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The map label for this gene is hldD

Identifier: 74316981

GI number: 74316981

Start: 1025200

End: 1026198

Strand: Direct

Name: hldD

Synonym: Tbd_0963

Alternate gene names: 74316981

Gene position: 1025200-1026198 (Clockwise)

Preceding gene: 74316980

Following gene: 74316982

Centisome position: 35.23

GC content: 63.66

Gene sequence:

>999_bases
ATGAGCCAGTACACCGTGGTCACCGGCGCCGCCGGTTTCATCGGCGCCAACATCGTCAAGGCGCTGAACGAGCGCGGCGA
GACGAACATCATCGCAGTCGACAACCTCACCAAGGCCGACAAGTTCAAGAACCTGACCGACTGTGAAATCGCCGACTATC
TCGACAAGACCGAATTTCTCAGCGTGGTCGAAGAGGGTGTGCTCGACGGCAGCGTCGCGGCGATCTTCCACGAGGGCGCC
TGCTCCGACACAATGGAGACCGACGGCCGCTACATGATGGACAACAACTACCGCTATTCGGGCGCGTTGCTGAAGTTCTG
CCAGGATGAAGGCGCGCAGTTCCTGTACGCCTCGTCGGCGAGCGTCTACGGCAGCGGGCGGGTGTTTTCCGAATCGCGCG
AGTGCGAGTCGCCGCTCAACGTCTACGGCTACTCGAAGTTCCTGTTCGACCAGAGCGTGCGCCGGCTGTGGGCAGAGCGC
ACGGCGCAGATCGCGGGCTTCCGCTACTTCAACGTCTACGGGCCGCGCGAGCAGCACAAGGGCCGCATGGCCTCGGTCGC
CTTCCACTTCTTCAACCAGTACCGTGCCGAGGGCCGGGTGAAGCTGTTCGAGGGGTGCGACGGCTATCCGAACGGCGAGC
AGCGCCGCGACTTCGTCTCGGTCGAGGACGTCGTGCGGGTCAACATGTGGTTCCTCGACCATCCCGAGGTGTCGGGCATC
TTCAACGTCGGAACCGGGCGCTGCCAGAGCTTCAACGACGTCGCCGTTGCCACGGTCAACGCCTGCCGCGCGGCCGAGGG
CCAGGATGCGTTGACGCTCGACGAGATGCAGGCTCAGGGGCTCATCGGCTACGTAGCCTTCCCCGAGGCGCTCAAGGGCA
AGTACCAGAGCTATACCGAAGCGGATACGGCGGCCCTGCGTCGCGCCGGCTACGACGGCTCGTTCTACAGTGTCGAAGAG
GGAACTGCACGCTACATCGAGCGTCTGCTGCAGTCATGA

Upstream 100 bases:

>100_bases
GGCTGGCGAACCGCGCCGCAGGCATCGTCGTCGGCAAGTTCGGCACCGCGGTCGCGACGGCGGACGAGGTTTTTGCAAAC
AGCTCAACCGGAGGACAGCC

Downstream 100 bases:

>100_bases
GCACTTACAAGACCATCGAGGATACGGTCGGCAATACGCCGCTGGTGCGTCTCAAGCGTCTGCCCGGCGAGACGTCGAAC
ATCGTGCTGGTCAAGCTCGA

Product: ADP-glyceromanno-heptose 6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MSQYTVVTGAAGFIGANIVKALNERGETNIIAVDNLTKADKFKNLTDCEIADYLDKTEFLSVVEEGVLDGSVAAIFHEGA
CSDTMETDGRYMMDNNYRYSGALLKFCQDEGAQFLYASSASVYGSGRVFSESRECESPLNVYGYSKFLFDQSVRRLWAER
TAQIAGFRYFNVYGPREQHKGRMASVAFHFFNQYRAEGRVKLFEGCDGYPNGEQRRDFVSVEDVVRVNMWFLDHPEVSGI
FNVGTGRCQSFNDVAVATVNACRAAEGQDALTLDEMQAQGLIGYVAFPEALKGKYQSYTEADTAALRRAGYDGSFYSVEE
GTARYIERLLQS

Sequences:

>Translated_332_residues
MSQYTVVTGAAGFIGANIVKALNERGETNIIAVDNLTKADKFKNLTDCEIADYLDKTEFLSVVEEGVLDGSVAAIFHEGA
CSDTMETDGRYMMDNNYRYSGALLKFCQDEGAQFLYASSASVYGSGRVFSESRECESPLNVYGYSKFLFDQSVRRLWAER
TAQIAGFRYFNVYGPREQHKGRMASVAFHFFNQYRAEGRVKLFEGCDGYPNGEQRRDFVSVEDVVRVNMWFLDHPEVSGI
FNVGTGRCQSFNDVAVATVNACRAAEGQDALTLDEMQAQGLIGYVAFPEALKGKYQSYTEADTAALRRAGYDGSFYSVEE
GTARYIERLLQS
>Mature_331_residues
SQYTVVTGAAGFIGANIVKALNERGETNIIAVDNLTKADKFKNLTDCEIADYLDKTEFLSVVEEGVLDGSVAAIFHEGAC
SDTMETDGRYMMDNNYRYSGALLKFCQDEGAQFLYASSASVYGSGRVFSESRECESPLNVYGYSKFLFDQSVRRLWAERT
AQIAGFRYFNVYGPREQHKGRMASVAFHFFNQYRAEGRVKLFEGCDGYPNGEQRRDFVSVEDVVRVNMWFLDHPEVSGIF
NVGTGRCQSFNDVAVATVNACRAAEGQDALTLDEMQAQGLIGYVAFPEALKGKYQSYTEADTAALRRAGYDGSFYSVEEG
TARYIERLLQS

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily

Homologues:

Organism=Escherichia coli, GI1790049, Length=326, Percent_Identity=54.9079754601227, Blast_Score=334, Evalue=4e-93,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): HLDD_THIDA (Q3SK74)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314721.1
- ProteinModelPortal:   Q3SK74
- SMR:   Q3SK74
- STRING:   Q3SK74
- GeneID:   3672755
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0963
- NMPDR:   fig|292415.3.peg.591
- eggNOG:   COG0451
- HOGENOM:   HBG755066
- OMA:   GFIGSAM
- PhylomeDB:   Q3SK74
- ProtClustDB:   CLSK2770245
- BioCyc:   TDEN292415:TBD_0963-MONOMER
- HAMAP:   MF_01601
- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10366:SF29
- TIGRFAMs:   TIGR02197

Pfam domain/function: PF01370 Epimerase

EC number: =5.1.3.20

Molecular weight: Translated: 37012; Mature: 36880

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: ACT_SITE 142-142 ACT_SITE 180-180 BINDING 41-41 BINDING 56-56 BINDING 95-95 BINDING 146-146 BINDING 171-171 BINDING 172-172 BINDING 180-180 BINDING 182-182 BINDING 189-189 BINDING 216-216 BINDING 295-295

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQYTVVTGAAGFIGANIVKALNERGETNIIAVDNLTKADKFKNLTDCEIADYLDKTEFL
CCCEEEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHCCCCCCHHHHHHHHHHHH
SVVEEGVLDGSVAAIFHEGACSDTMETDGRYMMDNNYRYSGALLKFCQDEGAQFLYASSA
HHHHHHCCCCCHHEEEECCCCCCCHHCCCCEEECCCEEEHHHHHHHHHHCCCEEEEECCC
SVYGSGRVFSESRECESPLNVYGYSKFLFDQSVRRLWAERTAQIAGFRYFNVYGPREQHK
CEECCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCHHHC
GRMASVAFHFFNQYRAEGRVKLFEGCDGYPNGEQRRDFVSVEDVVRVNMWFLDHPEVSGI
CHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHCCHHHHHEEEEEEECCCCCCCE
FNVGTGRCQSFNDVAVATVNACRAAEGQDALTLDEMQAQGLIGYVAFPEALKGKYQSYTE
EECCCCCCCCCCCEEEEEHHHHHCCCCCCCEEHHHHHHCCEEEEEECCHHHCCHHHHHHH
ADTAALRRAGYDGSFYSVEEGTARYIERLLQS
HHHHHHHHCCCCCCEEECCCHHHHHHHHHHCC
>Mature Secondary Structure 
SQYTVVTGAAGFIGANIVKALNERGETNIIAVDNLTKADKFKNLTDCEIADYLDKTEFL
CCEEEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHCCCCCCHHHHHHHHHHHH
SVVEEGVLDGSVAAIFHEGACSDTMETDGRYMMDNNYRYSGALLKFCQDEGAQFLYASSA
HHHHHHCCCCCHHEEEECCCCCCCHHCCCCEEECCCEEEHHHHHHHHHHCCCEEEEECCC
SVYGSGRVFSESRECESPLNVYGYSKFLFDQSVRRLWAERTAQIAGFRYFNVYGPREQHK
CEECCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCHHHC
GRMASVAFHFFNQYRAEGRVKLFEGCDGYPNGEQRRDFVSVEDVVRVNMWFLDHPEVSGI
CHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHCCHHHHHEEEEEEECCCCCCCE
FNVGTGRCQSFNDVAVATVNACRAAEGQDALTLDEMQAQGLIGYVAFPEALKGKYQSYTE
EECCCCCCCCCCCEEEEEHHHHHCCCCCCCEEHHHHHHCCEEEEEECCHHHCCHHHHHHH
ADTAALRRAGYDGSFYSVEEGTARYIERLLQS
HHHHHHHHCCCCCCEEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA