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The map label for this gene is dctB [H]

Identifier: 74316216

GI number: 74316216

Start: 213568

End: 215649

Strand: Reverse

Name: dctB [H]

Synonym: Tbd_0198

Alternate gene names: 74316216

Gene position: 215649-213568 (Counterclockwise)

Preceding gene: 74316217

Following gene: 74316215

Centisome position: 7.41

GC content: 66.76

Gene sequence:

>2082_bases
ATGGCCGTCACGCTGCTCCTCCTGTCCGCGCTCGGCCATGGACTCGCGGCGCTCGCCTTCCTGGCCCTGTCGGGCCTGAT
CGTCGCGAGCTGGCGCCGCCGGTCACAGGGACGTCTGCTCGGCCTCGCGACCGCGCTCACTGCCGTCTGGGCGGCTTCGG
CCGCGCTCGCCGCCTTCGCCACGCCGCTCCCGCGCTTACAACTGGTCTTCGAAGTCGCGCGCGACGGCGCGTGGCTCGCG
CTGTTGCTCTACATCCTGCGTCTGCGCCTTGCATCGGGCACGCCATTTCCGGTGCCCCTGCGTCTGATACAGGCGCTCGC
CACGGCGCTGGTCGCGGGCCTGCTGCTCCTGAGCGTGCTGCCTTTCTGGGCGCCTGCATCGCGCGCTTTTGCGCTCTGGA
CGACCAACCTCTTCCTGCTGATGCTCGCAACGATCGGCCTGGTGCTAACCGAGCAGGTGTATCGCAGCACCCGCCCGGAA
GACCGCTGGGCGATCAAGTTTCTCTGCCTCGGCCTCGGCGGCCTGTACGTCTACGATTTTTATCTGTACGCGAACGCCAT
GCTGTTCGGCGGACTCGACCTGCGGGTCTGGGCCGCTCGCGGCTACGTCGCTGCCCTGATCACGCCGCTGATCGCGATCT
CGGCCGCGCGCAATCCGGAATGGTCCGCGCCGGTCGGCCTGTCGCGCAGCATGGCCTTCCATACCGCGAGCCTTCTCGGC
GCCGGAATCTACCTGCTGTTCATGGCGGGCGCCGGGTATTACCTGCGACTGTTCGGCGGCGAATGGGGCGACGTCGTGCA
GACGGTCTTCATCTTCGCCGCCGCGATGGTACTCGCGCTGCTGATTTTTTCCGGCACGCTGCGCGCGCGGCTGCGGGTGT
TCCTCGCCAAACACTTCTTCAGTTACCGCTACGACTACCGCGAGGAATGGCTGAAGTTCACGCGGGCGCTGACCGAAGGC
AGGCCCGGCGAGGCCTTGTGCGACCGTGCCGTCGAGGCACTCGCGAGACTGGTCGAAAGCCCCGGCGGGGCGGTATGGCT
GCGCGAAGGCAACGCCGGGTATCAGCGCGCGAGCCACTGGAACTGGGCCGATTTGCAGGGCGTCGAGCCCACCGATTCGG
CCTTCCTCCAATGGCTCACAAGCAAGCAGTGGGTCGTCGACCTCGACGAGATGAAAACCCGTCCGGACCTGTACGGCGAT
CTCGACGCGCCGCGCTGGCTGCGTGAGGCCGGCGACGCCTGGCTAGTTATTCCGCTGATGCTGCACGAGGAATTGCTCGG
CTTCGTCGTGCTCAAGCATTCGCTCGGCAAGGTCACCTTCAACTGGGAGGTGAGCGACCTGCTCAAGGTCACCGCGCGCC
AGGCGGCGGCCCATCTGGCGCAGATGCGTGCCTCGAACGAACTCATCGTCGCGCGCCAGTTCGAGTCGTTCAACCGCACC
ACGACTTTCGTCATCCACGACCTGAAAAACCTGGTCGCCCAACTCTCGCTGCTTCTCGCCAACGCCGAGAAACACAAGCA
CAATCCGGAGTTCCAGGCGGACATGCTCGAGACGGTGGAAAGCGCCGTCACGCGGATGAACAAGGTGCTGGCCCAACTGC
GCCGCGGCGGTGGCGACACCGAGGTGCAGTCGGTCGTCCTGGCCGACGTGCTGCGTGAAGCCATTGCCAGCAAACAGGCG
TTCAAGCTGCGCCCGGAGTTGAGCGCGCCGCCCGGGCTGCGCGTGCGCGCCGAGCGTCATCGGCTCGAACGCGCGGTCGG
GCACCTGTTGCAGAACGCGCTCGAGGCGACGCCGCAGACCGGGTCGGTCAGCCTCCGCGCGTTCGAGGAAGGGGGGCAGG
CCGTGGTCGAGATCGCCGACACCGGCAGCGGCATGGACGAGGACTTCATCCGTCACCGCCTCTTTCAACCCTTCGACTCG
ACCAAGGGCGCGGGTATGGGCATCGGCGCCTACGAATGCCGCGAGACCTTGCGCGCGCTCGGCGGAAACATCGAGGTCGA
AAGCAGCCCCGGTCAGGGCACCCGCTTCCGCCTGACCCTGCCGTTAGACAATAATGCACCTTCCGGAGGAGACGCCGCAT
GA

Upstream 100 bases:

>100_bases
GTCAAGAACCACAGCCTGTTTCTCGACCTCATGATCCTCTCCCAGACGGCGCAGGTCGTGCTCTGGGGAAAGGGCGTGCG
CTAAGCGCGCCCAAGTCGCG

Downstream 100 bases:

>100_bases
GCGACGCCAAACAAAAGATTCTGCTGGTCGAGGACGACCTTGGGCTGCAAAAGCAGCTCAAGTGGAGCCTTGCCGATTAC
GAGCTGATCGTCGCCGCAGA

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 693; Mature: 692

Protein sequence:

>693_residues
MAVTLLLLSALGHGLAALAFLALSGLIVASWRRRSQGRLLGLATALTAVWAASAALAAFATPLPRLQLVFEVARDGAWLA
LLLYILRLRLASGTPFPVPLRLIQALATALVAGLLLLSVLPFWAPASRAFALWTTNLFLLMLATIGLVLTEQVYRSTRPE
DRWAIKFLCLGLGGLYVYDFYLYANAMLFGGLDLRVWAARGYVAALITPLIAISAARNPEWSAPVGLSRSMAFHTASLLG
AGIYLLFMAGAGYYLRLFGGEWGDVVQTVFIFAAAMVLALLIFSGTLRARLRVFLAKHFFSYRYDYREEWLKFTRALTEG
RPGEALCDRAVEALARLVESPGGAVWLREGNAGYQRASHWNWADLQGVEPTDSAFLQWLTSKQWVVDLDEMKTRPDLYGD
LDAPRWLREAGDAWLVIPLMLHEELLGFVVLKHSLGKVTFNWEVSDLLKVTARQAAAHLAQMRASNELIVARQFESFNRT
TTFVIHDLKNLVAQLSLLLANAEKHKHNPEFQADMLETVESAVTRMNKVLAQLRRGGGDTEVQSVVLADVLREAIASKQA
FKLRPELSAPPGLRVRAERHRLERAVGHLLQNALEATPQTGSVSLRAFEEGGQAVVEIADTGSGMDEDFIRHRLFQPFDS
TKGAGMGIGAYECRETLRALGGNIEVESSPGQGTRFRLTLPLDNNAPSGGDAA

Sequences:

>Translated_693_residues
MAVTLLLLSALGHGLAALAFLALSGLIVASWRRRSQGRLLGLATALTAVWAASAALAAFATPLPRLQLVFEVARDGAWLA
LLLYILRLRLASGTPFPVPLRLIQALATALVAGLLLLSVLPFWAPASRAFALWTTNLFLLMLATIGLVLTEQVYRSTRPE
DRWAIKFLCLGLGGLYVYDFYLYANAMLFGGLDLRVWAARGYVAALITPLIAISAARNPEWSAPVGLSRSMAFHTASLLG
AGIYLLFMAGAGYYLRLFGGEWGDVVQTVFIFAAAMVLALLIFSGTLRARLRVFLAKHFFSYRYDYREEWLKFTRALTEG
RPGEALCDRAVEALARLVESPGGAVWLREGNAGYQRASHWNWADLQGVEPTDSAFLQWLTSKQWVVDLDEMKTRPDLYGD
LDAPRWLREAGDAWLVIPLMLHEELLGFVVLKHSLGKVTFNWEVSDLLKVTARQAAAHLAQMRASNELIVARQFESFNRT
TTFVIHDLKNLVAQLSLLLANAEKHKHNPEFQADMLETVESAVTRMNKVLAQLRRGGGDTEVQSVVLADVLREAIASKQA
FKLRPELSAPPGLRVRAERHRLERAVGHLLQNALEATPQTGSVSLRAFEEGGQAVVEIADTGSGMDEDFIRHRLFQPFDS
TKGAGMGIGAYECRETLRALGGNIEVESSPGQGTRFRLTLPLDNNAPSGGDAA
>Mature_692_residues
AVTLLLLSALGHGLAALAFLALSGLIVASWRRRSQGRLLGLATALTAVWAASAALAAFATPLPRLQLVFEVARDGAWLAL
LLYILRLRLASGTPFPVPLRLIQALATALVAGLLLLSVLPFWAPASRAFALWTTNLFLLMLATIGLVLTEQVYRSTRPED
RWAIKFLCLGLGGLYVYDFYLYANAMLFGGLDLRVWAARGYVAALITPLIAISAARNPEWSAPVGLSRSMAFHTASLLGA
GIYLLFMAGAGYYLRLFGGEWGDVVQTVFIFAAAMVLALLIFSGTLRARLRVFLAKHFFSYRYDYREEWLKFTRALTEGR
PGEALCDRAVEALARLVESPGGAVWLREGNAGYQRASHWNWADLQGVEPTDSAFLQWLTSKQWVVDLDEMKTRPDLYGDL
DAPRWLREAGDAWLVIPLMLHEELLGFVVLKHSLGKVTFNWEVSDLLKVTARQAAAHLAQMRASNELIVARQFESFNRTT
TFVIHDLKNLVAQLSLLLANAEKHKHNPEFQADMLETVESAVTRMNKVLAQLRRGGGDTEVQSVVLADVLREAIASKQAF
KLRPELSAPPGLRVRAERHRLERAVGHLLQNALEATPQTGSVSLRAFEEGGQAVVEIADTGSGMDEDFIRHRLFQPFDST
KGAGMGIGAYECRETLRALGGNIEVESSPGQGTRFRLTLPLDNNAPSGGDAA

Specific function: Member of the two-component regulatory system dctB/dctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates dctD in response to environmental signals [H]

COG id: COG4191

COG function: function code T; Signal transduction histidine kinase regulating C4-dicarboxylate transport system

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=220, Percent_Identity=25.9090909090909, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790436, Length=109, Percent_Identity=32.1100917431193, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR017055
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 76136; Mature: 76005

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTLLLLSALGHGLAALAFLALSGLIVASWRRRSQGRLLGLATALTAVWAASAALAAFA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
TPLPRLQLVFEVARDGAWLALLLYILRLRLASGTPFPVPLRLIQALATALVAGLLLLSVL
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
PFWAPASRAFALWTTNLFLLMLATIGLVLTEQVYRSTRPEDRWAIKFLCLGLGGLYVYDF
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHH
YLYANAMLFGGLDLRVWAARGYVAALITPLIAISAARNPEWSAPVGLSRSMAFHTASLLG
HHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
AGIYLLFMAGAGYYLRLFGGEWGDVVQTVFIFAAAMVLALLIFSGTLRARLRVFLAKHFF
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SYRYDYREEWLKFTRALTEGRPGEALCDRAVEALARLVESPGGAVWLREGNAGYQRASHW
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC
NWADLQGVEPTDSAFLQWLTSKQWVVDLDEMKTRPDLYGDLDAPRWLREAGDAWLVIPLM
CCCCCCCCCCCHHHHHHHHCCCCCEEEHHHHCCCCCCCCCCCCCHHHHHCCCCEEEHHHH
LHEELLGFVVLKHSLGKVTFNWEVSDLLKVTARQAAAHLAQMRASNELIVARQFESFNRT
HHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHCCCH
TTFVIHDLKNLVAQLSLLLANAEKHKHNPEFQADMLETVESAVTRMNKVLAQLRRGGGDT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
EVQSVVLADVLREAIASKQAFKLRPELSAPPGLRVRAERHRLERAVGHLLQNALEATPQT
HHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCC
GSVSLRAFEEGGQAVVEIADTGSGMDEDFIRHRLFQPFDSTKGAGMGIGAYECRETLRAL
CCEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHC
GGNIEVESSPGQGTRFRLTLPLDNNAPSGGDAA
CCCEEEECCCCCCCEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
AVTLLLLSALGHGLAALAFLALSGLIVASWRRRSQGRLLGLATALTAVWAASAALAAFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
TPLPRLQLVFEVARDGAWLALLLYILRLRLASGTPFPVPLRLIQALATALVAGLLLLSVL
CCCHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
PFWAPASRAFALWTTNLFLLMLATIGLVLTEQVYRSTRPEDRWAIKFLCLGLGGLYVYDF
HCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHH
YLYANAMLFGGLDLRVWAARGYVAALITPLIAISAARNPEWSAPVGLSRSMAFHTASLLG
HHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
AGIYLLFMAGAGYYLRLFGGEWGDVVQTVFIFAAAMVLALLIFSGTLRARLRVFLAKHFF
HHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SYRYDYREEWLKFTRALTEGRPGEALCDRAVEALARLVESPGGAVWLREGNAGYQRASHW
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCC
NWADLQGVEPTDSAFLQWLTSKQWVVDLDEMKTRPDLYGDLDAPRWLREAGDAWLVIPLM
CCCCCCCCCCCHHHHHHHHCCCCCEEEHHHHCCCCCCCCCCCCCHHHHHCCCCEEEHHHH
LHEELLGFVVLKHSLGKVTFNWEVSDLLKVTARQAAAHLAQMRASNELIVARQFESFNRT
HHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHCCCH
TTFVIHDLKNLVAQLSLLLANAEKHKHNPEFQADMLETVESAVTRMNKVLAQLRRGGGDT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
EVQSVVLADVLREAIASKQAFKLRPELSAPPGLRVRAERHRLERAVGHLLQNALEATPQT
HHHHHHHHHHHHHHHCCCHHEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCC
GSVSLRAFEEGGQAVVEIADTGSGMDEDFIRHRLFQPFDSTKGAGMGIGAYECRETLRAL
CCEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHC
GGNIEVESSPGQGTRFRLTLPLDNNAPSGGDAA
CCCEEEECCCCCCCEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2134335; 2793824; 11481431; 2551890; 2695394 [H]