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The map label for this gene is nuoH

Identifier: 74317167

GI number: 74317167

Start: 1203946

End: 1204977

Strand: Direct

Name: nuoH

Synonym: Tbd_1149

Alternate gene names: 74317167

Gene position: 1203946-1204977 (Clockwise)

Preceding gene: 74317166

Following gene: 74317168

Centisome position: 41.38

GC content: 63.08

Gene sequence:

>1032_bases
ATGGAGGCGGGTATCGTGGAGGCCGCGGGAATGGATTGGGAGGCGTTCCAGACCGTCGCATGGACGCTGGTCAAGATCAT
GGCGCTGGTCGTGCCGCTGATGCTCGGCGTCGCGTATCTGACCTATGCCGAGCGCAAGATCATCGGCTGGATGCAGGTCC
GGATTGGCCCCAACCGCGTCGGTTTCCAGGGTCTTCTGCAGCCGATCGCCGACGCCGTGAAGCTGCTGATGAAGGAAATC
ATCATTCCTTCCGGCGCCAGCCGCGCGCTTTTCATCCTCGGCCCGATCCTCGCTATCGCGCCGGCGCTCGCGGCTTGGGC
GGTCATCCCGTTCAGCGACGGGCTCGTTCTCGCCGACATCAACGCGGGACTGCTCTACGTGATGGCGATCACGTCGATGG
GCGTCTATGGCGTGATCATCGCGGGCTGGGCATCCAACTCGAAGTACGCATTCCTCGGCGCGATGCGCTCGGCGGCGCAG
ATCGTGTCCTACGAGATCGCGATGGGCTTCGCGCTCGTCGGCGTATTGATGGCCTCGCAGTCGCTCAATCTGAGCGCGAT
CGTGCAGGGCCAGGCCGGCGGCATCCAGCAGTGGTATCTGTGGCCATTGTTCCCGCTTTTCGTCGTCTATCTCGTCGCCG
GCGTCGCCGAGACCAACCGCGCGCCGTTCGACGTCGCGGAGGGCGAGTCCGAAATCGTCGCCGGCTTCCACGTCGAATAC
TCGGGCATGGCTTTCGCCGTGTTCTTCCTTGCGGAATACGCCAACATGATCCTGGTCGCCGCGCTGACGACGCTCATGTT
CCTCGGCGGCTGGCTGTCGCCGGTCGCCTTCCTGCCGGACGGCATCGTCTGGTGGTTGCTGAAGACCGGCTTCGTGTTGT
TCCTCTTCCTGTGGTTCCGCGCGACCTTCCCGCGTTATCGCTACGACCAGATCATGCGTCTCGGCTGGAAGGTCTTCATC
CCGATCACCATTGTCTGGATCGTCTTCGTCGGCGGCATGATGCAGACGCCCTACGGTCACCTTTTCCATTGA

Upstream 100 bases:

>100_bases
ACGACCTGCTGCCTGACAACTGCGTGCGTATTCCGAGCGGCCATCCGTTGACGGCCGGGCTCGGCCCGATGTTTGGGCCG
ATCACCGCGGAGCCGGTCTG

Downstream 100 bases:

>100_bases
GCGCCCGATGAGACGGATCACCCATTTCTTCGGCAGCCTGTTCCTCGTCGAGCTTCTGCGCGGCATGATGCTGACCGGGC
GCCATCTGTTCGCGCGCAAG

Product: NADH dehydrogenase I subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MEAGIVEAAGMDWEAFQTVAWTLVKIMALVVPLMLGVAYLTYAERKIIGWMQVRIGPNRVGFQGLLQPIADAVKLLMKEI
IIPSGASRALFILGPILAIAPALAAWAVIPFSDGLVLADINAGLLYVMAITSMGVYGVIIAGWASNSKYAFLGAMRSAAQ
IVSYEIAMGFALVGVLMASQSLNLSAIVQGQAGGIQQWYLWPLFPLFVVYLVAGVAETNRAPFDVAEGESEIVAGFHVEY
SGMAFAVFFLAEYANMILVAALTTLMFLGGWLSPVAFLPDGIVWWLLKTGFVLFLFLWFRATFPRYRYDQIMRLGWKVFI
PITIVWIVFVGGMMQTPYGHLFH

Sequences:

>Translated_343_residues
MEAGIVEAAGMDWEAFQTVAWTLVKIMALVVPLMLGVAYLTYAERKIIGWMQVRIGPNRVGFQGLLQPIADAVKLLMKEI
IIPSGASRALFILGPILAIAPALAAWAVIPFSDGLVLADINAGLLYVMAITSMGVYGVIIAGWASNSKYAFLGAMRSAAQ
IVSYEIAMGFALVGVLMASQSLNLSAIVQGQAGGIQQWYLWPLFPLFVVYLVAGVAETNRAPFDVAEGESEIVAGFHVEY
SGMAFAVFFLAEYANMILVAALTTLMFLGGWLSPVAFLPDGIVWWLLKTGFVLFLFLWFRATFPRYRYDQIMRLGWKVFI
PITIVWIVFVGGMMQTPYGHLFH
>Mature_343_residues
MEAGIVEAAGMDWEAFQTVAWTLVKIMALVVPLMLGVAYLTYAERKIIGWMQVRIGPNRVGFQGLLQPIADAVKLLMKEI
IIPSGASRALFILGPILAIAPALAAWAVIPFSDGLVLADINAGLLYVMAITSMGVYGVIIAGWASNSKYAFLGAMRSAAQ
IVSYEIAMGFALVGVLMASQSLNLSAIVQGQAGGIQQWYLWPLFPLFVVYLVAGVAETNRAPFDVAEGESEIVAGFHVEY
SGMAFAVFFLAEYANMILVAALTTLMFLGGWLSPVAFLPDGIVWWLLKTGFVLFLFLWFRATFPRYRYDQIMRLGWKVFI
PITIVWIVFVGGMMQTPYGHLFH

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=292, Percent_Identity=44.5205479452055, Blast_Score=246, Evalue=2e-65,
Organism=Escherichia coli, GI1788618, Length=304, Percent_Identity=41.7763157894737, Blast_Score=263, Evalue=9e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_THIDA (Q3SJQ0)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314907.1
- STRING:   Q3SJQ0
- GeneID:   3673221
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_1149
- NMPDR:   fig|292415.3.peg.1149
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   SSHKAMF
- PhylomeDB:   Q3SJQ0
- BioCyc:   TDEN292415:TBD_1149-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 37614; Mature: 37614

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd1b55f0)-; HASH(0x1aceafa8)-; HASH(0x1bd52f4c)-; HASH(0x1b64d1c8)-; HASH(0x1bb44470)-; HASH(0x1bfbf0c8)-; HASH(0x1ba5cc10)-; HASH(0x1bf96ed4)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAGIVEAAGMDWEAFQTVAWTLVKIMALVVPLMLGVAYLTYAERKIIGWMQVRIGPNRV
CCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCC
GFQGLLQPIADAVKLLMKEIIIPSGASRALFILGPILAIAPALAAWAVIPFSDGLVLADI
CHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEC
NAGLLYVMAITSMGVYGVIIAGWASNSKYAFLGAMRSAAQIVSYEIAMGFALVGVLMASQ
CCHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SLNLSAIVQGQAGGIQQWYLWPLFPLFVVYLVAGVAETNRAPFDVAEGESEIVAGFHVEY
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEE
SGMAFAVFFLAEYANMILVAALTTLMFLGGWLSPVAFLPDGIVWWLLKTGFVLFLFLWFR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
ATFPRYRYDQIMRLGWKVFIPITIVWIVFVGGMMQTPYGHLFH
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCH
>Mature Secondary Structure
MEAGIVEAAGMDWEAFQTVAWTLVKIMALVVPLMLGVAYLTYAERKIIGWMQVRIGPNRV
CCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCCC
GFQGLLQPIADAVKLLMKEIIIPSGASRALFILGPILAIAPALAAWAVIPFSDGLVLADI
CHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEC
NAGLLYVMAITSMGVYGVIIAGWASNSKYAFLGAMRSAAQIVSYEIAMGFALVGVLMASQ
CCHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SLNLSAIVQGQAGGIQQWYLWPLFPLFVVYLVAGVAETNRAPFDVAEGESEIVAGFHVEY
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEEE
SGMAFAVFFLAEYANMILVAALTTLMFLGGWLSPVAFLPDGIVWWLLKTGFVLFLFLWFR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
ATFPRYRYDQIMRLGWKVFIPITIVWIVFVGGMMQTPYGHLFH
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA