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The map label for this gene is cysM [H]

Identifier: 74316982

GI number: 74316982

Start: 1026195

End: 1027088

Strand: Direct

Name: cysM [H]

Synonym: Tbd_0964

Alternate gene names: 74316982

Gene position: 1026195-1027088 (Clockwise)

Preceding gene: 74316981

Following gene: 74316983

Centisome position: 35.27

GC content: 67.0

Gene sequence:

>894_bases
ATGAGCACTTACAAGACCATCGAGGATACGGTCGGCAATACGCCGCTGGTGCGTCTCAAGCGTCTGCCCGGCGAGACGTC
GAACATCGTGCTGGTCAAGCTCGAAGGCAACAATCCGGCCGGTTCGGTGAAGGACCGCCCCGCGCTGTCGATGATCGAGC
AGGCCGAGGCGCGCGGCGAGATCCGGCCCGGTGACACGCTGATCGAGGCGACCAGCGGCAACACGGGCATCGCGCTCGCG
ATGGCGGCGGCGATGCGTGGCTACAAGATGGTGCTCATCATGCCCGAGCATCTGTCGATCGAGCGGCGCCAGACCATGCG
TGCCTTCGGCGCGGAGTTGCGGCTCGTCAGCCGGGAGGCGGGCATGGAGGGGGCGCGCGATCTGGCGATCGAACTCGAGA
AACAGGGCGTCGGCCGCGTCCTCGACCAGTTCACCAACCCCGACAATCCGGCCGCGCATTACCGCAGCACCGGCCCGGAG
ATCTGGCGCGACACCGAAGGCCGGATCAGCCATTTCGTCTCGAGCATGGGCACGACCGGCACGATCATGGGCTGCTCGCG
CTACCTCAAGGAGCAGAACCCCGCGATCCAGATCGTCGGCGTGCAGCCGACCGAAGGCGCGCAGATTCCCGGCATCCGTA
AGTGGCCGGCCGAATACGTGCCGAAGATCTGCGACCCGAGCCGCGTCGACCGCATGATCTACGTCGGCCAGCAGGACGCC
GAGGAGACGACCCGGCGCCTCGCGCGCGAGGAAGGCATCTTCGCCGGCATCTCTTCGGGCGGCGCGCTGTGGGCCGCGCT
GCAACTGTCGAAGGAAGTCGAGAACGCGACCATCGTCTCGATCGTCTGCGACCGCGGCGACCGCTATCTGTCGACCGGCG
TGTTCCCCGCGTAA

Upstream 100 bases:

>100_bases
CCGAAGCGGATACGGCGGCCCTGCGTCGCGCCGGCTACGACGGCTCGTTCTACAGTGTCGAAGAGGGAACTGCACGCTAC
ATCGAGCGTCTGCTGCAGTC

Downstream 100 bases:

>100_bases
GCGGCGTCATGGCGAAGGCCAAAACGGTTTACACCTGCACCGAGTGCGGCGGCAGCTCGCCCAAATGGCAGGGCCAGTGC
CCGGCGTGCAACGCCTGGAA

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSTYKTIEDTVGNTPLVRLKRLPGETSNIVLVKLEGNNPAGSVKDRPALSMIEQAEARGEIRPGDTLIEATSGNTGIALA
MAAAMRGYKMVLIMPEHLSIERRQTMRAFGAELRLVSREAGMEGARDLAIELEKQGVGRVLDQFTNPDNPAAHYRSTGPE
IWRDTEGRISHFVSSMGTTGTIMGCSRYLKEQNPAIQIVGVQPTEGAQIPGIRKWPAEYVPKICDPSRVDRMIYVGQQDA
EETTRRLAREEGIFAGISSGGALWAALQLSKEVENATIVSIVCDRGDRYLSTGVFPA

Sequences:

>Translated_297_residues
MSTYKTIEDTVGNTPLVRLKRLPGETSNIVLVKLEGNNPAGSVKDRPALSMIEQAEARGEIRPGDTLIEATSGNTGIALA
MAAAMRGYKMVLIMPEHLSIERRQTMRAFGAELRLVSREAGMEGARDLAIELEKQGVGRVLDQFTNPDNPAAHYRSTGPE
IWRDTEGRISHFVSSMGTTGTIMGCSRYLKEQNPAIQIVGVQPTEGAQIPGIRKWPAEYVPKICDPSRVDRMIYVGQQDA
EETTRRLAREEGIFAGISSGGALWAALQLSKEVENATIVSIVCDRGDRYLSTGVFPA
>Mature_296_residues
STYKTIEDTVGNTPLVRLKRLPGETSNIVLVKLEGNNPAGSVKDRPALSMIEQAEARGEIRPGDTLIEATSGNTGIALAM
AAAMRGYKMVLIMPEHLSIERRQTMRAFGAELRLVSREAGMEGARDLAIELEKQGVGRVLDQFTNPDNPAAHYRSTGPEI
WRDTEGRISHFVSSMGTTGTIMGCSRYLKEQNPAIQIVGVQPTEGAQIPGIRKWPAEYVPKICDPSRVDRMIYVGQQDAE
ETTRRLAREEGIFAGISSGGALWAALQLSKEVENATIVSIVCDRGDRYLSTGVFPA

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=308, Percent_Identity=36.6883116883117, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI295821200, Length=308, Percent_Identity=36.6883116883117, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI4557415, Length=308, Percent_Identity=36.6883116883117, Blast_Score=179, Evalue=2e-45,
Organism=Escherichia coli, GI2367138, Length=290, Percent_Identity=64.1379310344827, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI1788754, Length=313, Percent_Identity=44.408945686901, Blast_Score=216, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17562970, Length=298, Percent_Identity=43.9597315436242, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI32566674, Length=293, Percent_Identity=44.7098976109215, Blast_Score=233, Evalue=6e-62,
Organism=Caenorhabditis elegans, GI17535051, Length=298, Percent_Identity=43.2885906040268, Blast_Score=231, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI115535073, Length=296, Percent_Identity=42.2297297297297, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17561720, Length=298, Percent_Identity=42.2818791946309, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI32566672, Length=212, Percent_Identity=40.5660377358491, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25147552, Length=314, Percent_Identity=36.624203821656, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17534315, Length=312, Percent_Identity=36.8589743589744, Blast_Score=147, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=38.8535031847134, Blast_Score=181, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6321449, Length=324, Percent_Identity=31.7901234567901, Blast_Score=131, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24643623, Length=305, Percent_Identity=37.0491803278689, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI20129101, Length=305, Percent_Identity=37.0491803278689, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32388; Mature: 32257

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTYKTIEDTVGNTPLVRLKRLPGETSNIVLVKLEGNNPAGSVKDRPALSMIEQAEARGE
CCCCCCHHHHCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCC
IRPGDTLIEATSGNTGIALAMAAAMRGYKMVLIMPEHLSIERRQTMRAFGAELRLVSREA
CCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHEEHHHHC
GMEGARDLAIELEKQGVGRVLDQFTNPDNPAAHYRSTGPEIWRDTEGRISHFVSSMGTTG
CCCCCHHHEEEEHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHCCCHHHHHHHHHHCCCCC
TIMGCSRYLKEQNPAIQIVGVQPTEGAQIPGIRKWPAEYVPKICDPSRVDRMIYVGQQDA
HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHCCCCCCHHHHCEEEEECCCCH
EETTRRLAREEGIFAGISSGGALWAALQLSKEVENATIVSIVCDRGDRYLSTGVFPA
HHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCCCCC
>Mature Secondary Structure 
STYKTIEDTVGNTPLVRLKRLPGETSNIVLVKLEGNNPAGSVKDRPALSMIEQAEARGE
CCCCCHHHHCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCC
IRPGDTLIEATSGNTGIALAMAAAMRGYKMVLIMPEHLSIERRQTMRAFGAELRLVSREA
CCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHEEHHHHC
GMEGARDLAIELEKQGVGRVLDQFTNPDNPAAHYRSTGPEIWRDTEGRISHFVSSMGTTG
CCCCCHHHEEEEHHHHHHHHHHHHCCCCCCHHHHCCCCHHHHCCCHHHHHHHHHHCCCCC
TIMGCSRYLKEQNPAIQIVGVQPTEGAQIPGIRKWPAEYVPKICDPSRVDRMIYVGQQDA
HHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHCCCCCCHHHHCEEEEECCCCH
EETTRRLAREEGIFAGISSGGALWAALQLSKEVENATIVSIVCDRGDRYLSTGVFPA
HHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]