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The map label for this gene is mtnP [H]

Identifier: 74316796

GI number: 74316796

Start: 822174

End: 822935

Strand: Direct

Name: mtnP [H]

Synonym: Tbd_0778

Alternate gene names: 74316796

Gene position: 822174-822935 (Clockwise)

Preceding gene: 74316795

Following gene: 74316797

Centisome position: 28.26

GC content: 66.93

Gene sequence:

>762_bases
ATGTTGGGAATCATCGGCGGCACTGGGTTGACCCAGCTCGCCAACCTCAAGATCACGCATCGCCGCGTCGCGCGCACGCC
CTACGGCGAGCCTTCCGGCGCGCTCACGTTCGGTCGCCTGTGCGACCAGGACGTGATCTTTCTCGCGCGCCACGGCTACG
GCCATACGATCCCGCCGCACGAGGTCAATTACCGGGCGAATCTGTGGGCGCTCAAGGAGCACGGCGTCAACCGCATCGTG
TCGGTCGCCACCGTCGGCGGCATCCATCCCGAGCTCATTCCCGGGACACTGGTCATCCCCGACCAGATCATCGACTACAC
CCACGGCCGCGACGGCACGTTTTTCGTCGAAGGCGACCGGCCCGTCACCCATCGCGACTTCACGCAGCCCTACTGCGCGG
CGATGCGCGCCGCGCTGCTGCAGGCCGCGACGAGTGCCGACATCAGCCTGCGCGACGGCGGCGTCTACGCGGCGGTGCAG
GGGCCGCGCCTCGAAACCGCCGCCGAGATCAATCGCCTGGAGCGGGACGGCGCCGACATGGTCGGCATGACCGGCATGCC
CGAAGCCTATCTCGCGTGCGAGCTCGACCTTTGCTATGCCACCGTCGGCACGGTCGTGAACCATGCGGCGGGCCGCGGAC
TTTCCGCCGACGGCATTCAGATGGTCGAAATCCAGGTGGTGCTTGGCGAGGTCATGCTGCAGGTGCGTCATCTCCTGGAA
CAGCTCGTGACCAACGACTCGGCCGGACTCTGCACCTTCTGA

Upstream 100 bases:

>100_bases
TACGTCTTTGGTTGCGGCATGGACGCCTACGGACTGTGGCGCAACCTGCCAGCGATTTACGCTTTGAGCCCCGACGCCGC
GTCGGGATAAGGAAAACTAC

Downstream 100 bases:

>100_bases
AAGCAGGATTGCCGGCGGAATGAAGCTCTATCGTGCGCTGCAGTCGCAGGGGCTCGGCAGCCGCCGCGGCTGCGCGGCGC
TTGTGCGCGCCGGCGCGGTT

Product: 5'-methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MLGIIGGTGLTQLANLKITHRRVARTPYGEPSGALTFGRLCDQDVIFLARHGYGHTIPPHEVNYRANLWALKEHGVNRIV
SVATVGGIHPELIPGTLVIPDQIIDYTHGRDGTFFVEGDRPVTHRDFTQPYCAAMRAALLQAATSADISLRDGGVYAAVQ
GPRLETAAEINRLERDGADMVGMTGMPEAYLACELDLCYATVGTVVNHAAGRGLSADGIQMVEIQVVLGEVMLQVRHLLE
QLVTNDSAGLCTF

Sequences:

>Translated_253_residues
MLGIIGGTGLTQLANLKITHRRVARTPYGEPSGALTFGRLCDQDVIFLARHGYGHTIPPHEVNYRANLWALKEHGVNRIV
SVATVGGIHPELIPGTLVIPDQIIDYTHGRDGTFFVEGDRPVTHRDFTQPYCAAMRAALLQAATSADISLRDGGVYAAVQ
GPRLETAAEINRLERDGADMVGMTGMPEAYLACELDLCYATVGTVVNHAAGRGLSADGIQMVEIQVVLGEVMLQVRHLLE
QLVTNDSAGLCTF
>Mature_253_residues
MLGIIGGTGLTQLANLKITHRRVARTPYGEPSGALTFGRLCDQDVIFLARHGYGHTIPPHEVNYRANLWALKEHGVNRIV
SVATVGGIHPELIPGTLVIPDQIIDYTHGRDGTFFVEGDRPVTHRDFTQPYCAAMRAALLQAATSADISLRDGGVYAAVQ
GPRLETAAEINRLERDGADMVGMTGMPEAYLACELDLCYATVGTVVNHAAGRGLSADGIQMVEIQVVLGEVMLQVRHLLE
QLVTNDSAGLCTF

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=215, Percent_Identity=36.7441860465116, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI71980569, Length=215, Percent_Identity=36.7441860465116, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323045, Length=244, Percent_Identity=29.9180327868852, Blast_Score=105, Evalue=7e-24,
Organism=Drosophila melanogaster, GI20130079, Length=241, Percent_Identity=34.4398340248963, Blast_Score=150, Evalue=6e-37,
Organism=Drosophila melanogaster, GI221459247, Length=209, Percent_Identity=35.4066985645933, Blast_Score=128, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 27258; Mature: 27258

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGIIGGTGLTQLANLKITHRRVARTPYGEPSGALTFGRLCDQDVIFLARHGYGHTIPPH
CEEEECCCCHHHHHCEEEHHHHHHCCCCCCCCCCEEHHHHCCCCEEEEEECCCCCCCCCC
EVNYRANLWALKEHGVNRIVSVATVGGIHPELIPGTLVIPDQIIDYTHGRDGTFFVEGDR
CCCCCEEEEEEHHCCHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHCCCCCCEEEEECCC
PVTHRDFTQPYCAAMRAALLQAATSADISLRDGGVYAAVQGPRLETAAEINRLERDGADM
CCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCEEEEEECCCCHHHHHHHHHHHCCCCE
VGMTGMPEAYLACELDLCYATVGTVVNHAAGRGLSADGIQMVEIQVVLGEVMLQVRHLLE
ECCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHH
QLVTNDSAGLCTF
HHHCCCCCCCCCC
>Mature Secondary Structure
MLGIIGGTGLTQLANLKITHRRVARTPYGEPSGALTFGRLCDQDVIFLARHGYGHTIPPH
CEEEECCCCHHHHHCEEEHHHHHHCCCCCCCCCCEEHHHHCCCCEEEEEECCCCCCCCCC
EVNYRANLWALKEHGVNRIVSVATVGGIHPELIPGTLVIPDQIIDYTHGRDGTFFVEGDR
CCCCCEEEEEEHHCCHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHCCCCCCEEEEECCC
PVTHRDFTQPYCAAMRAALLQAATSADISLRDGGVYAAVQGPRLETAAEINRLERDGADM
CCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCEEEEEECCCCHHHHHHHHHHHCCCCE
VGMTGMPEAYLACELDLCYATVGTVVNHAAGRGLSADGIQMVEIQVVLGEVMLQVRHLLE
ECCCCCCCEEEEEEHHHHHHHHHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHH
QLVTNDSAGLCTF
HHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]