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The map label for this gene is sdhA [H]

Identifier: 74317202

GI number: 74317202

Start: 1243085

End: 1244839

Strand: Direct

Name: sdhA [H]

Synonym: Tbd_1184

Alternate gene names: 74317202

Gene position: 1243085-1244839 (Clockwise)

Preceding gene: 74317201

Following gene: 74317203

Centisome position: 42.72

GC content: 69.74

Gene sequence:

>1755_bases
GTGAACCGGCGCCGCTTCGACGCGCTGATCGTCGGCGGCGGCGGTGCCGGCCTGCGCGCCGCGCTGCAGCTTGCGCGCTC
GGACCACAAGGTCGCCGTGGTGTCGAAGGTATTCCCGACACGCTCGCACACCGTTTCTGCACAGGGCGGCATCACGGCGG
CGCTGGCGAACGTCGACGACGACCGCTGGGAATGGCACATGTACGACACGGTCAAGGGCGGCGACTGGCTGGGCGACCAG
GATGCGATCGAGTTCATGTGCCGCGAGGCGGCGTCGGCCGTCTACGAACTCGAACACATGGGGCTGCCGTTCTCGCGGCT
CGACGATGGCAGGATCTACCAGCGGCCCTTCGGCGGGCAGTCGAAAAACTTCGGCGGCGAGCAGGCGACGCGCACCTGCG
CCGCGGCCGACCGCACCGGCCATGCGCTGCTGCACACGCTCTACCAGCAGAACATCGCGCACCGCACGCAATTCTTCGAC
GAATACTTCGCGCTCGACCTCGTGCGCGACGACGCGGGCTACTGCCTCGGCGTGACCGCGCTTTCCATCGAAACCGGCGA
GCCGGTGTTGATCGAGGCGCGCACGACGCTGCTCGCGACGGGCGGGGCAGGGCGCATTTTCGGCAACACCAGCAACGCGA
TGATCAACACCGGCGACGGCCTCGGCATGGTCCTGCGCGCCGGCCTGCCGCTGCAGGACATGGAGTTCTGGCAGTTCCAC
CCGACCGGGATCGCCGGCGTCGGCAGCCTTATTACCGAAGGCGCGCGTGGCGAGGGCGGCTACCTGCTGAACCGTCACGG
CGAGCGCTTCATGGAGCGCTACGCACCGCACGCCCGGGACCTCGCCGGCCGCGACGTGGTCGCCCGCGCGATCGCGATCG
AGATCGCGGAAGGGCGCGGCTGCGGGCCCCGGGCGGACTACGTCGAGCTCAAGATCGACCAGCTCGGCGAACAGACCATT
TCGGAGAAACTGCCGGGCATCCGCGAACTCGCGATCCGCTTCGCCGGCGTCGACCCGGTCGAGAAGCCGATTCCAGTCGC
ACCGACGGCGCACTACATGATGGGCGGCATTCCGACCGACCTGCATGGCCAGGTCGTCGCCCCCGCGCGCTTCGGCCCCG
AGGAGCCGGTGCCCGGCCTCTATGCCGTCGGCGAGTGTGCCTGCGTGTCGGTGCACGGCGCGAACCGCCTCGGCGGCAAC
TCGCTGCTCGACCTCATCGTCTTCGGCCGCGCCGCGGGCCGGCACATGCTCGACTACCTGCGCGACAACCCCTACCCGCG
CGCGCTGCCCGAGAATGCCGCCGAAGCGAGCCTGCAGCGCCTCGCGCGCTGGGAGCGCCCGGGCGGCGAACGCGTCGCCG
CGATCACCGACGACCTGCGGCGCATGATGGGCGCGCACGCCGGCGTTTTCCGCACCGAGACGAGCCTGCGCGAAGGCCTG
CGCAAACTCGACCTGCTCGAAGCGCGGCTCGCGCACGCCGGCCTGCAGGACACCAGCCGCATCTTCAACACGGCGCGCAT
CGAAGCGCTCGAGCTGGAAAACCTGATCGGGGTCGCGCGCGCGACCCTGGTCTCGGCGATCCACCGCACCGAGAGCCGCG
GCGCCCATACGCGCGAGGACTTCCCGCGACGCGACGACGAGAACTGGCTCAGGCACACCCTCTATTCGCGCGAGGGGGAT
CAGGTGGATAGCAAGCCGGTGCGCTTGAAGCCGTTGACCGTGGAGTCGATACGGCCGAAGGAGAGGGTGTATTGA

Upstream 100 bases:

>100_bases
GACTGCGCCTGACGATATATATGGCCGTGATCGGCACCCTGGCGACGAGTGTCGCGTGGCTCGCCGCGATCCTGTTCGGC
CCGGTCTTCGGGCGCGCGGC

Downstream 100 bases:

>100_bases
TGGTTCAGGGGCGGGTTAAGCAACGGGCGAAACGCGAAGCCATTGCCCATACTGGACGGCATTCACGGCGTTGGCGTAGG
ACGCCGATATGAAATTCCGC

Product: succinate dehydrogenase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MNRRRFDALIVGGGGAGLRAALQLARSDHKVAVVSKVFPTRSHTVSAQGGITAALANVDDDRWEWHMYDTVKGGDWLGDQ
DAIEFMCREAASAVYELEHMGLPFSRLDDGRIYQRPFGGQSKNFGGEQATRTCAAADRTGHALLHTLYQQNIAHRTQFFD
EYFALDLVRDDAGYCLGVTALSIETGEPVLIEARTTLLATGGAGRIFGNTSNAMINTGDGLGMVLRAGLPLQDMEFWQFH
PTGIAGVGSLITEGARGEGGYLLNRHGERFMERYAPHARDLAGRDVVARAIAIEIAEGRGCGPRADYVELKIDQLGEQTI
SEKLPGIRELAIRFAGVDPVEKPIPVAPTAHYMMGGIPTDLHGQVVAPARFGPEEPVPGLYAVGECACVSVHGANRLGGN
SLLDLIVFGRAAGRHMLDYLRDNPYPRALPENAAEASLQRLARWERPGGERVAAITDDLRRMMGAHAGVFRTETSLREGL
RKLDLLEARLAHAGLQDTSRIFNTARIEALELENLIGVARATLVSAIHRTESRGAHTREDFPRRDDENWLRHTLYSREGD
QVDSKPVRLKPLTVESIRPKERVY

Sequences:

>Translated_584_residues
MNRRRFDALIVGGGGAGLRAALQLARSDHKVAVVSKVFPTRSHTVSAQGGITAALANVDDDRWEWHMYDTVKGGDWLGDQ
DAIEFMCREAASAVYELEHMGLPFSRLDDGRIYQRPFGGQSKNFGGEQATRTCAAADRTGHALLHTLYQQNIAHRTQFFD
EYFALDLVRDDAGYCLGVTALSIETGEPVLIEARTTLLATGGAGRIFGNTSNAMINTGDGLGMVLRAGLPLQDMEFWQFH
PTGIAGVGSLITEGARGEGGYLLNRHGERFMERYAPHARDLAGRDVVARAIAIEIAEGRGCGPRADYVELKIDQLGEQTI
SEKLPGIRELAIRFAGVDPVEKPIPVAPTAHYMMGGIPTDLHGQVVAPARFGPEEPVPGLYAVGECACVSVHGANRLGGN
SLLDLIVFGRAAGRHMLDYLRDNPYPRALPENAAEASLQRLARWERPGGERVAAITDDLRRMMGAHAGVFRTETSLREGL
RKLDLLEARLAHAGLQDTSRIFNTARIEALELENLIGVARATLVSAIHRTESRGAHTREDFPRRDDENWLRHTLYSREGD
QVDSKPVRLKPLTVESIRPKERVY
>Mature_584_residues
MNRRRFDALIVGGGGAGLRAALQLARSDHKVAVVSKVFPTRSHTVSAQGGITAALANVDDDRWEWHMYDTVKGGDWLGDQ
DAIEFMCREAASAVYELEHMGLPFSRLDDGRIYQRPFGGQSKNFGGEQATRTCAAADRTGHALLHTLYQQNIAHRTQFFD
EYFALDLVRDDAGYCLGVTALSIETGEPVLIEARTTLLATGGAGRIFGNTSNAMINTGDGLGMVLRAGLPLQDMEFWQFH
PTGIAGVGSLITEGARGEGGYLLNRHGERFMERYAPHARDLAGRDVVARAIAIEIAEGRGCGPRADYVELKIDQLGEQTI
SEKLPGIRELAIRFAGVDPVEKPIPVAPTAHYMMGGIPTDLHGQVVAPARFGPEEPVPGLYAVGECACVSVHGANRLGGN
SLLDLIVFGRAAGRHMLDYLRDNPYPRALPENAAEASLQRLARWERPGGERVAAITDDLRRMMGAHAGVFRTETSLREGL
RKLDLLEARLAHAGLQDTSRIFNTARIEALELENLIGVARATLVSAIHRTESRGAHTREDFPRRDDENWLRHTLYSREGD
QVDSKPVRLKPLTVESIRPKERVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=550, Percent_Identity=52, Blast_Score=550, Evalue=1e-156,
Organism=Escherichia coli, GI1786942, Length=583, Percent_Identity=61.9210977701544, Blast_Score=689, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=574, Percent_Identity=41.8118466898955, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1788928, Length=558, Percent_Identity=33.3333333333333, Blast_Score=229, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17550100, Length=526, Percent_Identity=53.4220532319392, Blast_Score=554, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI17505833, Length=528, Percent_Identity=52.6515151515151, Blast_Score=548, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6322701, Length=568, Percent_Identity=54.0492957746479, Blast_Score=585, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6322416, Length=568, Percent_Identity=53.6971830985916, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI17137288, Length=568, Percent_Identity=53.3450704225352, Blast_Score=569, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24655642, Length=568, Percent_Identity=53.3450704225352, Blast_Score=569, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24655647, Length=568, Percent_Identity=53.3450704225352, Blast_Score=569, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24663005, Length=610, Percent_Identity=47.5409836065574, Blast_Score=524, Evalue=1e-149,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64038; Mature: 64038

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRRFDALIVGGGGAGLRAALQLARSDHKVAVVSKVFPTRSHTVSAQGGITAALANVDD
CCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEEEHHCCCCCCEEECCCCCEEEEECCCC
DRWEWHMYDTVKGGDWLGDQDAIEFMCREAASAVYELEHMGLPFSRLDDGRIYQRPFGGQ
CCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEECCCCCC
SKNFGGEQATRTCAAADRTGHALLHTLYQQNIAHRTQFFDEYFALDLVRDDAGYCLGVTA
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEE
LSIETGEPVLIEARTTLLATGGAGRIFGNTSNAMINTGDGLGMVLRAGLPLQDMEFWQFH
EEEECCCEEEEEECEEEEEECCCCEEECCCCCCEEECCCCCHHHHHCCCCCCCCCCEEEC
PTGIAGVGSLITEGARGEGGYLLNRHGERFMERYAPHARDLAGRDVVARAIAIEIAEGRG
CCCHHHHHHHHHCCCCCCCCEEECHHHHHHHHHHCCHHHHHCCHHHHHHHHEEEEECCCC
CGPRADYVELKIDQLGEQTISEKLPGIRELAIRFAGVDPVEKPIPVAPTAHYMMGGIPTD
CCCCCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCC
LHGQVVAPARFGPEEPVPGLYAVGECACVSVHGANRLGGNSLLDLIVFGRAAGRHMLDYL
CCCCEEECCCCCCCCCCCCEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RDNPYPRALPENAAEASLQRLARWERPGGERVAAITDDLRRMMGAHAGVFRTETSLREGL
HCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHCCCCHHCCHHHHHHHH
RKLDLLEARLAHAGLQDTSRIFNTARIEALELENLIGVARATLVSAIHRTESRGAHTRED
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHC
FPRRDDENWLRHTLYSREGDQVDSKPVRLKPLTVESIRPKERVY
CCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCHHCCCCHHCCC
>Mature Secondary Structure
MNRRRFDALIVGGGGAGLRAALQLARSDHKVAVVSKVFPTRSHTVSAQGGITAALANVDD
CCCCEEEEEEECCCCHHHHHHHHHHHCCCCEEEEEHHCCCCCCEEECCCCCEEEEECCCC
DRWEWHMYDTVKGGDWLGDQDAIEFMCREAASAVYELEHMGLPFSRLDDGRIYQRPFGGQ
CCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCEEECCCCCC
SKNFGGEQATRTCAAADRTGHALLHTLYQQNIAHRTQFFDEYFALDLVRDDAGYCLGVTA
CCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEEEEE
LSIETGEPVLIEARTTLLATGGAGRIFGNTSNAMINTGDGLGMVLRAGLPLQDMEFWQFH
EEEECCCEEEEEECEEEEEECCCCEEECCCCCCEEECCCCCHHHHHCCCCCCCCCCEEEC
PTGIAGVGSLITEGARGEGGYLLNRHGERFMERYAPHARDLAGRDVVARAIAIEIAEGRG
CCCHHHHHHHHHCCCCCCCCEEECHHHHHHHHHHCCHHHHHCCHHHHHHHHEEEEECCCC
CGPRADYVELKIDQLGEQTISEKLPGIRELAIRFAGVDPVEKPIPVAPTAHYMMGGIPTD
CCCCCCEEEEEHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCC
LHGQVVAPARFGPEEPVPGLYAVGECACVSVHGANRLGGNSLLDLIVFGRAAGRHMLDYL
CCCCEEECCCCCCCCCCCCEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
RDNPYPRALPENAAEASLQRLARWERPGGERVAAITDDLRRMMGAHAGVFRTETSLREGL
HCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHCCCCHHCCHHHHHHHH
RKLDLLEARLAHAGLQDTSRIFNTARIEALELENLIGVARATLVSAIHRTESRGAHTRED
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHC
FPRRDDENWLRHTLYSREGDQVDSKPVRLKPLTVESIRPKERVY
CCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCCHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7698664; 12704232 [H]