Click here to switch to the map view.

The map label for this gene is gcvT [H]

Identifier: 74316196

GI number: 74316196

Start: 190335

End: 191423

Strand: Reverse

Name: gcvT [H]

Synonym: Tbd_0178

Alternate gene names: 74316196

Gene position: 191423-190335 (Counterclockwise)

Preceding gene: 74316197

Following gene: 74316195

Centisome position: 6.58

GC content: 64.46

Gene sequence:

>1089_bases
ATGTCCGATCCGCTCAAACAGACGCCACTCAATGCCACCCATCGCGAGCTCGGCGCCAGGATGGTCGACTTCGGCGGCTG
GGACATGCCGGTCAACTACGGCTCGCAGATCGAGGAACATCACGCGGTCCGTAGCGGCTGCGGTCTCTTCGACGTCTCGC
ACATGCTGCCGCTCGACATCCGGGGCACGAACGTGCGTGCCTTCCTGCGCCGCCTCGTCGCGAACAACGTCGACAAGCTG
CAGGTTGCGGGCAAGGCGCTCTATTCGTGCATGCTCAACGAGGCCGGCGGCGTCATCGACGACCTCATCATCTATTTCAT
GGACGAATCCTGGTTCCGCCTCGTGGTCAACGCCGGCACCGCGGAAAAGGACCTCGCGTGGATGGAGAAGATGAACGCCG
AGTGGAACATGGGGCTCTCGCTTACCCCGCGTCGTGACCTCGCGATGATCGCGATCCAGGGGCCGAACGCCACCCAGGCG
CTCAACGAAGCCCTGCCCGGCGTCGACCAGATCACCGCGAACCTCAAACCCTTCAACGCCGCCGCGATGGGCGAAATGTT
CATCGCCCGCACCGGCTACACCGGCGAGGACGGCTTCGAAGTCATGGTGCTCGCCAAGTCCGCGCCCTTCTTCTGGAAGG
CGCTCATGGAAGCCGGCGGCAAGCCGATCGGCCTCGGTGCGCGCGACACGTTGCGCCTCGAAGCCGGCATGAACCTCTAC
GGCCAGGACATGGACGAGACGACCTCGCCGCTCGAGTCCGGCCTCGCGTGGACCGTCGACCTCAAGAGCGAACGCGACTT
CGTCGGCCGCAAGGCGCTCGAAACCAGCGAAGTGACCAAGCAGCTCGCCGGCCTCGTGCTCGTCGACAAGGGCGTGCTGC
GCGGCCACCAGAAGGTCCACACCCGGCACGGCGACGGCGAAATCACCTCCGGCACCTTCTCGCCTACACTGCAGCAGTCC
ATCGCCCTCGCCCGCATCCCGCTCGGCATCGCCCCGGGCGACGAAGTCGAAGTCGAGATCCGCGACAAGAAGCTGAAAGC
CAAAGTGGTGAAATATCCGTTCGTGCGCAACGGCAAAGCTTTGATTTGA

Upstream 100 bases:

>100_bases
CCACCGAAGGGGCAGCGGCGCCGGTTGATCAACCTGGCACCGTAATCTCTCAGGTACCAAGGACAGAGGGGTTCACCCTT
AATCATTTTTTTGGTGCCCC

Downstream 100 bases:

>100_bases
GGGGTCAGGGGTCAGGGGCCAGGAGTCAGGGATCAGAGGATGTGCGGCCGCGCGCGCTTTTCAAAAACAGACGCGGGCAA
AGCCCGCTCGTCCCCTGAGT

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSDPLKQTPLNATHRELGARMVDFGGWDMPVNYGSQIEEHHAVRSGCGLFDVSHMLPLDIRGTNVRAFLRRLVANNVDKL
QVAGKALYSCMLNEAGGVIDDLIIYFMDESWFRLVVNAGTAEKDLAWMEKMNAEWNMGLSLTPRRDLAMIAIQGPNATQA
LNEALPGVDQITANLKPFNAAAMGEMFIARTGYTGEDGFEVMVLAKSAPFFWKALMEAGGKPIGLGARDTLRLEAGMNLY
GQDMDETTSPLESGLAWTVDLKSERDFVGRKALETSEVTKQLAGLVLVDKGVLRGHQKVHTRHGDGEITSGTFSPTLQQS
IALARIPLGIAPGDEVEVEIRDKKLKAKVVKYPFVRNGKALI

Sequences:

>Translated_362_residues
MSDPLKQTPLNATHRELGARMVDFGGWDMPVNYGSQIEEHHAVRSGCGLFDVSHMLPLDIRGTNVRAFLRRLVANNVDKL
QVAGKALYSCMLNEAGGVIDDLIIYFMDESWFRLVVNAGTAEKDLAWMEKMNAEWNMGLSLTPRRDLAMIAIQGPNATQA
LNEALPGVDQITANLKPFNAAAMGEMFIARTGYTGEDGFEVMVLAKSAPFFWKALMEAGGKPIGLGARDTLRLEAGMNLY
GQDMDETTSPLESGLAWTVDLKSERDFVGRKALETSEVTKQLAGLVLVDKGVLRGHQKVHTRHGDGEITSGTFSPTLQQS
IALARIPLGIAPGDEVEVEIRDKKLKAKVVKYPFVRNGKALI
>Mature_361_residues
SDPLKQTPLNATHRELGARMVDFGGWDMPVNYGSQIEEHHAVRSGCGLFDVSHMLPLDIRGTNVRAFLRRLVANNVDKLQ
VAGKALYSCMLNEAGGVIDDLIIYFMDESWFRLVVNAGTAEKDLAWMEKMNAEWNMGLSLTPRRDLAMIAIQGPNATQAL
NEALPGVDQITANLKPFNAAAMGEMFIARTGYTGEDGFEVMVLAKSAPFFWKALMEAGGKPIGLGARDTLRLEAGMNLYG
QDMDETTSPLESGLAWTVDLKSERDFVGRKALETSEVTKQLAGLVLVDKGVLRGHQKVHTRHGDGEITSGTFSPTLQQSI
ALARIPLGIAPGDEVEVEIRDKKLKAKVVKYPFVRNGKALI

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=372, Percent_Identity=37.6344086021505, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI257796258, Length=357, Percent_Identity=36.9747899159664, Blast_Score=192, Evalue=4e-49,
Organism=Homo sapiens, GI257796254, Length=367, Percent_Identity=32.6975476839237, Blast_Score=158, Evalue=7e-39,
Organism=Homo sapiens, GI257796256, Length=316, Percent_Identity=36.0759493670886, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI24797151, Length=344, Percent_Identity=27.3255813953488, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI197927446, Length=326, Percent_Identity=26.6871165644172, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI21361378, Length=326, Percent_Identity=26.6871165644172, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI194306651, Length=354, Percent_Identity=24.8587570621469, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789272, Length=366, Percent_Identity=55.4644808743169, Blast_Score=376, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17560118, Length=374, Percent_Identity=36.6310160427808, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71994045, Length=378, Percent_Identity=24.8677248677249, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71994052, Length=378, Percent_Identity=24.8677248677249, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI32563613, Length=274, Percent_Identity=27.3722627737226, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320222, Length=383, Percent_Identity=36.2924281984334, Blast_Score=183, Evalue=5e-47,
Organism=Drosophila melanogaster, GI20129441, Length=379, Percent_Identity=33.509234828496, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI28571104, Length=254, Percent_Identity=26.7716535433071, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 39644; Mature: 39513

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPLKQTPLNATHRELGARMVDFGGWDMPVNYGSQIEEHHAVRSGCGLFDVSHMLPLDI
CCCCCCCCCCCHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEHHHCCEEEE
RGTNVRAFLRRLVANNVDKLQVAGKALYSCMLNEAGGVIDDLIIYFMDESWFRLVVNAGT
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEECCC
AEKDLAWMEKMNAEWNMGLSLTPRRDLAMIAIQGPNATQALNEALPGVDQITANLKPFNA
CHHHHHHHHHCCCCCCCCEEECCCCCEEEEEEECCCHHHHHHHHCCCHHHHHCCCCCCCH
AAMGEMFIARTGYTGEDGFEVMVLAKSAPFFWKALMEAGGKPIGLGARDTLRLEAGMNLY
HHHHHHHEEECCCCCCCCCEEEEEECCCCHHHHHHHHCCCCEEECCCCCEEEEECCCCCC
GQDMDETTSPLESGLAWTVDLKSERDFVGRKALETSEVTKQLAGLVLVDKGVLRGHQKVH
CCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCEEEECCHHHCCCHHHH
TRHGDGEITSGTFSPTLQQSIALARIPLGIAPGDEVEVEIRDKKLKAKVVKYPFVRNGKA
EECCCCCEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHEECCEECCCCC
LI
CC
>Mature Secondary Structure 
SDPLKQTPLNATHRELGARMVDFGGWDMPVNYGSQIEEHHAVRSGCGLFDVSHMLPLDI
CCCCCCCCCCHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEHHHCCEEEE
RGTNVRAFLRRLVANNVDKLQVAGKALYSCMLNEAGGVIDDLIIYFMDESWFRLVVNAGT
CCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEEEECCC
AEKDLAWMEKMNAEWNMGLSLTPRRDLAMIAIQGPNATQALNEALPGVDQITANLKPFNA
CHHHHHHHHHCCCCCCCCEEECCCCCEEEEEEECCCHHHHHHHHCCCHHHHHCCCCCCCH
AAMGEMFIARTGYTGEDGFEVMVLAKSAPFFWKALMEAGGKPIGLGARDTLRLEAGMNLY
HHHHHHHEEECCCCCCCCCEEEEEECCCCHHHHHHHHCCCCEEECCCCCEEEEECCCCCC
GQDMDETTSPLESGLAWTVDLKSERDFVGRKALETSEVTKQLAGLVLVDKGVLRGHQKVH
CCCCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCEEEECCHHHCCCHHHH
TRHGDGEITSGTFSPTLQQSIALARIPLGIAPGDEVEVEIRDKKLKAKVVKYPFVRNGKA
EECCCCCEECCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCHHHHHHEECCEECCCCC
LI
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA