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The map label for this gene is dacC [H]

Identifier: 74316665

GI number: 74316665

Start: 687863

End: 689071

Strand: Direct

Name: dacC [H]

Synonym: Tbd_0647

Alternate gene names: 74316665

Gene position: 687863-689071 (Clockwise)

Preceding gene: 74316654

Following gene: 74316674

Centisome position: 23.64

GC content: 66.58

Gene sequence:

>1209_bases
ATGCGGGTAAGATTTCCCGCTTTAATTTCCAGCCCTGTCGCGACCGAGCCAATGTCCCTGACCTCACGCCTTGCCGCCGT
TTTTCTGCTGTTCGTCCCCCTCGCCGCCGCCGCCGCCGCAGCGGTCGTTCCCCCGCCCCCTGAACTCGCGGCCAAATCCT
GGGTGTTGATGGATGCCGCGAGCGGCAGCGTCCTCGTCGATCATCGTGGACGCGAGCGCCTGCCGCCGGCGAGCCTGACC
AAGCTCATGACCTCGCACGTCGCCGCGCTCGAACTCCAGCGCGGCCGCATCAAGGAGAACGACCTCGTCACGATCAGCGA
AAAAGCCTGGCGCATGGGCGGCTCGAAAATGTTCGTCCGCGTCGGCAACCAGGTCGCGGTGCACGATCTGCTGCGCGGCA
TCATCGTGCAGTCGGGCAACGACGCGAGCATCGCGCTCGCCGAGCATCTGGCGGGCGGCGAGGATACCTTCGCCGCGCTC
ATGAATCAGGAAGCGAAGCGGCTGGGCCTCGCCGACACGCATTTCGTCAACGCCACGGGCTGGCCGGCCGAAGGCCATTA
CTCGAGCGCGCTCGACATGGCCAAGCTTGCGCGCGCGATCATCATCGAGGACCCCGCGCACTACGGCCTCTACGCCGAAA
AGGAATTCGTCTGGAACGGTATCAAGCAGCCGAACCGCAATCTGCTGCTGTGGCGTGACCCGTCGGTCGACGGCCTGAAG
ACCGGCCACACCGAGGAAGCCGGTTATTGCCTCGTCGCGTCGAGCCAGCGCGACGGCCAGCGCATGATCGCCGCCGTGTT
CGGCACGGAAAGCGAAGCCGCGCGCGCGACCGAAACCGCGAAACTGCTCGCCTACGGCTTCAACTTCTTCGACAGCAAGA
CCTTCTTCAAGAAAGGTCAGGCGGTGCAGACCGTCGAGGTGTGGAAAGGCGCCGCGCGCACGCTCAAGGCCGGGGTCGCG
GCGGACTTCGCGGCGGTGCTGCCCAAGCGCACGAGCGGCGAATTCAAGACGCGCACCGTGGTGACGAGCGACCCGCTGGT
CGCGCCCGTCAAGGCGGGCGCGCCGCTCGGGCGCGTCGAACTTGTCGGCGGCGACGGCAAGGTCGTCAAGCAGGCGCCGC
TCGTCGCGCTGGAAACGGTCGAGGAGGGTGGCTTCTTCCGCCGGATCTGGGACAGCATCCGGCTGTTCTTCAAGGGGCTG
TTCGGCTGA

Upstream 100 bases:

>100_bases
TGCGGTCGGACCGCTCGCGCCCCATGTGAAGGCGCGTCGATCCGCACGGCCCTTGCAGCTGCGGACAGCCGATGCGAGTT
CGCGTCCGCGGCGTCCGCAA

Downstream 100 bases:

>100_bases
ACCGGGTCAGTCGCCGCGGCCAGCCTCAGCGGCGCAGGTCGGCGCGTTGCTTGAGAAACGTGTCGCGGTCGATTTCGCCG
CGCGCATAGCGGGCTTCGAG

Product: serine-type D-ala-D-ala-carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MRVRFPALISSPVATEPMSLTSRLAAVFLLFVPLAAAAAAAVVPPPPELAAKSWVLMDAASGSVLVDHRGRERLPPASLT
KLMTSHVAALELQRGRIKENDLVTISEKAWRMGGSKMFVRVGNQVAVHDLLRGIIVQSGNDASIALAEHLAGGEDTFAAL
MNQEAKRLGLADTHFVNATGWPAEGHYSSALDMAKLARAIIIEDPAHYGLYAEKEFVWNGIKQPNRNLLLWRDPSVDGLK
TGHTEEAGYCLVASSQRDGQRMIAAVFGTESEAARATETAKLLAYGFNFFDSKTFFKKGQAVQTVEVWKGAARTLKAGVA
ADFAAVLPKRTSGEFKTRTVVTSDPLVAPVKAGAPLGRVELVGGDGKVVKQAPLVALETVEEGGFFRRIWDSIRLFFKGL
FG

Sequences:

>Translated_402_residues
MRVRFPALISSPVATEPMSLTSRLAAVFLLFVPLAAAAAAAVVPPPPELAAKSWVLMDAASGSVLVDHRGRERLPPASLT
KLMTSHVAALELQRGRIKENDLVTISEKAWRMGGSKMFVRVGNQVAVHDLLRGIIVQSGNDASIALAEHLAGGEDTFAAL
MNQEAKRLGLADTHFVNATGWPAEGHYSSALDMAKLARAIIIEDPAHYGLYAEKEFVWNGIKQPNRNLLLWRDPSVDGLK
TGHTEEAGYCLVASSQRDGQRMIAAVFGTESEAARATETAKLLAYGFNFFDSKTFFKKGQAVQTVEVWKGAARTLKAGVA
ADFAAVLPKRTSGEFKTRTVVTSDPLVAPVKAGAPLGRVELVGGDGKVVKQAPLVALETVEEGGFFRRIWDSIRLFFKGL
FG
>Mature_402_residues
MRVRFPALISSPVATEPMSLTSRLAAVFLLFVPLAAAAAAAVVPPPPELAAKSWVLMDAASGSVLVDHRGRERLPPASLT
KLMTSHVAALELQRGRIKENDLVTISEKAWRMGGSKMFVRVGNQVAVHDLLRGIIVQSGNDASIALAEHLAGGEDTFAAL
MNQEAKRLGLADTHFVNATGWPAEGHYSSALDMAKLARAIIIEDPAHYGLYAEKEFVWNGIKQPNRNLLLWRDPSVDGLK
TGHTEEAGYCLVASSQRDGQRMIAAVFGTESEAARATETAKLLAYGFNFFDSKTFFKKGQAVQTVEVWKGAARTLKAGVA
ADFAAVLPKRTSGEFKTRTVVTSDPLVAPVKAGAPLGRVELVGGDGKVVKQAPLVALETVEEGGFFRRIWDSIRLFFKGL
FG

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=385, Percent_Identity=42.3376623376623, Blast_Score=301, Evalue=7e-83,
Organism=Escherichia coli, GI1786851, Length=392, Percent_Identity=41.0714285714286, Blast_Score=294, Evalue=6e-81,
Organism=Escherichia coli, GI87082022, Length=383, Percent_Identity=42.0365535248042, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI87082054, Length=213, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 43263; Mature: 43263

Theoretical pI: Translated: 9.85; Mature: 9.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVRFPALISSPVATEPMSLTSRLAAVFLLFVPLAAAAAAAVVPPPPELAAKSWVLMDAA
CCEECCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCEEEEECC
SGSVLVDHRGRERLPPASLTKLMTSHVAALELQRGRIKENDLVTISEKAWRMGGSKMFVR
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHCCCCEEEEE
VGNQVAVHDLLRGIIVQSGNDASIALAEHLAGGEDTFAALMNQEAKRLGLADTHFVNATG
ECCCHHHHHHHHHHEEECCCCCEEEHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEECCCC
WPAEGHYSSALDMAKLARAIIIEDPAHYGLYAEKEFVWNGIKQPNRNLLLWRDPSVDGLK
CCCCCCHHHHHHHHHHHHEEEEECCCCCCCEECHHHHHCCCCCCCCCEEEEECCCCCCCC
TGHTEEAGYCLVASSQRDGQRMIAAVFGTESEAARATETAKLLAYGFNFFDSKTFFKKGQ
CCCCCCCCEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCHHCCHHHHHCCC
AVQTVEVWKGAARTLKAGVAADFAAVLPKRTSGEFKTRTVVTSDPLVAPVKAGAPLGRVE
CEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEECCCCCCCCEEE
LVGGDGKVVKQAPLVALETVEEGGFFRRIWDSIRLFFKGLFG
EECCCCCEECCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRVRFPALISSPVATEPMSLTSRLAAVFLLFVPLAAAAAAAVVPPPPELAAKSWVLMDAA
CCEECCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCEEEEECC
SGSVLVDHRGRERLPPASLTKLMTSHVAALELQRGRIKENDLVTISEKAWRMGGSKMFVR
CCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHCCCCEEEEE
VGNQVAVHDLLRGIIVQSGNDASIALAEHLAGGEDTFAALMNQEAKRLGLADTHFVNATG
ECCCHHHHHHHHHHEEECCCCCEEEHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEECCCC
WPAEGHYSSALDMAKLARAIIIEDPAHYGLYAEKEFVWNGIKQPNRNLLLWRDPSVDGLK
CCCCCCHHHHHHHHHHHHEEEEECCCCCCCEECHHHHHCCCCCCCCCEEEEECCCCCCCC
TGHTEEAGYCLVASSQRDGQRMIAAVFGTESEAARATETAKLLAYGFNFFDSKTFFKKGQ
CCCCCCCCEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCCHHCCHHHHHCCC
AVQTVEVWKGAARTLKAGVAADFAAVLPKRTSGEFKTRTVVTSDPLVAPVKAGAPLGRVE
CEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCEEECCCCCCCCEEE
LVGGDGKVVKQAPLVALETVEEGGFFRRIWDSIRLFFKGLFG
EECCCCCEECCCCEEEEEEHHCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]