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The map label for this gene is nuoI

Identifier: 74317168

GI number: 74317168

Start: 1204985

End: 1205473

Strand: Direct

Name: nuoI

Synonym: Tbd_1150

Alternate gene names: 74317168

Gene position: 1204985-1205473 (Clockwise)

Preceding gene: 74317167

Following gene: 74317169

Centisome position: 41.41

GC content: 64.21

Gene sequence:

>489_bases
ATGAGACGGATCACCCATTTCTTCGGCAGCCTGTTCCTCGTCGAGCTTCTGCGCGGCATGATGCTGACCGGGCGCCATCT
GTTCGCGCGCAAGGTCACGGTGCAGTTTCCCGAGGAAAAAACGCCACAGTCGCCGCGTTTCCGCGGCCTCCACGCGCTGC
GACGCTATCCCAACGGCGAAGAGCGCTGCATCGCGTGCAAGCTCTGCGAGGCCGTGTGCCCGGCGCTCGCGATCACGATC
GACTCCGAGCAGCGCGCCGACGGCACGCGCCGCACGACGCGCTACGACATCGATCTGACGAAATGCATCTTCTGCGGGTT
CTGCGAAGAGTCCTGCCCGGTCGACTCCATCGTCGAGACGCGCATTCTCGAATACCACGGCGAGCAGCGCGGCGACCTCA
TCTACACCAAGCCGATGCTGCTCGCGATCGGCGACAAGTACGAGGCGCAGATCGCGCAGGACCGAGCCCAGGACGCTAAG
TATCGGTAG

Upstream 100 bases:

>100_bases
CTCGGCTGGAAGGTCTTCATCCCGATCACCATTGTCTGGATCGTCTTCGTCGGCGGCATGATGCAGACGCCCTACGGTCA
CCTTTTCCATTGAGCGCCCG

Downstream 100 bases:

>100_bases
AGCAGTATCCAGGCGCTGGATACGCGATTTAGGGGTGGCGCGCTGCGCGCCACTTGATTGAAAACAAACGAAACGGGAGG
CAGGCAAACGGATAACTTCG

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MRRITHFFGSLFLVELLRGMMLTGRHLFARKVTVQFPEEKTPQSPRFRGLHALRRYPNGEERCIACKLCEAVCPALAITI
DSEQRADGTRRTTRYDIDLTKCIFCGFCEESCPVDSIVETRILEYHGEQRGDLIYTKPMLLAIGDKYEAQIAQDRAQDAK
YR

Sequences:

>Translated_162_residues
MRRITHFFGSLFLVELLRGMMLTGRHLFARKVTVQFPEEKTPQSPRFRGLHALRRYPNGEERCIACKLCEAVCPALAITI
DSEQRADGTRRTTRYDIDLTKCIFCGFCEESCPVDSIVETRILEYHGEQRGDLIYTKPMLLAIGDKYEAQIAQDRAQDAK
YR
>Mature_162_residues
MRRITHFFGSLFLVELLRGMMLTGRHLFARKVTVQFPEEKTPQSPRFRGLHALRRYPNGEERCIACKLCEAVCPALAITI
DSEQRADGTRRTTRYDIDLTKCIFCGFCEESCPVDSIVETRILEYHGEQRGDLIYTKPMLLAIGDKYEAQIAQDRAQDAK
YR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains

Homologues:

Organism=Homo sapiens, GI4505371, Length=153, Percent_Identity=60.7843137254902, Blast_Score=198, Evalue=2e-51,
Organism=Escherichia coli, GI1788617, Length=128, Percent_Identity=40.625, Blast_Score=107, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17555194, Length=159, Percent_Identity=54.0880503144654, Blast_Score=187, Evalue=2e-48,
Organism=Drosophila melanogaster, GI17864306, Length=154, Percent_Identity=60.3896103896104, Blast_Score=202, Evalue=7e-53,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NUOI_THIDA (Q3SJP9)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314908.1
- ProteinModelPortal:   Q3SJP9
- SMR:   Q3SJP9
- STRING:   Q3SJP9
- GeneID:   3673222
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1150
- NMPDR:   fig|292415.3.peg.1150
- eggNOG:   COG1143
- HOGENOM:   HBG724359
- OMA:   NKAADAP
- PhylomeDB:   Q3SJP9
- ProtClustDB:   PRK05888
- BioCyc:   TDEN292415:TBD_1150-MONOMER
- HAMAP:   MF_01351
- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226
- Gene3D:   G3DSA:1.10.1060.10
- TIGRFAMs:   TIGR01971

Pfam domain/function: PF00037 Fer4

EC number: =1.6.99.5

Molecular weight: Translated: 18695; Mature: 18695

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00198 4FE4S_FER_1; PS51379 4FE4S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
7.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRITHFFGSLFLVELLRGMMLTGRHLFARKVTVQFPEEKTPQSPRFRGLHALRRYPNGE
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEEEECCCCCCCCCCCHHHHHHHHCCCCCC
ERCIACKLCEAVCPALAITIDSEQRADGTRRTTRYDIDLTKCIFCGFCEESCPVDSIVET
HHHHHHHHHHHHHHHEEEEECCHHCCCCCCCCEEECCHHHHHHHHHCCCCCCCHHHHHHH
RILEYHGEQRGDLIYTKPMLLAIGDKYEAQIAQDRAQDAKYR
HHHHHCCCCCCCEEEECCEEEEECCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRRITHFFGSLFLVELLRGMMLTGRHLFARKVTVQFPEEKTPQSPRFRGLHALRRYPNGE
CCHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEEEECCCCCCCCCCCHHHHHHHHCCCCCC
ERCIACKLCEAVCPALAITIDSEQRADGTRRTTRYDIDLTKCIFCGFCEESCPVDSIVET
HHHHHHHHHHHHHHHEEEEECCHHCCCCCCCCEEECCHHHHHHHHHCCCCCCCHHHHHHH
RILEYHGEQRGDLIYTKPMLLAIGDKYEAQIAQDRAQDAKYR
HHHHHCCCCCCCEEEECCEEEEECCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA