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The map label for this gene is pepA [H]

Identifier: 74316674

GI number: 74316674

Start: 696819

End: 698279

Strand: Direct

Name: pepA [H]

Synonym: Tbd_0656

Alternate gene names: 74316674

Gene position: 696819-698279 (Clockwise)

Preceding gene: 74316665

Following gene: 74316676

Centisome position: 23.95

GC content: 67.35

Gene sequence:

>1461_bases
ATGCTGCCCAAGCTTTCTCAAAACCGGCAGGAAATCAGCGCCACGACGCTCGAAGGCGCCAGCCATGTGTTGGTGCTGCT
GCCGCTGACGAAGAATCTGCCCGATGTGGCCGGAAACGCCGCGCTCAAGGCGGTGATGAAGCGGCGGAATATCAAGGTCG
ACGCGCTCGCGAAGTCGCCGGTCGCCGTCCAGTTGCCCGGCGGCACGCTCGCGGTCTACGCGATGCTGAAGTCCGCCGCG
AACACATTCGACACGCACGAGCAGCTGCGCAAGGCGCTCGCCCTGCTGCTCGGCGAGCATCCGAAGATCGTCACGCTCGC
GGTCTTCGGCGACGCCGCGTTCCGGGGGCGGATCGCCGAAGCAGCGGTCTACACGACCTGGGTCAATGCCGTGCCGCTGC
CCTCGCGCAAATCGAAGAGCGATCCGGCGCTCAAGGCGATCGAGCTCTTCGGCTACAAATCGGCCGATGGCTTCAGCCGC
GCGCAGGCGCTCGCCGAAGGCAACACGCTCACCCGCAGCCTGACCGTGCAAGGCCCCGACGAACTCACGCCCGGGGTGTA
TCGCAAGCGCATCAAGGCGCTTGCCAAGGAATACGGGTGGACCGTCGAGGAATACGGTTTCGACAAACTGAAGGCCATGG
GCGCCGGCGCGTTCTGCGCGGTCGCCCAGGGCTCGCCGGCGAAGGACGCGGCGATCGTGCGCGTGAGCTACAAGGGAACG
GGCGCGAAGGGCAGGGGCAGGAAGATCGCCTTCGTCGGCAAGGGCATCTGCTTCGACACCGGCGGCCACAACCTCAAGCC
GGCCAAGTACATGCAGGGCATGCACGAGGACATGAACGGTTCGGCGGTCGTGCTCGGCATTCTCGCCGCGGCGTCACGGA
TGAAGCTGCCGGTGGCACTGGAGGGCTGGGTCGCGCTCGCCGAGAACCACATCAGCCCGCAGGCCTACCGCCAGAACGAG
GTCGTCACGGCGCTCAACGGCACCTCGATCGAAGTCGTCCACACCGACGCCGAAGGCCGCATGGTGCTCGCCGACACACT
GACCCTCGCCGCGCGCGGCAAGCCCGAGCTCATCGCCGATTTCGCCACCCTGACCGGCTCGATGCACTACGCCCTCGGCA
GCCGCATGTCGGGTGTGTTCGCGTCCTCCGACGCGCTCGCGCAGGCGGCCACCCGCGCGGCGGCCGCGAGCGGCGAACGC
ATCGTCGTCTTTCCGCATCCCGAGGATTACGACAGCGCGCTCGACTCGACCGTCGCCGACGTCAAGCAGTGCACGATGGA
AGGCGAGGCCGATCACATCCTCGCCGCGCGTCTGCTCTCGCGCTTCGTCGGCGAGACACCGTGGTTGCACATGGACTTGT
CGGCGCACAGCTGCAAGGGCGGGCTCGGTGCCGTCATGAGTGACGCCAACGGCTTCGGCGTCGCTTGGGCGCTCGCCTTG
CTGGACGGCCTGAAGGGCTGA

Upstream 100 bases:

>100_bases
TGTCGGACGGGCTCGGAAAAAGCGCCGGGAAAATGCAAACGCGCAATTATCCGAGAAACCCCGTCGACCATCAAGAAAAC
GCCTCTCCCAAGGATTGCCT

Downstream 100 bases:

>100_bases
GCGCTTTTCCCGGTCGGCGCTACGGCGCGTGCGTCACGTCACCGGCCCAGCTCAACGCGGCCGACACGGTGGGAAAGCCG
ACGGTGCTGGTGAGGAGGAC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MLPKLSQNRQEISATTLEGASHVLVLLPLTKNLPDVAGNAALKAVMKRRNIKVDALAKSPVAVQLPGGTLAVYAMLKSAA
NTFDTHEQLRKALALLLGEHPKIVTLAVFGDAAFRGRIAEAAVYTTWVNAVPLPSRKSKSDPALKAIELFGYKSADGFSR
AQALAEGNTLTRSLTVQGPDELTPGVYRKRIKALAKEYGWTVEEYGFDKLKAMGAGAFCAVAQGSPAKDAAIVRVSYKGT
GAKGRGRKIAFVGKGICFDTGGHNLKPAKYMQGMHEDMNGSAVVLGILAAASRMKLPVALEGWVALAENHISPQAYRQNE
VVTALNGTSIEVVHTDAEGRMVLADTLTLAARGKPELIADFATLTGSMHYALGSRMSGVFASSDALAQAATRAAAASGER
IVVFPHPEDYDSALDSTVADVKQCTMEGEADHILAARLLSRFVGETPWLHMDLSAHSCKGGLGAVMSDANGFGVAWALAL
LDGLKG

Sequences:

>Translated_486_residues
MLPKLSQNRQEISATTLEGASHVLVLLPLTKNLPDVAGNAALKAVMKRRNIKVDALAKSPVAVQLPGGTLAVYAMLKSAA
NTFDTHEQLRKALALLLGEHPKIVTLAVFGDAAFRGRIAEAAVYTTWVNAVPLPSRKSKSDPALKAIELFGYKSADGFSR
AQALAEGNTLTRSLTVQGPDELTPGVYRKRIKALAKEYGWTVEEYGFDKLKAMGAGAFCAVAQGSPAKDAAIVRVSYKGT
GAKGRGRKIAFVGKGICFDTGGHNLKPAKYMQGMHEDMNGSAVVLGILAAASRMKLPVALEGWVALAENHISPQAYRQNE
VVTALNGTSIEVVHTDAEGRMVLADTLTLAARGKPELIADFATLTGSMHYALGSRMSGVFASSDALAQAATRAAAASGER
IVVFPHPEDYDSALDSTVADVKQCTMEGEADHILAARLLSRFVGETPWLHMDLSAHSCKGGLGAVMSDANGFGVAWALAL
LDGLKG
>Mature_486_residues
MLPKLSQNRQEISATTLEGASHVLVLLPLTKNLPDVAGNAALKAVMKRRNIKVDALAKSPVAVQLPGGTLAVYAMLKSAA
NTFDTHEQLRKALALLLGEHPKIVTLAVFGDAAFRGRIAEAAVYTTWVNAVPLPSRKSKSDPALKAIELFGYKSADGFSR
AQALAEGNTLTRSLTVQGPDELTPGVYRKRIKALAKEYGWTVEEYGFDKLKAMGAGAFCAVAQGSPAKDAAIVRVSYKGT
GAKGRGRKIAFVGKGICFDTGGHNLKPAKYMQGMHEDMNGSAVVLGILAAASRMKLPVALEGWVALAENHISPQAYRQNE
VVTALNGTSIEVVHTDAEGRMVLADTLTLAARGKPELIADFATLTGSMHYALGSRMSGVFASSDALAQAATRAAAASGER
IVVFPHPEDYDSALDSTVADVKQCTMEGEADHILAARLLSRFVGETPWLHMDLSAHSCKGGLGAVMSDANGFGVAWALAL
LDGLKG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=323, Percent_Identity=33.1269349845201, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI47155554, Length=368, Percent_Identity=30.1630434782609, Blast_Score=122, Evalue=6e-28,
Organism=Escherichia coli, GI1790710, Length=256, Percent_Identity=35.9375, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI87082123, Length=270, Percent_Identity=36.2962962962963, Blast_Score=138, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17556903, Length=284, Percent_Identity=30.2816901408451, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17565172, Length=366, Percent_Identity=28.4153005464481, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21355725, Length=322, Percent_Identity=31.3664596273292, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI24661038, Length=339, Percent_Identity=30.3834808259587, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI161077148, Length=337, Percent_Identity=28.486646884273, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI20130057, Length=337, Percent_Identity=28.486646884273, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI20129969, Length=323, Percent_Identity=29.1021671826625, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI19922386, Length=336, Percent_Identity=28.8690476190476, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24662227, Length=335, Percent_Identity=26.865671641791, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI21355645, Length=335, Percent_Identity=27.1641791044776, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24662223, Length=335, Percent_Identity=27.1641791044776, Blast_Score=118, Evalue=7e-27,
Organism=Drosophila melanogaster, GI21357381, Length=310, Percent_Identity=30, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI221379063, Length=312, Percent_Identity=30.1282051282051, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI221379062, Length=312, Percent_Identity=30.1282051282051, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI20129963, Length=322, Percent_Identity=27.9503105590062, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24646701, Length=264, Percent_Identity=27.6515151515151, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24646703, Length=264, Percent_Identity=27.6515151515151, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21358201, Length=264, Percent_Identity=27.6515151515151, Blast_Score=79, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 51279; Mature: 51279

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS00019 ACTININ_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPKLSQNRQEISATTLEGASHVLVLLPLTKNLPDVAGNAALKAVMKRRNIKVDALAKSP
CCCCCCCCHHHHHHHEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCC
VAVQLPGGTLAVYAMLKSAANTFDTHEQLRKALALLLGEHPKIVTLAVFGDAAFRGRIAE
EEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHCHHHH
AAVYTTWVNAVPLPSRKSKSDPALKAIELFGYKSADGFSRAQALAEGNTLTRSLTVQGPD
HHHEEHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEEEECCCC
ELTPGVYRKRIKALAKEYGWTVEEYGFDKLKAMGAGAFCAVAQGSPAKDAAIVRVSYKGT
CCCHHHHHHHHHHHHHHHCCCHHHCCCHHHHHCCCCCEEEECCCCCCCCEEEEEEEECCC
GAKGRGRKIAFVGKGICFDTGGHNLKPAKYMQGMHEDMNGSAVVLGILAAASRMKLPVAL
CCCCCCCEEEEEECCEEEECCCCCCCHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCCEEH
EGWVALAENHISPQAYRQNEVVTALNGTSIEVVHTDAEGRMVLADTLTLAARGKPELIAD
HHHHHHHHCCCCCHHHCCCCEEEEECCCEEEEEEECCCCCEEEEEEEEEECCCCHHHHHH
FATLTGSMHYALGSRMSGVFASSDALAQAATRAAAASGERIVVFPHPEDYDSALDSTVAD
HHHHHCCHHHHHHCHHCCCEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHH
VKQCTMEGEADHILAARLLSRFVGETPWLHMDLSAHSCKGGLGAVMSDANGFGVAWALAL
HHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHCCCCCCHHHHHHHH
LDGLKG
HHHCCC
>Mature Secondary Structure
MLPKLSQNRQEISATTLEGASHVLVLLPLTKNLPDVAGNAALKAVMKRRNIKVDALAKSP
CCCCCCCCHHHHHHHEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECCCC
VAVQLPGGTLAVYAMLKSAANTFDTHEQLRKALALLLGEHPKIVTLAVFGDAAFRGRIAE
EEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHHCHHHH
AAVYTTWVNAVPLPSRKSKSDPALKAIELFGYKSADGFSRAQALAEGNTLTRSLTVQGPD
HHHEEHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEEEECCCC
ELTPGVYRKRIKALAKEYGWTVEEYGFDKLKAMGAGAFCAVAQGSPAKDAAIVRVSYKGT
CCCHHHHHHHHHHHHHHHCCCHHHCCCHHHHHCCCCCEEEECCCCCCCCEEEEEEEECCC
GAKGRGRKIAFVGKGICFDTGGHNLKPAKYMQGMHEDMNGSAVVLGILAAASRMKLPVAL
CCCCCCCEEEEEECCEEEECCCCCCCHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCCEEH
EGWVALAENHISPQAYRQNEVVTALNGTSIEVVHTDAEGRMVLADTLTLAARGKPELIAD
HHHHHHHHCCCCCHHHCCCCEEEEECCCEEEEEEECCCCCEEEEEEEEEECCCCHHHHHH
FATLTGSMHYALGSRMSGVFASSDALAQAATRAAAASGERIVVFPHPEDYDSALDSTVAD
HHHHHCCHHHHHHCHHCCCEECCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHH
VKQCTMEGEADHILAARLLSRFVGETPWLHMDLSAHSCKGGLGAVMSDANGFGVAWALAL
HHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHCCCCCCHHHHHHHH
LDGLKG
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA