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The map label for this gene is gcvPB

Identifier: 74316191

GI number: 74316191

Start: 185810

End: 187261

Strand: Reverse

Name: gcvPB

Synonym: Tbd_0173

Alternate gene names: 74316191

Gene position: 187261-185810 (Counterclockwise)

Preceding gene: 74316192

Following gene: 74316190

Centisome position: 6.44

GC content: 67.7

Gene sequence:

>1452_bases
ATGCTGATATTCGACCATTCCCGCCCCGGCCGCACCGCCGCCGCCCAGCTGCCCGCCACCGGCGGCGACCTCGGCGACCT
GCCTGCCGAACTGCGCCGCAAGGACGCGCCCGCATTGCCCGAAGTCTCCGAGCTCGACGTCGTGCGCCATTACACGCGCC
TCTCGCAGAAGAACTTCTCGATCGACACGCAGTTCTACCCGCTCGGCTCGTGCACGATGAAGTACAACCCGCGCGCGTGC
AATTCGCTCGCGATGCTGCCGCAGTTCCTCGCGCGCCACCCGGCGAGCCCGGACGAGACGGGGCAGGGCTTTCTCGCCAG
CATGTTCGAGCTGCAGGAGATGCTGAAGGACGTGACCGGCATGGCCGGCGTGTCGATGGCGCCGATGGCCGGCGCGCACG
GCGAATTCGCCGGGGTGGCGATGATCCGCGCCTACCACGACGCGAAGGGCGATGCCGCGCGGCGGGAGATCATCGTCCCC
GACGCGGCGCACGGCACCAACCCGGCGACGGCGACGATGTGCGGCTACACGGTCAAGGAAATTCCGACCGACGCCACCGG
CGCGGTCGACCTCGCTGCACTGAAGGCCGCGGTCGGCCCGCAGACTGCGGGACTCATGCTGACCAATCCGTCGACGCTCG
GCGTGTTCGAGAAGACGATCGCCGAGATCCAGAAGATCGTCCACGACGCGGGCGGATTGCTCTACTACGACGGCGCGAAT
CTCAACGCGATCCTCGGCAAGGTGCGACCGGGCGACATGGGTTTCGACGTCATCCACATGAACCTGCACAAGACCTTCTC
GACCCCGCACGGCGGCGGTGGGCCGGGCGCGGGTCCGGTCGGCGTCTCCGGGCGCCTCTTGCCCTTCATGCCGATTCCGC
TCGTGCTCAACGACAACGGTTTCTACCGGCTCGCGACCGAGGCCGACCTGCCGCAGTCGATCGGCCGCATGTCGGCCAAC
ATGGGCAACGCCGGCGTGCTGATGCGCGCCTACGTCTACGCGCGCCTTCTCGGCCGCGAAGGCATGCACCGCGTCGCCGA
ATACGCGACGCTCAACGCCAACTACCTGATGGCGAAGCTGCGCGAGGCCGGCTTCGATCTCGCCTACCCGACGCGGCGCG
CGAGCCACGAATTCATCGTCACGCTGAAGAAGCTCAAGGATGCGACCGGCGTCTCGGCGATGGACTTCGCCAAGCGCCTG
CTCGACTACGGCTACCACGCGCCGACGACGTATTTCCCGCTGCTGGTGCCCGAATGCCTGCTGATCGAGCCGACCGAGAC
CGAGAGCCGCGAGACGCTCGACGGCTTCGTCGACGCGATGAAGACAATCAAGCACGAAGCCGAAACGAATCCCGACCTCG
TCAAGGGCGCGCCTTACACGCTGCCGGTGCGCCGGCTCGACGACGTCAAGGCCGCGCGCGAGCTCGATCTCGCCTACAAG
CCCGCGGCGTGA

Upstream 100 bases:

>100_bases
GCATCATCAGATCGGTGCGGGCTTTGCCCGCTCATTCCCCTGAATCCTGATCCCTGAATCCTGACCCCTATCGACCCTGA
ATCCCTGACCCCTAGAAAAC

Downstream 100 bases:

>100_bases
TCGAGCCGCCGAGTCCGTTCAAGGGGAAAACGGGCCTCAGGCGCGTGTGGAACGCCCTCGGCTATTCGCGGGCCGGCCTC
GTCGCCGCCTTCAAGAGCGA

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MLIFDHSRPGRTAAAQLPATGGDLGDLPAELRRKDAPALPEVSELDVVRHYTRLSQKNFSIDTQFYPLGSCTMKYNPRAC
NSLAMLPQFLARHPASPDETGQGFLASMFELQEMLKDVTGMAGVSMAPMAGAHGEFAGVAMIRAYHDAKGDAARREIIVP
DAAHGTNPATATMCGYTVKEIPTDATGAVDLAALKAAVGPQTAGLMLTNPSTLGVFEKTIAEIQKIVHDAGGLLYYDGAN
LNAILGKVRPGDMGFDVIHMNLHKTFSTPHGGGGPGAGPVGVSGRLLPFMPIPLVLNDNGFYRLATEADLPQSIGRMSAN
MGNAGVLMRAYVYARLLGREGMHRVAEYATLNANYLMAKLREAGFDLAYPTRRASHEFIVTLKKLKDATGVSAMDFAKRL
LDYGYHAPTTYFPLLVPECLLIEPTETESRETLDGFVDAMKTIKHEAETNPDLVKGAPYTLPVRRLDDVKAARELDLAYK
PAA

Sequences:

>Translated_483_residues
MLIFDHSRPGRTAAAQLPATGGDLGDLPAELRRKDAPALPEVSELDVVRHYTRLSQKNFSIDTQFYPLGSCTMKYNPRAC
NSLAMLPQFLARHPASPDETGQGFLASMFELQEMLKDVTGMAGVSMAPMAGAHGEFAGVAMIRAYHDAKGDAARREIIVP
DAAHGTNPATATMCGYTVKEIPTDATGAVDLAALKAAVGPQTAGLMLTNPSTLGVFEKTIAEIQKIVHDAGGLLYYDGAN
LNAILGKVRPGDMGFDVIHMNLHKTFSTPHGGGGPGAGPVGVSGRLLPFMPIPLVLNDNGFYRLATEADLPQSIGRMSAN
MGNAGVLMRAYVYARLLGREGMHRVAEYATLNANYLMAKLREAGFDLAYPTRRASHEFIVTLKKLKDATGVSAMDFAKRL
LDYGYHAPTTYFPLLVPECLLIEPTETESRETLDGFVDAMKTIKHEAETNPDLVKGAPYTLPVRRLDDVKAARELDLAYK
PAA
>Mature_483_residues
MLIFDHSRPGRTAAAQLPATGGDLGDLPAELRRKDAPALPEVSELDVVRHYTRLSQKNFSIDTQFYPLGSCTMKYNPRAC
NSLAMLPQFLARHPASPDETGQGFLASMFELQEMLKDVTGMAGVSMAPMAGAHGEFAGVAMIRAYHDAKGDAARREIIVP
DAAHGTNPATATMCGYTVKEIPTDATGAVDLAALKAAVGPQTAGLMLTNPSTLGVFEKTIAEIQKIVHDAGGLLYYDGAN
LNAILGKVRPGDMGFDVIHMNLHKTFSTPHGGGGPGAGPVGVSGRLLPFMPIPLVLNDNGFYRLATEADLPQSIGRMSAN
MGNAGVLMRAYVYARLLGREGMHRVAEYATLNANYLMAKLREAGFDLAYPTRRASHEFIVTLKKLKDATGVSAMDFAKRL
LDYGYHAPTTYFPLLVPECLLIEPTETESRETLDGFVDAMKTIKHEAETNPDLVKGAPYTLPVRRLDDVKAARELDLAYK
PAA

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily

Homologues:

Organism=Homo sapiens, GI108773801, Length=455, Percent_Identity=39.1208791208791, Blast_Score=281, Evalue=1e-75,
Organism=Escherichia coli, GI1789269, Length=424, Percent_Identity=41.5094339622642, Blast_Score=296, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17535605, Length=455, Percent_Identity=39.5604395604396, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI32564013, Length=412, Percent_Identity=39.3203883495146, Blast_Score=242, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6323843, Length=457, Percent_Identity=40.2625820568928, Blast_Score=295, Evalue=9e-81,
Organism=Drosophila melanogaster, GI24645648, Length=415, Percent_Identity=42.4096385542169, Blast_Score=289, Evalue=3e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCSPB_THIDA (Q3SMC1)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_313931.1
- ProteinModelPortal:   Q3SMC1
- SMR:   Q3SMC1
- STRING:   Q3SMC1
- GeneID:   3673619
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0173
- NMPDR:   fig|292415.3.peg.182
- eggNOG:   COG1003
- HOGENOM:   HBG288344
- OMA:   RHYTRLS
- ProtClustDB:   PRK04366
- BioCyc:   TDEN292415:TBD_0173-MONOMER
- HAMAP:   MF_00713
- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421
- Gene3D:   G3DSA:3.40.640.10
- PANTHER:   PTHR11773

Pfam domain/function: PF02347 GDC-P; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =1.4.4.2

Molecular weight: Translated: 52035; Mature: 52035

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIFDHSRPGRTAAAQLPATGGDLGDLPAELRRKDAPALPEVSELDVVRHYTRLSQKNFS
CEEECCCCCCCCHHHCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCC
IDTQFYPLGSCTMKYNPRACNSLAMLPQFLARHPASPDETGQGFLASMFELQEMLKDVTG
CCEEEEECCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHC
MAGVSMAPMAGAHGEFAGVAMIRAYHDAKGDAARREIIVPDAAHGTNPATATMCGYTVKE
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCHHHHCCCCHHH
IPTDATGAVDLAALKAAVGPQTAGLMLTNPSTLGVFEKTIAEIQKIVHDAGGLLYYDGAN
CCCCCCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEECCCC
LNAILGKVRPGDMGFDVIHMNLHKTFSTPHGGGGPGAGPVGVSGRLLPFMPIPLVLNDNG
CEEHEECCCCCCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCC
FYRLATEADLPQSIGRMSANMGNAGVLMRAYVYARLLGREGMHRVAEYATLNANYLMAKL
CEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
REAGFDLAYPTRRASHEFIVTLKKLKDATGVSAMDFAKRLLDYGYHAPTTYFPLLVPECL
HHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCCEE
LIEPTETESRETLDGFVDAMKTIKHEAETNPDLVKGAPYTLPVRRLDDVKAARELDLAYK
EECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECHHHHHHHHHHHHHCCCCC
PAA
CCC
>Mature Secondary Structure
MLIFDHSRPGRTAAAQLPATGGDLGDLPAELRRKDAPALPEVSELDVVRHYTRLSQKNFS
CEEECCCCCCCCHHHCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCC
IDTQFYPLGSCTMKYNPRACNSLAMLPQFLARHPASPDETGQGFLASMFELQEMLKDVTG
CCEEEEECCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHC
MAGVSMAPMAGAHGEFAGVAMIRAYHDAKGDAARREIIVPDAAHGTNPATATMCGYTVKE
CCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCHHHHCCCCHHH
IPTDATGAVDLAALKAAVGPQTAGLMLTNPSTLGVFEKTIAEIQKIVHDAGGLLYYDGAN
CCCCCCCCHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEECCCC
LNAILGKVRPGDMGFDVIHMNLHKTFSTPHGGGGPGAGPVGVSGRLLPFMPIPLVLNDNG
CEEHEECCCCCCCCCEEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCC
FYRLATEADLPQSIGRMSANMGNAGVLMRAYVYARLLGREGMHRVAEYATLNANYLMAKL
CEEEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
REAGFDLAYPTRRASHEFIVTLKKLKDATGVSAMDFAKRLLDYGYHAPTTYFPLLVPECL
HHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCHHHHCCCEE
LIEPTETESRETLDGFVDAMKTIKHEAETNPDLVKGAPYTLPVRRLDDVKAARELDLAYK
EECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECHHHHHHHHHHHHHCCCCC
PAA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA