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The map label for this gene is vllY [H]

Identifier: 73538860

GI number: 73538860

Start: 1769041

End: 1770939

Strand: Direct

Name: vllY [H]

Synonym: Reut_B5035

Alternate gene names: 73538860

Gene position: 1769041-1770939 (Clockwise)

Preceding gene: 73538858

Following gene: 73538861

Centisome position: 64.89

GC content: 68.19

Gene sequence:

>1899_bases
ATGCCCTTCCCTGCCGCACGTGCCATGTCAGCCGACCTTTCGCTCAAGCCGCTCCCCAAGTCCATCGCCACCGTCTCGCT
GTCCGGCACGCTGCCGGAGAAGCTCGAAGCCGCCGCGGCGGCCGGGTTCGACGGCGTGGAAATCTTCGAGAACGACCTGC
TCAACTTCGAGGGCTCGCCCGCCGAGGTGTGCCGCATGGCGACCGACCTCGGGCTGCGCATCATGCTCTACCAGCCGCTG
CGCGATTTCGAGGCGATGCCGGCGGAGCTGTTCGCGCGCAATATGGCGCGCGCCGAACGCAAGTTCGATGTGATGGAACA
GCTCGGCGCCGACACGGTGCTGGTCTGCAGCAACGTGCAAGACATCGCCATCGACGATCCCGCGCGCGCCGCCGCCGATC
TGCGCCAGATGGCCGAGGCCGCCGCGCGGCGCGGCCTGCGCGTCGGCTTCGAGGCGCTGGCATGGGGTCGCCACACGCGC
ACCTGGCGCCAGGCGTGGGACATTGTGCAGCACGCGGACCATCCGGCGCTCGGGCTGGTGCTGGACAGCTTCCATACGCT
TGCGCTCGGCGACGACCTGTCGGGGCTCGATGCCGTGCCCGCGGACAAGATCTTCTTTGTGCAGCTTGCCGACGCGCCGC
GCATGTCGATGGACGTGCTGGGCTGGAGCCGGCATTACCGTAACTTTCCGGGCCAGGGCGACCTGCCCGTCACCGCGTTC
GCGCGCGCCGTACTGCAGGCCGGCTATACGGGCCCGCTGTCGCTGGAAATTTTCAACGACGAGTTCCGTGCCGCACCGGC
GCGGCAGACCGCACTGGACGGGCTGCGCTCGCTGATCTGGCTCGAGTCCGAGGCGGGCGGGCATGCGCTGCCGGCGCCAC
CGGTTTTCGACGGGGTGGATTTCATCGAATTTGCCGTCGACTACGTGGCCGGCCGCGAACTGGCCCGGCGCCTGGAATCG
CTTGGCTTCGTGCATGCCGGACACCATCGCTCCAAGGCGGTCGACCTGTACCGGCAGGGCGGCATCAACCTGATCCTCAA
TGCGGAGCAGGACAGCGCCGCCGCCGAGCACTTCCAGCTGCACGGCCCTTCCGTTTGTGCGATCGGCCTCAAGGTGGACG
ACGCCGGCCGCGCCATCTCGCGTGCCCGTGCGCTGCTATGCAAGGAGTGGCGCGAACGGGTAGGCCCCGACGAGCGCGTG
ATTCCCGCGCTGCGCTCGCCAGACGGCTTGCTGTTCCACCTGATCGATGACCTCGACGCCGCACGCAGCATCTACGAGAG
CGACTTCGACTTGCGCGCGCCGGTGCAGGCCGACACCTCCGACGCCGGGCTGACGGCGATCGACCACATTGCACAGGCCC
TGCCCGCGCACAAGCTCGACACCTTCGTGCTGTTCTACCGCTCGGTGTTCGGCATGCAGGCCGAAGGCGTGCACGAGATC
GCGGATCCGTACGGGCTGGTCAAGAGCCGCGCCATGGTCAGCGCCGACCAGCGCGTGCGCATCCCGCTCAATGTGTCGGA
GAGCGGCCGCACCGCCACGGGCCGATTCGTCGCCGCCTATGCGGGATCGGGCGTGCACCACATCGCCTTCCGCTCCGCAG
AACTCACGCAGATGGTGGAGCAGATCGACCGCAGCCGTTCCGCGATGCTGCACGTGCCGGACAACTACTACGACGACCTC
GCCGCCCGGCTCGCGCTCGACGACACGCTGCTGGCCCGGCTGCAGCGCCTTGGCCTGCTCTACGACCGCGACGGCCATGG
CGAATTCCTGCACACCTATACCGAGCCCTTCCACGAGCGCTTCTTTTTCGAGCTCGTGCAGCGCAGCGGATATCTGGGCT
ATGGCGCGGCCAATGCCTCGGTCCGCATGGCGGCGCAAGCGAAGCTGCGCCACAACTGA

Upstream 100 bases:

>100_bases
CCCGAGTAATGCACGACTGTCGCGCGCCATCGCGCGATTATCGCTCGTCGGCGCGCGAATTGCGATTGTTTGGCCCACAG
TTGGCTCCTAACCTTGCGGC

Downstream 100 bases:

>100_bases
AGCCATTCGCCGAGGCCATCCCCTCTACGACTTTCACGACATCCCCCAAGGAGACATCGCATGCAAGACCCCTGCATCAT
CTCGGTGGCCATCACCGGTT

Product: 4-hydroxyphenylpyruvate dioxygenase

Products: homogentisate; CO2

Alternate protein names: NA

Number of amino acids: Translated: 632; Mature: 631

Protein sequence:

>632_residues
MPFPAARAMSADLSLKPLPKSIATVSLSGTLPEKLEAAAAAGFDGVEIFENDLLNFEGSPAEVCRMATDLGLRIMLYQPL
RDFEAMPAELFARNMARAERKFDVMEQLGADTVLVCSNVQDIAIDDPARAAADLRQMAEAAARRGLRVGFEALAWGRHTR
TWRQAWDIVQHADHPALGLVLDSFHTLALGDDLSGLDAVPADKIFFVQLADAPRMSMDVLGWSRHYRNFPGQGDLPVTAF
ARAVLQAGYTGPLSLEIFNDEFRAAPARQTALDGLRSLIWLESEAGGHALPAPPVFDGVDFIEFAVDYVAGRELARRLES
LGFVHAGHHRSKAVDLYRQGGINLILNAEQDSAAAEHFQLHGPSVCAIGLKVDDAGRAISRARALLCKEWRERVGPDERV
IPALRSPDGLLFHLIDDLDAARSIYESDFDLRAPVQADTSDAGLTAIDHIAQALPAHKLDTFVLFYRSVFGMQAEGVHEI
ADPYGLVKSRAMVSADQRVRIPLNVSESGRTATGRFVAAYAGSGVHHIAFRSAELTQMVEQIDRSRSAMLHVPDNYYDDL
AARLALDDTLLARLQRLGLLYDRDGHGEFLHTYTEPFHERFFFELVQRSGYLGYGAANASVRMAAQAKLRHN

Sequences:

>Translated_632_residues
MPFPAARAMSADLSLKPLPKSIATVSLSGTLPEKLEAAAAAGFDGVEIFENDLLNFEGSPAEVCRMATDLGLRIMLYQPL
RDFEAMPAELFARNMARAERKFDVMEQLGADTVLVCSNVQDIAIDDPARAAADLRQMAEAAARRGLRVGFEALAWGRHTR
TWRQAWDIVQHADHPALGLVLDSFHTLALGDDLSGLDAVPADKIFFVQLADAPRMSMDVLGWSRHYRNFPGQGDLPVTAF
ARAVLQAGYTGPLSLEIFNDEFRAAPARQTALDGLRSLIWLESEAGGHALPAPPVFDGVDFIEFAVDYVAGRELARRLES
LGFVHAGHHRSKAVDLYRQGGINLILNAEQDSAAAEHFQLHGPSVCAIGLKVDDAGRAISRARALLCKEWRERVGPDERV
IPALRSPDGLLFHLIDDLDAARSIYESDFDLRAPVQADTSDAGLTAIDHIAQALPAHKLDTFVLFYRSVFGMQAEGVHEI
ADPYGLVKSRAMVSADQRVRIPLNVSESGRTATGRFVAAYAGSGVHHIAFRSAELTQMVEQIDRSRSAMLHVPDNYYDDL
AARLALDDTLLARLQRLGLLYDRDGHGEFLHTYTEPFHERFFFELVQRSGYLGYGAANASVRMAAQAKLRHN
>Mature_631_residues
PFPAARAMSADLSLKPLPKSIATVSLSGTLPEKLEAAAAAGFDGVEIFENDLLNFEGSPAEVCRMATDLGLRIMLYQPLR
DFEAMPAELFARNMARAERKFDVMEQLGADTVLVCSNVQDIAIDDPARAAADLRQMAEAAARRGLRVGFEALAWGRHTRT
WRQAWDIVQHADHPALGLVLDSFHTLALGDDLSGLDAVPADKIFFVQLADAPRMSMDVLGWSRHYRNFPGQGDLPVTAFA
RAVLQAGYTGPLSLEIFNDEFRAAPARQTALDGLRSLIWLESEAGGHALPAPPVFDGVDFIEFAVDYVAGRELARRLESL
GFVHAGHHRSKAVDLYRQGGINLILNAEQDSAAAEHFQLHGPSVCAIGLKVDDAGRAISRARALLCKEWRERVGPDERVI
PALRSPDGLLFHLIDDLDAARSIYESDFDLRAPVQADTSDAGLTAIDHIAQALPAHKLDTFVLFYRSVFGMQAEGVHEIA
DPYGLVKSRAMVSADQRVRIPLNVSESGRTATGRFVAAYAGSGVHHIAFRSAELTQMVEQIDRSRSAMLHVPDNYYDDLA
ARLALDDTLLARLQRLGLLYDRDGHGEFLHTYTEPFHERFFFELVQRSGYLGYGAANASVRMAAQAKLRHN

Specific function: Unknown

COG id: COG3185

COG function: function code ER; 4-hydroxyphenylpyruvate dioxygenase and related hemolysins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 4HPPD family [H]

Homologues:

Organism=Homo sapiens, GI285002264, Length=305, Percent_Identity=21.9672131147541, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI4504477, Length=305, Percent_Identity=21.9672131147541, Blast_Score=77, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17555220, Length=303, Percent_Identity=25.0825082508251, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17550752, Length=187, Percent_Identity=28.3422459893048, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI21356105, Length=186, Percent_Identity=25.2688172043011, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667510, Length=186, Percent_Identity=25.2688172043011, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005956
- InterPro:   IPR004360 [H]

Pfam domain/function: PF00903 Glyoxalase [H]

EC number: 1.13.11.27

Molecular weight: Translated: 69431; Mature: 69300

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFPAARAMSADLSLKPLPKSIATVSLSGTLPEKLEAAAAAGFDGVEIFENDLLNFEGSP
CCCCCCHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCH
AEVCRMATDLGLRIMLYQPLRDFEAMPAELFARNMARAERKFDVMEQLGADTVLVCSNVQ
HHHHHHHHHCCCEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
DIAIDDPARAAADLRQMAEAAARRGLRVGFEALAWGRHTRTWRQAWDIVQHADHPALGLV
CEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHH
LDSFHTLALGDDLSGLDAVPADKIFFVQLADAPRMSMDVLGWSRHYRNFPGQGDLPVTAF
HHCCHHEEECCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHHH
ARAVLQAGYTGPLSLEIFNDEFRAAPARQTALDGLRSLIWLESEAGGHALPAPPVFDGVD
HHHHHHCCCCCCEEEEEECCHHHCCCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCHH
FIEFAVDYVAGRELARRLESLGFVHAGHHRSKAVDLYRQGGINLILNAEQDSAAAEHFQL
HHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHEE
HGPSVCAIGLKVDDAGRAISRARALLCKEWRERVGPDERVIPALRSPDGLLFHLIDDLDA
CCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCEEHHHHHHHHH
ARSIYESDFDLRAPVQADTSDAGLTAIDHIAQALPAHKLDTFVLFYRSVFGMQAEGVHEI
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHH
ADPYGLVKSRAMVSADQRVRIPLNVSESGRTATGRFVAAYAGSGVHHIAFRSAELTQMVE
HCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEEECCCCEEEEEECHHHHHHHHH
QIDRSRSAMLHVPDNYYDDLAARLALDDTLLARLQRLGLLYDRDGHGEFLHTYTEPFHER
HHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHH
FFFELVQRSGYLGYGAANASVRMAAQAKLRHN
HHHHHHHHCCCCEECCCCCCEEEHHHHHHCCC
>Mature Secondary Structure 
PFPAARAMSADLSLKPLPKSIATVSLSGTLPEKLEAAAAAGFDGVEIFENDLLNFEGSP
CCCCCHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCH
AEVCRMATDLGLRIMLYQPLRDFEAMPAELFARNMARAERKFDVMEQLGADTVLVCSNVQ
HHHHHHHHHCCCEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCC
DIAIDDPARAAADLRQMAEAAARRGLRVGFEALAWGRHTRTWRQAWDIVQHADHPALGLV
CEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHH
LDSFHTLALGDDLSGLDAVPADKIFFVQLADAPRMSMDVLGWSRHYRNFPGQGDLPVTAF
HHCCHHEEECCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHHH
ARAVLQAGYTGPLSLEIFNDEFRAAPARQTALDGLRSLIWLESEAGGHALPAPPVFDGVD
HHHHHHCCCCCCEEEEEECCHHHCCCHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCHH
FIEFAVDYVAGRELARRLESLGFVHAGHHRSKAVDLYRQGGINLILNAEQDSAAAEHFQL
HHHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHEE
HGPSVCAIGLKVDDAGRAISRARALLCKEWRERVGPDERVIPALRSPDGLLFHLIDDLDA
CCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCEEHHHHHHHHH
ARSIYESDFDLRAPVQADTSDAGLTAIDHIAQALPAHKLDTFVLFYRSVFGMQAEGVHEI
HHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCHHHH
ADPYGLVKSRAMVSADQRVRIPLNVSESGRTATGRFVAAYAGSGVHHIAFRSAELTQMVE
HCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEEEECCCCEEEEEECHHHHHHHHH
QIDRSRSAMLHVPDNYYDDLAARLALDDTLLARLQRLGLLYDRDGHGEFLHTYTEPFHER
HHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHH
FFFELVQRSGYLGYGAANASVRMAAQAKLRHN
HHHHHHHHCCCCEECCCCCCEEEHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-hydroxyphenylpyruvate; O2

Specific reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA