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The map label for this gene is serA [H]

Identifier: 74316968

GI number: 74316968

Start: 1012196

End: 1013371

Strand: Direct

Name: serA [H]

Synonym: Tbd_0950

Alternate gene names: 74316968

Gene position: 1012196-1013371 (Clockwise)

Preceding gene: 74316967

Following gene: 74316969

Centisome position: 34.79

GC content: 67.43

Gene sequence:

>1176_bases
ATGGCTGAGGCCCGCAAGATCCTCACGCTCAACGCGATTTCGGCGCGCGGTCTCGCGCGTCTGCCCGAGCACTACGTCGT
CGGCGGCGACCTCGCCGACCCCGACGCGATCCTCGTGCGCTCGGCGAACATGCACGAGATGGAGATTCCGACTTCCGTCT
GCGCCATTGGGCGGGCCGGTGCGGGGACCAACAACATCCCGGTCAAGAAGATGTCCGAGCGCGGCCTGCCGGTCTTCAAC
GCGCCGGGTGCGAACGCGAACGCGGTCAAGGAGCTCGTGATCGCCGGCATGCTCATGGGCGCGCGCAACCTCGTGCCGGC
GCTCAAGTTCGTCGAGAGTCTTGACGGAACGGACGAGGCGATGCACAAGGCGACCGAAGCCGGCAAGAAGCAGTTCGCCG
GCATGGAGCTGCCGGGCCGCACGCTCGGCGTGATCGGGCTCGGCGCGATCGGCTCGCACATCGCCGAAGCCGCGATCCGC
CTCGGCATGAACGTCGTCGGCTACGACCCGGCGATCACCGTCGACGCGGCCTGGCGCCTGCCTTCGCAGGTCAAGCGCGC
CGAGAACGTCGACGACGTGCTGCGCACGGCGGACTTCGTCACGCTGCATGTACCGCTGCTCGACGCCACCCGCAACCTGA
TCAACGCGCAGCGCCTGAGCCTGATGCGTTCGGGCGCCGTGCTGCTGAACTTTGCGCGCGAGGGTGTCGTCGACAACGCC
GCCGTGATCGAGGCGCTCGACGCCGGCAAGCTGCACGCCTACATCTGCGATTTCCCGGCGAACGCGCTCAAGGGCCACCC
GAAGGTCGTGGCCCTGCCGCATCTCGGCGCGAGCACCGAGGAGGCCGAGGAGAACTGCGCCGTGATGGTCGCCGAGCAGC
TCACCGACTATCTCGAGAACGGCAACATCCTCAATTCGGTCAATTTCCCCAGTGTCGCGATGCCTCGCGAGTCGGCCTTC
CGCCTCGCGATCGCCAACGCCAACGTGCCGAACATGGTCGGGCAGATCTCGTCGGTGCTCGCCGCCGCCGGCCTCAACAT
CCACAACATGGTCAACAAGTCGAAGGGCGACATGGCCTACACGCTCGTCGACGTCGACAGCGCGGTGGCGGGATCGGTCA
TCGCGCAGCTCAACGCGATCGGCGGCGTGCTCGGCGTGCGCTATCTGCCCGCATGA

Upstream 100 bases:

>100_bases
CACCGTTCGGTCGGCGGCATGCGCGCCTCGATCTACAACGCGATGCCGACCGAGGGGGTGAAGGCGCTCGTCGACTACCT
CCACGCGTTCGAGAAGAATC

Downstream 100 bases:

>100_bases
AGGACCAGGCAGGGACTAGGCCCGACGTGTCGGCGGAACTCGGTGCGCTGCGCGCGCGTATTGACAGCATCGACGACACG
CTCCTTGCGCTGATTTCGGA

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MAEARKILTLNAISARGLARLPEHYVVGGDLADPDAILVRSANMHEMEIPTSVCAIGRAGAGTNNIPVKKMSERGLPVFN
APGANANAVKELVIAGMLMGARNLVPALKFVESLDGTDEAMHKATEAGKKQFAGMELPGRTLGVIGLGAIGSHIAEAAIR
LGMNVVGYDPAITVDAAWRLPSQVKRAENVDDVLRTADFVTLHVPLLDATRNLINAQRLSLMRSGAVLLNFAREGVVDNA
AVIEALDAGKLHAYICDFPANALKGHPKVVALPHLGASTEEAEENCAVMVAEQLTDYLENGNILNSVNFPSVAMPRESAF
RLAIANANVPNMVGQISSVLAAAGLNIHNMVNKSKGDMAYTLVDVDSAVAGSVIAQLNAIGGVLGVRYLPA

Sequences:

>Translated_391_residues
MAEARKILTLNAISARGLARLPEHYVVGGDLADPDAILVRSANMHEMEIPTSVCAIGRAGAGTNNIPVKKMSERGLPVFN
APGANANAVKELVIAGMLMGARNLVPALKFVESLDGTDEAMHKATEAGKKQFAGMELPGRTLGVIGLGAIGSHIAEAAIR
LGMNVVGYDPAITVDAAWRLPSQVKRAENVDDVLRTADFVTLHVPLLDATRNLINAQRLSLMRSGAVLLNFAREGVVDNA
AVIEALDAGKLHAYICDFPANALKGHPKVVALPHLGASTEEAEENCAVMVAEQLTDYLENGNILNSVNFPSVAMPRESAF
RLAIANANVPNMVGQISSVLAAAGLNIHNMVNKSKGDMAYTLVDVDSAVAGSVIAQLNAIGGVLGVRYLPA
>Mature_390_residues
AEARKILTLNAISARGLARLPEHYVVGGDLADPDAILVRSANMHEMEIPTSVCAIGRAGAGTNNIPVKKMSERGLPVFNA
PGANANAVKELVIAGMLMGARNLVPALKFVESLDGTDEAMHKATEAGKKQFAGMELPGRTLGVIGLGAIGSHIAEAAIRL
GMNVVGYDPAITVDAAWRLPSQVKRAENVDDVLRTADFVTLHVPLLDATRNLINAQRLSLMRSGAVLLNFAREGVVDNAA
VIEALDAGKLHAYICDFPANALKGHPKVVALPHLGASTEEAEENCAVMVAEQLTDYLENGNILNSVNFPSVAMPRESAFR
LAIANANVPNMVGQISSVLAAAGLNIHNMVNKSKGDMAYTLVDVDSAVAGSVIAQLNAIGGVLGVRYLPA

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=322, Percent_Identity=31.055900621118, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4557497, Length=240, Percent_Identity=31.25, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI61743967, Length=240, Percent_Identity=31.25, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI145580578, Length=238, Percent_Identity=30.672268907563, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4557499, Length=238, Percent_Identity=30.672268907563, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI145580575, Length=238, Percent_Identity=30.672268907563, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI6912396, Length=252, Percent_Identity=25.3968253968254, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1789279, Length=354, Percent_Identity=33.3333333333333, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI87082289, Length=321, Percent_Identity=27.7258566978193, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787645, Length=193, Percent_Identity=28.4974093264249, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=305, Percent_Identity=34.0983606557377, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI25147481, Length=251, Percent_Identity=25.8964143426295, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320925, Length=402, Percent_Identity=29.8507462686567, Blast_Score=162, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6322116, Length=413, Percent_Identity=29.2978208232446, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6324055, Length=283, Percent_Identity=28.2685512367491, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324964, Length=228, Percent_Identity=27.1929824561404, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19921140, Length=317, Percent_Identity=35.6466876971609, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI24646446, Length=235, Percent_Identity=33.1914893617021, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24646448, Length=235, Percent_Identity=33.1914893617021, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24646452, Length=235, Percent_Identity=33.1914893617021, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24646450, Length=235, Percent_Identity=33.1914893617021, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI62472511, Length=235, Percent_Identity=33.1914893617021, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24585516, Length=248, Percent_Identity=24.5967741935484, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585514, Length=247, Percent_Identity=23.8866396761134, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28574282, Length=247, Percent_Identity=23.8866396761134, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI45551003, Length=247, Percent_Identity=23.8866396761134, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28574284, Length=247, Percent_Identity=23.8866396761134, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45552429, Length=244, Percent_Identity=24.1803278688525, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28574286, Length=240, Percent_Identity=24.1666666666667, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 40998; Mature: 40867

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEARKILTLNAISARGLARLPEHYVVGGDLADPDAILVRSANMHEMEIPTSVCAIGRAG
CCCCCEEEEEECHHHCCHHHCCCCEEECCCCCCCCEEEEECCCCCCCCCCHHHHHCCCCC
AGTNNIPVKKMSERGLPVFNAPGANANAVKELVIAGMLMGARNLVPALKFVESLDGTDEA
CCCCCCCCHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
MHKATEAGKKQFAGMELPGRTLGVIGLGAIGSHIAEAAIRLGMNVVGYDPAITVDAAWRL
HHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCEEECCCCEEEEEHHHCC
PSQVKRAENVDDVLRTADFVTLHVPLLDATRNLINAQRLSLMRSGAVLLNFAREGVVDNA
HHHHHHHCCHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCH
AVIEALDAGKLHAYICDFPANALKGHPKVVALPHLGASTEEAEENCAVMVAEQLTDYLEN
HHHHHHCCCCEEEEEECCCHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHC
GNILNSVNFPSVAMPRESAFRLAIANANVPNMVGQISSVLAAAGLNIHNMVNKSKGDMAY
CCEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEE
TLVDVDSAVAGSVIAQLNAIGGVLGVRYLPA
EEEECCHHHHHHHHHHHHHHHHHHHHEECCC
>Mature Secondary Structure 
AEARKILTLNAISARGLARLPEHYVVGGDLADPDAILVRSANMHEMEIPTSVCAIGRAG
CCCCEEEEEECHHHCCHHHCCCCEEECCCCCCCCEEEEECCCCCCCCCCHHHHHCCCCC
AGTNNIPVKKMSERGLPVFNAPGANANAVKELVIAGMLMGARNLVPALKFVESLDGTDEA
CCCCCCCCHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
MHKATEAGKKQFAGMELPGRTLGVIGLGAIGSHIAEAAIRLGMNVVGYDPAITVDAAWRL
HHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCEEECCCCEEEEEHHHCC
PSQVKRAENVDDVLRTADFVTLHVPLLDATRNLINAQRLSLMRSGAVLLNFAREGVVDNA
HHHHHHHCCHHHHHHHCCEEEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCH
AVIEALDAGKLHAYICDFPANALKGHPKVVALPHLGASTEEAEENCAVMVAEQLTDYLEN
HHHHHHCCCCEEEEEECCCHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHC
GNILNSVNFPSVAMPRESAFRLAIANANVPNMVGQISSVLAAAGLNIHNMVNKSKGDMAY
CCEEECCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEE
TLVDVDSAVAGSVIAQLNAIGGVLGVRYLPA
EEEECCHHHHHHHHHHHHHHHHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]