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The map label for this gene is lytS [H]

Identifier: 74316248

GI number: 74316248

Start: 252040

End: 253116

Strand: Direct

Name: lytS [H]

Synonym: Tbd_0230

Alternate gene names: 74316248

Gene position: 252040-253116 (Clockwise)

Preceding gene: 74316246

Following gene: 74316249

Centisome position: 8.66

GC content: 68.34

Gene sequence:

>1077_bases
GTGAAAAGAAGGAATCATAACAACCGCGAGGTCGAACTGCCGAACTTCTGCCGCCTCGGGGTCAGCCTGCGGATCGCACT
GACCGCCGAAGCGGCGCTGGCCGCGAGCGTCGCAGCACGGGCCGCCGACGCCGCGGCCTTCGCCGCCGAATTCGTCGCGC
TCTCGGCCTTCGCCCAGCCGGCACTGCTGCTTGCGCTGCTTGCGCTGTGTGGCGCCGGACGCGGGCTGCGCAGCCAGCCC
TATCGGCGTGGCGTCGTGATGGCGCTCGGACTCGGCGCCGCGGTGCCTTTCCTGGTCGCGCTGTGGCTCGCACCGATACT
CGCGGGGTCGGTACCCGTCTCGCCGCTCGGTGTCCTCGTGTTTGCGCTGGGGGTCGGCGGGGGGCTGCTTGGCTATTTCA
ACCTGCGCGCCCGCGCGCTGTCGCCCGCAGTCACCGAGGCGCGGCTGCAGGCGCTGCAGGCGAGGATCCGCCCGCATTTC
CTGTTCAACAGCCTCAATGCAGTGCTCGCGCTCGTCCGCAAGGACCCGCGGCGCGCAGAGCATGCGCTCGAAAACATGGC
CGACCTGTTCCGCGCCTTGATGGGCAACGCGCGCCAGCTCGCGCCGCTCGAGGACGAGGTCGCGCTCACGCGTGCCTATC
TCGAACTCGAACAGTTGCGCCTCGGCGACCGCCTGCGCGTGGTCTGGCACACCGGGAAGATGCCGGCGGACGCACTGATT
CCGCCGCTGGTCATCCAGCCCCTGGTCGAGAACGCGGTGTATCACGGCATCGAGCCGCTCGCCGACGGCGGCGAAATCAG
CCTCAATCTTTACCGCAGCGCCGACAAGGTCCACGTCGTCGTGCGCAACCCGATCGCCTCCGACGGTAGCCATCACCGCG
GCAATCGCATCGCGCTCGCCAACATCCGCGAGCGCCTGCTGCTGCACTTCGACCTCGATGCCCAACTCAAGTTGAAGCCG
CTCGGCTCCGTTTATCAGGTACACATCGTCATCCCCTATACCCGTGAACGGACCCAACCCGCCACTTCGCGTCCTCATCG
TCGACGACGAGGCGCCGGCACGCGCGCGGCTCGGTGA

Upstream 100 bases:

>100_bases
GTGTAGCGTTTGACGATTTCGGAAACAGGCTCGGAAAAGCGGCCCGACCAGGCGCCTTGCGGCGGCGTCGACGACGTGCT
CATGGGGACAGAAACGCACA

Downstream 100 bases:

>100_bases
CGTCCTGGCCGACTGCGCCGGGCGTCTGCCGGTCGAGGTCGTCGGCGAGGCCGAGAACGGTCTCGCGGCGTTGGCGCTGG
CGCAGCAGACCGCGGTCGAC

Product: two-component system sensor ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MKRRNHNNREVELPNFCRLGVSLRIALTAEAALAASVAARAADAAAFAAEFVALSAFAQPALLLALLALCGAGRGLRSQP
YRRGVVMALGLGAAVPFLVALWLAPILAGSVPVSPLGVLVFALGVGGGLLGYFNLRARALSPAVTEARLQALQARIRPHF
LFNSLNAVLALVRKDPRRAEHALENMADLFRALMGNARQLAPLEDEVALTRAYLELEQLRLGDRLRVVWHTGKMPADALI
PPLVIQPLVENAVYHGIEPLADGGEISLNLYRSADKVHVVVRNPIASDGSHHRGNRIALANIRERLLLHFDLDAQLKLKP
LGSVYQVHIVIPYTRERTQPATSRPHRRRRGAGTRAAR

Sequences:

>Translated_358_residues
MKRRNHNNREVELPNFCRLGVSLRIALTAEAALAASVAARAADAAAFAAEFVALSAFAQPALLLALLALCGAGRGLRSQP
YRRGVVMALGLGAAVPFLVALWLAPILAGSVPVSPLGVLVFALGVGGGLLGYFNLRARALSPAVTEARLQALQARIRPHF
LFNSLNAVLALVRKDPRRAEHALENMADLFRALMGNARQLAPLEDEVALTRAYLELEQLRLGDRLRVVWHTGKMPADALI
PPLVIQPLVENAVYHGIEPLADGGEISLNLYRSADKVHVVVRNPIASDGSHHRGNRIALANIRERLLLHFDLDAQLKLKP
LGSVYQVHIVIPYTRERTQPATSRPHRRRRGAGTRAAR
>Mature_358_residues
MKRRNHNNREVELPNFCRLGVSLRIALTAEAALAASVAARAADAAAFAAEFVALSAFAQPALLLALLALCGAGRGLRSQP
YRRGVVMALGLGAAVPFLVALWLAPILAGSVPVSPLGVLVFALGVGGGLLGYFNLRARALSPAVTEARLQALQARIRPHF
LFNSLNAVLALVRKDPRRAEHALENMADLFRALMGNARQLAPLEDEVALTRAYLELEQLRLGDRLRVVWHTGKMPADALI
PPLVIQPLVENAVYHGIEPLADGGEISLNLYRSADKVHVVVRNPIASDGSHHRGNRIALANIRERLLLHFDLDAQLKLKP
LGSVYQVHIVIPYTRERTQPATSRPHRRRRGAGTRAAR

Specific function: Member of the two-component regulatory system lytS/lytT that probably regulates genes involved in cell wall metabolism [H]

COG id: COG2972

COG function: function code T; Predicted signal transduction protein with a C-terminal ATPase domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788723, Length=186, Percent_Identity=31.7204301075269, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1788446, Length=140, Percent_Identity=29.2857142857143, Blast_Score=91, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR010559
- InterPro:   IPR011620 [H]

Pfam domain/function: PF07694 5TM-5TMR_LYT; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 38893; Mature: 38893

Theoretical pI: Translated: 11.47; Mature: 11.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRNHNNREVELPNFCRLGVSLRIALTAEAALAASVAARAADAAAFAAEFVALSAFAQP
CCCCCCCCCEEECCHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLLALLALCGAGRGLRSQPYRRGVVMALGLGAAVPFLVALWLAPILAGSVPVSPLGVLV
HHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
FALGVGGGLLGYFNLRARALSPAVTEARLQALQARIRPHFLFNSLNAVLALVRKDPRRAE
HHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHH
HALENMADLFRALMGNARQLAPLEDEVALTRAYLELEQLRLGDRLRVVWHTGKMPADALI
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHCC
PPLVIQPLVENAVYHGIEPLADGGEISLNLYRSADKVHVVVRNPIASDGSHHRGNRIALA
CHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCCCCCCCEEEHH
NIRERLLLHFDLDAQLKLKPLGSVYQVHIVIPYTRERTQPATSRPHRRRRGAGTRAAR
HHHHHEEEEECCCCCEEEEECCCEEEEEEEEEECCCCCCCCCCCCHHHHCCCCCCCCC
>Mature Secondary Structure
MKRRNHNNREVELPNFCRLGVSLRIALTAEAALAASVAARAADAAAFAAEFVALSAFAQP
CCCCCCCCCEEECCHHHHCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALLLALLALCGAGRGLRSQPYRRGVVMALGLGAAVPFLVALWLAPILAGSVPVSPLGVLV
HHHHHHHHHHCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
FALGVGGGLLGYFNLRARALSPAVTEARLQALQARIRPHFLFNSLNAVLALVRKDPRRAE
HHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCHHHHH
HALENMADLFRALMGNARQLAPLEDEVALTRAYLELEQLRLGDRLRVVWHTGKMPADALI
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHCC
PPLVIQPLVENAVYHGIEPLADGGEISLNLYRSADKVHVVVRNPIASDGSHHRGNRIALA
CHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCCCCCCCEEEHH
NIRERLLLHFDLDAQLKLKPLGSVYQVHIVIPYTRERTQPATSRPHRRRRGAGTRAAR
HHHHHEEEEECCCCCEEEEECCCEEEEEEEEEECCCCCCCCCCCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]