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The map label for this gene is dxs

Identifier: 74316897

GI number: 74316897

Start: 928492

End: 930348

Strand: Reverse

Name: dxs

Synonym: Tbd_0879

Alternate gene names: 74316897

Gene position: 930348-928492 (Counterclockwise)

Preceding gene: 74316898

Following gene: 74316896

Centisome position: 31.97

GC content: 69.14

Gene sequence:

>1857_bases
ATGCCGGCGTCGCTGCTCGACACGATAGAAAGCCCGGCCGATCTGCGCGCCCTGCCCGCCGCCGAGCTGCCCGGGCTCGC
CGCGGAAGTGCGCGCCTTCCTCATCGATTCGGTCGCCGGCACCGGCGGCCATCTCGCCTCCAACCTCGGCGCCGTGGAAC
TCACGCTCGCGCTGCATTACGTATTCGACACGCCGCGTGACCGCATCGTCTGGGACGTCGGGCACCAGAGCTACACCCAC
AAGATACTCACCGGCCGGCGCGACGCGATGCAGGGGCTCCGGCAACGCGGCGGGATCGCCGGTTTCCCGCGCCGGGCCGA
GAGCGAGTTCGACGCCTTCGGCACCGGACATTCGAGCACGTCAATCTCGGCGGCCCTCGGGATGGCCGAAGCCTTCCATC
AACTCGGCTCCGACCAGCGCGCGGTTGCGGTGATCGGCGACGGCGCGATGACCGCGGGCATGGCCTTCGAGGCGCTCAAC
AACGCCGGTGCGACCGAACTGCCGCTGCTCGTGGTCCTGAACGACAACGACATGTCGATTTCGCCAAACGTCGGCGCGCT
GAACAACTACCTCGCGCGCCTGATGTCGGGCCGCTTCTACGCCGCCGCGCGGCGCGCCGGCGACAAGGTCTTGTCGGTCG
CGCCGCCGATCCGCGAGCTCGCCAAGCGTGCCGAGGAACATATGAAGGGCATGGTGACGCCCGGCACCTTGTTCGAGGAA
TTCGGCTTCAACTACATCGGACCGATCGACGGCCACGACCTCGACGTGCTGGTCAACACGCTGCGCAATATTCGCCACCT
GCGCGGGCCGCAGTTCCTGCACGTCGTCACCCGCAAGGGCAAGGGTTACACGCCCGCCGAAACGAATCCCTGCCTCTACC
ACGGCGTCGCGCGCTTCGACCCCGCCGCTGGCGTCGCCGAAAAACGCGCGGGCAAGCCGAGCTACACCGAGGTATTCGGC
GACTGGCTGTGCGACATGGCGGCGTCCGACCCGCGTCTCGTCGGCATCACGCCGGCGATGCGCGAAGGCTCCGGCCTGGT
GCGCTTTTCGCAGGAATTCCCCGAGCGCTATTTCGACGTCGGCATCGCCGAACAGCACGCGCTGACCTTCGCCGCAGGCC
TCGCCTGCGAGGGCGTCAAGCCCGTCGTCGCGATCTATTCGACCTTCCTGCAGCGCGCCTACGATCAACTGATCCACGAC
ATCGCGCTGCAGAATCTGCCTGTGACGCTCGCGATCGACCGCGCCGGCCTCGTCGGCGCGGACGGGCCGACGCACGCCGG
CAGCTTCGATCTGTCGTTTTTGCGCTGCGTGCCCGATCTCGTGATCGCCGCACCTTCCGACGAGAACGAATGCCGTCGCC
TGCTCAGCACGGCCTTCCTGCACGACGGGCCGGCGGCCGTTCGTTATCCGCGTGGCTGCGGCACCGGTGCGGCGATCGAA
CCCGGGCTCGAACCGGTCGAGATCGGCAAGGGCGTGTGCCGCCGCCGGGGTCGCGACGTCGCCCTGCTCGCTTTCGGCAG
CCTCGTCGCCCCCGCCCTGACTGCCGCGGAGCGGCTCGATGCGACGGTCGCCGACATGCGCTTCGTCAAGCCGCTCGACG
TCGACCTCGTGGGCGAGCTCGCAGCGGGCCACCGCCTGCTCGTGACGCTCGAGGAAAACGCGGTGGCCGGCGGTGCCGGT
GCGGCCGTGGCGGAACTCCTGGCACAGCTCGGAATCGTCGTCCCCGTCCTGCAGTTGGGACTGTCGGACGTGTTCATCGA
GCACGGCGACGCTGCCGCGATGCTCGCCGCCTGCGGCCTCGACGCCCCCGGGATCGAGCGCGCCGTGAGTGAGCGCCTCG
CCGCGCTACCGGAGTAA

Upstream 100 bases:

>100_bases
GAATTGCGCGCCGACGCCTGCGCCGCGCTCGATCCGCTCGGTCCGTCCGCGCGACGCCTGCGCGAGCTGGCGGATTTCGT
CGTCGAGCGGACGTTCTGAC

Downstream 100 bases:

>100_bases
AGCAGCCCCGCGCGCGGGGCTCGGCTAAGTCCGAGTAGTTTACTCAACTATTATGGCAGTTTATACTTGGTCTAAATTGC
CATCGAGGAGCCTTCCATGA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 618; Mature: 617

Protein sequence:

>618_residues
MPASLLDTIESPADLRALPAAELPGLAAEVRAFLIDSVAGTGGHLASNLGAVELTLALHYVFDTPRDRIVWDVGHQSYTH
KILTGRRDAMQGLRQRGGIAGFPRRAESEFDAFGTGHSSTSISAALGMAEAFHQLGSDQRAVAVIGDGAMTAGMAFEALN
NAGATELPLLVVLNDNDMSISPNVGALNNYLARLMSGRFYAAARRAGDKVLSVAPPIRELAKRAEEHMKGMVTPGTLFEE
FGFNYIGPIDGHDLDVLVNTLRNIRHLRGPQFLHVVTRKGKGYTPAETNPCLYHGVARFDPAAGVAEKRAGKPSYTEVFG
DWLCDMAASDPRLVGITPAMREGSGLVRFSQEFPERYFDVGIAEQHALTFAAGLACEGVKPVVAIYSTFLQRAYDQLIHD
IALQNLPVTLAIDRAGLVGADGPTHAGSFDLSFLRCVPDLVIAAPSDENECRRLLSTAFLHDGPAAVRYPRGCGTGAAIE
PGLEPVEIGKGVCRRRGRDVALLAFGSLVAPALTAAERLDATVADMRFVKPLDVDLVGELAAGHRLLVTLEENAVAGGAG
AAVAELLAQLGIVVPVLQLGLSDVFIEHGDAAAMLAACGLDAPGIERAVSERLAALPE

Sequences:

>Translated_618_residues
MPASLLDTIESPADLRALPAAELPGLAAEVRAFLIDSVAGTGGHLASNLGAVELTLALHYVFDTPRDRIVWDVGHQSYTH
KILTGRRDAMQGLRQRGGIAGFPRRAESEFDAFGTGHSSTSISAALGMAEAFHQLGSDQRAVAVIGDGAMTAGMAFEALN
NAGATELPLLVVLNDNDMSISPNVGALNNYLARLMSGRFYAAARRAGDKVLSVAPPIRELAKRAEEHMKGMVTPGTLFEE
FGFNYIGPIDGHDLDVLVNTLRNIRHLRGPQFLHVVTRKGKGYTPAETNPCLYHGVARFDPAAGVAEKRAGKPSYTEVFG
DWLCDMAASDPRLVGITPAMREGSGLVRFSQEFPERYFDVGIAEQHALTFAAGLACEGVKPVVAIYSTFLQRAYDQLIHD
IALQNLPVTLAIDRAGLVGADGPTHAGSFDLSFLRCVPDLVIAAPSDENECRRLLSTAFLHDGPAAVRYPRGCGTGAAIE
PGLEPVEIGKGVCRRRGRDVALLAFGSLVAPALTAAERLDATVADMRFVKPLDVDLVGELAAGHRLLVTLEENAVAGGAG
AAVAELLAQLGIVVPVLQLGLSDVFIEHGDAAAMLAACGLDAPGIERAVSERLAALPE
>Mature_617_residues
PASLLDTIESPADLRALPAAELPGLAAEVRAFLIDSVAGTGGHLASNLGAVELTLALHYVFDTPRDRIVWDVGHQSYTHK
ILTGRRDAMQGLRQRGGIAGFPRRAESEFDAFGTGHSSTSISAALGMAEAFHQLGSDQRAVAVIGDGAMTAGMAFEALNN
AGATELPLLVVLNDNDMSISPNVGALNNYLARLMSGRFYAAARRAGDKVLSVAPPIRELAKRAEEHMKGMVTPGTLFEEF
GFNYIGPIDGHDLDVLVNTLRNIRHLRGPQFLHVVTRKGKGYTPAETNPCLYHGVARFDPAAGVAEKRAGKPSYTEVFGD
WLCDMAASDPRLVGITPAMREGSGLVRFSQEFPERYFDVGIAEQHALTFAAGLACEGVKPVVAIYSTFLQRAYDQLIHDI
ALQNLPVTLAIDRAGLVGADGPTHAGSFDLSFLRCVPDLVIAAPSDENECRRLLSTAFLHDGPAAVRYPRGCGTGAAIEP
GLEPVEIGKGVCRRRGRDVALLAFGSLVAPALTAAERLDATVADMRFVKPLDVDLVGELAAGHRLLVTLEENAVAGGAGA
AVAELLAQLGIVVPVLQLGLSDVFIEHGDAAAMLAACGLDAPGIERAVSERLAALPE

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=642, Percent_Identity=22.7414330218069, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI4507521, Length=642, Percent_Identity=22.7414330218069, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI225637463, Length=253, Percent_Identity=27.6679841897233, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI225637461, Length=253, Percent_Identity=27.6679841897233, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI225637459, Length=253, Percent_Identity=27.6679841897233, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1786622, Length=611, Percent_Identity=59.7381342062193, Blast_Score=765, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=385, Percent_Identity=27.5324675324675, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24666278, Length=626, Percent_Identity=25.2396166134185, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI45551847, Length=593, Percent_Identity=25.9696458684654, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45550715, Length=593, Percent_Identity=25.9696458684654, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24645119, Length=490, Percent_Identity=26.9387755102041, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_THIDA (Q3SKF1)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314637.1
- ProteinModelPortal:   Q3SKF1
- SMR:   Q3SKF1
- STRING:   Q3SKF1
- GeneID:   3671644
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0879
- NMPDR:   fig|292415.3.peg.348
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- PhylomeDB:   Q3SKF1
- ProtClustDB:   PRK05444
- BioCyc:   TDEN292415:TBD_0879-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 65367; Mature: 65236

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPASLLDTIESPADLRALPAAELPGLAAEVRAFLIDSVAGTGGHLASNLGAVELTLALHY
CCCHHHHHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCEEHHHHHHH
VFDTPRDRIVWDVGHQSYTHKILTGRRDAMQGLRQRGGIAGFPRRAESEFDAFGTGHSST
HHCCCCCCEEEECCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCC
SISAALGMAEAFHQLGSDQRAVAVIGDGAMTAGMAFEALNNAGATELPLLVVLNDNDMSI
HHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEE
SPNVGALNNYLARLMSGRFYAAARRAGDKVLSVAPPIRELAKRAEEHMKGMVTPGTLFEE
CCCCCHHHHHHHHHHCCCHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCCCHHHHHH
FGFNYIGPIDGHDLDVLVNTLRNIRHLRGPQFLHVVTRKGKGYTPAETNPCLYHGVARFD
CCCCEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHCHHHCC
PAAGVAEKRAGKPSYTEVFGDWLCDMAASDPRLVGITPAMREGSGLVRFSQEFPERYFDV
CCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHC
GIAEQHALTFAAGLACEGVKPVVAIYSTFLQRAYDQLIHDIALQNLPVTLAIDRAGLVGA
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
DGPTHAGSFDLSFLRCVPDLVIAAPSDENECRRLLSTAFLHDGPAAVRYPRGCGTGAAIE
CCCCCCCCCCHHHHHHCCHHEEECCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCC
PGLEPVEIGKGVCRRRGRDVALLAFGSLVAPALTAAERLDATVADMRFVKPLDVDLVGEL
CCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AAGHRLLVTLEENAVAGGAGAAVAELLAQLGIVVPVLQLGLSDVFIEHGDAAAMLAACGL
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHCC
DAPGIERAVSERLAALPE
CCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PASLLDTIESPADLRALPAAELPGLAAEVRAFLIDSVAGTGGHLASNLGAVELTLALHY
CCHHHHHHCCCCCHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCEEHHHHHHH
VFDTPRDRIVWDVGHQSYTHKILTGRRDAMQGLRQRGGIAGFPRRAESEFDAFGTGHSST
HHCCCCCCEEEECCCCHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCC
SISAALGMAEAFHQLGSDQRAVAVIGDGAMTAGMAFEALNNAGATELPLLVVLNDNDMSI
HHHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEE
SPNVGALNNYLARLMSGRFYAAARRAGDKVLSVAPPIRELAKRAEEHMKGMVTPGTLFEE
CCCCCHHHHHHHHHHCCCHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCCCHHHHHH
FGFNYIGPIDGHDLDVLVNTLRNIRHLRGPQFLHVVTRKGKGYTPAETNPCLYHGVARFD
CCCCEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHCHHHCC
PAAGVAEKRAGKPSYTEVFGDWLCDMAASDPRLVGITPAMREGSGLVRFSQEFPERYFDV
CCCCHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHC
GIAEQHALTFAAGLACEGVKPVVAIYSTFLQRAYDQLIHDIALQNLPVTLAIDRAGLVGA
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
DGPTHAGSFDLSFLRCVPDLVIAAPSDENECRRLLSTAFLHDGPAAVRYPRGCGTGAAIE
CCCCCCCCCCHHHHHHCCHHEEECCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCC
PGLEPVEIGKGVCRRRGRDVALLAFGSLVAPALTAAERLDATVADMRFVKPLDVDLVGEL
CCCCHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
AAGHRLLVTLEENAVAGGAGAAVAELLAQLGIVVPVLQLGLSDVFIEHGDAAAMLAACGL
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHCC
DAPGIERAVSERLAALPE
CCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA