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The map label for this gene is folE2

Identifier: 74316896

GI number: 74316896

Start: 927586

End: 928395

Strand: Reverse

Name: folE2

Synonym: Tbd_0878

Alternate gene names: 74316896

Gene position: 928395-927586 (Counterclockwise)

Preceding gene: 74316897

Following gene: 74316894

Centisome position: 31.91

GC content: 60.0

Gene sequence:

>810_bases
ATGAACGAGATTTGCGACACCGCCGTTTGCATGCCAGACGTGCAAAGCTCGGCCGATACCCGGCAAATCGCCATCGACAA
GGTCGGCATCAAGAGCATTCGCCATCCCGTCCGCGTCGCCGACAAGGCCGACGGCGTGCAGCACACGATCGCGAATTTCA
ACATGTACGTATTCCTGCCCCATAACTTCAAGGGCACGCACATGTCGCGTTTCATCGAAATCCTCAACACGCGCGAGCGC
GAAATCTCGGTCGAGAATTTCGAGGGCATGCTGCGGCAGATGGTCGAGCGCCTGGAAGCCGAATCGGGCTACATCGAGAT
GACGTTCCCCTACTTCATCAACAAGTCGGCGCCCGTGTCCGGCGTGCAGAGCATGCTCGACTACGAAGTCACCTTCGTCG
GCGCGATCGAGAACGGCCAGTACACGCACACCACGAAGGTCGTCGTGCCGGTGACCAGCCTGTGCCCCTGCTCGAAGAAA
ATTTCCGAATACGGTGCGCACAACCAGCGCTCGCACGTCACCGTCACGGCGAAAACCCGCGGCTTCCTGTGGATCGAGGA
TCTCGTGCGCAAGGTCGAGGATCAGGCGTCGTGCGAACTGTTCGGCCTGCTCAAGCGCCCGGACGAGAAATACGTCACCG
AGCGCGCCTACGACAATCCGAAGTTCGTCGAGGACATCGTGCGCGACGTCGCGGCGGCGATGAATGCCGAGCCGCTGATC
GACGCCTACGTGGTCGAGGCGGAGAACTTCGAGTCGATCCATAACCACAGCGCCTACGCGCTGATCGAGCACGACAAGCG
CAAAAAATAG

Upstream 100 bases:

>100_bases
GTAAAGCAGCCCCGCGCGCGGGGCTCGGCTAAGTCCGAGTAGTTTACTCAACTATTATGGCAGTTTATACTTGGTCTAAA
TTGCCATCGAGGAGCCTTCC

Downstream 100 bases:

>100_bases
GCGCCTGCGACCTGGCCGCTACAGCGGTCGTCGTCAGTAGCGACGCGTCAGCGTCATCGTCTGGCCGTCGCGCGTCATGT
CCATCCGGTTGAGAAAGCTC

Product: GTP cyclohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MNEICDTAVCMPDVQSSADTRQIAIDKVGIKSIRHPVRVADKADGVQHTIANFNMYVFLPHNFKGTHMSRFIEILNTRER
EISVENFEGMLRQMVERLEAESGYIEMTFPYFINKSAPVSGVQSMLDYEVTFVGAIENGQYTHTTKVVVPVTSLCPCSKK
ISEYGAHNQRSHVTVTAKTRGFLWIEDLVRKVEDQASCELFGLLKRPDEKYVTERAYDNPKFVEDIVRDVAAAMNAEPLI
DAYVVEAENFESIHNHSAYALIEHDKRKK

Sequences:

>Translated_269_residues
MNEICDTAVCMPDVQSSADTRQIAIDKVGIKSIRHPVRVADKADGVQHTIANFNMYVFLPHNFKGTHMSRFIEILNTRER
EISVENFEGMLRQMVERLEAESGYIEMTFPYFINKSAPVSGVQSMLDYEVTFVGAIENGQYTHTTKVVVPVTSLCPCSKK
ISEYGAHNQRSHVTVTAKTRGFLWIEDLVRKVEDQASCELFGLLKRPDEKYVTERAYDNPKFVEDIVRDVAAAMNAEPLI
DAYVVEAENFESIHNHSAYALIEHDKRKK
>Mature_269_residues
MNEICDTAVCMPDVQSSADTRQIAIDKVGIKSIRHPVRVADKADGVQHTIANFNMYVFLPHNFKGTHMSRFIEILNTRER
EISVENFEGMLRQMVERLEAESGYIEMTFPYFINKSAPVSGVQSMLDYEVTFVGAIENGQYTHTTKVVVPVTSLCPCSKK
ISEYGAHNQRSHVTVTAKTRGFLWIEDLVRKVEDQASCELFGLLKRPDEKYVTERAYDNPKFVEDIVRDVAAAMNAEPLI
DAYVVEAENFESIHNHSAYALIEHDKRKK

Specific function: Converts GTP to 7,8-dihydroneopterin triphosphate

COG id: COG1469

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase IV family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCH4_THIDA (Q3SKF2)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314636.1
- ProteinModelPortal:   Q3SKF2
- SMR:   Q3SKF2
- STRING:   Q3SKF2
- GeneID:   3671643
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0878
- NMPDR:   fig|292415.3.peg.347
- eggNOG:   COG1469
- HOGENOM:   HBG626871
- OMA:   SLMDYEV
- BioCyc:   TDEN292415:TBD_0878-MONOMER
- HAMAP:   MF_01527_B
- InterPro:   IPR022838
- InterPro:   IPR003801
- InterPro:   IPR002042
- Gene3D:   G3DSA:3.10.270.10

Pfam domain/function: PF02649 DUF198

EC number: =3.5.4.16

Molecular weight: Translated: 30583; Mature: 30583

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEICDTAVCMPDVQSSADTRQIAIDKVGIKSIRHPVRVADKADGVQHTIANFNMYVFLP
CCCHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHCCHHHHHHCCCCHHHHHHCCEEEEEEE
HNFKGTHMSRFIEILNTREREISVENFEGMLRQMVERLEAESGYIEMTFPYFINKSAPVS
CCCCCHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHEECCCCCHH
GVQSMLDYEVTFVGAIENGQYTHTTKVVVPVTSLCPCSKKISEYGAHNQRSHVTVTAKTR
HHHHHHHEEEEEEEEECCCCEEEEEEEEEECCCCCCCHHHHHHHCCCCCCCEEEEEECCC
GFLWIEDLVRKVEDQASCELFGLLKRPDEKYVTERAYDNPKFVEDIVRDVAAAMNAEPLI
CCEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCH
DAYVVEAENFESIHNHSAYALIEHDKRKK
HEEEEECCCHHHHHCCCEEEEEECCCCCC
>Mature Secondary Structure
MNEICDTAVCMPDVQSSADTRQIAIDKVGIKSIRHPVRVADKADGVQHTIANFNMYVFLP
CCCHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHCCHHHHHHCCCCHHHHHHCCEEEEEEE
HNFKGTHMSRFIEILNTREREISVENFEGMLRQMVERLEAESGYIEMTFPYFINKSAPVS
CCCCCHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEEHHEECCCCCHH
GVQSMLDYEVTFVGAIENGQYTHTTKVVVPVTSLCPCSKKISEYGAHNQRSHVTVTAKTR
HHHHHHHEEEEEEEEECCCCEEEEEEEEEECCCCCCCHHHHHHHCCCCCCCEEEEEECCC
GFLWIEDLVRKVEDQASCELFGLLKRPDEKYVTERAYDNPKFVEDIVRDVAAAMNAEPLI
CCEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCH
DAYVVEAENFESIHNHSAYALIEHDKRKK
HEEEEECCCHHHHHCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA