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The map label for this gene is gabT [H]

Identifier: 73539485

GI number: 73539485

Start: 2492293

End: 2493582

Strand: Reverse

Name: gabT [H]

Synonym: Reut_B5663

Alternate gene names: 73539485

Gene position: 2493582-2492293 (Counterclockwise)

Preceding gene: 73539488

Following gene: 73539484

Centisome position: 91.47

GC content: 64.26

Gene sequence:

>1290_bases
ATGGCATTGGAAAGCACACATCAGGATCTGGCTGCGGCGCGCGCGCAGCACGTGGCCCGCGGCGTAGTAACCGCGCATCC
GATCTTCGTGGACCACGCTCAGGGCTCCCGCGTCTGGGATGTCAATGGCCGCAGCTATCTCGATTTCGTTGGCGGCATCG
GCGTGCTGAATGTCGGCCACAACCACCCGCGAGTCGTAGCGGCTGTCAAGCAGCAGCTCGAGCGTGTGAGCCACGCGGCG
TTCCAGGTTGCCGGCTATGACGTCTATATCGAGCTCGCTGCTCGGCTGAATCGCCTGGTGGGCGGTTCAGAGGCCTACAA
GACGGTCTTCCTGACCACCGGCGCCGAAGCGGTGGAGAACGCCGTCAAGATTGCCCGCGCGTATCGCAATGCGCCGGGCA
TCATTGCTTTCCGCGGCGGCTTTCACGGCCGTACGCTGCTGGGCATGACCCTGACCGGCATGAGCACGCCGTACAAGCAG
AACTTCGGACCGTTCGCTGGCGATGTCTATCACACGCCGTACCCCGACCCTTATCGCGGCTTCAGCGGCGACGATGCGCT
GCGAGCGCTCGATGACCTGTTTGCGACACAGATCGCTCCGGACCGCGTGGCGGCGATCATTCTCGAACTTGTTCAGGGCG
ATGGCGGCTTCCTGGCAGCCGGTTCGGATTTCCTGAAGAAGCTGCGCGCGCTGACCACGAAGCACGGCATCGTCCTGATT
GCCGATGAGATCCAGACGGGCTTCGGTCGCACTGGAGAACTTTTTGCGTTCCAGGAGGCGGGCATACAGCCCGATCTCGT
CACCGTGGCGAAGAGCCTCGCTGGTGGCCTGCCGCTGTCCGGCGTCGTGGGCCGTGCCGAAATCATGGATGCGCCGCTTC
CTGGCGGCCTCGGCGGCACGTACGCAGGCAACCCGCTGGCCTGTGCGGCTGCACTGGCGGTCCTCGACCTGTTCGAGGAC
GAAAAGCTGACGGAGCGCGCACGCGAACTGGGCACGACCTTGCGCGGCGGCCTCCTGGCTCTGGCCGACAAGTACCAGGA
GATTGGTACCATTCGCGGCGTGGGCCCGATGCTCGCGCTGGAGTTCGTCAAGCACGGCGACCCGCACCAGCCGGATGCGG
ATTTCGCTCAACGCGTGGTCGATGCCTGCCGCGATGAAGGTCTTCTGGTGATCAAGTGCGGCGTACATCGCAACAACGTT
CGTCTGCTTGCTCCGGTGAACACCGAGCTCGACGACGCACACGAGGCCATTGCCATCCTTGGCCGAGCCATCGCCAAGGT
CCGCGGATAA

Upstream 100 bases:

>100_bases
CAAGTTGCCAATCCTAAGATGGTGTCAACCCCTTGAAAGCAAGGGAAACCGGGCCGCATGCCGGCCACGCACTTCACAGT
TGACGACGACAGGACAGGAC

Downstream 100 bases:

>100_bases
CCGAGAGCCAAAATGCCCCGAGACACGTTAGTCAGTCACCGACAATCGGTAGATATTGGCGGAAAGTTTTCCGGCAAGAC
GGTGCTGACGTTAGACGTCT

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MALESTHQDLAAARAQHVARGVVTAHPIFVDHAQGSRVWDVNGRSYLDFVGGIGVLNVGHNHPRVVAAVKQQLERVSHAA
FQVAGYDVYIELAARLNRLVGGSEAYKTVFLTTGAEAVENAVKIARAYRNAPGIIAFRGGFHGRTLLGMTLTGMSTPYKQ
NFGPFAGDVYHTPYPDPYRGFSGDDALRALDDLFATQIAPDRVAAIILELVQGDGGFLAAGSDFLKKLRALTTKHGIVLI
ADEIQTGFGRTGELFAFQEAGIQPDLVTVAKSLAGGLPLSGVVGRAEIMDAPLPGGLGGTYAGNPLACAAALAVLDLFED
EKLTERARELGTTLRGGLLALADKYQEIGTIRGVGPMLALEFVKHGDPHQPDADFAQRVVDACRDEGLLVIKCGVHRNNV
RLLAPVNTELDDAHEAIAILGRAIAKVRG

Sequences:

>Translated_429_residues
MALESTHQDLAAARAQHVARGVVTAHPIFVDHAQGSRVWDVNGRSYLDFVGGIGVLNVGHNHPRVVAAVKQQLERVSHAA
FQVAGYDVYIELAARLNRLVGGSEAYKTVFLTTGAEAVENAVKIARAYRNAPGIIAFRGGFHGRTLLGMTLTGMSTPYKQ
NFGPFAGDVYHTPYPDPYRGFSGDDALRALDDLFATQIAPDRVAAIILELVQGDGGFLAAGSDFLKKLRALTTKHGIVLI
ADEIQTGFGRTGELFAFQEAGIQPDLVTVAKSLAGGLPLSGVVGRAEIMDAPLPGGLGGTYAGNPLACAAALAVLDLFED
EKLTERARELGTTLRGGLLALADKYQEIGTIRGVGPMLALEFVKHGDPHQPDADFAQRVVDACRDEGLLVIKCGVHRNNV
RLLAPVNTELDDAHEAIAILGRAIAKVRG
>Mature_428_residues
ALESTHQDLAAARAQHVARGVVTAHPIFVDHAQGSRVWDVNGRSYLDFVGGIGVLNVGHNHPRVVAAVKQQLERVSHAAF
QVAGYDVYIELAARLNRLVGGSEAYKTVFLTTGAEAVENAVKIARAYRNAPGIIAFRGGFHGRTLLGMTLTGMSTPYKQN
FGPFAGDVYHTPYPDPYRGFSGDDALRALDDLFATQIAPDRVAAIILELVQGDGGFLAAGSDFLKKLRALTTKHGIVLIA
DEIQTGFGRTGELFAFQEAGIQPDLVTVAKSLAGGLPLSGVVGRAEIMDAPLPGGLGGTYAGNPLACAAALAVLDLFEDE
KLTERARELGTTLRGGLLALADKYQEIGTIRGVGPMLALEFVKHGDPHQPDADFAQRVVDACRDEGLLVIKCGVHRNNVR
LLAPVNTELDDAHEAIAILGRAIAKVRG

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=416, Percent_Identity=33.1730769230769, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI13994255, Length=438, Percent_Identity=31.2785388127854, Blast_Score=185, Evalue=9e-47,
Organism=Homo sapiens, GI37574042, Length=440, Percent_Identity=31.1363636363636, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI226442705, Length=440, Percent_Identity=30.6818181818182, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI226442709, Length=386, Percent_Identity=31.6062176165803, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI284507298, Length=324, Percent_Identity=34.8765432098765, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI24119277, Length=408, Percent_Identity=28.921568627451, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI188536080, Length=406, Percent_Identity=25.1231527093596, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI38679950, Length=406, Percent_Identity=25.1231527093596, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI38679946, Length=406, Percent_Identity=25.1231527093596, Blast_Score=112, Evalue=7e-25,
Organism=Escherichia coli, GI1789016, Length=424, Percent_Identity=50.4716981132076, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI1787560, Length=422, Percent_Identity=49.0521327014218, Blast_Score=385, Evalue=1e-108,
Organism=Escherichia coli, GI1789759, Length=405, Percent_Identity=36.0493827160494, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1788044, Length=389, Percent_Identity=33.1619537275064, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI145693181, Length=398, Percent_Identity=32.9145728643216, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1786349, Length=409, Percent_Identity=29.5843520782396, Blast_Score=142, Evalue=5e-35,
Organism=Escherichia coli, GI1786991, Length=357, Percent_Identity=31.9327731092437, Blast_Score=132, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI32564660, Length=447, Percent_Identity=30.6487695749441, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI25144271, Length=415, Percent_Identity=28.433734939759, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71992977, Length=427, Percent_Identity=31.3817330210773, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI25144274, Length=301, Percent_Identity=28.2392026578073, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17541228, Length=402, Percent_Identity=26.865671641791, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71981843, Length=161, Percent_Identity=26.0869565217391, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323470, Length=415, Percent_Identity=34.9397590361446, Blast_Score=216, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6324432, Length=402, Percent_Identity=30.3482587064677, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6321456, Length=366, Percent_Identity=28.9617486338798, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324386, Length=300, Percent_Identity=25.6666666666667, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI28574759, Length=452, Percent_Identity=31.6371681415929, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI161085790, Length=449, Percent_Identity=30.9576837416481, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI21357415, Length=407, Percent_Identity=30.958230958231, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI21356575, Length=423, Percent_Identity=30.0236406619385, Blast_Score=148, Evalue=7e-36,
Organism=Drosophila melanogaster, GI281366494, Length=375, Percent_Identity=26.6666666666667, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24667139, Length=375, Percent_Identity=26.6666666666667, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24667143, Length=375, Percent_Identity=26.6666666666667, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 45580; Mature: 45448

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALESTHQDLAAARAQHVARGVVTAHPIFVDHAQGSRVWDVNGRSYLDFVGGIGVLNVGH
CCCCCHHHHHHHHHHHHHHHHHHEECCEEEECCCCCEEEECCCCHHHHHHCCCEEEECCC
NHPRVVAAVKQQLERVSHAAFQVAGYDVYIELAARLNRLVGGSEAYKTVFLTTGAEAVEN
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHHH
AVKIARAYRNAPGIIAFRGGFHGRTLLGMTLTGMSTPYKQNFGPFAGDVYHTPYPDPYRG
HHHHHHHHCCCCCEEEEECCCCCCEEEEEEEECCCCCCHHCCCCCCCCCCCCCCCCCCCC
FSGDDALRALDDLFATQIAPDRVAAIILELVQGDGGFLAAGSDFLKKLRALTTKHGIVLI
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCEEEE
ADEIQTGFGRTGELFAFQEAGIQPDLVTVAKSLAGGLPLSGVVGRAEIMDAPLPGGLGGT
EECHHCCCCCCCCEEEEHHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCC
YAGNPLACAAALAVLDLFEDEKLTERARELGTTLRGGLLALADKYQEIGTIRGVGPMLAL
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHH
EFVKHGDPHQPDADFAQRVVDACRDEGLLVIKCGVHRNNVRLLAPVNTELDDAHEAIAIL
HHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHH
GRAIAKVRG
HHHHHHHCC
>Mature Secondary Structure 
ALESTHQDLAAARAQHVARGVVTAHPIFVDHAQGSRVWDVNGRSYLDFVGGIGVLNVGH
CCCCHHHHHHHHHHHHHHHHHHEECCEEEECCCCCEEEECCCCHHHHHHCCCEEEECCC
NHPRVVAAVKQQLERVSHAAFQVAGYDVYIELAARLNRLVGGSEAYKTVFLTTGAEAVEN
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHEEEEEECCHHHHHH
AVKIARAYRNAPGIIAFRGGFHGRTLLGMTLTGMSTPYKQNFGPFAGDVYHTPYPDPYRG
HHHHHHHHCCCCCEEEEECCCCCCEEEEEEEECCCCCCHHCCCCCCCCCCCCCCCCCCCC
FSGDDALRALDDLFATQIAPDRVAAIILELVQGDGGFLAAGSDFLKKLRALTTKHGIVLI
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHCCCEEEE
ADEIQTGFGRTGELFAFQEAGIQPDLVTVAKSLAGGLPLSGVVGRAEIMDAPLPGGLGGT
EECHHCCCCCCCCEEEEHHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCC
YAGNPLACAAALAVLDLFEDEKLTERARELGTTLRGGLLALADKYQEIGTIRGVGPMLAL
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCHHHHHH
EFVKHGDPHQPDADFAQRVVDACRDEGLLVIKCGVHRNNVRLLAPVNTELDDAHEAIAIL
HHHHCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHH
GRAIAKVRG
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]