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The map label for this gene is gmhA

Identifier: 74316125

GI number: 74316125

Start: 113626

End: 114219

Strand: Reverse

Name: gmhA

Synonym: Tbd_0107

Alternate gene names: 74316125

Gene position: 114219-113626 (Counterclockwise)

Preceding gene: 74316146

Following gene: 74316124

Centisome position: 3.93

GC content: 66.5

Gene sequence:

>594_bases
ATGCCTTTACACGACAGAATCGTCGGCCATTTCCAGGCGTCGGCGCAGAGCAAGCTCGACGCTGCCGACGCGCTCGCGCC
CCGCATCGAACAAGGCGCGCGCTTGCTCGTGCACAGCCTTGCGCAAGGCGGGAAGATTCTCGCCTGCGGCAACGGCGGAT
CGGCCGCCGACGCGCAGCATTTCGCTTCCGAGATGCTCAACCGCTTCGAGCAGGAGCGCCCCGGGCTCGCGGCGCTCGCG
CTCACGACCGACACGTCGACGCTGACCTCGATCGCCAACGACTACGCCTACGACCAGGTGTTCGCGCGCCAAGTCAAGGC
GCTCGGCCAGCCCGGCGACGTGCTGCTGGCGATCTCGACGAGCGGCAACTCCGCCAACGTGCTGCAGGCCGTCGCCGCCG
CTCACGCCCGCAGCATGCAGGTCATCGCGCTGACAGGTCGCAGCGGGGGCGGTCTCGCCGAGCAGATCGACGACGGCGAC
GTCTGCATCTGCGTGCCGGCCGAGTCCACTGCACGCATCCAGGAAATCCATCTGCTGACCATCCATTGCCTCTGCGATGC
GGTGGACAGCCTTTTATTAGGAGTCGAAGAATGA

Upstream 100 bases:

>100_bases
GAAACACGCGCCCGTCACGGGCTCGGTAGCGATGCCGGATGCCATCGACAGCCGCGGGTTCGCACAGCCGCGACGAAGCC
AATTTAGACACCCGAACACC

Downstream 100 bases:

>100_bases
ACAAGCTCGTTTATGGCGTATTGATCGGCGTCGCGCTGACGCAATTGCATGGCTGCGCCGCGACCCTCGCGGGGGGCGCG
GCAGCCGGCACCGCGGCGGC

Product: phosphoheptose isomerase

Products: NA

Alternate protein names: Sedoheptulose 7-phosphate isomerase

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MPLHDRIVGHFQASAQSKLDAADALAPRIEQGARLLVHSLAQGGKILACGNGGSAADAQHFASEMLNRFEQERPGLAALA
LTTDTSTLTSIANDYAYDQVFARQVKALGQPGDVLLAISTSGNSANVLQAVAAAHARSMQVIALTGRSGGGLAEQIDDGD
VCICVPAESTARIQEIHLLTIHCLCDAVDSLLLGVEE

Sequences:

>Translated_197_residues
MPLHDRIVGHFQASAQSKLDAADALAPRIEQGARLLVHSLAQGGKILACGNGGSAADAQHFASEMLNRFEQERPGLAALA
LTTDTSTLTSIANDYAYDQVFARQVKALGQPGDVLLAISTSGNSANVLQAVAAAHARSMQVIALTGRSGGGLAEQIDDGD
VCICVPAESTARIQEIHLLTIHCLCDAVDSLLLGVEE
>Mature_196_residues
PLHDRIVGHFQASAQSKLDAADALAPRIEQGARLLVHSLAQGGKILACGNGGSAADAQHFASEMLNRFEQERPGLAALAL
TTDTSTLTSIANDYAYDQVFARQVKALGQPGDVLLAISTSGNSANVLQAVAAAHARSMQVIALTGRSGGGLAEQIDDGDV
CICVPAESTARIQEIHLLTIHCLCDAVDSLLLGVEE

Specific function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1789539, Length=191, Percent_Identity=53.9267015706806, Blast_Score=204, Evalue=3e-54,
Organism=Escherichia coli, GI1786416, Length=172, Percent_Identity=46.5116279069767, Blast_Score=155, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHA_THIDA (Q3SMI5)

Other databases:

- EMBL:   CP000116
- RefSeq:   YP_313865.1
- ProteinModelPortal:   Q3SMI5
- SMR:   Q3SMI5
- STRING:   Q3SMI5
- GeneID:   3673885
- GenomeReviews:   CP000116_GR
- KEGG:   tbd:Tbd_0107
- NMPDR:   fig|292415.3.peg.1006
- eggNOG:   COG0279
- HOGENOM:   HBG671955
- OMA:   HDREMIV
- PhylomeDB:   Q3SMI5
- BioCyc:   TDEN292415:TBD_0107-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00067
- InterPro:   IPR020620
- InterPro:   IPR001347

Pfam domain/function: PF01380 SIS

EC number: =5.3.1.28

Molecular weight: Translated: 20496; Mature: 20365

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS51464 SIS

Important sites: BINDING 64-64 BINDING 124-124 BINDING 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLHDRIVGHFQASAQSKLDAADALAPRIEQGARLLVHSLAQGGKILACGNGGSAADAQH
CCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHH
FASEMLNRFEQERPGLAALALTTDTSTLTSIANDYAYDQVFARQVKALGQPGDVLLAIST
HHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
SGNSANVLQAVAAAHARSMQVIALTGRSGGGLAEQIDDGDVCICVPAESTARIQEIHLLT
CCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHCCCCCEEEEECCCCCHHHHHHHHHH
IHCLCDAVDSLLLGVEE
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PLHDRIVGHFQASAQSKLDAADALAPRIEQGARLLVHSLAQGGKILACGNGGSAADAQH
CCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHH
FASEMLNRFEQERPGLAALALTTDTSTLTSIANDYAYDQVFARQVKALGQPGDVLLAIST
HHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
SGNSANVLQAVAAAHARSMQVIALTGRSGGGLAEQIDDGDVCICVPAESTARIQEIHLLT
CCCCHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHCCCCCEEEEECCCCCHHHHHHHHHH
IHCLCDAVDSLLLGVEE
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA