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The map label for this gene is moaC

Identifier: 74316587

GI number: 74316587

Start: 597376

End: 597855

Strand: Direct

Name: moaC

Synonym: Tbd_0569

Alternate gene names: 74316587

Gene position: 597376-597855 (Clockwise)

Preceding gene: 74316559

Following gene: 74316588

Centisome position: 20.53

GC content: 65.21

Gene sequence:

>480_bases
ATGAGCGAGTTTACCCATTTTGACGAAAGCGGCCGCGCCATCATGGTCGACGTGGCGGGCAAGGACGACACCCGCCGTGT
TGCCACGGCACGCGGCGCCATCCACATGTTACCCGACACCCTCGGACGCATTCTCGGCGGGCAGGCCGCCAAGGGCGACG
TCCTTGCGGTCGCGCGCATCGCTGCGATACAGGCGACCAAACGCACGGCCGACTTGATCCCGCTCTGCCACCCGATCGCG
CTGACTCGAGTTGTGGTCGATTTTGCGCCCGAAACCGAGGTCTCGCGCATCGTGTGCACGGTGACAGCCGAGACCGTGGG
CAAGACCGGGGTGGAAATGGAGGCACTGACCGGGGTCAGTGTAGCCCTCCTCACGATCTACGACATGTGCAAGGCAGTCG
ACCGCGGCATGCAGATCGGCGACATCCAGCTCGTCGAGAAACAGGGCGGCCGCTCCGGCCACTGGCGCCTGCCCGATTAG

Upstream 100 bases:

>100_bases
GCGAGCAGCAATCGCAGCATCAGCAGCGCACGCGGGCCAAAGTCGAGGCGGGAGTAGACATTTGGTTTACGATTCGTGAA
TCGACACAAGGTTCCCAGCA

Downstream 100 bases:

>100_bases
CCCGGTGCCCAGCAGGGCGGCGGTGGCCATCTGCTGGAACGGGCGAGTGCCTTCCGCCGGGCGTCACCGCAAAGGCGACA
AGTTGCATGGCAGGGCCGGC

Product: GTP cyclohydrolase subunit MoaC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MSEFTHFDESGRAIMVDVAGKDDTRRVATARGAIHMLPDTLGRILGGQAAKGDVLAVARIAAIQATKRTADLIPLCHPIA
LTRVVVDFAPETEVSRIVCTVTAETVGKTGVEMEALTGVSVALLTIYDMCKAVDRGMQIGDIQLVEKQGGRSGHWRLPD

Sequences:

>Translated_159_residues
MSEFTHFDESGRAIMVDVAGKDDTRRVATARGAIHMLPDTLGRILGGQAAKGDVLAVARIAAIQATKRTADLIPLCHPIA
LTRVVVDFAPETEVSRIVCTVTAETVGKTGVEMEALTGVSVALLTIYDMCKAVDRGMQIGDIQLVEKQGGRSGHWRLPD
>Mature_158_residues
SEFTHFDESGRAIMVDVAGKDDTRRVATARGAIHMLPDTLGRILGGQAAKGDVLAVARIAAIQATKRTADLIPLCHPIAL
TRVVVDFAPETEVSRIVCTVTAETVGKTGVEMEALTGVSVALLTIYDMCKAVDRGMQIGDIQLVEKQGGRSGHWRLPD

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaC family

Homologues:

Organism=Escherichia coli, GI1787001, Length=157, Percent_Identity=52.2292993630573, Blast_Score=159, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI32566331, Length=151, Percent_Identity=47.682119205298, Blast_Score=139, Evalue=5e-34,
Organism=Drosophila melanogaster, GI28574490, Length=156, Percent_Identity=46.1538461538462, Blast_Score=126, Evalue=6e-30,
Organism=Drosophila melanogaster, GI28574492, Length=142, Percent_Identity=46.4788732394366, Blast_Score=115, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAC_THIDA (Q3SL94)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314327.1
- ProteinModelPortal:   Q3SL94
- SMR:   Q3SL94
- STRING:   Q3SL94
- GeneID:   3673679
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0569
- NMPDR:   fig|292415.3.peg.331
- eggNOG:   COG0315
- HOGENOM:   HBG605231
- OMA:   RIKEGTI
- PhylomeDB:   Q3SL94
- BioCyc:   TDEN292415:TBD_0569-MONOMER
- HAMAP:   MF_01224_B
- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR002820
- Gene3D:   G3DSA:3.30.70.640
- TIGRFAMs:   TIGR00581

Pfam domain/function: PF01967 MoaC; SSF55040 MoaC

EC number: NA

Molecular weight: Translated: 16983; Mature: 16852

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: ACT_SITE 128-128

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFTHFDESGRAIMVDVAGKDDTRRVATARGAIHMLPDTLGRILGGQAAKGDVLAVARI
CCCCCCCCCCCCEEEEEECCCCCHHHHHHHCCCEEECHHHHHHHHCCCCCCCCHHHHHHH
AAIQATKRTADLIPLCHPIALTRVVVDFAPETEVSRIVCTVTAETVGKTGVEMEALTGVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCCCCCCHHHHCCHH
VALLTIYDMCKAVDRGMQIGDIQLVEKQGGRSGHWRLPD
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
SEFTHFDESGRAIMVDVAGKDDTRRVATARGAIHMLPDTLGRILGGQAAKGDVLAVARI
CCCCCCCCCCCEEEEEECCCCCHHHHHHHCCCEEECHHHHHHHHCCCCCCCCHHHHHHH
AAIQATKRTADLIPLCHPIALTRVVVDFAPETEVSRIVCTVTAETVGKTGVEMEALTGVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHCCCCCCCHHHHCCHH
VALLTIYDMCKAVDRGMQIGDIQLVEKQGGRSGHWRLPD
HHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA