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The map label for this gene is lysA [H]

Identifier: 74316735

GI number: 74316735

Start: 756309

End: 757517

Strand: Reverse

Name: lysA [H]

Synonym: Tbd_0717

Alternate gene names: 74316735

Gene position: 757517-756309 (Counterclockwise)

Preceding gene: 74316736

Following gene: 74316734

Centisome position: 26.03

GC content: 70.31

Gene sequence:

>1209_bases
ATGGAACTGAGGCTCGCCGAGGTGTTCGCCCACCTGCGCGAAGCCGAAGCCGAGGCCGGCGCGCCCCTGTGCGCCTACCT
CTACGACCTCGCCGCGCTCGACGCACACGCCGCGGCGCTCGCCGCGAGCCTGCCGCCGGGCTGCGACCTCTTCTACGCGA
TCAAGGCTAATTCCGATCTGCCGATCCTGCAGACGCTGGCGCCGCACGTCGCCGGCTTCGAGGTCTCGTCGGGCGGCGAA
CTCGCCTGGGTGCGCGCACATTTCGCCGAGATCCCGGTGATCTTCAGCGGGCCGGGCAAGCTCGACGACGAGCTCCGGCA
GGCGCTCGAACACGGCGTCGATTGCCTGCATGTCGAGAGCCGGCACGAATTGCAGCGGCTCGCAGAAATCGCGGCCCGGC
TCGGTCGTACCGCGCCTGTGGCCCTGCGCGTCAACCTTACGCTCGACGCGCTCGCCGAGACCCCGCTCATGATGGGCGGC
AAGCCGACGCCGTTCGGCATTCCGACCGAGCAGCTGCCGGCATGCCTGGACTGGCTGCGCGAGCGGCCCGAGATCCGCCT
GCGCGGCCTGCATTTCCACCTGCTGTCGCACCAGCTCGATGCCGCCGCGCACCTACGGCTCGTCGCGGCCTACCTCGCGC
AGACCCGCCGCTGGTGCGAGGCGCACGGCCTCGCCCTCGACCACGTCAACGTCGGCGGCGGCATCGGCATCAACTACCGC
GAGCCCGCCCGGCAGTTCGACTGGCCCGCGTTCAGCGCCGGGCTCGCATCGCTGCTGCACGAAGCCGGCCTGCCGGGCGT
GCGCGTGCGCTTCGAACTCGGCCGCTATGTGACCGCCGCCTGCGGCTACTACGCGATGCAGGTCGTCGACATCAAGCACA
GCCATGGCAAGACCTTCGTCGTCGGCCGCGGCGGCTCGCATCACTTCCGCACGCCCTACGCGCAAGGCCACAGCCACCCC
TTCCACGTGCTGCCGGTCGATGACTGGCCGTATGCGTTCGCGCGCCCGCAGGCGGCGGATCAGCGCGTCAGCGTCGTCGG
CCAGCTGTGCACGCCGAAGGACCTGCTGGCCTTCGACGCCCCGGTCGAATCGGTGCGCTGCAACGACGTGCTGGTCTTTC
CCTACGCCGGCGCCTATGCCTGGCACATCTCGCATCACGACTTCCTGCGCCACCCGCATCCGGCGCAGTGGTACCTGCCC
GTGGAGTGA

Upstream 100 bases:

>100_bases
GCAAGGCCAATCTGATCAACCGCTTCTTCAAGCGCGCCGACCGCGCCTCCGGCTACCTGCCGGTCAACAACCCCCTCGGC
ACGCTCGCGGAGCGCCGCGC

Downstream 100 bases:

>100_bases
CGCGCATGCTGCAGACCAATCGCCTCAAACGCGCGCTCGCCGACGGCAAGTCCGTGTTCGGCCTGCTCAATTCGATTCCG
TCGCCGCTCGTCGTCGAAAT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MELRLAEVFAHLREAEAEAGAPLCAYLYDLAALDAHAAALAASLPPGCDLFYAIKANSDLPILQTLAPHVAGFEVSSGGE
LAWVRAHFAEIPVIFSGPGKLDDELRQALEHGVDCLHVESRHELQRLAEIAARLGRTAPVALRVNLTLDALAETPLMMGG
KPTPFGIPTEQLPACLDWLRERPEIRLRGLHFHLLSHQLDAAAHLRLVAAYLAQTRRWCEAHGLALDHVNVGGGIGINYR
EPARQFDWPAFSAGLASLLHEAGLPGVRVRFELGRYVTAACGYYAMQVVDIKHSHGKTFVVGRGGSHHFRTPYAQGHSHP
FHVLPVDDWPYAFARPQAADQRVSVVGQLCTPKDLLAFDAPVESVRCNDVLVFPYAGAYAWHISHHDFLRHPHPAQWYLP
VE

Sequences:

>Translated_402_residues
MELRLAEVFAHLREAEAEAGAPLCAYLYDLAALDAHAAALAASLPPGCDLFYAIKANSDLPILQTLAPHVAGFEVSSGGE
LAWVRAHFAEIPVIFSGPGKLDDELRQALEHGVDCLHVESRHELQRLAEIAARLGRTAPVALRVNLTLDALAETPLMMGG
KPTPFGIPTEQLPACLDWLRERPEIRLRGLHFHLLSHQLDAAAHLRLVAAYLAQTRRWCEAHGLALDHVNVGGGIGINYR
EPARQFDWPAFSAGLASLLHEAGLPGVRVRFELGRYVTAACGYYAMQVVDIKHSHGKTFVVGRGGSHHFRTPYAQGHSHP
FHVLPVDDWPYAFARPQAADQRVSVVGQLCTPKDLLAFDAPVESVRCNDVLVFPYAGAYAWHISHHDFLRHPHPAQWYLP
VE
>Mature_402_residues
MELRLAEVFAHLREAEAEAGAPLCAYLYDLAALDAHAAALAASLPPGCDLFYAIKANSDLPILQTLAPHVAGFEVSSGGE
LAWVRAHFAEIPVIFSGPGKLDDELRQALEHGVDCLHVESRHELQRLAEIAARLGRTAPVALRVNLTLDALAETPLMMGG
KPTPFGIPTEQLPACLDWLRERPEIRLRGLHFHLLSHQLDAAAHLRLVAAYLAQTRRWCEAHGLALDHVNVGGGIGINYR
EPARQFDWPAFSAGLASLLHEAGLPGVRVRFELGRYVTAACGYYAMQVVDIKHSHGKTFVVGRGGSHHFRTPYAQGHSHP
FHVLPVDDWPYAFARPQAADQRVSVVGQLCTPKDLLAFDAPVESVRCNDVLVFPYAGAYAWHISHHDFLRHPHPAQWYLP
VE

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=270, Percent_Identity=27.4074074074074, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44217; Mature: 44217

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELRLAEVFAHLREAEAEAGAPLCAYLYDLAALDAHAAALAASLPPGCDLFYAIKANSDL
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
PILQTLAPHVAGFEVSSGGELAWVRAHFAEIPVIFSGPGKLDDELRQALEHGVDCLHVES
CHHHHHHHHHCCEEECCCCCEEEEEEHHHHCCEEECCCCCCHHHHHHHHHCCCEEEEECH
RHELQRLAEIAARLGRTAPVALRVNLTLDALAETPLMMGGKPTPFGIPTEQLPACLDWLR
HHHHHHHHHHHHHHCCCCCEEEEEEEEHHHHHCCCHHCCCCCCCCCCCHHHHHHHHHHHH
ERPEIRLRGLHFHLLSHQLDAAAHLRLVAAYLAQTRRWCEAHGLALDHVNVGGGIGINYR
CCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCC
EPARQFDWPAFSAGLASLLHEAGLPGVRVRFELGRYVTAACGYYAMQVVDIKHSHGKTFV
CCHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHEEEEEEEEEECCCCEEE
VGRGGSHHFRTPYAQGHSHPFHVLPVDDWPYAFARPQAADQRVSVVGQLCTPKDLLAFDA
EECCCCCCCCCCCCCCCCCCEEEEECCCCCCHHCCCCCHHHHHHHHHHHCCCHHHHEECC
PVESVRCNDVLVFPYAGAYAWHISHHDFLRHPHPAQWYLPVE
CCCCCCCCCEEEEECCCEEEEEECCHHHHCCCCCCCEEEECC
>Mature Secondary Structure
MELRLAEVFAHLREAEAEAGAPLCAYLYDLAALDAHAAALAASLPPGCDLFYAIKANSDL
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
PILQTLAPHVAGFEVSSGGELAWVRAHFAEIPVIFSGPGKLDDELRQALEHGVDCLHVES
CHHHHHHHHHCCEEECCCCCEEEEEEHHHHCCEEECCCCCCHHHHHHHHHCCCEEEEECH
RHELQRLAEIAARLGRTAPVALRVNLTLDALAETPLMMGGKPTPFGIPTEQLPACLDWLR
HHHHHHHHHHHHHHCCCCCEEEEEEEEHHHHHCCCHHCCCCCCCCCCCHHHHHHHHHHHH
ERPEIRLRGLHFHLLSHQLDAAAHLRLVAAYLAQTRRWCEAHGLALDHVNVGGGIGINYR
CCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCC
EPARQFDWPAFSAGLASLLHEAGLPGVRVRFELGRYVTAACGYYAMQVVDIKHSHGKTFV
CCHHHCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHEEEEEEEEEECCCCEEE
VGRGGSHHFRTPYAQGHSHPFHVLPVDDWPYAFARPQAADQRVSVVGQLCTPKDLLAFDA
EECCCCCCCCCCCCCCCCCCEEEEECCCCCCHHCCCCCHHHHHHHHHHHCCCHHHHEECC
PVESVRCNDVLVFPYAGAYAWHISHHDFLRHPHPAQWYLPVE
CCCCCCCCCEEEEECCCEEEEEECCHHHHCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]