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The map label for this gene is gmhB [H]

Identifier: 74316759

GI number: 74316759

Start: 785498

End: 786079

Strand: Direct

Name: gmhB [H]

Synonym: Tbd_0741

Alternate gene names: 74316759

Gene position: 785498-786079 (Clockwise)

Preceding gene: 74316758

Following gene: 74316760

Centisome position: 26.99

GC content: 71.13

Gene sequence:

>582_bases
ATGACCCGCGCCGTGTTTCTCGACAAGGACGGCACGCTCGTCGACGACGTGCCGTACAACGCCGACCCGACGAAGATCCG
GCTCGCCGCGGGCGCCGGCCGCGCGCTCGCCGCGCTGCTCGCCGGCGGCTTTCGCCTGTTCGTCGTCTCCAACCAGCCGG
GCGTCGGCCTCGGCTACTTCCCGCTCGCGGCCCTGCAGCCGCTGTCGCAGCGCATCCGACAGCTCGTGCGCGCGGACGGC
GCCGATCTCCACGGCTTCTATTACTGTCCGCACGCGCCGGCGCGGGGGCAGCCCGCCTGCGGCTGCCGCAAGCCGGCGCC
GGGCCTGGTGCTGCAGGCGGCCGCCGAGCATGGCATCGCGCTCGAGAATTCGTGGTTCATTGGCGACATCCTCGACGACG
TCGAGGCCGGTCATCGCGCCGGCTGCCGCAGCATCCTCATCGACAACGGCAACGAAACCGAATGGCTGAGATCACCAATA
CGCGAGCCCGACCACGTCGTGCGCAACCTGCACGACGCGGCGGCACACATTCTGAGCGCGGCGCAGCGCGAAACCGGGCG
GGCGAGGGCCCTCGCGTCATGA

Upstream 100 bases:

>100_bases
GATGGGACGCGCCGGCGGCAATCGTCACCCCGTTGCGTCCGCCGCGGGCGCTCCCGCCCGAAGCCGAATTGCCCGGCGTG
CTCGGAGGCGCGCTCTTGCC

Downstream 100 bases:

>100_bases
GCGGCAACTGGCACGACGCGCGGCGCATCCTCTGCGTGCGGCTCGACAACATGGGCGACGTGCTGATGACGACGCCGGCG
ATCCGCGCCTTGAAGGCCGC

Product: histidinol-phosphate phosphatase

Products: NA

Alternate protein names: D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [H]

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MTRAVFLDKDGTLVDDVPYNADPTKIRLAAGAGRALAALLAGGFRLFVVSNQPGVGLGYFPLAALQPLSQRIRQLVRADG
ADLHGFYYCPHAPARGQPACGCRKPAPGLVLQAAAEHGIALENSWFIGDILDDVEAGHRAGCRSILIDNGNETEWLRSPI
REPDHVVRNLHDAAAHILSAAQRETGRARALAS

Sequences:

>Translated_193_residues
MTRAVFLDKDGTLVDDVPYNADPTKIRLAAGAGRALAALLAGGFRLFVVSNQPGVGLGYFPLAALQPLSQRIRQLVRADG
ADLHGFYYCPHAPARGQPACGCRKPAPGLVLQAAAEHGIALENSWFIGDILDDVEAGHRAGCRSILIDNGNETEWLRSPI
REPDHVVRNLHDAAAHILSAAQRETGRARALAS
>Mature_192_residues
TRAVFLDKDGTLVDDVPYNADPTKIRLAAGAGRALAALLAGGFRLFVVSNQPGVGLGYFPLAALQPLSQRIRQLVRADGA
DLHGFYYCPHAPARGQPACGCRKPAPGLVLQAAAEHGIALENSWFIGDILDDVEAGHRAGCRSILIDNGNETEWLRSPIR
EPDHVVRNLHDAAAHILSAAQRETGRARALAS

Specific function: Converts the D-glycero-beta-D-manno-heptose 1,7- bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1- phosphate by removing the phosphate group at the C-7 position [H]

COG id: COG0241

COG function: function code E; Histidinol phosphatase and related phosphatases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gmhB family [H]

Homologues:

Organism=Escherichia coli, GI1786399, Length=138, Percent_Identity=35.5072463768116, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI87082027, Length=192, Percent_Identity=28.6458333333333, Blast_Score=79, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR004446
- InterPro:   IPR006543
- InterPro:   IPR013954 [H]

Pfam domain/function: PF08645 PNK3P [H]

EC number: NA

Molecular weight: Translated: 20618; Mature: 20486

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRAVFLDKDGTLVDDVPYNADPTKIRLAAGAGRALAALLAGGFRLFVVSNQPGVGLGYF
CCCEEEECCCCCEECCCCCCCCCCEEEEECCCCHHHHHHHHCCEEEEEEECCCCCCCCHH
PLAALQPLSQRIRQLVRADGADLHGFYYCPHAPARGQPACGCRKPAPGLVLQAAAEHGIA
HHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEHHHHHCCEE
LENSWFIGDILDDVEAGHRAGCRSILIDNGNETEWLRSPIREPDHVVRNLHDAAAHILSA
ECCCEEHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHH
AQRETGRARALAS
HHHHCCCHHCCCC
>Mature Secondary Structure 
TRAVFLDKDGTLVDDVPYNADPTKIRLAAGAGRALAALLAGGFRLFVVSNQPGVGLGYF
CCEEEECCCCCEECCCCCCCCCCEEEEECCCCHHHHHHHHCCEEEEEEECCCCCCCCHH
PLAALQPLSQRIRQLVRADGADLHGFYYCPHAPARGQPACGCRKPAPGLVLQAAAEHGIA
HHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEHHHHHCCEE
LENSWFIGDILDDVEAGHRAGCRSILIDNGNETEWLRSPIREPDHVVRNLHDAAAHILSA
ECCCEEHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHH
AQRETGRARALAS
HHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682; 12101286 [H]