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The map label for this gene is accC [H]

Identifier: 74316199

GI number: 74316199

Start: 193851

End: 195200

Strand: Reverse

Name: accC [H]

Synonym: Tbd_0181

Alternate gene names: 74316199

Gene position: 195200-193851 (Counterclockwise)

Preceding gene: 74316200

Following gene: 74316198

Centisome position: 6.71

GC content: 65.11

Gene sequence:

>1350_bases
ATGTTTGAAAAGATTCTGATCGCCAACCGCGGCGAGATAGCCCTGAGAATCCAGCGCGCCTGCCGCGAAATGGGGATCAA
GACGGTCGCGGTCTACTCGGAGGCCGACCGCGACGCCAAATACGTCAAGCTCGCCGACGAATCGGTGTGCATCGGACCCG
CCCCGTCCGCGCAAAGCTATCTGCACGTGCCGTCGATCATCGCTGCCGCCGAAGTCACCGACGCCGCCGCCATCCATCCC
GGCTACGGCTTCCTTTCCGAGAACGCCGACTTCGCCGAACGCGTCGAATCGTCGGGTTTCACGTTCATCGGCCCGCGCCC
CGACAACATCCGCCTGATGGGCGACAAAGTCGCGGCCAAGCAGGCCATGATCGACGCCAAGGTGCCCTGCGTGCCCGGCT
CGGACGGCGCACTCGCCGATGACCCGCAGGAGATCCTCAAGACCGCGCGCGCGATCGGCTACCCGGTCATCATCAAGGCC
GCGGGCGGCGGCGGCGGACGCGGGATGCGCGTCGTCCACACCGAAGCCGCGCTGCTCAACGCCGTCACGATGACCAAGAC
CGAAGCCGGCGCCGCCTTCGGCAATCCGATGGTCTACATGGAAAAGTTTCTCGAGACGCCGCGCCATATCGAGATCCAGA
TCCTTGCCGACGAACACGGCAATGCCGTCCATCTCGGCGAGCGCGACTGCTCGATGCAGCGCCGCCACCAGAAGGTTCTC
GAGGAAGCGCCGGCGCCCGGACTCGACCCGAAGCTGCGCGACAAGATCGGCGAGCGCTGCGCCGAAGCCTGCCGCAAGAT
CGGCTACCGCGGCGCGGGCACCTTCGAATTCCTGTACGAGAACGGCGAGTTCTACTTCATCGAGATGAACACGCGCGTCC
AGGTCGAGCATCCGGTCACCGAACTCATTACCGGCATCGACATCGTGCAGACGCAGATCCGCGTCGCCGCCGGCGAGAAG
CTGCCCTTCCAGCAGAAGGACATCCGCTTTCGCGGGCACGCGGTCGAGTGCCGCATCAATGCCGAGCACCCGACGACCTT
CGTGCCGAGCCCGGGCAAACTCACCAATTACCACGCCGCGGGCGGCCCCGGCATCCGCGTCGACTCGCACGTCTACCACG
GCTATTACGTGCCGCCGCATTACGACTCGATGATCGGCAAGCTCATCGCCTACGGCGACACCCGCGACCAGGCCATCGCC
CGCATGCGCGGGGCGCTCATGGAAATGGTCGTCGAAGGCATCCAGAGCAATATTCCGCTGCATCAGGAGCTGATGAATGA
CGCGGCGTTCATCGCCGGCGGGACGAGCATCCACTACCTCGAGCACAAGCTCGCGGGGGAGAAAGGGTGA

Upstream 100 bases:

>100_bases
GGCGAACCCCTGTTTGTCATCGCGTGAAGCAGCGGCCATGAGGCGTCAGGCGTAGCCGTCGTCACTTCCCGTCCCTCATC
CTCACCGAGCCTCATCCAAC

Downstream 100 bases:

>100_bases
GGGGGAGGGTTCAGGATTTAGGGGCTAGGATCTAGGGACTAGGGGGGTGCGGCCGGAGGCCGCGCCCCATCAAACTAGGC
GCGAAGCACAAAGCCCCCTG

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MFEKILIANRGEIALRIQRACREMGIKTVAVYSEADRDAKYVKLADESVCIGPAPSAQSYLHVPSIIAAAEVTDAAAIHP
GYGFLSENADFAERVESSGFTFIGPRPDNIRLMGDKVAAKQAMIDAKVPCVPGSDGALADDPQEILKTARAIGYPVIIKA
AGGGGGRGMRVVHTEAALLNAVTMTKTEAGAAFGNPMVYMEKFLETPRHIEIQILADEHGNAVHLGERDCSMQRRHQKVL
EEAPAPGLDPKLRDKIGERCAEACRKIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVTELITGIDIVQTQIRVAAGEK
LPFQQKDIRFRGHAVECRINAEHPTTFVPSPGKLTNYHAAGGPGIRVDSHVYHGYYVPPHYDSMIGKLIAYGDTRDQAIA
RMRGALMEMVVEGIQSNIPLHQELMNDAAFIAGGTSIHYLEHKLAGEKG

