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The map label for this gene is accB [H]

Identifier: 74316200

GI number: 74316200

Start: 195274

End: 195723

Strand: Reverse

Name: accB [H]

Synonym: Tbd_0182

Alternate gene names: 74316200

Gene position: 195723-195274 (Counterclockwise)

Preceding gene: 74316201

Following gene: 74316199

Centisome position: 6.73

GC content: 63.33

Gene sequence:

>450_bases
ATGGATCTCAGAAAACTGAAAAAGCTCATTGATCTGGTCGAGGCCTCCGGCATCGCCGAACTCGAAATCACCGAAGGCGA
GGAAAAGGTCCGCATCGCCAAGAGTATCGCCGGCGCGCCGATGATGATGCAGGCGCCCCAAGTGATGCAGGCGACCCTCC
CGGCCGCCGCCCCTGCGGCGGCGCCGGCTGCGGTTGCAGAGGATGCAGTGCCCGAAGGCCACATCGTGCGCTCGCCGATG
GTCGGCACCTTCTACCGCGCCCCCTCGCCCGGTTCCAAGAATTTTGCCGAAGTCGGCCAGAACGTGAGCGCCGGCGACAC
CCTGTGCATCATCGAAGCGATGAAGCTCCTGAACGAGATCGAAGCCGACCAGGGCGGCGTCATCAAGGCGATCCTGGTCG
AGAACGGCCAGCCGGTCGAATACGGCGAACCCCTGTTTGTCATCGCGTGA

Upstream 100 bases:

>100_bases
TTTCCGACCTGGCGATCGGCGTCATTTCCGGCCTCGGTGCACAGGGATACGAACTGGCGCTGGAACACGCGCTGCGCCAC
TTTCAAGACAGGACCCCCCA

Downstream 100 bases:

>100_bases
AGCAGCGGCCATGAGGCGTCAGGCGTAGCCGTCGTCACTTCCCGTCCCTCATCCTCACCGAGCCTCATCCAACATGTTTG
AAAAGATTCTGATCGCCAAC

Product: biotin carboxyl carrier protein

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MDLRKLKKLIDLVEASGIAELEITEGEEKVRIAKSIAGAPMMMQAPQVMQATLPAAAPAAAPAAVAEDAVPEGHIVRSPM
VGTFYRAPSPGSKNFAEVGQNVSAGDTLCIIEAMKLLNEIEADQGGVIKAILVENGQPVEYGEPLFVIA

Sequences:

>Translated_149_residues
MDLRKLKKLIDLVEASGIAELEITEGEEKVRIAKSIAGAPMMMQAPQVMQATLPAAAPAAAPAAVAEDAVPEGHIVRSPM
VGTFYRAPSPGSKNFAEVGQNVSAGDTLCIIEAMKLLNEIEADQGGVIKAILVENGQPVEYGEPLFVIA
>Mature_149_residues
MDLRKLKKLIDLVEASGIAELEITEGEEKVRIAKSIAGAPMMMQAPQVMQATLPAAAPAAAPAAVAEDAVPEGHIVRSPM
VGTFYRAPSPGSKNFAEVGQNVSAGDTLCIIEAMKLLNEIEADQGGVIKAILVENGQPVEYGEPLFVIA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=155, Percent_Identity=61.2903225806452, Blast_Score=182, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: NA

Molecular weight: Translated: 15609; Mature: 15609

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: PS50968 BIOTINYL_LIPOYL ; PS00188 BIOTIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRKLKKLIDLVEASGIAELEITEGEEKVRIAKSIAGAPMMMQAPQVMQATLPAAAPAA
CCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCHHCCHHHHHHHCCCCCCCC
APAAVAEDAVPEGHIVRSPMVGTFYRAPSPGSKNFAEVGQNVSAGDTLCIIEAMKLLNEI
CCHHHHHHCCCCCCEECCCCCCEEECCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHH
EADQGGVIKAILVENGQPVEYGEPLFVIA
CCCCCCEEEEEEECCCCCCCCCCCEEEEC
>Mature Secondary Structure
MDLRKLKKLIDLVEASGIAELEITEGEEKVRIAKSIAGAPMMMQAPQVMQATLPAAAPAA
CCHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCCCHHCCHHHHHHHCCCCCCCC
APAAVAEDAVPEGHIVRSPMVGTFYRAPSPGSKNFAEVGQNVSAGDTLCIIEAMKLLNEI
CCHHHHHHCCCCCCEECCCCCCEEECCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHH
EADQGGVIKAILVENGQPVEYGEPLFVIA
CCCCCCEEEEEEECCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]