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The map label for this gene is tpx [H]

Identifier: 74316192

GI number: 74316192

Start: 187410

End: 187901

Strand: Reverse

Name: tpx [H]

Synonym: Tbd_0174

Alternate gene names: 74316192

Gene position: 187901-187410 (Counterclockwise)

Preceding gene: 74316193

Following gene: 74316191

Centisome position: 6.46

GC content: 64.23

Gene sequence:

>492_bases
ATGGCAGTGACCCTAGGCGGCAACCCCATCGACATCGCAGGCAGCTTCCCCAAGGTCGGCGACACCGCGCCCGACTTCAA
GCTCGTGAACAAGGATCTGGCCGACGTCTCGCTGGCCGACTTCGCCGGCAAGAAAAAGATCCTCAACATCGTGCCGAGCC
TCGACACCCCGGTGTGCGCGACGTCGACCAAGAAATTCAACGACGCCGCCGTCGGCAACGCCGTCGTGCTGATCATCTCG
GCCGACCTGCCGTTCGCGATGAGCCGCTTCTGCGGCGTCGAGAACACCGACAAGGTCGTGACGCTGTCGACCATGCGCGG
CGCCGAGTTCATGAAGAACTACGGCGTCGCGATCACCAGCGGCCCGCTCGCCGGCGTCACCGCCCGCGCCGTGGTCGTGC
TCGACGAGGCCAACAAGGTGCTCCACGCCGAACTCGTTCCCGAGATCAAGCAGGAGCCGAATTACGAGGCCGCTTTGGCG
GCTCTGAAATAA

Upstream 100 bases:

>100_bases
AGCACCTGGCGCGTTTCGACCAGCAAGCCGGCTGAACGAAGCGCAGAGAGAGACGGGCGATCGCCCGAGGTTTGACAGAC
GTGATTCAAGGAGAAGAGAC

Downstream 100 bases:

>100_bases
AGGGGTCAGGGGTCGGGATTCAGGGGTCAGGGAATGCGCGGCGAAGCCGCATCATCAGATCGGTGCGGGCTTTGCCCGCT
CATTCCCCTGAATCCTGATC

Product: thiol peroxidase

Products: oxidized thioredoxin; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MAVTLGGNPIDIAGSFPKVGDTAPDFKLVNKDLADVSLADFAGKKKILNIVPSLDTPVCATSTKKFNDAAVGNAVVLIIS
ADLPFAMSRFCGVENTDKVVTLSTMRGAEFMKNYGVAITSGPLAGVTARAVVVLDEANKVLHAELVPEIKQEPNYEAALA
ALK

Sequences:

>Translated_163_residues
MAVTLGGNPIDIAGSFPKVGDTAPDFKLVNKDLADVSLADFAGKKKILNIVPSLDTPVCATSTKKFNDAAVGNAVVLIIS
ADLPFAMSRFCGVENTDKVVTLSTMRGAEFMKNYGVAITSGPLAGVTARAVVVLDEANKVLHAELVPEIKQEPNYEAALA
ALK
>Mature_162_residues
AVTLGGNPIDIAGSFPKVGDTAPDFKLVNKDLADVSLADFAGKKKILNIVPSLDTPVCATSTKKFNDAAVGNAVVLIISA
DLPFAMSRFCGVENTDKVVTLSTMRGAEFMKNYGVAITSGPLAGVTARAVVVLDEANKVLHAELVPEIKQEPNYEAALAA
LK

Specific function: Has antioxidant activity. Could remove peroxides or H(2)O(2) [H]

COG id: COG2077

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787584, Length=163, Percent_Identity=59.5092024539877, Blast_Score=196, Evalue=8e-52,

Paralogues:

None

Copy number: 2480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018219
- InterPro:   IPR002065
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF08534 Redoxin [H]

EC number: 1.11.1.- [C]

Molecular weight: Translated: 17033; Mature: 16902

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS01265 TPX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTLGGNPIDIAGSFPKVGDTAPDFKLVNKDLADVSLADFAGKKKILNIVPSLDTPVCA
CEEECCCCEEEECCCCCCCCCCCCCCEECCCCCHHHHHHHHCCCHHHHEECCCCCCCEEC
TSTKKFNDAAVGNAVVLIISADLPFAMSRFCGVENTDKVVTLSTMRGAEFMKNYGVAITS
CCCCCCCCCCCCCEEEEEEECCCCHHHHHHCCCCCCCCEEEEECCCCHHHHHHCCEEEEC
GPLAGVTARAVVVLDEANKVLHAELVPEIKQEPNYEAALAALK
CCCCCCEEEEEEEEECCCCEEEHHHCHHHHCCCCHHHHHEECC
>Mature Secondary Structure 
AVTLGGNPIDIAGSFPKVGDTAPDFKLVNKDLADVSLADFAGKKKILNIVPSLDTPVCA
EEECCCCEEEECCCCCCCCCCCCCCEECCCCCHHHHHHHHCCCHHHHEECCCCCCCEEC
TSTKKFNDAAVGNAVVLIISADLPFAMSRFCGVENTDKVVTLSTMRGAEFMKNYGVAITS
CCCCCCCCCCCCCEEEEEEECCCCHHHHHHCCCCCCCCEEEEECCCCHHHHHHCCEEEEC
GPLAGVTARAVVVLDEANKVLHAELVPEIKQEPNYEAALAALK
CCCCCCEEEEEEEEECCCCEEEHHHCHHHHCCCCHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: reduced thioredoxin; H2O2 [C]

Specific reaction: reduced thioredoxin + H2O2 = oxidized thioredoxin + H2O [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]