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The map label for this gene is clpA [H]

Identifier: 74317255

GI number: 74317255

Start: 1297664

End: 1299916

Strand: Direct

Name: clpA [H]

Synonym: Tbd_1237

Alternate gene names: 74317255

Gene position: 1297664-1299916 (Clockwise)

Preceding gene: 74317254

Following gene: 74317256

Centisome position: 44.6

GC content: 64.27

Gene sequence:

>2253_bases
ATGATTGCCCAAGAACTTGAAGTCTCGCTGCACATGGCCTTCATGGATGCGCGGCAGAAGCGCCACGAGTTCATTTCGGT
GGAACATCTGCTGATGGCGATGCTCGACAACCCCTCCGCTGCGGAAGTGTTGCGTGCCTGCGGCGCCAACATCGACACCA
TGCGCGAGCAGCTCGGAAAATTCATCGACGAGCACACGCCGCGCGTCGGCGGCGACGGCGAAGTCGATACCCAGCCCACG
CTCGGTTTCCAACGCGTGATCCAGCGCGCGATCCTGCACGTCCAGTCCTCGGGCAAGAAGGAAGTGACCGGAGCGAACGT
GCTCGTTGCGGTGTTCGGTGAAAAGGATTCGCACGCCGTCTACTTCCTGACCCAGCAGGGCGTCACGCGGCTCGATATCG
TCAATTTCATCTCCCACGGCATCACGAAGACGCCGCAGAGCGAGCCGACCCGTCCGGAGGACGCGACCGAGGCGAGCGCC
GAAGCCGTCTCCAACGCGCCGCTCGACAGTTTTGCGCAGAACCTCAACGCCCAGGCGCTGGCAGGCCGCATCGACCCGCT
GATCGGGCGCGATCCCGAACTCGAGCGCGTCGTCCAGACTCTGTGCCGCCGGCGCAAGAACAATCCTCTGCTCGTTGGCG
AGGCCGGCGTCGGCAAGACCGCGATCGCGGAAGGCCTGGCGCGCCGTATCGTCGAAGGCAACGTTCCCGACATCCTCGCG
CAGAGCACGGTCTACGCCCTCGACATGGGTGCCTTGCTCGCCGGCACGAAATACCGCGGTGATTTCGAGCAGCGCTTGAA
GGGCGTGCTGAAGCAGTTGGCGGACAATCCGAAGGCGATCCTGTTCATCGACGAAATTCATACCCTGATCGGCGCCGGCG
CCGCGTCCGGCGGCACGCTCGACGCGTCCAACCTGTTGAAGCCCGCGCTCTCGTCGGGGCAGCTCCGCTGCATCGGCGCG
ACGACCTATACCGAATACCGCGGGATCTTCGAGAAGGACCACGCGCTGTCGCGGCGCTTCCAGAAGGTCGACGTCCCCGA
GCCGTCGGTCAACGAGACGGTCGCAATCCTGCGTGGTCTCAAGTCGCGCTTCGAGGACCACCATGGCGTCAAATACACCG
CGGCGGCCTTGAGCACGGCGGCGCAACTGGCGGCACGCTACATCAACGACCGCCATCTGCCCGACAAGGCGATCGACGTG
ATCGACGAGGCCGGCGCGGCGCAGCGGATTCTGCCGAAGTCGAAGCAGCGCCGCGTGATCACGCCACGCGAGATCGAAGA
GATCATTTCCAAGATTGCGCGCATCCCGCCGAAGACCGTGTCGTCGGACGACAAGAATTCGTTGAAGACGCTCGATCGCG
ACCTCAAGGCAGTCGTCTATGGCCAGGACGCGGCGATCGACGCGCTGTCGACCGCGATCAAGATGTCGCGCAGCGGCCTG
GGCAATCCGCAGAAGCCGATCGGCAACTTCCTGTTCTCCGGCCCGACCGGTGTCGGCAAGACCGAAGTGGCCCGCCAGCT
CGCTTATGTGCTCGGCGTCGAGCTGATCCGCTTCGACATGTCCGAATACATGGAACGGCACGCCGTCTCGCGCCTGATCG
GCGCCCCGCCCGGCTACGTCGGTTTCGACCAGGGCGGGCTGTTGACGGAAGCGGTGACGAAACATCCCTACGCCGTTGTT
TTGCTGGATGAAGTCGAGAAGGCGCATCCGGATATCTTCAACGTGCTCCTCCAGGTGATGGATCACGGCACCCTGACCGA
CACCAACGGCCGCAAGGCGGACTTCCGCAACGTCGTGCTGATCATGACGACGAACGCCGGCGCAGAGATGCTGAACAAGG
CGACCATCGGCTTTGCGGGCGCGCGCGAAAGCGGCGACGAGATGGGCGAGATCAAGCGCATGTTCACGCCCGAATTCCGC
AACCGCCTCGACGCGATCATTCCGTTCGCGCCCTTGAGCGAGCCGGTCATCCTCCAGGTCGTCGAGAAGTTCCTGATGCA
GCTCGAGGAGCAGCTGCACGAGAAGAAGGTCGAGGCGGTCTTCACGGACGCGCTCAAGGCCTATCTGGCGAAGCATGGCT
TCGATCCATCGATGGGCGCGCGGCCGATGGCACGCCTGATCCAGGACACGATCCGCAAGGCGCTCGCCGATGAGCTGCTG
TTCGGCCGACTCGCGACCGGTGGACGCGTCACGATCGACGTCGGCGCCGACGACCGGGTCGCGCTCGAGTTCGAGGAGGC
CGTGCCAGCTTAG

Upstream 100 bases:

>100_bases
TGTGTTCACGCGGGATATCGCGCATACCAAGGTCGAGCAGGTTGTGGATTTCGCGCGGCAGCATCAGCACCCGCTGCAGT
GCACGATGGAGGAAACTTAG

Downstream 100 bases:

>100_bases
TCGGGCAAGGGCCGGGTAAAGATTCCGCGTCGGTGGCCGTTAGCCGTGGCAGCGGCAGAGCCCGACCCGGCTCCTGGCTG
ATCGTGATCAGGGAGACTGT

Product: ATP-dependent Clp protease ATP-binding subunit ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 750; Mature: 750

Protein sequence:

>750_residues
MIAQELEVSLHMAFMDARQKRHEFISVEHLLMAMLDNPSAAEVLRACGANIDTMREQLGKFIDEHTPRVGGDGEVDTQPT
LGFQRVIQRAILHVQSSGKKEVTGANVLVAVFGEKDSHAVYFLTQQGVTRLDIVNFISHGITKTPQSEPTRPEDATEASA
EAVSNAPLDSFAQNLNAQALAGRIDPLIGRDPELERVVQTLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVEGNVPDILA
QSTVYALDMGALLAGTKYRGDFEQRLKGVLKQLADNPKAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGQLRCIGA
TTYTEYRGIFEKDHALSRRFQKVDVPEPSVNETVAILRGLKSRFEDHHGVKYTAAALSTAAQLAARYINDRHLPDKAIDV
IDEAGAAQRILPKSKQRRVITPREIEEIISKIARIPPKTVSSDDKNSLKTLDRDLKAVVYGQDAAIDALSTAIKMSRSGL
GNPQKPIGNFLFSGPTGVGKTEVARQLAYVLGVELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKHPYAVV
LLDEVEKAHPDIFNVLLQVMDHGTLTDTNGRKADFRNVVLIMTTNAGAEMLNKATIGFAGARESGDEMGEIKRMFTPEFR
NRLDAIIPFAPLSEPVILQVVEKFLMQLEEQLHEKKVEAVFTDALKAYLAKHGFDPSMGARPMARLIQDTIRKALADELL
FGRLATGGRVTIDVGADDRVALEFEEAVPA

Sequences:

>Translated_750_residues
MIAQELEVSLHMAFMDARQKRHEFISVEHLLMAMLDNPSAAEVLRACGANIDTMREQLGKFIDEHTPRVGGDGEVDTQPT
LGFQRVIQRAILHVQSSGKKEVTGANVLVAVFGEKDSHAVYFLTQQGVTRLDIVNFISHGITKTPQSEPTRPEDATEASA
EAVSNAPLDSFAQNLNAQALAGRIDPLIGRDPELERVVQTLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVEGNVPDILA
QSTVYALDMGALLAGTKYRGDFEQRLKGVLKQLADNPKAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGQLRCIGA
TTYTEYRGIFEKDHALSRRFQKVDVPEPSVNETVAILRGLKSRFEDHHGVKYTAAALSTAAQLAARYINDRHLPDKAIDV
IDEAGAAQRILPKSKQRRVITPREIEEIISKIARIPPKTVSSDDKNSLKTLDRDLKAVVYGQDAAIDALSTAIKMSRSGL
GNPQKPIGNFLFSGPTGVGKTEVARQLAYVLGVELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKHPYAVV
LLDEVEKAHPDIFNVLLQVMDHGTLTDTNGRKADFRNVVLIMTTNAGAEMLNKATIGFAGARESGDEMGEIKRMFTPEFR
NRLDAIIPFAPLSEPVILQVVEKFLMQLEEQLHEKKVEAVFTDALKAYLAKHGFDPSMGARPMARLIQDTIRKALADELL
FGRLATGGRVTIDVGADDRVALEFEEAVPA
>Mature_750_residues
MIAQELEVSLHMAFMDARQKRHEFISVEHLLMAMLDNPSAAEVLRACGANIDTMREQLGKFIDEHTPRVGGDGEVDTQPT
LGFQRVIQRAILHVQSSGKKEVTGANVLVAVFGEKDSHAVYFLTQQGVTRLDIVNFISHGITKTPQSEPTRPEDATEASA
EAVSNAPLDSFAQNLNAQALAGRIDPLIGRDPELERVVQTLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVEGNVPDILA
QSTVYALDMGALLAGTKYRGDFEQRLKGVLKQLADNPKAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGQLRCIGA
TTYTEYRGIFEKDHALSRRFQKVDVPEPSVNETVAILRGLKSRFEDHHGVKYTAAALSTAAQLAARYINDRHLPDKAIDV
IDEAGAAQRILPKSKQRRVITPREIEEIISKIARIPPKTVSSDDKNSLKTLDRDLKAVVYGQDAAIDALSTAIKMSRSGL
GNPQKPIGNFLFSGPTGVGKTEVARQLAYVLGVELIRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKHPYAVV
LLDEVEKAHPDIFNVLLQVMDHGTLTDTNGRKADFRNVVLIMTTNAGAEMLNKATIGFAGARESGDEMGEIKRMFTPEFR
NRLDAIIPFAPLSEPVILQVVEKFLMQLEEQLHEKKVEAVFTDALKAYLAKHGFDPSMGARPMARLIQDTIRKALADELL
FGRLATGGRVTIDVGADDRVALEFEEAVPA

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=331, Percent_Identity=30.5135951661631, Blast_Score=156, Evalue=7e-38,
Organism=Escherichia coli, GI1787109, Length=733, Percent_Identity=61.5279672578445, Blast_Score=951, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=437, Percent_Identity=42.79176201373, Blast_Score=306, Evalue=4e-84,
Organism=Saccharomyces cerevisiae, GI6320464, Length=269, Percent_Identity=54.6468401486989, Blast_Score=280, Evalue=6e-76,
Organism=Saccharomyces cerevisiae, GI6323002, Length=258, Percent_Identity=52.3255813953488, Blast_Score=265, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 81833; Mature: 81833

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAQELEVSLHMAFMDARQKRHEFISVEHLLMAMLDNPSAAEVLRACGANIDTMREQLGK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHH
FIDEHTPRVGGDGEVDTQPTLGFQRVIQRAILHVQSSGKKEVTGANVLVAVFGEKDSHAV
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEE
YFLTQQGVTRLDIVNFISHGITKTPQSEPTRPEDATEASAEAVSNAPLDSFAQNLNAQAL
EEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHCCCHHHH
AGRIDPLIGRDPELERVVQTLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVEGNVPDILA
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHH
QSTVYALDMGALLAGTKYRGDFEQRLKGVLKQLADNPKAILFIDEIHTLIGAGAASGGTL
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCCC
DASNLLKPALSSGQLRCIGATTYTEYRGIFEKDHALSRRFQKVDVPEPSVNETVAILRGL
CHHHHHHHHHCCCCEEEEECCHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
KSRFEDHHGVKYTAAALSTAAQLAARYINDRHLPDKAIDVIDEAGAAQRILPKSKQRRVI
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHCCCCCCCCCC
TPREIEEIISKIARIPPKTVSSDDKNSLKTLDRDLKAVVYGQDAAIDALSTAIKMSRSGL
CHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHCCC
GNPQKPIGNFLFSGPTGVGKTEVARQLAYVLGVELIRFDMSEYMERHAVSRLIGAPPGYV
CCCCCHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GFDQGGLLTEAVTKHPYAVVLLDEVEKAHPDIFNVLLQVMDHGTLTDTNGRKADFRNVVL
CCCCCCHHHHHHHCCCEEEEEEHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEE
IMTTNAGAEMLNKATIGFAGARESGDEMGEIKRMFTPEFRNRLDAIIPFAPLSEPVILQV
EEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHH
VEKFLMQLEEQLHEKKVEAVFTDALKAYLAKHGFDPSMGARPMARLIQDTIRKALADELL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FGRLATGGRVTIDVGADDRVALEFEEAVPA
HHHHCCCCEEEEEECCCCCEEEEECCCCCC
>Mature Secondary Structure
MIAQELEVSLHMAFMDARQKRHEFISVEHLLMAMLDNPSAAEVLRACGANIDTMREQLGK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHH
FIDEHTPRVGGDGEVDTQPTLGFQRVIQRAILHVQSSGKKEVTGANVLVAVFGEKDSHAV
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCEE
YFLTQQGVTRLDIVNFISHGITKTPQSEPTRPEDATEASAEAVSNAPLDSFAQNLNAQAL
EEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHCCCHHHH
AGRIDPLIGRDPELERVVQTLCRRRKNNPLLVGEAGVGKTAIAEGLARRIVEGNVPDILA
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHH
QSTVYALDMGALLAGTKYRGDFEQRLKGVLKQLADNPKAILFIDEIHTLIGAGAASGGTL
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCCC
DASNLLKPALSSGQLRCIGATTYTEYRGIFEKDHALSRRFQKVDVPEPSVNETVAILRGL
CHHHHHHHHHCCCCEEEEECCHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
KSRFEDHHGVKYTAAALSTAAQLAARYINDRHLPDKAIDVIDEAGAAQRILPKSKQRRVI
HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHCCCCCCCCCC
TPREIEEIISKIARIPPKTVSSDDKNSLKTLDRDLKAVVYGQDAAIDALSTAIKMSRSGL
CHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHCCC
GNPQKPIGNFLFSGPTGVGKTEVARQLAYVLGVELIRFDMSEYMERHAVSRLIGAPPGYV
CCCCCHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GFDQGGLLTEAVTKHPYAVVLLDEVEKAHPDIFNVLLQVMDHGTLTDTNGRKADFRNVVL
CCCCCCHHHHHHHCCCEEEEEEHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEE
IMTTNAGAEMLNKATIGFAGARESGDEMGEIKRMFTPEFRNRLDAIIPFAPLSEPVILQV
EEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHH
VEKFLMQLEEQLHEKKVEAVFTDALKAYLAKHGFDPSMGARPMARLIQDTIRKALADELL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
FGRLATGGRVTIDVGADDRVALEFEEAVPA
HHHHCCCCEEEEEECCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]