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The map label for this gene is cvrA [H]

Identifier: 74316518

GI number: 74316518

Start: 520273

End: 522009

Strand: Reverse

Name: cvrA [H]

Synonym: Tbd_0500

Alternate gene names: 74316518

Gene position: 522009-520273 (Counterclockwise)

Preceding gene: 74316521

Following gene: 74316516

Centisome position: 17.94

GC content: 67.47

Gene sequence:

>1737_bases
ATGGAACTCATCAACCAGCTCGTACTCGCGGGCGCGGTCCTGCTGCTCGTGGCCGTGCTCGCAAGCGCACTCTCCTACCG
CATCGGCATGCCGCTGCTGCTGGTGTTTCTCGCCGTCGGCATGCTGGCGGGCGAGGACGGCCCGGGCGGAATCGTATTCA
ACCACAGCGGCTTCGCCTACATGGCCGGCAGCGTCGCGCTTGCCGTCATCCTGCTCGACGGCGGACTCAATACGCGGGCG
GAAAGTTTCAGGGGCAGCCTGCGCCCGGCCGCGACGCTCGCGACCGCCGGCGTCGTGATCACCTGCGTGGTCACCGGGTT
CTTCGCCGCCTGGGTGCTCGACTTCAGCTATCTGCAAGGCATGCTCGTCGGCGCGGTGGTCGGATCGACCGACGCCGCCG
CGGTATTCGCGCTGTTGCGCGCCAAGGGCCTCACGCTCAAGGAGCGCCTGGCGGCGACGCTCGAAATCGAATCCGGCAGC
AACGATCCGATGGCAGCCCTGCTCACGCTCGCCTTCATCGCCTTGATCACCGCGGGACGCTCGACCCCGGGCTGGGAAAC
GCTCGCACTGCTGATTCAGCAGTTGGGCCTTGGCCTGATCGCCGGGCTCGGCGGCGGGGCACTGCTCGTCTGGTTGACCA
ACCGGCTGCGGCTCGAACGCGGCATGTATCCGATGATGATTCTGGCCGGCGGGCTGCTGTCCTACAGTCTTACGACGGTA
CTCGGCGGAAGCGGCTTTCTTGCGATCTACTTGTGCGGCGTCGTCGTCAGCAACCGCAATCCGCGGGAGGCGAGCAACAT
CCTGCAGGTGCACGATGGCCTGGCATGGCTCGCGCAGATAGGCATGTTCCTGATGCTCGGGTTACTGGCGTCGCCGCACG
AGCTCGTCGACAACGCCGCGGCGGGGCTGGCTATCGCGCTGGTGCTGATGCTGGTCGCACGACCCGTGGCGGTCGGGCTT
TGCCTGCTGCCCTTCCGTTTTTCCGGGCGCGAGCAGATTTTCATCGCCTGGGTCGGCCTGCGCGGCGCCGTGCCCATCGT
TCTTGCCTTGTTTCCGCTGCTCGCCGGCATCCCGGAGGCGTCGCTGATTCTCGATGTCGCCTTCTTCGTCGTGCTGATTT
CGCTGACCGTACAGGGCTGGACGATCCCCTTGTTCGCACGCTTGCTGCAGCTCGAGGTGCCGCCCGCCCCCGAGCCGAAC
GAACGACACGACCTGGAAGCGAGCGCGGAGAGCGGGCACGCTTTCCTCGGGTTCAAGCTGCCGCCCAATTCCACGCTCAT
TGGCCAGCCTGCCAATGCCCTCTGGCTTCCCGGCGCTGCCCGCCCGGTCGCGATCGCGCGCGGAAACGAGACGCTGACGC
CCGAGATCGCCGGCAGGCTGCTTCCCGGCGACACCCTGTACCTGCTCGCGCCGAGCGCCGACTGCGACACACTGAGCGAG
CTCCTGGTCGCGCCGGTCGCGCCGCCCCACCTCGAGCGACGCCATTTCTACGGGGTCTTCGTTCTGCATGGCGACGCGTC
GATGGCAGCCGTAGCCGGCCAGTACGACCTGCCCTTGCCCGCGGGGGCGGCAGAGCTGACGCTCGCGCAATTCCTCACGC
GGACGCTGCGCCGTCATCCAGGCCCGGGCGACCGCGTGCGCCTCGGCAAACTCGAGTTCGTCGTGCGCACCGTCGTCAAA
GGCCGTATCACCCGGGTCGGTCTACGCATCCCGACGCAACTCGATCGCAAGCGCTGA

Upstream 100 bases:

>100_bases
CTATGCTGACACCTCGGTTTCCGTGCGCCGCGACCCGCCGCACGGTATGCACGTCCCGCCGCGCTGCCACGGGGCGAGGT
CGGGCCTGAGGGCGCCCTCC

Downstream 100 bases:

>100_bases
GCGCCCTGCCGCACGCGGCGCAGCCGCGACGATCGGACGTAGACCTCCCCCCGGGGAGGATGCCCAAAATCTTTCCAGGA
TTCACCCTGTTACCGGCCTG

Product: sodium/hydrogen exchanger family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MELINQLVLAGAVLLLVAVLASALSYRIGMPLLLVFLAVGMLAGEDGPGGIVFNHSGFAYMAGSVALAVILLDGGLNTRA
ESFRGSLRPAATLATAGVVITCVVTGFFAAWVLDFSYLQGMLVGAVVGSTDAAAVFALLRAKGLTLKERLAATLEIESGS
NDPMAALLTLAFIALITAGRSTPGWETLALLIQQLGLGLIAGLGGGALLVWLTNRLRLERGMYPMMILAGGLLSYSLTTV
LGGSGFLAIYLCGVVVSNRNPREASNILQVHDGLAWLAQIGMFLMLGLLASPHELVDNAAAGLAIALVLMLVARPVAVGL
CLLPFRFSGREQIFIAWVGLRGAVPIVLALFPLLAGIPEASLILDVAFFVVLISLTVQGWTIPLFARLLQLEVPPAPEPN
ERHDLEASAESGHAFLGFKLPPNSTLIGQPANALWLPGAARPVAIARGNETLTPEIAGRLLPGDTLYLLAPSADCDTLSE
LLVAPVAPPHLERRHFYGVFVLHGDASMAAVAGQYDLPLPAGAAELTLAQFLTRTLRRHPGPGDRVRLGKLEFVVRTVVK
GRITRVGLRIPTQLDRKR

Sequences:

>Translated_578_residues
MELINQLVLAGAVLLLVAVLASALSYRIGMPLLLVFLAVGMLAGEDGPGGIVFNHSGFAYMAGSVALAVILLDGGLNTRA
ESFRGSLRPAATLATAGVVITCVVTGFFAAWVLDFSYLQGMLVGAVVGSTDAAAVFALLRAKGLTLKERLAATLEIESGS
NDPMAALLTLAFIALITAGRSTPGWETLALLIQQLGLGLIAGLGGGALLVWLTNRLRLERGMYPMMILAGGLLSYSLTTV
LGGSGFLAIYLCGVVVSNRNPREASNILQVHDGLAWLAQIGMFLMLGLLASPHELVDNAAAGLAIALVLMLVARPVAVGL
CLLPFRFSGREQIFIAWVGLRGAVPIVLALFPLLAGIPEASLILDVAFFVVLISLTVQGWTIPLFARLLQLEVPPAPEPN
ERHDLEASAESGHAFLGFKLPPNSTLIGQPANALWLPGAARPVAIARGNETLTPEIAGRLLPGDTLYLLAPSADCDTLSE
LLVAPVAPPHLERRHFYGVFVLHGDASMAAVAGQYDLPLPAGAAELTLAQFLTRTLRRHPGPGDRVRLGKLEFVVRTVVK
GRITRVGLRIPTQLDRKR
>Mature_578_residues
MELINQLVLAGAVLLLVAVLASALSYRIGMPLLLVFLAVGMLAGEDGPGGIVFNHSGFAYMAGSVALAVILLDGGLNTRA
ESFRGSLRPAATLATAGVVITCVVTGFFAAWVLDFSYLQGMLVGAVVGSTDAAAVFALLRAKGLTLKERLAATLEIESGS
NDPMAALLTLAFIALITAGRSTPGWETLALLIQQLGLGLIAGLGGGALLVWLTNRLRLERGMYPMMILAGGLLSYSLTTV
LGGSGFLAIYLCGVVVSNRNPREASNILQVHDGLAWLAQIGMFLMLGLLASPHELVDNAAAGLAIALVLMLVARPVAVGL
CLLPFRFSGREQIFIAWVGLRGAVPIVLALFPLLAGIPEASLILDVAFFVVLISLTVQGWTIPLFARLLQLEVPPAPEPN
ERHDLEASAESGHAFLGFKLPPNSTLIGQPANALWLPGAARPVAIARGNETLTPEIAGRLLPGDTLYLLAPSADCDTLSE
LLVAPVAPPHLERRHFYGVFVLHGDASMAAVAGQYDLPLPAGAAELTLAQFLTRTLRRHPGPGDRVRLGKLEFVVRTVVK
GRITRVGLRIPTQLDRKR

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=573, Percent_Identity=43.979057591623, Blast_Score=392, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 60916; Mature: 60916

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELINQLVLAGAVLLLVAVLASALSYRIGMPLLLVFLAVGMLAGEDGPGGIVFNHSGFAY
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEECCCCHHH
MAGSVALAVILLDGGLNTRAESFRGSLRPAATLATAGVVITCVVTGFFAAWVLDFSYLQG
HHHHHHEEEEEEECCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLVGAVVGSTDAAAVFALLRAKGLTLKERLAATLEIESGSNDPMAALLTLAFIALITAGR
HHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHCCC
STPGWETLALLIQQLGLGLIAGLGGGALLVWLTNRLRLERGMYPMMILAGGLLSYSLTTV
CCCCHHHHHHHHHHHCHHHHHCCCCCEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LGGSGFLAIYLCGVVVSNRNPREASNILQVHDGLAWLAQIGMFLMLGLLASPHELVDNAA
HCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AGLAIALVLMLVARPVAVGLCLLPFRFSGREQIFIAWVGLRGAVPIVLALFPLLAGIPEA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCH
SLILDVAFFVVLISLTVQGWTIPLFARLLQLEVPPAPEPNERHDLEASAESGHAFLGFKL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEC
PPNSTLIGQPANALWLPGAARPVAIARGNETLTPEIAGRLLPGDTLYLLAPSADCDTLSE
CCCCCEECCCCCCEECCCCCCCEEEECCCCCCCHHHHCCCCCCCEEEEEECCCCHHHHHH
LLVAPVAPPHLERRHFYGVFVLHGDASMAAVAGQYDLPLPAGAAELTLAQFLTRTLRRHP
HHHCCCCCCCCCCCEEEEEEEEECCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
GPGDRVRLGKLEFVVRTVVKGRITRVGLRIPTQLDRKR
CCCCCEEHHHHHHHHHHHHHHHHHEEEEECCCHHCCCC
>Mature Secondary Structure
MELINQLVLAGAVLLLVAVLASALSYRIGMPLLLVFLAVGMLAGEDGPGGIVFNHSGFAY
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCEEECCCCHHH
MAGSVALAVILLDGGLNTRAESFRGSLRPAATLATAGVVITCVVTGFFAAWVLDFSYLQG
HHHHHHEEEEEEECCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLVGAVVGSTDAAAVFALLRAKGLTLKERLAATLEIESGSNDPMAALLTLAFIALITAGR
HHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHCCC
STPGWETLALLIQQLGLGLIAGLGGGALLVWLTNRLRLERGMYPMMILAGGLLSYSLTTV
CCCCHHHHHHHHHHHCHHHHHCCCCCEEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LGGSGFLAIYLCGVVVSNRNPREASNILQVHDGLAWLAQIGMFLMLGLLASPHELVDNAA
HCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AGLAIALVLMLVARPVAVGLCLLPFRFSGREQIFIAWVGLRGAVPIVLALFPLLAGIPEA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCH
SLILDVAFFVVLISLTVQGWTIPLFARLLQLEVPPAPEPNERHDLEASAESGHAFLGFKL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEC
PPNSTLIGQPANALWLPGAARPVAIARGNETLTPEIAGRLLPGDTLYLLAPSADCDTLSE
CCCCCEECCCCCCEECCCCCCCEEEECCCCCCCHHHHCCCCCCCEEEEEECCCCHHHHHH
LLVAPVAPPHLERRHFYGVFVLHGDASMAAVAGQYDLPLPAGAAELTLAQFLTRTLRRHP
HHHCCCCCCCCCCCEEEEEEEEECCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
GPGDRVRLGKLEFVVRTVVKGRITRVGLRIPTQLDRKR
CCCCCEEHHHHHHHHHHHHHHHHHEEEEECCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA