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The map label for this gene is ndk

Identifier: 74316608

GI number: 74316608

Start: 619256

End: 619684

Strand: Direct

Name: ndk

Synonym: Tbd_0590

Alternate gene names: 74316608

Gene position: 619256-619684 (Clockwise)

Preceding gene: 74316607

Following gene: 74316609

Centisome position: 21.28

GC content: 62.24

Gene sequence:

>429_bases
ATGGCTGTTCAGCGCACTTTCTCCATCATCAAACCCGACGCGGTCGCCAAGAACGTGATCGGCAAGATCGTCAGCCGTTT
CGAGACCAACGGCCTCAAGGTCGTCGCGTCGAAGATGAAGCATCTCTCGCGTCAGGAAGCCGAAGGTTTCTACGCCGTGC
ACAAGGATCGCCCCTTCTTCAAGGATCTCGTCGACTTCATGGTCTCCGGTCCCGTCGTGCTGCAGGTGCTCGAGGGTGAG
GACGCGATCGCCAAGAACCGCACGCTGATGGGCGCGACCGACCCGAAGAAAGCCGAGCCGGGCACGATCCGCGCCGACTT
CGCCGAGAGCATCGACGCCAACGCCGTTCACGGTTCCGACGCGCCCGAAACGGCGGCAGTCGAGATTGCCTACTTCTTCC
CGGCGAGCGAAGTCTACGCCGGACGCTGA

Upstream 100 bases:

>100_bases
CAAGCTGCCGCGCAAGACAGCGGCGGCTGCGGCGTGCTATCCTAGCGGGCTGATTTTCATCGTTTTTTGAACGTTTTCAC
TCATCGTCCGGAGCACACAC

Downstream 100 bases:

>100_bases
GCGCGCATGCCGCAGAATCTGCTCGATTTCGACCTCGCAGGACTGACCGCCTGGTTCGGCGAACGCGGCGAGAAGCCGTT
TCGCGCCCGCCAGGTGTTTC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 142; Mature: 141

Protein sequence:

>142_residues
MAVQRTFSIIKPDAVAKNVIGKIVSRFETNGLKVVASKMKHLSRQEAEGFYAVHKDRPFFKDLVDFMVSGPVVLQVLEGE
DAIAKNRTLMGATDPKKAEPGTIRADFAESIDANAVHGSDAPETAAVEIAYFFPASEVYAGR

Sequences:

>Translated_142_residues
MAVQRTFSIIKPDAVAKNVIGKIVSRFETNGLKVVASKMKHLSRQEAEGFYAVHKDRPFFKDLVDFMVSGPVVLQVLEGE
DAIAKNRTLMGATDPKKAEPGTIRADFAESIDANAVHGSDAPETAAVEIAYFFPASEVYAGR
>Mature_141_residues
AVQRTFSIIKPDAVAKNVIGKIVSRFETNGLKVVASKMKHLSRQEAEGFYAVHKDRPFFKDLVDFMVSGPVVLQVLEGED
AIAKNRTLMGATDPKKAEPGTIRADFAESIDANAVHGSDAPETAAVEIAYFFPASEVYAGR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=139, Percent_Identity=45.3237410071942, Blast_Score=129, Evalue=6e-31,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=41.9117647058824, Blast_Score=122, Evalue=7e-29,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=41.9117647058824, Blast_Score=122, Evalue=7e-29,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=41.9117647058824, Blast_Score=122, Evalue=7e-29,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=41.9117647058824, Blast_Score=122, Evalue=7e-29,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=41.9117647058824, Blast_Score=122, Evalue=8e-29,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=41.9117647058824, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=41.9117647058824, Blast_Score=121, Evalue=2e-28,
Organism=Homo sapiens, GI4826862, Length=135, Percent_Identity=37.7777777777778, Blast_Score=107, Evalue=4e-24,
Organism=Homo sapiens, GI37574614, Length=141, Percent_Identity=36.8794326241135, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI7019465, Length=141, Percent_Identity=36.8794326241135, Blast_Score=92, Evalue=1e-19,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=38.6861313868613, Blast_Score=91, Evalue=4e-19,
Organism=Homo sapiens, GI30023828, Length=137, Percent_Identity=35.036496350365, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=33.0882352941176, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1788866, Length=138, Percent_Identity=59.4202898550725, Blast_Score=177, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17506807, Length=136, Percent_Identity=44.8529411764706, Blast_Score=129, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=41.9117647058824, Blast_Score=122, Evalue=3e-29,
Organism=Drosophila melanogaster, GI45549037, Length=135, Percent_Identity=45.9259259259259, Blast_Score=129, Evalue=7e-31,
Organism=Drosophila melanogaster, GI18860097, Length=132, Percent_Identity=32.5757575757576, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24645457, Length=136, Percent_Identity=31.6176470588235, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_THIDA (Q3SL74)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314348.1
- ProteinModelPortal:   Q3SL74
- SMR:   Q3SL74
- STRING:   Q3SL74
- GeneID:   3673700
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0590
- NMPDR:   fig|292415.3.peg.392
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   IRAEFAE
- PhylomeDB:   Q3SL74
- BioCyc:   TDEN292415:TBD_0590-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15429; Mature: 15298

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVQRTFSIIKPDAVAKNVIGKIVSRFETNGLKVVASKMKHLSRQEAEGFYAVHKDRPFF
CCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHH
KDLVDFMVSGPVVLQVLEGEDAIAKNRTLMGATDPKKAEPGTIRADFAESIDANAVHGSD
HHHHHHHHCCCCEEEEECCCCHHHHCCEEECCCCCCCCCCCCEEHHHHHCCCCCCCCCCC
APETAAVEIAYFFPASEVYAGR
CCCCEEEEEEEECCCHHHCCCC
>Mature Secondary Structure 
AVQRTFSIIKPDAVAKNVIGKIVSRFETNGLKVVASKMKHLSRQEAEGFYAVHKDRPFF
CCCHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHH
KDLVDFMVSGPVVLQVLEGEDAIAKNRTLMGATDPKKAEPGTIRADFAESIDANAVHGSD
HHHHHHHHCCCCEEEEECCCCHHHHCCEEECCCCCCCCCCCCEEHHHHHCCCCCCCCCCC
APETAAVEIAYFFPASEVYAGR
CCCCEEEEEEEECCCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA