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The map label for this gene is sucD [H]

Identifier: 74316824

GI number: 74316824

Start: 847923

End: 848816

Strand: Direct

Name: sucD [H]

Synonym: Tbd_0806

Alternate gene names: 74316824

Gene position: 847923-848816 (Clockwise)

Preceding gene: 74316823

Following gene: 74316825

Centisome position: 29.14

GC content: 67.23

Gene sequence:

>894_bases
ATGAGCATTCTGGTCGACAAGGACACCAAGGTCATCTGCCAGGGCTTCACGGGCAAGCAGGGCAGCTTCCATTCCGAGCA
GGCGATCGCCTACGGCACCCGCATGGTCGGCGGCGTGACGCCGGGCAAAGGCGGGCAGACCCACCTGAACCTGCCCGTGT
TCAACACGGTGCGCGACGCGGTGCGCGAAACCGGCGCGCAGGCGACGATGATCTACGTCCCGGCCGCGTTCGCCGCCGAC
TCGATCCTCGAAGCGGCCGACGCGGGCATCGAGGTCATCGTCTGCATCACCGAGGGCATTCCGGTGCTCGACATGCTTCA
GGTCAAAACGGCGCTCAACGTGAAGGCCGCGCTCAAGGCCAACGGCGCGAAGCTCATCGGCCCGAACTGCCCGGGCATCA
TCACGTCGGGCGAATGCAAGATCGGCATCATGCCCGGCGTCATCCACCAGAAGGGTCGCATCGGCATCGTCTCGCGCTCG
GGGACGCTGACCTACGAGGCGGTCCACCAGACGACACAGCTGGGGCTCGGGCAATCGACTTGCGTTGGCATCGGCGGAGA
CCCGATCAAGGGGCTCGATTTCATCGATTGCCTCGAGATGTTCGAGGCCGATCCGCAGACCGAAGCCGTGATCCTGGTCG
GCGAGATCGGCGGCAGCAGCGAGGAGGAAGCCGCCGAGTACATCCACACGCGCATGAAGAAGCCCGTCGCCGCCTACATC
GCCGGCCGCACGGCGCCGAAGGGCAAGCGCATGGGCCACGCCGGCGCGATCATCGCGGGCGGCGCGGGGACGGCCGATGC
AAAAATCCGCGCACTCGAAGCCGCGGGCGTCGTCGTCGCGCAGAGTCCGGCAGGCCTCGGCGAAGCAGTGCAGCTTGCGC
TCGGCGCCCGCTAG

Upstream 100 bases:

>100_bases
ATGCCGAACTCGGCCGCACCCTGCTGGCCGAATCGGGCCTCGCGATCGTCGCGGCCGAGAGCCTGACCCAGGCCGCGAAA
TTCGCCGTGGAGAAAGCGGC

Downstream 100 bases:

>100_bases
GGTGCGATGAAGCTCGCCCTCGCGCAGTTCAATTTCACGGTCGGCGACATCGCCGGCAACGCCGCGAAGCTGCTCGACGC
CGCGCAGGCTGCGCACGCGG

Product: succinyl-CoA synthetase (ADP-forming) subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSILVDKDTKVICQGFTGKQGSFHSEQAIAYGTRMVGGVTPGKGGQTHLNLPVFNTVRDAVRETGAQATMIYVPAAFAAD
SILEAADAGIEVIVCITEGIPVLDMLQVKTALNVKAALKANGAKLIGPNCPGIITSGECKIGIMPGVIHQKGRIGIVSRS
GTLTYEAVHQTTQLGLGQSTCVGIGGDPIKGLDFIDCLEMFEADPQTEAVILVGEIGGSSEEEAAEYIHTRMKKPVAAYI
AGRTAPKGKRMGHAGAIIAGGAGTADAKIRALEAAGVVVAQSPAGLGEAVQLALGAR

Sequences:

>Translated_297_residues
MSILVDKDTKVICQGFTGKQGSFHSEQAIAYGTRMVGGVTPGKGGQTHLNLPVFNTVRDAVRETGAQATMIYVPAAFAAD
SILEAADAGIEVIVCITEGIPVLDMLQVKTALNVKAALKANGAKLIGPNCPGIITSGECKIGIMPGVIHQKGRIGIVSRS
GTLTYEAVHQTTQLGLGQSTCVGIGGDPIKGLDFIDCLEMFEADPQTEAVILVGEIGGSSEEEAAEYIHTRMKKPVAAYI
AGRTAPKGKRMGHAGAIIAGGAGTADAKIRALEAAGVVVAQSPAGLGEAVQLALGAR
>Mature_296_residues
SILVDKDTKVICQGFTGKQGSFHSEQAIAYGTRMVGGVTPGKGGQTHLNLPVFNTVRDAVRETGAQATMIYVPAAFAADS
ILEAADAGIEVIVCITEGIPVLDMLQVKTALNVKAALKANGAKLIGPNCPGIITSGECKIGIMPGVIHQKGRIGIVSRSG
TLTYEAVHQTTQLGLGQSTCVGIGGDPIKGLDFIDCLEMFEADPQTEAVILVGEIGGSSEEEAAEYIHTRMKKPVAAYIA
GRTAPKGKRMGHAGAIIAGGAGTADAKIRALEAAGVVVAQSPAGLGEAVQLALGAR

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=299, Percent_Identity=64.8829431438127, Blast_Score=337, Evalue=8e-93,
Organism=Homo sapiens, GI38569423, Length=263, Percent_Identity=32.319391634981, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI38569421, Length=263, Percent_Identity=32.319391634981, Blast_Score=96, Evalue=5e-20,
Organism=Escherichia coli, GI1786949, Length=294, Percent_Identity=71.7687074829932, Blast_Score=422, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17553126, Length=297, Percent_Identity=63.6363636363636, Blast_Score=352, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI17550194, Length=297, Percent_Identity=60.2693602693603, Blast_Score=342, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI17557344, Length=314, Percent_Identity=28.6624203821656, Blast_Score=81, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17551266, Length=314, Percent_Identity=27.3885350318471, Blast_Score=78, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6324716, Length=297, Percent_Identity=52.5252525252525, Blast_Score=286, Evalue=3e-78,
Organism=Drosophila melanogaster, GI28574296, Length=293, Percent_Identity=59.0443686006826, Blast_Score=320, Evalue=9e-88,
Organism=Drosophila melanogaster, GI21356559, Length=302, Percent_Identity=52.317880794702, Blast_Score=316, Evalue=1e-86,
Organism=Drosophila melanogaster, GI281363477, Length=265, Percent_Identity=29.4339622641509, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI281363475, Length=265, Percent_Identity=29.4339622641509, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI281363473, Length=265, Percent_Identity=29.4339622641509, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30431; Mature: 30299

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILVDKDTKVICQGFTGKQGSFHSEQAIAYGTRMVGGVTPGKGGQTHLNLPVFNTVRDA
CEEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHH
VRETGAQATMIYVPAAFAADSILEAADAGIEVIVCITEGIPVLDMLQVKTALNVKAALKA
HHHCCCCEEEEEEEHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHCEEEEEEC
NGAKLIGPNCPGIITSGECKIGIMPGVIHQKGRIGIVSRSGTLTYEAVHQTTQLGLGQST
CCCEEECCCCCCEEECCCEEEEECCCCEECCCCEEEEECCCCEEHHHHHHHHHCCCCCCE
CVGIGGDPIKGLDFIDCLEMFEADPQTEAVILVGEIGGSSEEEAAEYIHTRMKKPVAAYI
EEECCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEE
AGRTAPKGKRMGHAGAIIAGGAGTADAKIRALEAAGVVVAQSPAGLGEAVQLALGAR
ECCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEECCEEEEECCCCCCHHHHHEECCC
>Mature Secondary Structure 
SILVDKDTKVICQGFTGKQGSFHSEQAIAYGTRMVGGVTPGKGGQTHLNLPVFNTVRDA
EEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHH
VRETGAQATMIYVPAAFAADSILEAADAGIEVIVCITEGIPVLDMLQVKTALNVKAALKA
HHHCCCCEEEEEEEHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHHHHHHCEEEEEEC
NGAKLIGPNCPGIITSGECKIGIMPGVIHQKGRIGIVSRSGTLTYEAVHQTTQLGLGQST
CCCEEECCCCCCEEECCCEEEEECCCCEECCCCEEEEECCCCEEHHHHHHHHHCCCCCCE
CVGIGGDPIKGLDFIDCLEMFEADPQTEAVILVGEIGGSSEEEAAEYIHTRMKKPVAAYI
EEECCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEE
AGRTAPKGKRMGHAGAIIAGGAGTADAKIRALEAAGVVVAQSPAGLGEAVQLALGAR
ECCCCCCCCCCCCCCEEEECCCCCCCCEEEEEEECCEEEEECCCCCCHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]