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The map label for this gene is serC

Identifier: 74316967

GI number: 74316967

Start: 1011124

End: 1012203

Strand: Direct

Name: serC

Synonym: Tbd_0949

Alternate gene names: 74316967

Gene position: 1011124-1012203 (Clockwise)

Preceding gene: 74316966

Following gene: 74316968

Centisome position: 34.75

GC content: 64.54

Gene sequence:

>1080_bases
ATGACCATTTACAACTTCAGCGCCGGCCCGGCCGTGCTTCCCAAGGATGTGCTGCAGCAGGTGCAAGCCGAGCTCGTCGA
CTGGCACGGCAGCGGCATGTCGGTCATGGAAATGAGTCACCGCGGCAAGGAGTTCATGGGCATCGCGGCCGAGGCCGAAG
CCGACCTGCGCGAGCTCATGGCGATTCCGGCGAATTACAAGGTCCTGTTCCTGCAGGGCGGGGCGTCGTCGCAGTTCGCG
ATGGTGCCGATGAACCTGCTGCGCGGAAAAGCCTCGGCCGACTATCTCAACACCGGCGAGTGGTCGAAGAAGGCGATCAA
GGAGGCGAAGAAGTACGCGGCCGTCAACGTCGTCGCGTCGAGCGAAGACCGGAACTTCAGCTATGCGCCGACGCAGGACC
GGTGGAAGCTCGACCCGAACGCGGCCTACGTCCACTACACGCCGAACGAGACGATCGGCGGGGTCGAGATCTTCTGGACG
CCCGAGGCCGGCGATGTCCCGATCGCCGCCGACATGTCGTCGACGATCCTCTCGCGTCCGATCGACGTCTCGAAGTACGG
CGTGATCTACGCCGGCGCGCAGAAGAACATCGGCCCGGCCGGGCTCACGATCGTGATCGTGCGCGAGGACCTGATGGGCG
AAACCGTCGCCGGCACGCCGACGATGTTCGACTACAAGATCCACGCCGACAACGAATCGATGTACAACACCCCGGCGACC
TTTGCCATGTATACCGCTGGGCTCGTCTTCAAGTGGCTGAAGGCGCGCGGCGGCCTGGCCGGCATGGAGAAGATCAACCG
CGAGAAGGCGGCGCTGCTCTACGAAGCGCTCGACGCGACCGACTTCTACGCGTCGCCCGTGGCGAAGGACAACCGCTCGC
TGATGAACGTGCCGTTCACCCTGAAGGACGCCGCGCTCGACGAGGCCTTCCTCAAGGGCGCCAAGGAGCGCGGCCTGCTG
CAACTGAAGGGCCACCGTTCGGTCGGCGGCATGCGCGCCTCGATCTACAACGCGATGCCGACCGAGGGGGTGAAGGCGCT
CGTCGACTACCTCCACGCGTTCGAGAAGAATCATGGCTGA

Upstream 100 bases:

>100_bases
CCAGGGCGTCACGCTGATCAATCTGGACAAGGGCGAAAAGCTCATCAGCCTGGAAAAAGTAGCCGAGACCGACAACGAAG
AGGAATGAGAGGGTAACCGC

Downstream 100 bases:

>100_bases
GGCCCGCAAGATCCTCACGCTCAACGCGATTTCGGCGCGCGGTCTCGCGCGTCTGCCCGAGCACTACGTCGTCGGCGGCG
ACCTCGCCGACCCCGACGCG

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MTIYNFSAGPAVLPKDVLQQVQAELVDWHGSGMSVMEMSHRGKEFMGIAAEAEADLRELMAIPANYKVLFLQGGASSQFA
MVPMNLLRGKASADYLNTGEWSKKAIKEAKKYAAVNVVASSEDRNFSYAPTQDRWKLDPNAAYVHYTPNETIGGVEIFWT
PEAGDVPIAADMSSTILSRPIDVSKYGVIYAGAQKNIGPAGLTIVIVREDLMGETVAGTPTMFDYKIHADNESMYNTPAT
FAMYTAGLVFKWLKARGGLAGMEKINREKAALLYEALDATDFYASPVAKDNRSLMNVPFTLKDAALDEAFLKGAKERGLL
QLKGHRSVGGMRASIYNAMPTEGVKALVDYLHAFEKNHG

Sequences:

>Translated_359_residues
MTIYNFSAGPAVLPKDVLQQVQAELVDWHGSGMSVMEMSHRGKEFMGIAAEAEADLRELMAIPANYKVLFLQGGASSQFA
MVPMNLLRGKASADYLNTGEWSKKAIKEAKKYAAVNVVASSEDRNFSYAPTQDRWKLDPNAAYVHYTPNETIGGVEIFWT
PEAGDVPIAADMSSTILSRPIDVSKYGVIYAGAQKNIGPAGLTIVIVREDLMGETVAGTPTMFDYKIHADNESMYNTPAT
FAMYTAGLVFKWLKARGGLAGMEKINREKAALLYEALDATDFYASPVAKDNRSLMNVPFTLKDAALDEAFLKGAKERGLL
QLKGHRSVGGMRASIYNAMPTEGVKALVDYLHAFEKNHG
>Mature_358_residues
TIYNFSAGPAVLPKDVLQQVQAELVDWHGSGMSVMEMSHRGKEFMGIAAEAEADLRELMAIPANYKVLFLQGGASSQFAM
VPMNLLRGKASADYLNTGEWSKKAIKEAKKYAAVNVVASSEDRNFSYAPTQDRWKLDPNAAYVHYTPNETIGGVEIFWTP
EAGDVPIAADMSSTILSRPIDVSKYGVIYAGAQKNIGPAGLTIVIVREDLMGETVAGTPTMFDYKIHADNESMYNTPATF
AMYTAGLVFKWLKARGGLAGMEKINREKAALLYEALDATDFYASPVAKDNRSLMNVPFTLKDAALDEAFLKGAKERGLLQ
LKGHRSVGGMRASIYNAMPTEGVKALVDYLHAFEKNHG

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=363, Percent_Identity=47.9338842975207, Blast_Score=357, Evalue=8e-99,
Organism=Homo sapiens, GI10863955, Length=359, Percent_Identity=42.3398328690808, Blast_Score=298, Evalue=4e-81,
Organism=Escherichia coli, GI1787136, Length=360, Percent_Identity=61.6666666666667, Blast_Score=447, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17506897, Length=360, Percent_Identity=46.1111111111111, Blast_Score=333, Evalue=6e-92,
Organism=Saccharomyces cerevisiae, GI6324758, Length=386, Percent_Identity=43.0051813471503, Blast_Score=274, Evalue=1e-74,
Organism=Drosophila melanogaster, GI21356589, Length=362, Percent_Identity=50.5524861878453, Blast_Score=372, Evalue=1e-103,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_THIDA (Q3SK88)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314707.1
- HSSP:   Q59196
- ProteinModelPortal:   Q3SK88
- SMR:   Q3SK88
- STRING:   Q3SK88
- GeneID:   3672741
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0949
- NMPDR:   fig|292415.3.peg.539
- eggNOG:   COG1932
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- PhylomeDB:   Q3SK88
- ProtClustDB:   PRK05355
- BioCyc:   TDEN292415:TBD_0949-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 39200; Mature: 39069

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 41-41 BINDING 101-101 BINDING 151-151 BINDING 171-171 BINDING 194-194

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIYNFSAGPAVLPKDVLQQVQAELVDWHGSGMSVMEMSHRGKEFMGIAAEAEADLRELM
CEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHEEEEHHHHHHHHHHH
AIPANYKVLFLQGGASSQFAMVPMNLLRGKASADYLNTGEWSKKAIKEAKKYAAVNVVAS
HCCCCCEEEEEECCCCCCEEEECHHHHCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEEC
SEDRNFSYAPTQDRWKLDPNAAYVHYTPNETIGGVEIFWTPEAGDVPIAADMSSTILSRP
CCCCCCCCCCCCCCEEECCCCEEEEECCCCCCCCEEEEECCCCCCCCEECCCHHHHHHCC
IDVSKYGVIYAGAQKNIGPAGLTIVIVREDLMGETVAGTPTMFDYKIHADNESMYNTPAT
CCCCCCEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEEEEECCCCCCCCCCHH
FAMYTAGLVFKWLKARGGLAGMEKINREKAALLYEALDATDFYASPVAKDNRSLMNVPFT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCEEECCEE
LKDAALDEAFLKGAKERGLLQLKGHRSVGGMRASIYNAMPTEGVKALVDYLHAFEKNHG
EHHHHHHHHHHCCHHHCCEEEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TIYNFSAGPAVLPKDVLQQVQAELVDWHGSGMSVMEMSHRGKEFMGIAAEAEADLRELM
EEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHEEEEHHHHHHHHHHH
AIPANYKVLFLQGGASSQFAMVPMNLLRGKASADYLNTGEWSKKAIKEAKKYAAVNVVAS
HCCCCCEEEEEECCCCCCEEEECHHHHCCCCCCCCCCCCCHHHHHHHHHHHHEEEEEEEC
SEDRNFSYAPTQDRWKLDPNAAYVHYTPNETIGGVEIFWTPEAGDVPIAADMSSTILSRP
CCCCCCCCCCCCCCEEECCCCEEEEECCCCCCCCEEEEECCCCCCCCEECCCHHHHHHCC
IDVSKYGVIYAGAQKNIGPAGLTIVIVREDLMGETVAGTPTMFDYKIHADNESMYNTPAT
CCCCCCEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCEEEEEEEECCCCCCCCCCHH
FAMYTAGLVFKWLKARGGLAGMEKINREKAALLYEALDATDFYASPVAKDNRSLMNVPFT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCEEECCEE
LKDAALDEAFLKGAKERGLLQLKGHRSVGGMRASIYNAMPTEGVKALVDYLHAFEKNHG
EHHHHHHHHHHCCHHHCCEEEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA