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The map label for this gene is dnaX [H]

Identifier: 74316533

GI number: 74316533

Start: 544784

End: 546529

Strand: Direct

Name: dnaX [H]

Synonym: Tbd_0515

Alternate gene names: 74316533

Gene position: 544784-546529 (Clockwise)

Preceding gene: 74316532

Following gene: 74316534

Centisome position: 18.72

GC content: 70.68

Gene sequence:

>1746_bases
ATGACTGACCTCTTCGGCGAATCCGCTTCCCCCGCAATGGCGCTGGCGCGCAAATGGCGGCCGCGCGCGTTTGCCGATCT
GCGCGGCCAGGAGCATGTCGTGCAGGCGCTGTCGAACGCGCTGACCCAGGGGCGACTGCATCACGCCTACCTGCTCACCG
GCACGCGCGGCGTCGGCAAGACCACGCTGGCGCGGATTCTCGCCAAGTGCCTGAATTGCGAAAGCGGCGTGAGTGCGACG
CCTTGCGGGACCTGCTCGGCGTGCACCCAGATCGACGCGGGACGCTTCGTCGACCTGCTCGAGCTCGACGCGGCGTCGAA
CACCGGCGTCGACAACATGCGCGAGGTGCTCGACAACGCGCAATACGCGCCGACCGTCGGCCGCTACAAGGTCTACATCA
TCGACGAAGTGCACATGCTCTCGAAGCCGGCCTTCAACTCGATGCTGAAGACGCTTGAAGAACCGCCCGCGCACGTCAAG
TTCATCCTCGCGACGACCGATCCGCAGAAGATTCCGGTGACGGTGCTGTCGCGCTGCCTGCAGTTCAACCTCAAGCCGAT
GACGCCCGCGCTCGTGGCCGGGCACCTCGGTGACGTGCTCGCCCAGGAGCGCGTCGACGCGGAACCTGCCGCGCTGAACC
TGCTCGCGCGCGCGGCCGCCGGCAGCATGCGCGACGCGCTCTCGCTGACCGACCAGGCGATCGCCTACGGCGGCGGCAGG
ATCGAGGCGGCAGCGGTCGAGGCGATGCTCGGCACCGTGCGTCGCGATTATCTGTTCGACCTGCTCGACGCGCTGGCGGC
GGGTGACGGCGACGCGCTCATGACGCAGGCGCGCCTGCTCGCCGAACGCGGCATCGCGTTCGACGCGACGCTGCAGGACC
TTGGCAACCTGCTGACCCAACTGGCGCTCGTGCTGCACGCGCCGGGCGCCGTCGAGGACGGCGCGGACGCCGAGCGGACA
CGCGCGGCCGCCGAAAAGCTCGACGCCGAAACGGTTCAGCTCTATTACCAGATCGCGCTGAACGGCCGCCGCGACCTGCC
TTACGCGCCCGACGAGTTTTCCGGGTTCTGCATGACGCTGCTGCGCATGCTGGCCTTCGCGCCGGCGACCGATCCCACGC
CGCGCAGCCCGGGGGGCGGACGCGCCCCTGTCGCCTCGGCGGACTCGACGCCGGCCGCTGCCCCCCTCGCCGCACCTGCG
CCGGCCCGCGTCCCGGCCGCAGCGCCAGCGCCTTTGCAGCAACCGGAAGCCGCCCGCCAGGTGGCCTCCGCTGAGCCGCT
CGCAGCCGAGGACGCCGACTCCCCTCGCGCTGCTGCGGCTCCGCCGGACGCGCCGTTCGTCGCCGCCGAGCCGGCACCCG
CTGCGCAATGGGACTGGCTCGCCGTCGTCGCGGGGCTCCGGCTCGGGGGCATGGCCAAGATGCTCGCCGACCATTGCGAA
CTCGTCGCGCAGACAGGCGACTCGGTCACGCTGCGGGTCGGCGAAGCGCACAAGCATCTGCTCGACCGCGCCTATCAGGA
CCGGCTCACTGGCGCGCTGCGCGAGAAGTACGGGCCGGCGCTCCAGATCACCTTCGAGGTCGGCAGCGCGGCAGATCAGA
CGCCGCAACAGGTGCGCACGCGGATCAAGGAAGCGCGCCAGGCCGAAGCCATCGCCGCGATCGAGGCGGACCCGTTCGTG
CGCGAACTGGTCGAGCAGTTCGGCGGCCAGGTCGAGGCTTCAACCATCCAGCCGCTGGCGCCCTGA

Upstream 100 bases:

>100_bases
CGTTGTCGCGCCTTGCCGTACTGATCTGTACTGTCTGCGGCGCGCCGCCTTGCCTCCGCCCGAATGCGGCCAGGAATGGC
CATAGCCACCGACATCACCC

Downstream 100 bases:

>100_bases
GCCGGCAGGCCTCAGCGCGCGGGCGAGCACGCGATCAACATTGACCCGACTCGGGACATCAGGAGAAACAGCATGATCAA
GGGCGGCATCGGCAACATGA

Product: DNA polymerase subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 581; Mature: 580

Protein sequence:

>581_residues
MTDLFGESASPAMALARKWRPRAFADLRGQEHVVQALSNALTQGRLHHAYLLTGTRGVGKTTLARILAKCLNCESGVSAT
PCGTCSACTQIDAGRFVDLLELDAASNTGVDNMREVLDNAQYAPTVGRYKVYIIDEVHMLSKPAFNSMLKTLEEPPAHVK
FILATTDPQKIPVTVLSRCLQFNLKPMTPALVAGHLGDVLAQERVDAEPAALNLLARAAAGSMRDALSLTDQAIAYGGGR
IEAAAVEAMLGTVRRDYLFDLLDALAAGDGDALMTQARLLAERGIAFDATLQDLGNLLTQLALVLHAPGAVEDGADAERT
RAAAEKLDAETVQLYYQIALNGRRDLPYAPDEFSGFCMTLLRMLAFAPATDPTPRSPGGGRAPVASADSTPAAAPLAAPA
PARVPAAAPAPLQQPEAARQVASAEPLAAEDADSPRAAAAPPDAPFVAAEPAPAAQWDWLAVVAGLRLGGMAKMLADHCE
LVAQTGDSVTLRVGEAHKHLLDRAYQDRLTGALREKYGPALQITFEVGSAADQTPQQVRTRIKEARQAEAIAAIEADPFV
RELVEQFGGQVEASTIQPLAP

Sequences:

>Translated_581_residues
MTDLFGESASPAMALARKWRPRAFADLRGQEHVVQALSNALTQGRLHHAYLLTGTRGVGKTTLARILAKCLNCESGVSAT
PCGTCSACTQIDAGRFVDLLELDAASNTGVDNMREVLDNAQYAPTVGRYKVYIIDEVHMLSKPAFNSMLKTLEEPPAHVK
FILATTDPQKIPVTVLSRCLQFNLKPMTPALVAGHLGDVLAQERVDAEPAALNLLARAAAGSMRDALSLTDQAIAYGGGR
IEAAAVEAMLGTVRRDYLFDLLDALAAGDGDALMTQARLLAERGIAFDATLQDLGNLLTQLALVLHAPGAVEDGADAERT
RAAAEKLDAETVQLYYQIALNGRRDLPYAPDEFSGFCMTLLRMLAFAPATDPTPRSPGGGRAPVASADSTPAAAPLAAPA
PARVPAAAPAPLQQPEAARQVASAEPLAAEDADSPRAAAAPPDAPFVAAEPAPAAQWDWLAVVAGLRLGGMAKMLADHCE
LVAQTGDSVTLRVGEAHKHLLDRAYQDRLTGALREKYGPALQITFEVGSAADQTPQQVRTRIKEARQAEAIAAIEADPFV
RELVEQFGGQVEASTIQPLAP
>Mature_580_residues
TDLFGESASPAMALARKWRPRAFADLRGQEHVVQALSNALTQGRLHHAYLLTGTRGVGKTTLARILAKCLNCESGVSATP
CGTCSACTQIDAGRFVDLLELDAASNTGVDNMREVLDNAQYAPTVGRYKVYIIDEVHMLSKPAFNSMLKTLEEPPAHVKF
ILATTDPQKIPVTVLSRCLQFNLKPMTPALVAGHLGDVLAQERVDAEPAALNLLARAAAGSMRDALSLTDQAIAYGGGRI
EAAAVEAMLGTVRRDYLFDLLDALAAGDGDALMTQARLLAERGIAFDATLQDLGNLLTQLALVLHAPGAVEDGADAERTR
AAAEKLDAETVQLYYQIALNGRRDLPYAPDEFSGFCMTLLRMLAFAPATDPTPRSPGGGRAPVASADSTPAAAPLAAPAP
ARVPAAAPAPLQQPEAARQVASAEPLAAEDADSPRAAAAPPDAPFVAAEPAPAAQWDWLAVVAGLRLGGMAKMLADHCEL
VAQTGDSVTLRVGEAHKHLLDRAYQDRLTGALREKYGPALQITFEVGSAADQTPQQVRTRIKEARQAEAIAAIEADPFVR
ELVEQFGGQVEASTIQPLAP

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=293, Percent_Identity=25.5972696245734, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI194306571, Length=296, Percent_Identity=25.3378378378378, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI194306567, Length=296, Percent_Identity=25.3378378378378, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI194306569, Length=212, Percent_Identity=25.9433962264151, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786676, Length=639, Percent_Identity=41.6275430359937, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1787341, Length=172, Percent_Identity=33.7209302325581, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1787119, Length=179, Percent_Identity=28.4916201117318, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17541988, Length=214, Percent_Identity=27.5700934579439, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322528, Length=286, Percent_Identity=23.7762237762238, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI18859927, Length=305, Percent_Identity=26.2295081967213, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17647857, Length=255, Percent_Identity=28.6274509803922, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 61386; Mature: 61255

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDLFGESASPAMALARKWRPRAFADLRGQEHVVQALSNALTQGRLHHAYLLTGTRGVGK
CCCCCCCCCCHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCH
TTLARILAKCLNCESGVSATPCGTCSACTQIDAGRFVDLLELDAASNTGVDNMREVLDNA
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHCCCCCCCCHHHHHHHHCCC
QYAPTVGRYKVYIIDEVHMLSKPAFNSMLKTLEEPPAHVKFILATTDPQKIPVTVLSRCL
CCCCCCCCEEEEEEECHHHHCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHH
QFNLKPMTPALVAGHLGDVLAQERVDAEPAALNLLARAAAGSMRDALSLTDQAIAYGGGR
HCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
IEAAAVEAMLGTVRRDYLFDLLDALAAGDGDALMTQARLLAERGIAFDATLQDLGNLLTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LALVLHAPGAVEDGADAERTRAAAEKLDAETVQLYYQIALNGRRDLPYAPDEFSGFCMTL
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHH
LRMLAFAPATDPTPRSPGGGRAPVASADSTPAAAPLAAPAPARVPAAAPAPLQQPEAARQ
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
VASAEPLAAEDADSPRAAAAPPDAPFVAAEPAPAAQWDWLAVVAGLRLGGMAKMLADHCE
HHCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LVAQTGDSVTLRVGEAHKHLLDRAYQDRLTGALREKYGPALQITFEVGSAADQTPQQVRT
HHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHH
RIKEARQAEAIAAIEADPFVRELVEQFGGQVEASTIQPLAP
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEECCCCCCCC
>Mature Secondary Structure 
TDLFGESASPAMALARKWRPRAFADLRGQEHVVQALSNALTQGRLHHAYLLTGTRGVGK
CCCCCCCCCHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHCCCEEEEEEECCCCCCH
TTLARILAKCLNCESGVSATPCGTCSACTQIDAGRFVDLLELDAASNTGVDNMREVLDNA
HHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHCCCCCCCCHHHHHHHHCCC
QYAPTVGRYKVYIIDEVHMLSKPAFNSMLKTLEEPPAHVKFILATTDPQKIPVTVLSRCL
CCCCCCCCEEEEEEECHHHHCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHH
QFNLKPMTPALVAGHLGDVLAQERVDAEPAALNLLARAAAGSMRDALSLTDQAIAYGGGR
HCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
IEAAAVEAMLGTVRRDYLFDLLDALAAGDGDALMTQARLLAERGIAFDATLQDLGNLLTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LALVLHAPGAVEDGADAERTRAAAEKLDAETVQLYYQIALNGRRDLPYAPDEFSGFCMTL
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCHHHHHH
LRMLAFAPATDPTPRSPGGGRAPVASADSTPAAAPLAAPAPARVPAAAPAPLQQPEAARQ
HHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHH
VASAEPLAAEDADSPRAAAAPPDAPFVAAEPAPAAQWDWLAVVAGLRLGGMAKMLADHCE
HHCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LVAQTGDSVTLRVGEAHKHLLDRAYQDRLTGALREKYGPALQITFEVGSAADQTPQQVRT
HHHHCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHH
RIKEARQAEAIAAIEADPFVRELVEQFGGQVEASTIQPLAP
HHHHHHHHHHHHHHCCCHHHHHHHHHHCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]