPSALLDRMEVIRLSGYITAEKIDIAKHHLWPRVLERAGLKKNQLTITESALRHVIEGYA
REAGVRNLEKQLGRVARKAVVKILGGADTPIKIGVREIEAYLDKPVFLRERPLSGIGVVTGLAWTSMGGATLPVEATRVH
TLNRGFKLTGKLGEVMRESAEIAYSYVASHLKDYGADRSFFDTSFVHLHVPEGATPKDGPSAGVTMASALLSLAKNTKIA
RPLAMTGELTLTGQVLPVGGIREKVIAARRVGIGELILPEANRRDFDKLPEHIRAGLTVHFAKRYRDVADVIFGPRA
>Mature_796_residues
ANDFSDATLEGEVIPDDRSLPAAPVLPPELYLLPLTEKPFFPAQTLPLLMNEAPWLSTVEAIGETPQHMVGLVVVKPDNT
DDVKRGDFQTVGTAVRIHHPVRADGKMQFIAEGVRRFRVVEWLSDTAPYRVRVDYPNETGKPESEEIRAYSIAIINTIKE
LLPLNPLYSEELKFFLNRFGPNEPSQLTDFAASLTTASKLELQDVLEAFSLKKRMEKVLVLLKKELDVARLQSQIRERVD
EKMSEQQREFFLRQQLKAIQKELGIAKDDKTAELDTFRERIAKLALPEQAKKRIDEEMHKLSMLETGSAEYTVTRNYLDW
LTVLPWGVHTQDKIDLERARRILDRDHDGLDDVKDRIIEFLAVGAMRGEMAGSILLLIGPPGVGKTSIGKSVAEALGRKF
FRFSVGGMRDEAEIKGHRRTYIGAMPGKFVQALKEAGSANPVIMLDEVDKIGASYQGDPASALLEVLDPEQNADFLDHYL
DVRFDLSKALFICTANDFSIPSALLDRMEVIRLSGYITAEKIDIAKHHLWPRVLERAGLKKNQLTITESALRHVIEGYAR
EAGVRNLEKQLGRVARKAVVKILGGADTPIKIGVREIEAYLDKPVFLRERPLSGIGVVTGLAWTSMGGATLPVEATRVHT
LNRGFKLTGKLGEVMRESAEIAYSYVASHLKDYGADRSFFDTSFVHLHVPEGATPKDGPSAGVTMASALLSLAKNTKIAR
PLAMTGELTLTGQVLPVGGIREKVIAARRVGIGELILPEANRRDFDKLPEHIRAGLTVHFAKRYRDVADVIFGPRA

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=663, Percent_Identity=49.9245852187029, Blast_Score=664, Evalue=0.0,
Organism=Homo sapiens, GI31377667, Length=839, Percent_Identity=36.3528009535161, Blast_Score=478, Evalue=1e-134,
Organism=Escherichia coli, GI1786643, Length=763, Percent_Identity=41.5465268676278, Blast_Score=582, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI17505831, Length=699, Percent_Identity=44.9213161659514, Blast_Score=594, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI17556486, Length=534, Percent_Identity=40.4494382022472, Blast_Score=427, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319449, Length=716, Percent_Identity=45.6703910614525, Blast_Score=625, Evalue=1e-179,
Organism=Drosophila melanogaster, GI221513036, Length=665, Percent_Identity=49.3233082706767, Blast_Score=650, Evalue=0.0,
Organism=Drosophila melanogaster, GI24666867, Length=665, Percent_Identity=49.3233082706767, Blast_Score=649, Evalue=0.0,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 88709; Mature: 88578

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANDFSDATLEGEVIPDDRSLPAAPVLPPELYLLPLTEKPFFPAQTLPLLMNEAPWLSTV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCHHHHH
EAIGETPQHMVGLVVVKPDNTDDVKRGDFQTVGTAVRIHHPVRADGKMQFIAEGVRRFRV
HHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHH
VEWLSDTAPYRVRVDYPNETGKPESEEIRAYSIAIINTIKELLPLNPLYSEELKFFLNRF
HHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
GPNEPSQLTDFAASLTTASKLELQDVLEAFSLKKRMEKVLVLLKKELDVARLQSQIRERV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
DEKMSEQQREFFLRQQLKAIQKELGIAKDDKTAELDTFRERIAKLALPEQAKKRIDEEMH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
KLSMLETGSAEYTVTRNYLDWLTVLPWGVHTQDKIDLERARRILDRDHDGLDDVKDRIIE
HHHHHCCCCCCEEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHH
FLAVGAMRGEMAGSILLLIGPPGVGKTSIGKSVAEALGRKFFRFSVGGMRDEAEIKGHRR
HHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCE
TYIGAMPGKFVQALKEAGSANPVIMLDEVDKIGASYQGDPASALLEVLDPEQNADFLDHY
EEEECCCHHHHHHHHHCCCCCCEEEEECHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHH
LDVRFDLSKALFICTANDFSIPSALLDRMEVIRLSGYITAEKIDIAKHHLWPRVLERAGL
HHHEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHCCC
KKNQLTITESALRHVIEGYAREAGVRNLEKQLGRVARKAVVKILGGADTPIKIGVREIEA
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
YLDKPVFLRERPLSGIGVVTGLAWTSMGGATLPVEATRVHTLNRGFKLTGKLGEVMRESA
HHCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEECHHHHHHHHHH
EIAYSYVASHLKDYGADRSFFDTSFVHLHVPEGATPKDGPSAGVTMASALLSLAKNTKIA
HHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
RPLAMTGELTLTGQVLPVGGIREKVIAARRVGIGELILPEANRRDFDKLPEHIRAGLTVH
CCEEECCCEEEEEEEEECCCHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHCCCHHH
FAKRYRDVADVIFGPRA
HHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ANDFSDATLEGEVIPDDRSLPAAPVLPPELYLLPLTEKPFFPAQTLPLLMNEAPWLSTV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCHHHHH
EAIGETPQHMVGLVVVKPDNTDDVKRGDFQTVGTAVRIHHPVRADGKMQFIAEGVRRFRV
HHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHH
VEWLSDTAPYRVRVDYPNETGKPESEEIRAYSIAIINTIKELLPLNPLYSEELKFFLNRF
HHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHC
GPNEPSQLTDFAASLTTASKLELQDVLEAFSLKKRMEKVLVLLKKELDVARLQSQIRERV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
DEKMSEQQREFFLRQQLKAIQKELGIAKDDKTAELDTFRERIAKLALPEQAKKRIDEEMH
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
KLSMLETGSAEYTVTRNYLDWLTVLPWGVHTQDKIDLERARRILDRDHDGLDDVKDRIIE
HHHHHCCCCCCEEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHH
FLAVGAMRGEMAGSILLLIGPPGVGKTSIGKSVAEALGRKFFRFSVGGMRDEAEIKGHRR
HHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCE
TYIGAMPGKFVQALKEAGSANPVIMLDEVDKIGASYQGDPASALLEVLDPEQNADFLDHY
EEEECCCHHHHHHHHHCCCCCCEEEEECHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHH
LDVRFDLSKALFICTANDFSIPSALLDRMEVIRLSGYITAEKIDIAKHHLWPRVLERAGL
HHHEEECCCEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHCCC
KKNQLTITESALRHVIEGYAREAGVRNLEKQLGRVARKAVVKILGGADTPIKIGVREIEA
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
YLDKPVFLRERPLSGIGVVTGLAWTSMGGATLPVEATRVHTLNRGFKLTGKLGEVMRESA
HHCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEEECHHHHHHHHHH
EIAYSYVASHLKDYGADRSFFDTSFVHLHVPEGATPKDGPSAGVTMASALLSLAKNTKIA
HHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
RPLAMTGELTLTGQVLPVGGIREKVIAARRVGIGELILPEANRRDFDKLPEHIRAGLTVH
CCEEECCCEEEEEEEEECCCHHHHHHHHHHCCCCCEECCCCCCCCHHHHHHHHHCCCHHH
FAKRYRDVADVIFGPRA
HHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA