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The map label for this gene is yciC [H]

Identifier: 73539578

GI number: 73539578

Start: 2578512

End: 2579468

Strand: Direct

Name: yciC [H]

Synonym: Reut_B5758

Alternate gene names: 73539578

Gene position: 2578512-2579468 (Clockwise)

Preceding gene: 73539577

Following gene: 73539582

Centisome position: 94.58

GC content: 64.37

Gene sequence:

>957_bases
ATGAATAAGCGCGCGCCGGTGCCGATGGTCGTCGTCGGCGGCTATCTTGGGGCGGGAAAGACGACAATGCTGAACCGTCT
GCTGGCCAACGGCGAGGGCCGGCGCATCACGTTGCTCGTCAACGACTTTGGCGAGATCAATATCGACGCCGTACTCGTTC
GCTCGCGCAGCGACGACGTGATTCAGTTGGAGAACGGTTGCATTTGCTGCTCGATTGGAGGACGGCTGGCCGCCGCGCTG
GTCGAAATCGGCCAGCGCGAGAAGCGCCCTGACTTGCTGGTGATCGAGGCGAGCGGGGTCTCCGACCCGCAGCGGATTGC
ACAGGTCGGATTGCTCGATGCAGCGCTTCGACTCAACGGCGTCGTGGTGGCGGTTGACGCTGAAAGCGTGTTCGAGCGTC
TGGCCGATCCGCTCGTAGGCGACATGGTGCGGCGGCAGATCACTGGGGCGTCGGCGGTAGTGCTGACCAAGGCGGATTTG
GCTGGGCCGACAGGCCTTGAAAGGGCGAGGGCGCTAATGGCGGAAATCGCGCCGCAGGCGACGGTGTTGGTCGCACACCA
TGGCGACGTGCCGTGGGAAGTCTTTGCGGACGTGGCCGAGCCTCGGCCTGTCTCACCGGGACTGCTAGACGGTCGAGAAG
GCTGGCATAGCGTGTCCGGGGCGGCGCAGCACGCTGGCATACGCACTCTCGCATACCGCACCGGCCGCGTGTTTGACAAA
AGTCGCCTGTGCCAGGCACTCAAAAACTTGCCAGTGCGCCTGCTGCGCGCCAAAGGGGTAGTGCGGCTGGCCGGCGATGT
GTGTCTGCACGAAGTCCATCTGGTCGGAGGACGTCTGCGTATCGGCCGACTGGCATGCACCGATCGCATGAGCGAATCGG
CGCTGGTGTTCATCGGCGCCTTCGGCGATGCAGCAGAAGCCGCCGTGCGCGCAACAATGGATCAGGCGGTCGTGTGA

Upstream 100 bases:

>100_bases
TGCTCGACGACGACCCGATTGCGCTTGGCGCCGAACGGCTCAAGGATACGCGCGTGTGGGGCACAGTGCTCGGGGGACGT
ATTTTCCCTGCGCCGACGCG

Downstream 100 bases:

>100_bases
GCGCGCTGCCAACAAATCTTCCCGGTCCCAGATCAGCGAGGGCAGAGGGCGCCATGACGCGCGCACACGGCGCTCGCCAG
GTCCGGGCGCCCTCAGGGCA

Product: cobalamin synthesis protein CobW

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MNKRAPVPMVVVGGYLGAGKTTMLNRLLANGEGRRITLLVNDFGEINIDAVLVRSRSDDVIQLENGCICCSIGGRLAAAL
VEIGQREKRPDLLVIEASGVSDPQRIAQVGLLDAALRLNGVVVAVDAESVFERLADPLVGDMVRRQITGASAVVLTKADL
AGPTGLERARALMAEIAPQATVLVAHHGDVPWEVFADVAEPRPVSPGLLDGREGWHSVSGAAQHAGIRTLAYRTGRVFDK
SRLCQALKNLPVRLLRAKGVVRLAGDVCLHEVHLVGGRLRIGRLACTDRMSESALVFIGAFGDAAEAAVRATMDQAVV

Sequences:

>Translated_318_residues
MNKRAPVPMVVVGGYLGAGKTTMLNRLLANGEGRRITLLVNDFGEINIDAVLVRSRSDDVIQLENGCICCSIGGRLAAAL
VEIGQREKRPDLLVIEASGVSDPQRIAQVGLLDAALRLNGVVVAVDAESVFERLADPLVGDMVRRQITGASAVVLTKADL
AGPTGLERARALMAEIAPQATVLVAHHGDVPWEVFADVAEPRPVSPGLLDGREGWHSVSGAAQHAGIRTLAYRTGRVFDK
SRLCQALKNLPVRLLRAKGVVRLAGDVCLHEVHLVGGRLRIGRLACTDRMSESALVFIGAFGDAAEAAVRATMDQAVV
>Mature_318_residues
MNKRAPVPMVVVGGYLGAGKTTMLNRLLANGEGRRITLLVNDFGEINIDAVLVRSRSDDVIQLENGCICCSIGGRLAAAL
VEIGQREKRPDLLVIEASGVSDPQRIAQVGLLDAALRLNGVVVAVDAESVFERLADPLVGDMVRRQITGASAVVLTKADL
AGPTGLERARALMAEIAPQATVLVAHHGDVPWEVFADVAEPRPVSPGLLDGREGWHSVSGAAQHAGIRTLAYRTGRVFDK
SRLCQALKNLPVRLLRAKGVVRLAGDVCLHEVHLVGGRLRIGRLACTDRMSESALVFIGAFGDAAEAAVRATMDQAVV

Specific function: May bind GTP. Might act as metal chaperone (Potential). Contributes to optimal growth under starvation for zinc [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=185, Percent_Identity=30.8108108108108, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI126722884, Length=185, Percent_Identity=29.7297297297297, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI223941779, Length=185, Percent_Identity=29.7297297297297, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI146231952, Length=185, Percent_Identity=28.6486486486486, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI148727351, Length=185, Percent_Identity=28.6486486486486, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI223941776, Length=173, Percent_Identity=28.9017341040462, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI119120938, Length=166, Percent_Identity=28.9156626506024, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI87082430, Length=273, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788499, Length=184, Percent_Identity=25, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324356, Length=225, Percent_Identity=24.4444444444444, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 33720; Mature: 33720

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKRAPVPMVVVGGYLGAGKTTMLNRLLANGEGRRITLLVNDFGEINIDAVLVRSRSDDV
CCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEEECCCCCE
IQLENGCICCSIGGRLAAALVEIGQREKRPDLLVIEASGVSDPQRIAQVGLLDAALRLNG
EEECCCEEEEECCHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCC
VVVAVDAESVFERLADPLVGDMVRRQITGASAVVLTKADLAGPTGLERARALMAEIAPQA
EEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCE
TVLVAHHGDVPWEVFADVAEPRPVSPGLLDGREGWHSVSGAAQHAGIRTLAYRTGRVFDK
EEEEEECCCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHCCHHHHCCHHEEHHHCCCCCCH
SRLCQALKNLPVRLLRAKGVVRLAGDVCLHEVHLVGGRLRIGRLACTDRMSESALVFIGA
HHHHHHHHCCCHHHHHHCCEEEEHHHHHHHHHHHCCCEEEEEEEHHHCCCCCCEEEEEEE
FGDAAEAAVRATMDQAVV
CCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKRAPVPMVVVGGYLGAGKTTMLNRLLANGEGRRITLLVNDFGEINIDAVLVRSRSDDV
CCCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEEECCCCCE
IQLENGCICCSIGGRLAAALVEIGQREKRPDLLVIEASGVSDPQRIAQVGLLDAALRLNG
EEECCCEEEEECCHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCC
VVVAVDAESVFERLADPLVGDMVRRQITGASAVVLTKADLAGPTGLERARALMAEIAPQA
EEEEECHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCE
TVLVAHHGDVPWEVFADVAEPRPVSPGLLDGREGWHSVSGAAQHAGIRTLAYRTGRVFDK
EEEEEECCCCCHHHHHHCCCCCCCCCCCCCCCCCHHHHCCHHHHCCHHEEHHHCCCCCCH
SRLCQALKNLPVRLLRAKGVVRLAGDVCLHEVHLVGGRLRIGRLACTDRMSESALVFIGA
HHHHHHHHCCCHHHHHHCCEEEEHHHHHHHHHHHCCCEEEEEEEHHHCCCCCCEEEEEEE
FGDAAEAAVRATMDQAVV
CCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377; 9811636 [H]