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The map label for this gene is gmk

Identifier: 74316491

GI number: 74316491

Start: 496096

End: 496725

Strand: Reverse

Name: gmk

Synonym: Tbd_0473

Alternate gene names: 74316491

Gene position: 496725-496096 (Counterclockwise)

Preceding gene: 74316492

Following gene: 74316490

Centisome position: 17.07

GC content: 66.67

Gene sequence:

>630_bases
ATGACCCCCCCCGCCAGCCCTGGTGTTCTTTACATCGTCAGCGCCCCCTCCGGCGCCGGCAAGACCAGCCTCGTCAAGGC
GCTGCTGAAGAGCGACCCGGCGATCCGCCTGTCCGTTTCCCACACCACGCGCGCCCCGCGTCCGGGCGAGAGCGACGGCC
GCGACTACCACTTCGTCGCGCGCGACACCTTCGAGAAAATGCTGGCCGACGGCGAATTTCTCGAACACGCCGAGGTGTAC
GGCAACTTCTACGGCACCTCCCGGGGCCGCATCGGGCAGGAACTCGACGCCGGGCGCGACCTTCTGCTGGAGATCGACTG
GCAGGGCGCCGAGCAGGTCAAGCGGCACTTCCCGCAATCGACGTCGATATTCATCCTGCCGCCGACCTTCAGCGCCTTGC
GCACGCGCCTGACCGGACGCGGCCAGGACAGCCCGGAAATCATCGAGCGCCGGCTCGCCGCGGCGGCGCACGACGTCGCT
CATGCCGAGGCGTTCGACTATATAATCGTCAACGATGACTTCGACCACGCCCTCCAGGATCTGGTCGCGATCACCCGCAG
CATTCGCCTCGAAGCGCAGCGCCAGCTGAAACGCCACGCCGCCCTTTTCGGGGAATTCCGACGCATTTGA

Upstream 100 bases:

>100_bases
GTCGCGGTCGAGACCTCGCGCACCTCGCTCGAACTCAAGGTGCTGATCGAGCAGATGCGCGAGCAGGTGCAGAATATTGA
ATGAGCGATCCGGAGCAACC

Downstream 100 bases:

>100_bases
AACGCCCGAAGCAGGAGTATCCCCATGGCCCGCATCACCGTCGATGATTGCATTGACAACATCCCCAACCGTTTCGAACT
CACGCTGGCCGTGACCTACC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MTPPASPGVLYIVSAPSGAGKTSLVKALLKSDPAIRLSVSHTTRAPRPGESDGRDYHFVARDTFEKMLADGEFLEHAEVY
GNFYGTSRGRIGQELDAGRDLLLEIDWQGAEQVKRHFPQSTSIFILPPTFSALRTRLTGRGQDSPEIIERRLAAAAHDVA
HAEAFDYIIVNDDFDHALQDLVAITRSIRLEAQRQLKRHAALFGEFRRI

Sequences:

>Translated_209_residues
MTPPASPGVLYIVSAPSGAGKTSLVKALLKSDPAIRLSVSHTTRAPRPGESDGRDYHFVARDTFEKMLADGEFLEHAEVY
GNFYGTSRGRIGQELDAGRDLLLEIDWQGAEQVKRHFPQSTSIFILPPTFSALRTRLTGRGQDSPEIIERRLAAAAHDVA
HAEAFDYIIVNDDFDHALQDLVAITRSIRLEAQRQLKRHAALFGEFRRI
>Mature_208_residues
TPPASPGVLYIVSAPSGAGKTSLVKALLKSDPAIRLSVSHTTRAPRPGESDGRDYHFVARDTFEKMLADGEFLEHAEVYG
NFYGTSRGRIGQELDAGRDLLLEIDWQGAEQVKRHFPQSTSIFILPPTFSALRTRLTGRGQDSPEIIERRLAAAAHDVAH
AEAFDYIIVNDDFDHALQDLVAITRSIRLEAQRQLKRHAALFGEFRRI

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=188, Percent_Identity=40.4255319148936, Blast_Score=138, Evalue=4e-33,
Organism=Homo sapiens, GI4504221, Length=188, Percent_Identity=40.4255319148936, Blast_Score=138, Evalue=4e-33,
Organism=Homo sapiens, GI226874831, Length=188, Percent_Identity=40.4255319148936, Blast_Score=137, Evalue=6e-33,
Organism=Homo sapiens, GI38570142, Length=196, Percent_Identity=33.6734693877551, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI21361598, Length=200, Percent_Identity=28.5, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI14780902, Length=201, Percent_Identity=26.865671641791, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI52630447, Length=200, Percent_Identity=27.5, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI111154074, Length=177, Percent_Identity=29.9435028248588, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI262118263, Length=166, Percent_Identity=29.5180722891566, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI4505237, Length=166, Percent_Identity=29.5180722891566, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI262118259, Length=166, Percent_Identity=28.9156626506024, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI262118255, Length=174, Percent_Identity=29.3103448275862, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1790080, Length=201, Percent_Identity=55.7213930348259, Blast_Score=226, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI193203132, Length=188, Percent_Identity=35.6382978723404, Blast_Score=126, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17508835, Length=188, Percent_Identity=35.6382978723404, Blast_Score=125, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17557440, Length=193, Percent_Identity=25.3886010362694, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320662, Length=175, Percent_Identity=42.8571428571429, Blast_Score=148, Evalue=8e-37,
Organism=Drosophila melanogaster, GI21356141, Length=188, Percent_Identity=37.2340425531915, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI116007136, Length=184, Percent_Identity=28.804347826087, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI85724806, Length=184, Percent_Identity=28.804347826087, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45554489, Length=184, Percent_Identity=28.804347826087, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24640542, Length=184, Percent_Identity=28.804347826087, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI45554481, Length=184, Percent_Identity=28.804347826087, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI161077626, Length=184, Percent_Identity=28.804347826087, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221330166, Length=192, Percent_Identity=30.2083333333333, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI221330162, Length=192, Percent_Identity=30.2083333333333, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI221330164, Length=192, Percent_Identity=30.2083333333333, Blast_Score=74, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_THIDA (Q3SLI4)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_314231.1
- HSSP:   P60546
- ProteinModelPortal:   Q3SLI4
- SMR:   Q3SLI4
- STRING:   Q3SLI4
- GeneID:   3673106
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0473
- NMPDR:   fig|292415.3.peg.33
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   DIDWQGT
- PhylomeDB:   Q3SLI4
- BioCyc:   TDEN292415:TBD_0473-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23236; Mature: 23105

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPPASPGVLYIVSAPSGAGKTSLVKALLKSDPAIRLSVSHTTRAPRPGESDGRDYHFVA
CCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEHH
RDTFEKMLADGEFLEHAEVYGNFYGTSRGRIGQELDAGRDLLLEIDWQGAEQVKRHFPQS
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHCCCCEEEEEECCCCHHHHHHHCCCC
TSIFILPPTFSALRTRLTGRGQDSPEIIERRLAAAAHDVAHAEAFDYIIVNDDFDHALQD
CEEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHH
LVAITRSIRLEAQRQLKRHAALFGEFRRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPPASPGVLYIVSAPSGAGKTSLVKALLKSDPAIRLSVSHTTRAPRPGESDGRDYHFVA
CCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCEEEHH
RDTFEKMLADGEFLEHAEVYGNFYGTSRGRIGQELDAGRDLLLEIDWQGAEQVKRHFPQS
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCHHCCCCEEEEEECCCCHHHHHHHCCCC
TSIFILPPTFSALRTRLTGRGQDSPEIIERRLAAAAHDVAHAEAFDYIIVNDDFDHALQD
CEEEEECCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEEEEECCHHHHHHH
LVAITRSIRLEAQRQLKRHAALFGEFRRI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA