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The map label for this gene is hldE [H]

Identifier: 74316123

GI number: 74316123

Start: 112581

End: 113060

Strand: Reverse

Name: hldE [H]

Synonym: Tbd_0105

Alternate gene names: 74316123

Gene position: 113060-112581 (Counterclockwise)

Preceding gene: 74316124

Following gene: 74316122

Centisome position: 3.89

GC content: 68.54

Gene sequence:

>480_bases
GTGACGCAACTCGCCTTCGAGCGCAAGCTCTGCGCGCCCGGCGAACTCGCCGCGCGCGTGGCGCAGTTGCCGCGGCCGCT
CGTCTTCACCAACGGCTGCTTCGACATTCTGCACCGCGGGCACGTGACCTATCTCGCCGAGGCGCGCGCACTCGGGGGCG
CGTTGATCGTCGGCGTGAACTCCGATGCGTCGGTGCGTCGCCAGGACAAGGGCAGCGGCCGCCCGATCAACGGGCTCGAC
GATCGCATGGCCCTGCTCGCGGCGCTCGAATCGGTGTCGCTCGTGACCTCGTTCGACGCGGACACACCGCTCGAACTGAT
CCTCCGGATCCGGCCGGACATCCTCGTGAAAGGCGGCGACTGGCCACACGAGCGGATAGTCGGCGCGTCGGAAGTCGAGG
ACTGGGGCGGCGCCGTCCATTCGATCCCTTTCCGGCACCAGACATCGACGACGGCGCTGCTGCAACGCATTCGCTCCTGA

Upstream 100 bases:

>100_bases
TGATGGGACTCGTCACCGACAGCGAGGCCCACGAGGCGACCGAGATCGCGCGCACGACGGCGGGCGTGACCAAGGTCGTG
ACCCTGTTCGAATACATCAA

Downstream 100 bases:

>100_bases
ACGCCCGCAATGATCTATCACGACCTCCGAGACTTCGTCGCACAGCTCGAAAAAATGGGCGAGCTCAAGCGCATCGCCAC
CGAAGTCGATCCCCGCCTCG

Product: cytidyltransferase

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MTQLAFERKLCAPGELAARVAQLPRPLVFTNGCFDILHRGHVTYLAEARALGGALIVGVNSDASVRRQDKGSGRPINGLD
DRMALLAALESVSLVTSFDADTPLELILRIRPDILVKGGDWPHERIVGASEVEDWGGAVHSIPFRHQTSTTALLQRIRS

Sequences:

>Translated_159_residues
MTQLAFERKLCAPGELAARVAQLPRPLVFTNGCFDILHRGHVTYLAEARALGGALIVGVNSDASVRRQDKGSGRPINGLD
DRMALLAALESVSLVTSFDADTPLELILRIRPDILVKGGDWPHERIVGASEVEDWGGAVHSIPFRHQTSTTALLQRIRS
>Mature_158_residues
TQLAFERKLCAPGELAARVAQLPRPLVFTNGCFDILHRGHVTYLAEARALGGALIVGVNSDASVRRQDKGSGRPINGLDD
RMALLAALESVSLVTSFDADTPLELILRIRPDILVKGGDWPHERIVGASEVEDWGGAVHSIPFRHQTSTTALLQRIRS

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=132, Percent_Identity=54.5454545454545, Blast_Score=136, Evalue=7e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.- [C]

Molecular weight: Translated: 17273; Mature: 17142

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLAFERKLCAPGELAARVAQLPRPLVFTNGCFDILHRGHVTYLAEARALGGALIVGVN
CCCCCCHHCCCCCHHHHHHHHHCCCCEEEECCHHHHHHCCCHHHHHHHHHCCCEEEEEEC
SDASVRRQDKGSGRPINGLDDRMALLAALESVSLVTSFDADTPLELILRIRPDILVKGGD
CCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHCCCCEEEECCC
WPHERIVGASEVEDWGGAVHSIPFRHQTSTTALLQRIRS
CCHHHCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TQLAFERKLCAPGELAARVAQLPRPLVFTNGCFDILHRGHVTYLAEARALGGALIVGVN
CCCCCHHCCCCCHHHHHHHHHCCCCEEEECCHHHHHHCCCHHHHHHHHHCCCEEEEEEC
SDASVRRQDKGSGRPINGLDDRMALLAALESVSLVTSFDADTPLELILRIRPDILVKGGD
CCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHCCCCEEEECCC
WPHERIVGASEVEDWGGAVHSIPFRHQTSTTALLQRIRS
CCHHHCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA