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The map label for this gene is ppiC [C]

Identifier: 73538831

GI number: 73538831

Start: 1740402

End: 1741154

Strand: Direct

Name: ppiC [C]

Synonym: Reut_B5006

Alternate gene names: 73538831

Gene position: 1740402-1741154 (Clockwise)

Preceding gene: 73538830

Following gene: 73538832

Centisome position: 63.84

GC content: 68.92

Gene sequence:

>753_bases
ATGCCAGTCACCGTCAATGGCGTAGAACTGACCGATGACGATATCGAACGCGAGATGGACCAACACCGCGATGCGCGCAA
TCCCGCGCATATGGCCACCGTGTCGGCCATCCTGCGCCGCCTGATGCGCACGGAGGCCGAGCGCCTCGGCATTGCCGGCG
GCGACACGGATGACGATGCGCTCGCACTGGCACTGCTCGCGCATGAAGCGCCCGTACCGGACGCGGACGAAAGCAGCTGC
CGCCGCCACTACGACAGCCGGCCCGACCGCTTCCGCGAAGGCGAATGGGTCGAGGTCGAGCACATCCTGTTCCAGGTCAC
GCCGCGCGTGCCGCTCGACGCGCTGCGCGAGGTGGCACTGCAGACGCTGGCGCTGATCAAGGGCGATCCGTCGAGCTTCG
CGAGCCATGCGCAGGCGCTGTCGAACTGTCCGAGCGGCGCGGGCGGCGGCAGACTTGGACGCGTGTTCCGTGGCGAGACC
GCGCCGGAGTTCGAGCGCGCGGTCTTCTCCGCGCCGGTACAGGGCCTGTTGCCGCAACTGGTCGAGACGCGCTTCGGCCT
GCATATCGTACGCGTACTTGACCGCTGCGACGGCACGCGCCTGCCGTTCGACATGGTGCGCGCCGACATCGCCCACGCGC
TGACCGCCGCCGCGCGCGACCGTGCCTGGAAGCAGTACGCCAGCCTGCTGATCGGCAGGGCCAGCATCACGGGTATCGAG
CTCGAAGGCGCCGACAGCCCGCTGGTGCAGTAG

Upstream 100 bases:

>100_bases
CGTCCATGTCTGGAGCGGTTTCGCTTCCGTGGGCTATCTCGGCCGCGCGTGGCAACTCGTGCGCAGCCGTTAAGCGCATC
CATCAGAACCGGAGAACACC

Downstream 100 bases:

>100_bases
GGAAAACCGTCCCCGGAGGCTTCTGGCATGCACGAGATCGAACGTCTGCTGAAAGGGTTCGAGCGCTTCCAGCAGCATTA
CTTCGAGGACGAACCCGAGC

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: peptidylproline (omega=0) [C]

Alternate protein names: Peptidyl-Prolyl Cis-Trans Isomerase; Peptidyl-Prolyl Cis-Trans Isomerase PpiC-Type; Rotamase/Peptidyl-Prolyl Cis-Trans Isomerase Family Protein; Parvulin-Like Peptidyl-Prolyl Isomerase; Peptidylprolyl Isomerase; Peptidyl-Prolyl Cis-Trans Isomerase EpsD Family; PPIC-Type PPIASE Domain Protein; Probably Peptidyl-Prolyl CIS-Trans Isomerase C; Peptidyl-Prolyl Cis-Trans Isomerase C; Rotamase; Peptidylprolyl Cis-Trans Isomerase; Peptidylprolyl Isomerase Family Protein; Peptidil-Prolyl Cis-Trans Isomerase; PPIC-Type PPIASE Domain-Containing; Ppic-Type Peptidyl-Prolyl Cis-Trans Isomerase

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MPVTVNGVELTDDDIEREMDQHRDARNPAHMATVSAILRRLMRTEAERLGIAGGDTDDDALALALLAHEAPVPDADESSC
RRHYDSRPDRFREGEWVEVEHILFQVTPRVPLDALREVALQTLALIKGDPSSFASHAQALSNCPSGAGGGRLGRVFRGET
APEFERAVFSAPVQGLLPQLVETRFGLHIVRVLDRCDGTRLPFDMVRADIAHALTAAARDRAWKQYASLLIGRASITGIE
LEGADSPLVQ

Sequences:

>Translated_250_residues
MPVTVNGVELTDDDIEREMDQHRDARNPAHMATVSAILRRLMRTEAERLGIAGGDTDDDALALALLAHEAPVPDADESSC
RRHYDSRPDRFREGEWVEVEHILFQVTPRVPLDALREVALQTLALIKGDPSSFASHAQALSNCPSGAGGGRLGRVFRGET
APEFERAVFSAPVQGLLPQLVETRFGLHIVRVLDRCDGTRLPFDMVRADIAHALTAAARDRAWKQYASLLIGRASITGIE
LEGADSPLVQ
>Mature_249_residues
PVTVNGVELTDDDIEREMDQHRDARNPAHMATVSAILRRLMRTEAERLGIAGGDTDDDALALALLAHEAPVPDADESSCR
RHYDSRPDRFREGEWVEVEHILFQVTPRVPLDALREVALQTLALIKGDPSSFASHAQALSNCPSGAGGGRLGRVFRGETA
PEFERAVFSAPVQGLLPQLVETRFGLHIVRVLDRCDGTRLPFDMVRADIAHALTAAARDRAWKQYASLLIGRASITGIEL
EGADSPLVQ

Specific function: Ppiases Accelerate The Folding Of Proteins. It Prefers Amino Acid Residues With Hydrophobic Side Chains Like Leucine And Phenylalanine In The P1 Position Of The Peptides Substrates. [C]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 27360; Mature: 27229

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVTVNGVELTDDDIEREMDQHRDARNPAHMATVSAILRRLMRTEAERLGIAGGDTDDDA
CCEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LALALLAHEAPVPDADESSCRRHYDSRPDRFREGEWVEVEHILFQVTPRVPLDALREVAL
HHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCEEHHHHHHHCCCCCCHHHHHHHHH
QTLALIKGDPSSFASHAQALSNCPSGAGGGRLGRVFRGETAPEFERAVFSAPVQGLLPQL
HHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCHHHHHHHH
VETRFGLHIVRVLDRCDGTRLPFDMVRADIAHALTAAARDRAWKQYASLLIGRASITGIE
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
LEGADSPLVQ
ECCCCCCCCC
>Mature Secondary Structure 
PVTVNGVELTDDDIEREMDQHRDARNPAHMATVSAILRRLMRTEAERLGIAGGDTDDDA
CEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
LALALLAHEAPVPDADESSCRRHYDSRPDRFREGEWVEVEHILFQVTPRVPLDALREVAL
HHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCCCEEHHHHHHHCCCCCCHHHHHHHHH
QTLALIKGDPSSFASHAQALSNCPSGAGGGRLGRVFRGETAPEFERAVFSAPVQGLLPQL
HHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCHHHHHHHHHCCHHHHHHHH
VETRFGLHIVRVLDRCDGTRLPFDMVRADIAHALTAAARDRAWKQYASLLIGRASITGIE
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
LEGADSPLVQ
ECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Peptidoproline (omega=180) [C]

Specific reaction: Peptidoproline (omega=180) = peptidylproline (omega=0) [C]

General reaction: Rotation (Single bond) [C]

Inhibitor: cyclosporins [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA