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The map label for this gene is blh [H]

Identifier: 74316061

GI number: 74316061

Start: 44243

End: 44992

Strand: Reverse

Name: blh [H]

Synonym: Tbd_0043

Alternate gene names: 74316061

Gene position: 44992-44243 (Counterclockwise)

Preceding gene: 74316062

Following gene: 74316053

Centisome position: 1.55

GC content: 66.67

Gene sequence:

>750_bases
ATGATTTTCAAGCAACTGTTCGAGCCGGTCTCGAGCACCTACACCTATCTGCTCGGCTGCGAGGAAACGGGGGCGGCGCT
CCTGATCGACCCGGTGCTGCCGACCTGGGAGCGCGACCTCGCCGAGGTTAACAAACTCGGGCTCAGGCTCGCGTACACGC
TCGAGACGCACATCCACGCCGATCACATCACCTCGGCGCAGAAACTCAAGACCGAGGCCGGCAGCAAGATCGCCGGCCCC
GCGCTCGACGCGCTGCCGTGCACCGAGGTCGGCATCGTCGACGGCGTGCCGTTCACGATGGGCTCGGTCGAGCTCGCGCC
GATCCACACGCCGGGTCACACCGACAACCATTTCGCGTATTTTCACGACGGCCGGCTCTACACCGGCGACGCGCTGCTGA
TCGAGGCGTGCGGGCGTACCGACTTCCAGAGCGGCGACCCGGCCGCGCTGTATCACTCGGTACGCGGCAAGCTCTTCGCC
TACGACGACGATACGCTCGTCTATCCGGCGCACGACTACGAGCAGCGGCGCATCAGCACCGTCGGCCAGGAGAAGGCGCG
CAACCCGCGCCTCGGCGGCGAGCGCACGCTCGAGGATTTCGTCGCGCTGATGAACGCGCTCGACCTGCCCTATCCCAAGT
TCATCGACCACGCGCTGCCCGGCAATCGTGCATGCGGCGTCTGTCCGCCCGACGTGCCCGAGCATCTGCAGGCCTATTGC
GTGCAGATCGCCGACAGCCGCCAGGGCTGA

Upstream 100 bases:

>100_bases
CGCATCTGCAATCCGGTACCGCGACGCCGGTCAGGCACTGGGTGGAACTTTTGGACGAGGCGCTGGCCGCATCCTGAAGC
GCTTCGAGGAGGACTCCAGA

Downstream 100 bases:

>100_bases
GGACTCAGGGCGCGAGGTCGCCCGGTTCGTTGAGGTTGGCGAAGGCGGCGGCGTCGAAGCGCACACGCGTCGACGCGAGC
CCGGCCTGCCAATGACGCAC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 249; Mature: 249

Protein sequence:

>249_residues
MIFKQLFEPVSSTYTYLLGCEETGAALLIDPVLPTWERDLAEVNKLGLRLAYTLETHIHADHITSAQKLKTEAGSKIAGP
ALDALPCTEVGIVDGVPFTMGSVELAPIHTPGHTDNHFAYFHDGRLYTGDALLIEACGRTDFQSGDPAALYHSVRGKLFA
YDDDTLVYPAHDYEQRRISTVGQEKARNPRLGGERTLEDFVALMNALDLPYPKFIDHALPGNRACGVCPPDVPEHLQAYC
VQIADSRQG

Sequences:

>Translated_249_residues
MIFKQLFEPVSSTYTYLLGCEETGAALLIDPVLPTWERDLAEVNKLGLRLAYTLETHIHADHITSAQKLKTEAGSKIAGP
ALDALPCTEVGIVDGVPFTMGSVELAPIHTPGHTDNHFAYFHDGRLYTGDALLIEACGRTDFQSGDPAALYHSVRGKLFA
YDDDTLVYPAHDYEQRRISTVGQEKARNPRLGGERTLEDFVALMNALDLPYPKFIDHALPGNRACGVCPPDVPEHLQAYC
VQIADSRQG
>Mature_249_residues
MIFKQLFEPVSSTYTYLLGCEETGAALLIDPVLPTWERDLAEVNKLGLRLAYTLETHIHADHITSAQKLKTEAGSKIAGP
ALDALPCTEVGIVDGVPFTMGSVELAPIHTPGHTDNHFAYFHDGRLYTGDALLIEACGRTDFQSGDPAALYHSVRGKLFA
YDDDTLVYPAHDYEQRRISTVGQEKARNPRLGGERTLEDFVALMNALDLPYPKFIDHALPGNRACGVCPPDVPEHLQAYC
VQIADSRQG

Specific function: Unknown

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-B beta-lactamase family [H]

Homologues:

Organism=Homo sapiens, GI41327741, Length=238, Percent_Identity=44.1176470588235, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI21703352, Length=197, Percent_Identity=27.9187817258883, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI116642887, Length=197, Percent_Identity=27.9187817258883, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI94538322, Length=177, Percent_Identity=30.5084745762712, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI94538320, Length=177, Percent_Identity=30.5084745762712, Blast_Score=68, Evalue=8e-12,
Organism=Escherichia coli, GI1787158, Length=205, Percent_Identity=33.1707317073171, Blast_Score=89, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17538952, Length=233, Percent_Identity=44.206008583691, Blast_Score=184, Evalue=5e-47,
Organism=Drosophila melanogaster, GI221330176, Length=237, Percent_Identity=43.0379746835443, Blast_Score=180, Evalue=9e-46,
Organism=Drosophila melanogaster, GI24667703, Length=226, Percent_Identity=27.8761061946903, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24667711, Length=226, Percent_Identity=27.8761061946903, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21356335, Length=226, Percent_Identity=27.8761061946903, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005939
- InterPro:   IPR001279 [H]

Pfam domain/function: PF04273 DUF442; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 27336; Mature: 27336

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFKQLFEPVSSTYTYLLGCEETGAALLIDPVLPTWERDLAEVNKLGLRLAYTLETHIHA
CCHHHHHHHHHHHEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHCEEEEEEEEHHHHH
DHITSAQKLKTEAGSKIAGPALDALPCTEVGIVDGVPFTMGSVELAPIHTPGHTDNHFAY
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEE
FHDGRLYTGDALLIEACGRTDFQSGDPAALYHSVRGKLFAYDDDTLVYPAHDYEQRRIST
EECCEEEECCEEEEEECCCCCCCCCCHHHHHHHHCCCEEEECCCEEEECCCCHHHHHHHH
VGQEKARNPRLGGERTLEDFVALMNALDLPYPKFIDHALPGNRACGVCPPDVPEHLQAYC
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
VQIADSRQG
HHHHCCCCC
>Mature Secondary Structure
MIFKQLFEPVSSTYTYLLGCEETGAALLIDPVLPTWERDLAEVNKLGLRLAYTLETHIHA
CCHHHHHHHHHHHEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHCEEEEEEEEHHHHH
DHITSAQKLKTEAGSKIAGPALDALPCTEVGIVDGVPFTMGSVELAPIHTPGHTDNHFAY
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCEEE
FHDGRLYTGDALLIEACGRTDFQSGDPAALYHSVRGKLFAYDDDTLVYPAHDYEQRRIST
EECCEEEECCEEEEEECCCCCCCCCCHHHHHHHHCCCEEEECCCEEEECCCCHHHHHHHH
VGQEKARNPRLGGERTLEDFVALMNALDLPYPKFIDHALPGNRACGVCPPDVPEHLQAYC
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
VQIADSRQG
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]