Sequences:

>Translated_449_residues
MFEKILIANRGEIALRIQRACREMGIKTVAVYSEADRDAKYVKLADESVCIGPAPSAQSYLHVPSIIAAAEVTDAAAIHP
GYGFLSENADFAERVESSGFTFIGPRPDNIRLMGDKVAAKQAMIDAKVPCVPGSDGALADDPQEILKTARAIGYPVIIKA
AGGGGGRGMRVVHTEAALLNAVTMTKTEAGAAFGNPMVYMEKFLETPRHIEIQILADEHGNAVHLGERDCSMQRRHQKVL
EEAPAPGLDPKLRDKIGERCAEACRKIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVTELITGIDIVQTQIRVAAGEK
LPFQQKDIRFRGHAVECRINAEHPTTFVPSPGKLTNYHAAGGPGIRVDSHVYHGYYVPPHYDSMIGKLIAYGDTRDQAIA
RMRGALMEMVVEGIQSNIPLHQELMNDAAFIAGGTSIHYLEHKLAGEKG
>Mature_449_residues
MFEKILIANRGEIALRIQRACREMGIKTVAVYSEADRDAKYVKLADESVCIGPAPSAQSYLHVPSIIAAAEVTDAAAIHP
GYGFLSENADFAERVESSGFTFIGPRPDNIRLMGDKVAAKQAMIDAKVPCVPGSDGALADDPQEILKTARAIGYPVIIKA
AGGGGGRGMRVVHTEAALLNAVTMTKTEAGAAFGNPMVYMEKFLETPRHIEIQILADEHGNAVHLGERDCSMQRRHQKVL
EEAPAPGLDPKLRDKIGERCAEACRKIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVTELITGIDIVQTQIRVAAGEK
LPFQQKDIRFRGHAVECRINAEHPTTFVPSPGKLTNYHAAGGPGIRVDSHVYHGYYVPPHYDSMIGKLIAYGDTRDQAIA
RMRGALMEMVVEGIQSNIPLHQELMNDAAFIAGGTSIHYLEHKLAGEKG

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=48.7584650112867, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=48.7584650112867, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=48.7584650112867, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=47.7272727272727, Blast_Score=416, Evalue=1e-116,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=47.2035794183445, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=47.2035794183445, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=47.2035794183445, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI38679960, Length=517, Percent_Identity=31.1411992263056, Blast_Score=237, Evalue=1e-62,
Organism=Homo sapiens, GI38679974, Length=517, Percent_Identity=31.1411992263056, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI38679977, Length=517, Percent_Identity=31.1411992263056, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI38679967, Length=517, Percent_Identity=31.1411992263056, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI38679971, Length=517, Percent_Identity=31.1411992263056, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI134142062, Length=516, Percent_Identity=31.0077519379845, Blast_Score=225, Evalue=7e-59,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=68.6936936936937, Blast_Score=627, Evalue=0.0,
Organism=Escherichia coli, GI1786216, Length=248, Percent_Identity=25, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=47.8555304740406, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71987519, Length=441, Percent_Identity=48.2993197278912, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17562816, Length=447, Percent_Identity=44.2953020134228, Blast_Score=357, Evalue=6e-99,
Organism=Caenorhabditis elegans, GI133931226, Length=499, Percent_Identity=28.2565130260521, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71997168, Length=513, Percent_Identity=28.0701754385965, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI71997163, Length=513, Percent_Identity=28.0701754385965, Blast_Score=190, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=42.2121896162528, Blast_Score=350, Evalue=3e-97,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=45.8612975391499, Blast_Score=348, Evalue=1e-96,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=46.4285714285714, Blast_Score=343, Evalue=4e-95,
Organism=Saccharomyces cerevisiae, GI6323863, Length=463, Percent_Identity=31.7494600431965, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6324343, Length=528, Percent_Identity=29.9242424242424, Blast_Score=224, Evalue=2e-59,
Organism=Drosophila melanogaster, GI281363050, Length=444, Percent_Identity=47.972972972973, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652224, Length=444, Percent_Identity=47.972972972973, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652222, Length=444, Percent_Identity=47.972972972973, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652220, Length=444, Percent_Identity=47.972972972973, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652218, Length=444, Percent_Identity=47.972972972973, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652212, Length=444, Percent_Identity=47.972972972973, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652210, Length=444, Percent_Identity=47.972972972973, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652214, Length=444, Percent_Identity=47.972972972973, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI19921944, Length=444, Percent_Identity=47.972972972973, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652216, Length=444, Percent_Identity=47.972972972973, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24651757, Length=447, Percent_Identity=45.1901565995526, Blast_Score=385, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24651759, Length=410, Percent_Identity=44.390243902439, Blast_Score=343, Evalue=1e-94,
Organism=Drosophila melanogaster, GI161076407, Length=509, Percent_Identity=29.2730844793713, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI24586460, Length=509, Percent_Identity=29.2730844793713, Blast_Score=215, Evalue=5e-56,
Organism=Drosophila melanogaster, GI161076409, Length=509, Percent_Identity=29.2730844793713, Blast_Score=215, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24586458, Length=509, Percent_Identity=29.2730844793713, Blast_Score=215, Evalue=6e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49006; Mature: 49006

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEKILIANRGEIALRIQRACREMGIKTVAVYSEADRDAKYVKLADESVCIGPAPSAQSY
CCCEEEEECCCCEEHHHHHHHHHCCCEEEEEEECCCCCCEEEEECCCCEEECCCCCCCCE
LHVPSIIAAAEVTDAAAIHPGYGFLSENADFAERVESSGFTFIGPRPDNIRLMGDKVAAK
EECCHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHCCCEEECCCCCCEEEECCHHHHH
QAMIDAKVPCVPGSDGALADDPQEILKTARAIGYPVIIKAAGGGGGRGMRVVHTEAALLN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEHHHHHH
AVTMTKTEAGAAFGNPMVYMEKFLETPRHIEIQILADEHGNAVHLGERDCSMQRRHQKVL
HHHEECCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCHHHHHHHHHHHH
EEAPAPGLDPKLRDKIGERCAEACRKIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
ELITGIDIVQTQIRVAAGEKLPFQQKDIRFRGHAVECRINAEHPTTFVPSPGKLTNYHAA
HHHHHHHHHHHHHHEECCCCCCCCCCCEEECCEEEEEEEECCCCEEECCCCCCCCEEECC
GGPGIRVDSHVYHGYYVPPHYDSMIGKLIAYGDTRDQAIARMRGALMEMVVEGIQSNIPL
CCCCCEECCEEEECEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCH
HQELMNDAAFIAGGTSIHYLEHKLAGEKG
HHHHHCCCEEEECCCEEEHHHHHHCCCCC
>Mature Secondary Structure
MFEKILIANRGEIALRIQRACREMGIKTVAVYSEADRDAKYVKLADESVCIGPAPSAQSY
CCCEEEEECCCCEEHHHHHHHHHCCCEEEEEEECCCCCCEEEEECCCCEEECCCCCCCCE
LHVPSIIAAAEVTDAAAIHPGYGFLSENADFAERVESSGFTFIGPRPDNIRLMGDKVAAK
EECCHHHHHHHHCCCCEECCCCCCCCCCCHHHHHHHHCCCEEECCCCCCEEEECCHHHHH
QAMIDAKVPCVPGSDGALADDPQEILKTARAIGYPVIIKAAGGGGGRGMRVVHTEAALLN
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEEHHHHHH
AVTMTKTEAGAAFGNPMVYMEKFLETPRHIEIQILADEHGNAVHLGERDCSMQRRHQKVL
HHHEECCCCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCHHHHHHHHHHHH
EEAPAPGLDPKLRDKIGERCAEACRKIGYRGAGTFEFLYENGEFYFIEMNTRVQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
ELITGIDIVQTQIRVAAGEKLPFQQKDIRFRGHAVECRINAEHPTTFVPSPGKLTNYHAA
HHHHHHHHHHHHHHEECCCCCCCCCCCEEECCEEEEEEEECCCCEEECCCCCCCCEEECC
GGPGIRVDSHVYHGYYVPPHYDSMIGKLIAYGDTRDQAIARMRGALMEMVVEGIQSNIPL
CCCCCEECCEEEECEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCH
HQELMNDAAFIAGGTSIHYLEHKLAGEKG
HHHHHCCCEEEECCCEEEHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9560425 [H]