Click here to switch to the map view.

The map label for this gene is betC [H]

Identifier: 73539584

GI number: 73539584

Start: 2587911

End: 2589359

Strand: Direct

Name: betC [H]

Synonym: Reut_B5764

Alternate gene names: 73539584

Gene position: 2587911-2589359 (Clockwise)

Preceding gene: 73539583

Following gene: 73539585

Centisome position: 94.93

GC content: 64.94

Gene sequence:

>1449_bases
ATGGCAAGCAAGAATGTTGTGGTCATCATGTCCGATGAGCACGACCCGAGAATGATGGGCTGCTCCGGGCATCCCTTCGT
GAAAACTCCCAACCTGGATGCACTGGCCGCCCGCGGCGTGCGCTTCTCCAGCGCCTACACACCCAGCCCGATCTGCGTCC
CGGCCCGTGCAGCCTTTGCCACCGGCCGGCGGGTACATCAGGTCCGGCTTTGGGACAACGCCATGCCGTATACGGGCGAG
CAGCGCGGCTGGGGCCATGTGCTGCAGGACCGGGGCATCCGCGTCGAAAGTATCGGCAAGCTGCATTACCGCAATGAAGA
AGATCCGGCGGGCTTCGATGCGGAGCACCTGCCGATGCACGTGGTCGGTGGCCACGGCATGGTCTGGGCGTCGATCCGCA
ATCCGTTTCGTCCACGCGAAAACGGCCCGCGTATGCTGGGCGAGCACATCGGCCCCGGCGAGTCGTCGTACACGCAATAC
GACCGGGCGGTAACGCAACGGGCGGTGCAATGGCTGCAGGAGGCGGCACAGCGCCAGGAAGCCGGCTTTGTGCTGTACGT
CGGCCTGGTCGCGCCGCATTTCCCCTTCGTCGTACCTGAAGAGTTTTACAGCCTCTACCCGACCGACGGCCTGCCGGAGC
CGAAGCTGCACCCGCGTACCGGCTACGAACAGCATCCCTGGGTCAGGGAGTATTGCGACTTCATGGCGTCGGAACGGCAG
TTCGCCGATGCTGACGAACGCCTGCGCGCCTTCGCCGCGTACTACGGGCTCTGCACCTGGCTCGACCACAACGTCGGCCA
GATCCTCGGGGCGCTGCGCGACAACGGATTGGAAGACACCACGCACATCGTCTACACCTCCGACCACGGGGACAACCTCG
GCGCGCGTGGTGTCTGGGGCAAGTCGACCCTCTATGAAGAGAGCGTCAAGGTGCCGATGCTGCTGGCCGGCCCGATTGTC
ACGCCCGGTGTGTGCAACACCCCTGTCGACCTGCTGGACCTGTTCCCGACGATCCTGCAAGGCGCGGGTGTCGATCCGGC
GACGGAGATCGATGAACGGCCCGGCCGCTCCCTGTTCGAGCTTGCGCGCTCGGCGCCGGAACCGGATCGGGTCATCCTCA
GCGAGTACCACGCGGCAGGCAGCAATGCGGGTGGCTTCATGCTGCGCAAGGGACGCTGGAAGTACCACCATTACGTTGGC
TTCCGCCCGGAGTTGTTCGACCTGGAGTCAGACCCCGAGGAACTGACCGATCTGGCTGGCGATCCGGCATACGCCCCGGT
CCTTGCCAGCATGCACGAGGCCCTGCTGGCGATCTGCGACCCCGATGCAGTTGATCGGCAGGCCAAGTGTGATCAAGCCG
CCCTGATCGAGCACTACGGCGGCCCCGATATGGCCCATACGCTCGGCTCGTCCACATCCACGCCCGTGACGGCAAAGACC
GCTGCATAA

Upstream 100 bases:

>100_bases
AAATGAAACCTTCCTAGTCCGAGACAGTATTGGTTTCGGCGCAGCGGGTTGATTAGAGTTGTCTCCAGAGCGCACTGAGA
CGCCTTCGATGGAGACAAGC

Downstream 100 bases:

>100_bases
GACAGGGAGCGACATCATGGACGACCAGCTTCAACTCGCATCGTCGACCGAGATCGATGAGCGCTTTCTAAGGGACTGGA
GCGGACTCGCCGTTGGACGA

Product: sulfatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MASKNVVVIMSDEHDPRMMGCSGHPFVKTPNLDALAARGVRFSSAYTPSPICVPARAAFATGRRVHQVRLWDNAMPYTGE
QRGWGHVLQDRGIRVESIGKLHYRNEEDPAGFDAEHLPMHVVGGHGMVWASIRNPFRPRENGPRMLGEHIGPGESSYTQY
DRAVTQRAVQWLQEAAQRQEAGFVLYVGLVAPHFPFVVPEEFYSLYPTDGLPEPKLHPRTGYEQHPWVREYCDFMASERQ
FADADERLRAFAAYYGLCTWLDHNVGQILGALRDNGLEDTTHIVYTSDHGDNLGARGVWGKSTLYEESVKVPMLLAGPIV
TPGVCNTPVDLLDLFPTILQGAGVDPATEIDERPGRSLFELARSAPEPDRVILSEYHAAGSNAGGFMLRKGRWKYHHYVG
FRPELFDLESDPEELTDLAGDPAYAPVLASMHEALLAICDPDAVDRQAKCDQAALIEHYGGPDMAHTLGSSTSTPVTAKT
AA

Sequences:

>Translated_482_residues
MASKNVVVIMSDEHDPRMMGCSGHPFVKTPNLDALAARGVRFSSAYTPSPICVPARAAFATGRRVHQVRLWDNAMPYTGE
QRGWGHVLQDRGIRVESIGKLHYRNEEDPAGFDAEHLPMHVVGGHGMVWASIRNPFRPRENGPRMLGEHIGPGESSYTQY
DRAVTQRAVQWLQEAAQRQEAGFVLYVGLVAPHFPFVVPEEFYSLYPTDGLPEPKLHPRTGYEQHPWVREYCDFMASERQ
FADADERLRAFAAYYGLCTWLDHNVGQILGALRDNGLEDTTHIVYTSDHGDNLGARGVWGKSTLYEESVKVPMLLAGPIV
TPGVCNTPVDLLDLFPTILQGAGVDPATEIDERPGRSLFELARSAPEPDRVILSEYHAAGSNAGGFMLRKGRWKYHHYVG
FRPELFDLESDPEELTDLAGDPAYAPVLASMHEALLAICDPDAVDRQAKCDQAALIEHYGGPDMAHTLGSSTSTPVTAKT
AA
>Mature_481_residues
ASKNVVVIMSDEHDPRMMGCSGHPFVKTPNLDALAARGVRFSSAYTPSPICVPARAAFATGRRVHQVRLWDNAMPYTGEQ
RGWGHVLQDRGIRVESIGKLHYRNEEDPAGFDAEHLPMHVVGGHGMVWASIRNPFRPRENGPRMLGEHIGPGESSYTQYD
RAVTQRAVQWLQEAAQRQEAGFVLYVGLVAPHFPFVVPEEFYSLYPTDGLPEPKLHPRTGYEQHPWVREYCDFMASERQF
ADADERLRAFAAYYGLCTWLDHNVGQILGALRDNGLEDTTHIVYTSDHGDNLGARGVWGKSTLYEESVKVPMLLAGPIVT
PGVCNTPVDLLDLFPTILQGAGVDPATEIDERPGRSLFELARSAPEPDRVILSEYHAAGSNAGGFMLRKGRWKYHHYVGF
RPELFDLESDPEELTDLAGDPAYAPVLASMHEALLAICDPDAVDRQAKCDQAALIEHYGGPDMAHTLGSSTSTPVTAKTA
A

Specific function: Converts choline-O-sulfate into choline [H]

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI39930577, Length=464, Percent_Identity=30.8189655172414, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI4557659, Length=441, Percent_Identity=28.1179138321995, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI5360208, Length=307, Percent_Identity=29.3159609120521, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI4504061, Length=397, Percent_Identity=26.448362720403, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI240255478, Length=402, Percent_Identity=25.3731343283582, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI240255483, Length=402, Percent_Identity=25.3731343283582, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI29789100, Length=402, Percent_Identity=25.3731343283582, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI189571643, Length=369, Percent_Identity=24.1192411924119, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI189571641, Length=369, Percent_Identity=24.1192411924119, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI189571638, Length=369, Percent_Identity=24.1192411924119, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI189571636, Length=369, Percent_Identity=24.1192411924119, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI262118210, Length=278, Percent_Identity=29.4964028776978, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI146229331, Length=104, Percent_Identity=36.5384615384615, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI146229329, Length=104, Percent_Identity=36.5384615384615, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI6005990, Length=104, Percent_Identity=36.5384615384615, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI146229324, Length=104, Percent_Identity=36.5384615384615, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1790112, Length=458, Percent_Identity=28.6026200873362, Blast_Score=152, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17568795, Length=378, Percent_Identity=28.042328042328, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24653364, Length=400, Percent_Identity=29, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19922168, Length=400, Percent_Identity=28.25, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24656835, Length=458, Percent_Identity=23.5807860262009, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24647401, Length=378, Percent_Identity=26.984126984127, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR017785
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.6 [H]

Molecular weight: Translated: 53255; Mature: 53124

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASKNVVVIMSDEHDPRMMGCSGHPFVKTPNLDALAARGVRFSSAYTPSPICVPARAAFA
CCCCCEEEEECCCCCCCEECCCCCCCEECCCCHHHHHCCEEECCCCCCCCCEECCHHHHH
TGRRVHQVRLWDNAMPYTGEQRGWGHVLQDRGIRVESIGKLHYRNEEDPAGFDAEHLPMH
CCCEEEEEEEECCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCEE
VVGGHGMVWASIRNPFRPRENGPRMLGEHIGPGESSYTQYDRAVTQRAVQWLQEAAQRQE
EECCCCEEEHHHCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AGFVLYVGLVAPHFPFVVPEEFYSLYPTDGLPEPKLHPRTGYEQHPWVREYCDFMASERQ
CCEEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHH
FADADERLRAFAAYYGLCTWLDHNVGQILGALRDNGLEDTTHIVYTSDHGDNLGARGVWG
HCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCC
KSTLYEESVKVPMLLAGPIVTPGVCNTPVDLLDLFPTILQGAGVDPATEIDERPGRSLFE
CCHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHH
LARSAPEPDRVILSEYHAAGSNAGGFMLRKGRWKYHHYVGFRPELFDLESDPEELTDLAG
HHHCCCCCCHHHHHHHHCCCCCCCCEEEECCCEEEEEEECCCCCEECCCCCHHHHHHCCC
DPAYAPVLASMHEALLAICDPDAVDRQAKCDQAALIEHYGGPDMAHTLGSSTSTPVTAKT
CCHHHHHHHHHHHHHHHHCCCHHHCHHHHCCHHHHHHHCCCCHHHHHCCCCCCCCEEECC
AA
CC
>Mature Secondary Structure 
ASKNVVVIMSDEHDPRMMGCSGHPFVKTPNLDALAARGVRFSSAYTPSPICVPARAAFA
CCCCEEEEECCCCCCCEECCCCCCCEECCCCHHHHHCCEEECCCCCCCCCEECCHHHHH
TGRRVHQVRLWDNAMPYTGEQRGWGHVLQDRGIRVESIGKLHYRNEEDPAGFDAEHLPMH
CCCEEEEEEEECCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCEE
VVGGHGMVWASIRNPFRPRENGPRMLGEHIGPGESSYTQYDRAVTQRAVQWLQEAAQRQE
EECCCCEEEHHHCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AGFVLYVGLVAPHFPFVVPEEFYSLYPTDGLPEPKLHPRTGYEQHPWVREYCDFMASERQ
CCEEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHH
FADADERLRAFAAYYGLCTWLDHNVGQILGALRDNGLEDTTHIVYTSDHGDNLGARGVWG
HCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCC
KSTLYEESVKVPMLLAGPIVTPGVCNTPVDLLDLFPTILQGAGVDPATEIDERPGRSLFE
CCHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCCCCHHHHH
LARSAPEPDRVILSEYHAAGSNAGGFMLRKGRWKYHHYVGFRPELFDLESDPEELTDLAG
HHHCCCCCCHHHHHHHHCCCCCCCCEEEECCCEEEEEEECCCCCEECCCCCHHHHHHCCC
DPAYAPVLASMHEALLAICDPDAVDRQAKCDQAALIEHYGGPDMAHTLGSSTSTPVTAKT
CCHHHHHHHHHHHHHHHHCCCHHHCHHHHCCHHHHHHHCCCCHHHHHCCCCCCCCEEECC
AA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9141699; 11481430; 9736747 [H]