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The map label for this gene is algR [H]

Identifier: 74316249

GI number: 74316249

Start: 253043

End: 253807

Strand: Direct

Name: algR [H]

Synonym: Tbd_0231

Alternate gene names: 74316249

Gene position: 253043-253807 (Clockwise)

Preceding gene: 74316248

Following gene: 74316250

Centisome position: 8.7

GC content: 67.97

Gene sequence:

>765_bases
GTGAACGGACCCAACCCGCCACTTCGCGTCCTCATCGTCGACGACGAGGCGCCGGCACGCGCGCGGCTCGGTGACGTCCT
GGCCGACTGCGCCGGGCGTCTGCCGGTCGAGGTCGTCGGCGAGGCCGAGAACGGTCTCGCGGCGTTGGCGCTGGCGCAGC
AGACCGCGGTCGACGCCGTGCTGCTCGATATCCGCATGCCGGTCATGGACGGCCTCGAGTGCGCCGCGCATCTGAACCGG
CTCGCCGCGCCCCCCGCGATCATCTTCAGCACGGCCTATGACGCCTACGCCTGCCAGGCCTTCGACCTCAATGCCGTCGA
CTATCTGCTGAAGCCGGTACGGGCCGAGCGCCTCGTTCGCGCACTGTCGCGCGCGCATCGCCTGAGCGCGAAGACTCTCG
ATCAGTTGCGCGAGGCGCACCCCAAGGCGCGCACCCACCTGTCGCTGAACGAAAAAGGCCGCATCGTGCTGATTCCGGTC
GCGGACATCCTTTACCTCAAGGCCGAGCTCAAGTACGTCACCGTGCGCACGGCCGCCCGCGAGTTCCTGATCGAAGAATC
GCTGACCCAGCTCGAAGCCGAGTTCGGCGAGCGTTTTCTGCGTATCCATCGCAACTGCCTCGTCGCGCGCGACCGCGTCC
GCGAGGTCGGCAAATCACCGGGCGAAGACGAGGGCCACTTCCTGCGGCTCGACGGGCTAGACGAGCGGCTCACCGTCAGC
CGTCGCCAGTACACGGCGCTGCGCGAAACGCTCCGAGCTTTCTGA

Upstream 100 bases:

>100_bases
ATCCGCGAGCGCCTGCTGCTGCACTTCGACCTCGATGCCCAACTCAAGTTGAAGCCGCTCGGCTCCGTTTATCAGGTACA
CATCGTCATCCCCTATACCC

Downstream 100 bases:

>100_bases
GCGCGCTGCCTCGTGGGGGTTGCGGGCGAGATCGACGACCCGCGTCCGTACCGCCGGATTTAGCACCACGGGAAAAATAA
AAACCCAGTTAAATCAACGG

Product: LytR/AlgR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MNGPNPPLRVLIVDDEAPARARLGDVLADCAGRLPVEVVGEAENGLAALALAQQTAVDAVLLDIRMPVMDGLECAAHLNR
LAAPPAIIFSTAYDAYACQAFDLNAVDYLLKPVRAERLVRALSRAHRLSAKTLDQLREAHPKARTHLSLNEKGRIVLIPV
ADILYLKAELKYVTVRTAAREFLIEESLTQLEAEFGERFLRIHRNCLVARDRVREVGKSPGEDEGHFLRLDGLDERLTVS
RRQYTALRETLRAF

Sequences:

>Translated_254_residues
MNGPNPPLRVLIVDDEAPARARLGDVLADCAGRLPVEVVGEAENGLAALALAQQTAVDAVLLDIRMPVMDGLECAAHLNR
LAAPPAIIFSTAYDAYACQAFDLNAVDYLLKPVRAERLVRALSRAHRLSAKTLDQLREAHPKARTHLSLNEKGRIVLIPV
ADILYLKAELKYVTVRTAAREFLIEESLTQLEAEFGERFLRIHRNCLVARDRVREVGKSPGEDEGHFLRLDGLDERLTVS
RRQYTALRETLRAF
>Mature_254_residues
MNGPNPPLRVLIVDDEAPARARLGDVLADCAGRLPVEVVGEAENGLAALALAQQTAVDAVLLDIRMPVMDGLECAAHLNR
LAAPPAIIFSTAYDAYACQAFDLNAVDYLLKPVRAERLVRALSRAHRLSAKTLDQLREAHPKARTHLSLNEKGRIVLIPV
ADILYLKAELKYVTVRTAAREFLIEESLTQLEAEFGERFLRIHRNCLVARDRVREVGKSPGEDEGHFLRLDGLDERLTVS
RRQYTALRETLRAF

Specific function: Positive regulator of the algD gene, which codes for a GDP-mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway [H]

COG id: COG3279

COG function: function code KT; Response regulator of the LytR/AlgR family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788724, Length=251, Percent_Identity=30.2788844621514, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI87082052, Length=247, Percent_Identity=31.9838056680162, Blast_Score=99, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR007492
- InterPro:   IPR001789 [H]

Pfam domain/function: PF04397 LytTR; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 28249; Mature: 28249

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50930 HTH_LYTTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGPNPPLRVLIVDDEAPARARLGDVLADCAGRLPVEVVGEAENGLAALALAQQTAVDAV
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHH
LLDIRMPVMDGLECAAHLNRLAAPPAIIFSTAYDAYACQAFDLNAVDYLLKPVRAERLVR
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHEEEECCCHHHHHHHHHHHHHHHHH
ALSRAHRLSAKTLDQLREAHPKARTHLSLNEKGRIVLIPVADILYLKAELKYVTVRTAAR
HHHHHHHHHHHHHHHHHHHCCHHHHEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
EFLIEESLTQLEAEFGERFLRIHRNCLVARDRVREVGKSPGEDEGHFLRLDGLDERLTVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHH
RRQYTALRETLRAF
HHHHHHHHHHHHCC
>Mature Secondary Structure
MNGPNPPLRVLIVDDEAPARARLGDVLADCAGRLPVEVVGEAENGLAALALAQQTAVDAV
CCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHH
LLDIRMPVMDGLECAAHLNRLAAPPAIIFSTAYDAYACQAFDLNAVDYLLKPVRAERLVR
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHEEEECCCHHHHHHHHHHHHHHHHH
ALSRAHRLSAKTLDQLREAHPKARTHLSLNEKGRIVLIPVADILYLKAELKYVTVRTAAR
HHHHHHHHHHHHHHHHHHHCCHHHHEECCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHH
EFLIEESLTQLEAEFGERFLRIHRNCLVARDRVREVGKSPGEDEGHFLRLDGLDERLTVS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHH
RRQYTALRETLRAF
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2493441; 10984043; 2544550; 8159168 [H]