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The map label for this gene is pyrH

Identifier: 74316805

GI number: 74316805

Start: 830316

End: 831029

Strand: Direct

Name: pyrH

Synonym: Tbd_0787

Alternate gene names: 74316805

Gene position: 830316-831029 (Clockwise)

Preceding gene: 74316804

Following gene: 74316806

Centisome position: 28.54

GC content: 68.21

Gene sequence:

>714_bases
GTGGCGCCCGTTCGCCGCATCCTGCTGAAGCTCTCGGGCGAGGCCCTGATGGGACCGGACAGCTTCGGCTACCACGCCGG
GACGATGGCCGGTTTCGTCGGTCAGATCCGTGACGTGGTCGCGCTGGGCGTGCAGGTCGGGATCGTCGTCGGGGGCGGCA
ATCTGTTTCGGGGTGCGACCGGCGCGCTCGCCGGCATGAATCGTGCGACGGCCGATTCGATGGGCATGCTGGCGACCGTG
ATGAATGCGCTCGCGCTGAAGGACGCGCTGCAGCAGGCAGGCGTTGCGGCGCGCGTGCAGACCGCCGTGCACATTGCCCA
CGTCGGCGAAGGCTTCGAGCGCGACGCCGCCGTGCGCGAACTCGAGGCGGGGCGGGTGGTGATCTTCGGCGGCGGAACCG
GGAACCCGTTTTTCACGACGGACACCGCGGCTGCGCTGCGTGCTGCCGAGATCGACGCCGATCTGCTGCTCAAGGCGACC
AAGGTCGACGGCGTCTATACCGCGGACCCGAACAAGGACCCGGACGCTCGGCGCTACGATACGCTCTCGTTCGACGAGGC
GATCGCGAAGCAGCTCGGCGTGCTCGACACCGCGGCTTTCGCGCTGTGCCGCGAGCAGAAACTGTCCCTGGTCGTGTTCA
ACGTCTTCAAACCCGGCGCGCTCAAGCGCGTGGTGATGGGCGAGGACGAGGGCACGCGGGTCAGCAACCATTGA

Upstream 100 bases:

>100_bases
CAGTGCCACGGGTTCACGATGTACGTCGTCGGCGAGGGCATCGAGAAGAAGGTCTCCGACTTTGCTGCCGAGGTTGCCGC
GGCCGCCAAGGTCTGACGCA

Downstream 100 bases:

>100_bases
GGAATTGAAATGGCTGAAACCACGATCACCGACATCAAGCAGTCCGCCGAGCAGAAGATGGGCAAGACGCTCGAGGCGCT
GAAAAACGATCTCGCGAAGG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MAPVRRILLKLSGEALMGPDSFGYHAGTMAGFVGQIRDVVALGVQVGIVVGGGNLFRGATGALAGMNRATADSMGMLATV
MNALALKDALQQAGVAARVQTAVHIAHVGEGFERDAAVRELEAGRVVIFGGGTGNPFFTTDTAAALRAAEIDADLLLKAT
KVDGVYTADPNKDPDARRYDTLSFDEAIAKQLGVLDTAAFALCREQKLSLVVFNVFKPGALKRVVMGEDEGTRVSNH

Sequences:

>Translated_237_residues
MAPVRRILLKLSGEALMGPDSFGYHAGTMAGFVGQIRDVVALGVQVGIVVGGGNLFRGATGALAGMNRATADSMGMLATV
MNALALKDALQQAGVAARVQTAVHIAHVGEGFERDAAVRELEAGRVVIFGGGTGNPFFTTDTAAALRAAEIDADLLLKAT
KVDGVYTADPNKDPDARRYDTLSFDEAIAKQLGVLDTAAFALCREQKLSLVVFNVFKPGALKRVVMGEDEGTRVSNH
>Mature_236_residues
APVRRILLKLSGEALMGPDSFGYHAGTMAGFVGQIRDVVALGVQVGIVVGGGNLFRGATGALAGMNRATADSMGMLATVM
NALALKDALQQAGVAARVQTAVHIAHVGEGFERDAAVRELEAGRVVIFGGGTGNPFFTTDTAAALRAAEIDADLLLKATK
VDGVYTADPNKDPDARRYDTLSFDEAIAKQLGVLDTAAFALCREQKLSLVVFNVFKPGALKRVVMGEDEGTRVSNH

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=234, Percent_Identity=56.8376068376068, Blast_Score=261, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_THIDA (Q3SKN7)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314545.1
- HSSP:   P65938
- ProteinModelPortal:   Q3SKN7
- SMR:   Q3SKN7
- STRING:   Q3SKN7
- GeneID:   3673484
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0787
- NMPDR:   fig|292415.3.peg.51
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q3SKN7
- BioCyc:   TDEN292415:TBD_0787-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 24774; Mature: 24643

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: BINDING 52-52 BINDING 53-53 BINDING 57-57 BINDING 72-72 BINDING 160-160 BINDING 166-166 BINDING 169-169

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPVRRILLKLSGEALMGPDSFGYHAGTMAGFVGQIRDVVALGVQVGIVVGGGNLFRGAT
CCHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCH
GALAGMNRATADSMGMLATVMNALALKDALQQAGVAARVQTAVHIAHVGEGFERDAAVRE
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHH
LEAGRVVIFGGGTGNPFFTTDTAAALRAAEIDADLLLKATKVDGVYTADPNKDPDARRYD
HCCCEEEEEECCCCCCCEECCHHHHHHHHHCCHHHEEEEEECCEEEECCCCCCCCCCCCC
TLSFDEAIAKQLGVLDTAAFALCREQKLSLVVFNVFKPGALKRVVMGEDEGTRVSNH
CCCHHHHHHHHHCHHHHHHHHHHHHCCCEEEEEECCCCCHHEEEEECCCCCCCCCCC
>Mature Secondary Structure 
APVRRILLKLSGEALMGPDSFGYHAGTMAGFVGQIRDVVALGVQVGIVVGGGNLFRGAT
CHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCH
GALAGMNRATADSMGMLATVMNALALKDALQQAGVAARVQTAVHIAHVGEGFERDAAVRE
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHH
LEAGRVVIFGGGTGNPFFTTDTAAALRAAEIDADLLLKATKVDGVYTADPNKDPDARRYD
HCCCEEEEEECCCCCCCEECCHHHHHHHHHCCHHHEEEEEECCEEEECCCCCCCCCCCCC
TLSFDEAIAKQLGVLDTAAFALCREQKLSLVVFNVFKPGALKRVVMGEDEGTRVSNH
CCCHHHHHHHHHCHHHHHHHHHHHHCCCEEEEEECCCCCHHEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA