Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 74316215

GI number: 74316215

Start: 212222

End: 213571

Strand: Reverse

Name: atoC [H]

Synonym: Tbd_0197

Alternate gene names: 74316215

Gene position: 213571-212222 (Counterclockwise)

Preceding gene: 74316216

Following gene: 74316214

Centisome position: 7.34

GC content: 65.26

Gene sequence:

>1350_bases
ATGAGCGACGCCAAACAAAAGATTCTGCTGGTCGAGGACGACCTTGGGCTGCAAAAGCAGCTCAAGTGGAGCCTTGCCGA
TTACGAGCTGATCGTCGCCGCAGACCGCGACAGCGCGATCGCCCAGCTGCGCCGCCACGAACCGCCGGTCGTGCTGCTCG
ACCTCGGTCTGCCTCCGGACGTCGACGGCGCAACCGAAGGGCTCGAAGCGCTGCAACAGATCCTTTCACTCTCGCCGGTC
ACCAAGGTGATCGTGGTCACCGGCAATCTCGATCGCAGCAACGCGGTCAAAGCCATCCGCCTCGGTGCCTACGACTTTTT
CCAGAAGCCGTTCGATCCCGACGTCCTCGCGCTCATGATCGCGCGCGCGCTCCACGTCCACGGGCTGGAAACCGAAAACC
GCCGGCTTACGCGGCAGCGGGGTTCTTCCCTTCAGGGCCTCATCACGAGCAGCGAGCCGATGCTGAAGATCTGCCGCACG
ATCGAGAAAGTGGCCCCGGCCAATGCGACCGTGCTCCTGCTCGGCGAATCCGGCACAGGCAAGGAAGTTCTCGCACGCGG
CGTGCACGAGCTGTCGCCGCGCTCGAACAAGCGCTTCGTCGCGATCAACTGCGCGGCGATTCCCGACACGCTCCTCGAAT
CGGAATTGTTCGGCTACGAGAAAGGCGCGTTCACCGGGGCCGCCAAGCAAACCATCGGCCGCATCGAATACGCCAACGAA
GGCACGCTCTTCCTCGACGAGATCGGCGACCTGCCGATGCCGCTACAGGCCAAGCTGTTGCGCTTCCTGCAGGAACGCGT
GATCGAACGCCTCGGCGGGCGCGGCGAGATTCCCGTCGACGTGCGCGTCGTATGCGCGACGCACCGTGACCTCGCGGCGA
TGATCCGCGAGGGCGGCTTCCGCGAAGACCTCTATTACCGGCTCTCCGAAATTTCGGTGAACATCCCGCCGCTGCGCGAA
CGCCCTGGCGACGCCGTATTGCTCGCGCAGGCATTTCTCGAACGCTATGCCCGCGAGCTCGGCCGCCGCATCCGCGGCTT
CACCGCAGACGCCCTCGCGGCGCTGGAAGCGCATCCCTGGCCCGGCAACGTGCGCGAAATGGAAAACCTGATCAAGCGCG
CGACGATCATGGCGGACGGCAGCCAGATCACCGCCGCCGACCTCGGCCTCGACGCCGGCGAGGTCGAGCCGCGCCCCTTC
AATCTGCGTCAGGCCCGCGAGAACGCCGAACGGATCGCCGTCAGCCGCGCCTTGGCGCACAGCGACGGCAGCATTGCGCA
GGCCGCCGAACTGCTCGGAATCACCCGGCCGACCTTGTACGATCTGATGGCGAAGATCGGCATGAAATAA

Upstream 100 bases:

>100_bases
TCGGCGGAAACATCGAGGTCGAAAGCAGCCCCGGTCAGGGCACCCGCTTCCGCCTGACCCTGCCGTTAGACAATAATGCA
CCTTCCGGAGGAGACGCCGC

Downstream 100 bases:

>100_bases
GGGCTTCGCAGAGAACCCACACGACAATACCGGAGGTGCGCATGCCCGCGTTTCTTGAACTCCGCCGCCTTCTGCCCGCG
CTCTTCGTCGGCAGTGCGCT

Product: two component Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSDAKQKILLVEDDLGLQKQLKWSLADYELIVAADRDSAIAQLRRHEPPVVLLDLGLPPDVDGATEGLEALQQILSLSPV
TKVIVVTGNLDRSNAVKAIRLGAYDFFQKPFDPDVLALMIARALHVHGLETENRRLTRQRGSSLQGLITSSEPMLKICRT
IEKVAPANATVLLLGESGTGKEVLARGVHELSPRSNKRFVAINCAAIPDTLLESELFGYEKGAFTGAAKQTIGRIEYANE
GTLFLDEIGDLPMPLQAKLLRFLQERVIERLGGRGEIPVDVRVVCATHRDLAAMIREGGFREDLYYRLSEISVNIPPLRE
RPGDAVLLAQAFLERYARELGRRIRGFTADALAALEAHPWPGNVREMENLIKRATIMADGSQITAADLGLDAGEVEPRPF
NLRQARENAERIAVSRALAHSDGSIAQAAELLGITRPTLYDLMAKIGMK

Sequences:

>Translated_449_residues
MSDAKQKILLVEDDLGLQKQLKWSLADYELIVAADRDSAIAQLRRHEPPVVLLDLGLPPDVDGATEGLEALQQILSLSPV
TKVIVVTGNLDRSNAVKAIRLGAYDFFQKPFDPDVLALMIARALHVHGLETENRRLTRQRGSSLQGLITSSEPMLKICRT
IEKVAPANATVLLLGESGTGKEVLARGVHELSPRSNKRFVAINCAAIPDTLLESELFGYEKGAFTGAAKQTIGRIEYANE
GTLFLDEIGDLPMPLQAKLLRFLQERVIERLGGRGEIPVDVRVVCATHRDLAAMIREGGFREDLYYRLSEISVNIPPLRE
RPGDAVLLAQAFLERYARELGRRIRGFTADALAALEAHPWPGNVREMENLIKRATIMADGSQITAADLGLDAGEVEPRPF
NLRQARENAERIAVSRALAHSDGSIAQAAELLGITRPTLYDLMAKIGMK
>Mature_448_residues
SDAKQKILLVEDDLGLQKQLKWSLADYELIVAADRDSAIAQLRRHEPPVVLLDLGLPPDVDGATEGLEALQQILSLSPVT
KVIVVTGNLDRSNAVKAIRLGAYDFFQKPFDPDVLALMIARALHVHGLETENRRLTRQRGSSLQGLITSSEPMLKICRTI
EKVAPANATVLLLGESGTGKEVLARGVHELSPRSNKRFVAINCAAIPDTLLESELFGYEKGAFTGAAKQTIGRIEYANEG
TLFLDEIGDLPMPLQAKLLRFLQERVIERLGGRGEIPVDVRVVCATHRDLAAMIREGGFREDLYYRLSEISVNIPPLRER
PGDAVLLAQAFLERYARELGRRIRGFTADALAALEAHPWPGNVREMENLIKRATIMADGSQITAADLGLDAGEVEPRPFN
LRQARENAERIAVSRALAHSDGSIAQAAELLGITRPTLYDLMAKIGMK

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=459, Percent_Identity=41.6122004357298, Blast_Score=341, Evalue=5e-95,
Organism=Escherichia coli, GI1790437, Length=450, Percent_Identity=40.2222222222222, Blast_Score=302, Evalue=3e-83,
Organism=Escherichia coli, GI1790299, Length=471, Percent_Identity=37.3673036093418, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1789087, Length=325, Percent_Identity=46.7692307692308, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI87082117, Length=343, Percent_Identity=45.1895043731778, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1788905, Length=449, Percent_Identity=36.9710467706013, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1789233, Length=328, Percent_Identity=43.9024390243902, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI87082152, Length=317, Percent_Identity=41.3249211356467, Blast_Score=221, Evalue=9e-59,
Organism=Escherichia coli, GI87081872, Length=316, Percent_Identity=38.9240506329114, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI1786524, Length=351, Percent_Identity=38.1766381766382, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1787583, Length=287, Percent_Identity=38.3275261324042, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI87081858, Length=300, Percent_Identity=32.6666666666667, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1789828, Length=274, Percent_Identity=34.6715328467153, Blast_Score=135, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49297; Mature: 49165

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDAKQKILLVEDDLGLQKQLKWSLADYELIVAADRDSAIAQLRRHEPPVVLLDLGLPPD
CCCCCCEEEEEECCCCHHHHHHHHHCCEEEEEEECCCHHHHHHHHCCCCEEEEECCCCCC
VDGATEGLEALQQILSLSPVTKVIVVTGNLDRSNAVKAIRLGAYDFFQKPFDPDVLALMI
CCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHEEEECCHHHHCCCCCHHHHHHHH
ARALHVHGLETENRRLTRQRGSSLQGLITSSEPMLKICRTIEKVAPANATVLLLGESGTG
HHHHHHCCCCCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEECCCCC
KEVLARGVHELSPRSNKRFVAINCAAIPDTLLESELFGYEKGAFTGAAKQTIGRIEYANE
HHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHEEECCC
GTLFLDEIGDLPMPLQAKLLRFLQERVIERLGGRGEIPVDVRVVCATHRDLAAMIREGGF
CCEEHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECHHHHHHHHHCCCC
REDLYYRLSEISVNIPPLRERPGDAVLLAQAFLERYARELGRRIRGFTADALAALEAHPW
HHHHHHHHHHCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCC
PGNVREMENLIKRATIMADGSQITAADLGLDAGEVEPRPFNLRQARENAERIAVSRALAH
CCCHHHHHHHHHHHHEEECCCEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
SDGSIAQAAELLGITRPTLYDLMAKIGMK
CCCCHHHHHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
SDAKQKILLVEDDLGLQKQLKWSLADYELIVAADRDSAIAQLRRHEPPVVLLDLGLPPD
CCCCCEEEEEECCCCHHHHHHHHHCCEEEEEEECCCHHHHHHHHCCCCEEEEECCCCCC
VDGATEGLEALQQILSLSPVTKVIVVTGNLDRSNAVKAIRLGAYDFFQKPFDPDVLALMI
CCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHEEEECCHHHHCCCCCHHHHHHHH
ARALHVHGLETENRRLTRQRGSSLQGLITSSEPMLKICRTIEKVAPANATVLLLGESGTG
HHHHHHCCCCCHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEEEEECCCCC
KEVLARGVHELSPRSNKRFVAINCAAIPDTLLESELFGYEKGAFTGAAKQTIGRIEYANE
HHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHEEECCC
GTLFLDEIGDLPMPLQAKLLRFLQERVIERLGGRGEIPVDVRVVCATHRDLAAMIREGGF
CCEEHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECHHHHHHHHHCCCC
REDLYYRLSEISVNIPPLRERPGDAVLLAQAFLERYARELGRRIRGFTADALAALEAHPW
HHHHHHHHHHCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCC
PGNVREMENLIKRATIMADGSQITAADLGLDAGEVEPRPFNLRQARENAERIAVSRALAH
CCCHHHHHHHHHHHHEEECCCEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
SDGSIAQAAELLGITRPTLYDLMAKIGMK
CCCCHHHHHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]