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The map label for this gene is ctaD [H]

Identifier: 74316344

GI number: 74316344

Start: 349238

End: 350818

Strand: Direct

Name: ctaD [H]

Synonym: Tbd_0326

Alternate gene names: 74316344

Gene position: 349238-350818 (Clockwise)

Preceding gene: 74316343

Following gene: 74316345

Centisome position: 12.0

GC content: 62.3

Gene sequence:

>1581_bases
ATGTCTGACGCAGTCCACGCCCACGAAGACCACGGACACCACGCGCACCCGAGCGGGATCATGCGCTGGCTGACGACCAC
CAACCACAAGGACATCGGGACCCTCTATCTGTGGTTCTCGCTGATCATGCTGTTCTCCGCCGGGAGCATGGCGCTCATGA
TACGCGCCGAGCTGTTCCAGCCGGGTCTGCAGCTTACGCAGCCGGATTTCTTCAATCAGCTCACGACGATGCACGGGCTG
ATCATGATCTTCGGCGTGATCATGCCGGCCTTCTCGGGCTTCGCGAACTGGCAGGTGCCGCTGATGCTCGGCGCCCCGGA
CATGGCCTTCCCGCGCATGAACAACTGGGCGTTCTGGATCCTGCCGGTCGCGGCGATCCTGCTCTTGAGTTCCTTCGTGC
TGCCGGGCGGTGCAGTCGCGGGTGGCTGGACGATGTATCCGCCGCTCTACATCCAGGGCGGCATCTCCTACGATCTCACG
ATCCTCGCCGTGCACATCATGGGCCTGTCGTCGATCATGGGCTCGATCAACATTATCACGACCATCCTCAACATGCGTGC
GCCGGGCCTCACGCTGATGAAGATGCCGCTGTTCGTGTGGACCTGGCTGATCACCGCCTACCTGCTCATCGCGACCATGC
CGGTGCTCGCGGGGGCGGTGACGATGCTGCTGACCGACCGCAATTTCGGTACGCACTTCTTCAACGCGGCCGGTGGCGGC
GACCCGGTCATGTTCCAGCATATCTTCTGGTTCTTCGCGCATCCCGAGGTCTACATCCTGATCCTGCCCGCATTCGGCAT
CGTCTCGCAGGTGATTCCGACCTTCTCGCGCAAGCCGCTGTTCGGCTACGCCTCGATGGTGTACGCGACCGCCTCGATCG
CGATCCTGTCGTTCATCGTCTGGGCCCACCACATGTTCACGGTCGGCATGCCGGTCGCCGCGCAGTTGTTCTTCATGCTC
TCAACCATGCTGATCGCGGTGCCGACGGGAGTGAAGGTCTTCAACTGGACCGCGACGATGTGGAAGGGCTCGCTGACTTT
CGAGACGCCGATGCTGTTCGCGATCGCCTTCGTCTGCCTGTTCACGATCGGTGGCTTCTCGGGCCTCGTGCTCGCGATTG
CGCCGGTCGACATCCAGTTGCACGACACCTATTACGTGGTCGCGCACTTCCACTACGTGCTCGTCTCCGGCGCGCTATTC
TCGATCTTCGCCGGCATCTACTACTGGCTGCCGAAATGGACCGGCCACATGTACGACGAGCGGCTCGGCAAATGGCACTT
CTGGCTGTCGGTGATCGGCATGAACATCGTGTTCTTCCCGATGCATTTCCTCGGGCTCGCTGGCATGCCGCGGCGCATTC
CCGACTACTCGCTGCAGTTCACCGAGTTCAACCAGATCGCGACGGTCGGTGCCTTCATGTTCGGATTCAGCCAGCTCATC
TTCCTGGTCGTGGTCCTCAAGGCGATCCGCGGCGGCGTGAAAGCCCCGGCCCAGGTGTGGGAGGGCGCGGAAGGCCTCGA
GTGGACGGTGCCGTCGCCGGCGCCGTATCACACCTTCGTCACTGCGCCGGTGGTCAAATGA

Upstream 100 bases:

>100_bases
CGGCGATCGGGTGCAGCCGGCCGACATCGCGAGCGCACGGGGCGGGGCCAAGGTCGCCGCCGCGTCCGCCGCACAGTGAC
CATCCAGGGGAGAGCCGAGA

Downstream 100 bases:

>100_bases
GCGCGGAGCTCACGGGAATGGCCGACGACCGGCGCAAGGGCAAGCTCCGCACGGCCTTGCTGCTCGCGGCCTTCGCGCTC
GGCCTGTTTGTTTTCACGCT

Product: cytochrome c oxidase subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MSDAVHAHEDHGHHAHPSGIMRWLTTTNHKDIGTLYLWFSLIMLFSAGSMALMIRAELFQPGLQLTQPDFFNQLTTMHGL
IMIFGVIMPAFSGFANWQVPLMLGAPDMAFPRMNNWAFWILPVAAILLLSSFVLPGGAVAGGWTMYPPLYIQGGISYDLT
ILAVHIMGLSSIMGSINIITTILNMRAPGLTLMKMPLFVWTWLITAYLLIATMPVLAGAVTMLLTDRNFGTHFFNAAGGG
DPVMFQHIFWFFAHPEVYILILPAFGIVSQVIPTFSRKPLFGYASMVYATASIAILSFIVWAHHMFTVGMPVAAQLFFML
STMLIAVPTGVKVFNWTATMWKGSLTFETPMLFAIAFVCLFTIGGFSGLVLAIAPVDIQLHDTYYVVAHFHYVLVSGALF
SIFAGIYYWLPKWTGHMYDERLGKWHFWLSVIGMNIVFFPMHFLGLAGMPRRIPDYSLQFTEFNQIATVGAFMFGFSQLI
FLVVVLKAIRGGVKAPAQVWEGAEGLEWTVPSPAPYHTFVTAPVVK

Sequences:

>Translated_526_residues
MSDAVHAHEDHGHHAHPSGIMRWLTTTNHKDIGTLYLWFSLIMLFSAGSMALMIRAELFQPGLQLTQPDFFNQLTTMHGL
IMIFGVIMPAFSGFANWQVPLMLGAPDMAFPRMNNWAFWILPVAAILLLSSFVLPGGAVAGGWTMYPPLYIQGGISYDLT
ILAVHIMGLSSIMGSINIITTILNMRAPGLTLMKMPLFVWTWLITAYLLIATMPVLAGAVTMLLTDRNFGTHFFNAAGGG
DPVMFQHIFWFFAHPEVYILILPAFGIVSQVIPTFSRKPLFGYASMVYATASIAILSFIVWAHHMFTVGMPVAAQLFFML
STMLIAVPTGVKVFNWTATMWKGSLTFETPMLFAIAFVCLFTIGGFSGLVLAIAPVDIQLHDTYYVVAHFHYVLVSGALF
SIFAGIYYWLPKWTGHMYDERLGKWHFWLSVIGMNIVFFPMHFLGLAGMPRRIPDYSLQFTEFNQIATVGAFMFGFSQLI
FLVVVLKAIRGGVKAPAQVWEGAEGLEWTVPSPAPYHTFVTAPVVK
>Mature_525_residues
SDAVHAHEDHGHHAHPSGIMRWLTTTNHKDIGTLYLWFSLIMLFSAGSMALMIRAELFQPGLQLTQPDFFNQLTTMHGLI
MIFGVIMPAFSGFANWQVPLMLGAPDMAFPRMNNWAFWILPVAAILLLSSFVLPGGAVAGGWTMYPPLYIQGGISYDLTI
LAVHIMGLSSIMGSINIITTILNMRAPGLTLMKMPLFVWTWLITAYLLIATMPVLAGAVTMLLTDRNFGTHFFNAAGGGD
PVMFQHIFWFFAHPEVYILILPAFGIVSQVIPTFSRKPLFGYASMVYATASIAILSFIVWAHHMFTVGMPVAAQLFFMLS
TMLIAVPTGVKVFNWTATMWKGSLTFETPMLFAIAFVCLFTIGGFSGLVLAIAPVDIQLHDTYYVVAHFHYVLVSGALFS
IFAGIYYWLPKWTGHMYDERLGKWHFWLSVIGMNIVFFPMHFLGLAGMPRRIPDYSLQFTEFNQIATVGAFMFGFSQLIF
LVVVLKAIRGGVKAPAQVWEGAEGLEWTVPSPAPYHTFVTAPVVK

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=503, Percent_Identity=51.8886679920477, Blast_Score=472, Evalue=1e-133,
Organism=Escherichia coli, GI1786634, Length=511, Percent_Identity=40.7045009784736, Blast_Score=376, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6226519, Length=532, Percent_Identity=47.9323308270677, Blast_Score=491, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6226524, Length=323, Percent_Identity=51.0835913312694, Blast_Score=324, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6226523, Length=248, Percent_Identity=46.7741935483871, Blast_Score=207, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 58512; Mature: 58381

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS50855 COX1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAVHAHEDHGHHAHPSGIMRWLTTTNHKDIGTLYLWFSLIMLFSAGSMALMIRAELFQ
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
PGLQLTQPDFFNQLTTMHGLIMIFGVIMPAFSGFANWQVPLMLGAPDMAFPRMNNWAFWI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCEEHH
LPVAAILLLSSFVLPGGAVAGGWTMYPPLYIQGGISYDLTILAVHIMGLSSIMGSINIIT
HHHHHHHHHHHHHCCCCCCCCCCEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
TILNMRAPGLTLMKMPLFVWTWLITAYLLIATMPVLAGAVTMLLTDRNFGTHFFNAAGGG
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEECCCCC
DPVMFQHIFWFFAHPEVYILILPAFGIVSQVIPTFSRKPLFGYASMVYATASIAILSFIV
CHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
WAHHMFTVGMPVAAQLFFMLSTMLIAVPTGVKVFNWTATMWKGSLTFETPMLFAIAFVCL
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHEECCCEECHHHHHHHHHHHH
FTIGGFSGLVLAIAPVDIQLHDTYYVVAHFHYVLVSGALFSIFAGIYYWLPKWTGHMYDE
HHHCCCCCEEEEEEEEEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RLGKWHFWLSVIGMNIVFFPMHFLGLAGMPRRIPDYSLQFTEFNQIATVGAFMFGFSQLI
HHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
FLVVVLKAIRGGVKAPAQVWEGAEGLEWTVPSPAPYHTFVTAPVVK
HHHHHHHHHHCCCCCCHHHHCCCCCCEEECCCCCCCCEEEECCCCC
>Mature Secondary Structure 
SDAVHAHEDHGHHAHPSGIMRWLTTTNHKDIGTLYLWFSLIMLFSAGSMALMIRAELFQ
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHC
PGLQLTQPDFFNQLTTMHGLIMIFGVIMPAFSGFANWQVPLMLGAPDMAFPRMNNWAFWI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCEEHH
LPVAAILLLSSFVLPGGAVAGGWTMYPPLYIQGGISYDLTILAVHIMGLSSIMGSINIIT
HHHHHHHHHHHHHCCCCCCCCCCEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
TILNMRAPGLTLMKMPLFVWTWLITAYLLIATMPVLAGAVTMLLTDRNFGTHFFNAAGGG
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEECCCCC
DPVMFQHIFWFFAHPEVYILILPAFGIVSQVIPTFSRKPLFGYASMVYATASIAILSFIV
CHHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
WAHHMFTVGMPVAAQLFFMLSTMLIAVPTGVKVFNWTATMWKGSLTFETPMLFAIAFVCL
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHEECCCEECHHHHHHHHHHHH
FTIGGFSGLVLAIAPVDIQLHDTYYVVAHFHYVLVSGALFSIFAGIYYWLPKWTGHMYDE
HHHCCCCCEEEEEEEEEEEECCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
RLGKWHFWLSVIGMNIVFFPMHFLGLAGMPRRIPDYSLQFTEFNQIATVGAFMFGFSQLI
HHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
FLVVVLKAIRGGVKAPAQVWEGAEGLEWTVPSPAPYHTFVTAPVVK
HHHHHHHHHHCCCCCCHHHHCCCCCCEEECCCCCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2172930; 1965217; 12597275 [H]