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The map label for this gene is shc [H]

Identifier: 73538779

GI number: 73538779

Start: 1681532

End: 1683553

Strand: Direct

Name: shc [H]

Synonym: Reut_B4954

Alternate gene names: 73538779

Gene position: 1681532-1683553 (Clockwise)

Preceding gene: 73538778

Following gene: 73538780

Centisome position: 61.68

GC content: 69.04

Gene sequence:

>2022_bases
ATGTCGATGAACGAGGCCGTCCTTGCCGCTCCGCGCGCCGCGGTCGCGACCGCGGCGCCGGCCCTACAGGCCCCCATTGA
GGCCCTGTCCCCGCTGGATGCCGGCATCGGCCACGCGGTCGATGCGCTGCTCGCGCAGCAGAATGCCGACGGGCACTGGG
TCTACGAGCTCGAAGCCGACGCCACCATTCCCGCCGAGTACGTGCTCATGGTGCACTACCTCGGCGAGACGCCGGACCTG
TCGCTGGAAGCCCGCATCGCGCGCTACCTGCGGCGCATCCAGAATGCCGACGGCGGCTGGCCGCTGTTCCATGAAGGCCG
CTCCGATATCAGCGCCAGCGTGAAGGCCTACTTCGCGCTGAAGATGGCCGGCGACGATCCGCAGGCAGCGCACATGGCGC
GCGCGCGCGAGGTCATCCTCGCGATGGGCGGCGCGGAAACCAGCAACGTCTTCACGCGCACGCTGCTGGCGCTGTACGGC
GTGATGCCGTGGCAGGCCGTGCCGATGATGCCGGTGGAAATCATGCTGCTGCCGCAGTGGTTCCCGTTCCACCTGTCAAA
GGTTTCCTACTGGGCGCGCACGGTCATCGTGCCGCTGCTGGTGCTGAACAGCCTGCGGCCGCAGGCGCGCAATCCGCGCA
AGGTCGGTATCGACGAACTGTTCCTCGGCTCGCGCGATGCCGTACGGCTGCCGCCACGGGCACCGCACCAGCATAAGGGC
TGGCACGCGCTGTTTCACGGCGCCGACGTACTGCTGCGCACGGCCGAACACGTCATGCCGCGCGGCCTGCGCCGCCGCGC
CATCGACGCGGCGAAGGCGTTCGTGCGCGAACGGCTCAACGGCGAAGACGGTCTTGGCGCGATCTTCCCCGCCATGGCGA
ACTCGGTGATGATGTTCGACGTGCTCGGCGTCCCGCCCGACGATCCGGACCGCGCCATCGCCCGCCGCTCGATCGACAAG
CTGCTCGTGGTCCACGGTGATGAAGCCTATTGCCAGCCGTGCCTGTCGCCGGTCTGGGATACCGCGCTGGCTGCGCATGC
GTTGCTGGAAGCGTCGGAGCCGCGCGCTACCGCCGCCGTCACGCGCGCGCTGGACTGGCTGCGCCCGTTGCAGGTGCTCG
ACGTGCGCGGCGACTGGACGGTACGCCGGCCGGATGTGCGCCCGGGCGGCTGGGCGTTCCAGTACGCCAATCCGCATTAC
CCCGACGTGGACGACACCGCCGTGGTAGTCGCGGCGATGCACCGCGCCGCGCGTACGGATCATTCCGGACGCGCGGATCC
GAACGCCGAAGCCACCGCCCGCGCGATTGAATGGATCGTCGGCATGCAGAGCGCCAACGGCGGCTGGGGTGCGTTCGAGC
CCGAGAACACGCATCTGTACCTGAACAACATCCCGTTTGCGGACCATGGGGCCTTGCTCGACCCGCCCACGGCCGACGTG
TCGGCGCGCTGCCTGTCGATGCTGTGCCAGACCGGCGCCACGCCCGACAAGAGCGAACCGGCCGCGCGCGCGCTCCAATA
TCTGCTCGCCGAGCAGTTACCGGACGGAAGCTGGTTCGGGCGCTGGGGTACCAACTACATCTACGGCACCTGGAGCGCTT
TGTGCGCGCTCAACGCCGCGGGTCTGGGACCGGACGCGCCGCCGCTGCGGCGTGCTGCGGAATGGCTCGTGGCCATCCAG
AATCCGGATGGCGGCTGGGGCGAAGACGGCGACAGCTACAAGCTCGAATATCGTGGCTACGAAACGGCACCGAGCGTGGC
CTCCCAAACCGCCTGGGCATTGCTCGCGCTGATGGCTGCGGGCCAGGCCGCACACCCCGCGGTGACGCGCGGCATCGACT
ACCTGCTGCGCACGCAGCAAGCCGACGGCCTCTGGCACGAGCCACGCTTCACCGCCGTAGGATTCCCGCGCGTGTTCTAC
CTGCGCTATCACGGCTATGCGCGTTACTTCCCGCTGTGGGCGCTGGCGCGCTATCGCAACCTGGAGCGCAGCGGCAACCG
TCAGGTGGCGTGGGGACTGTGA

Upstream 100 bases:

>100_bases
GGATGTTGCAAAAGGATCCGCCTTGTGGCGCGACGCGTCCGGGGGTGTCCTGAACATCATCATCGAGGCACGCAAGCGTC
GTGCCGCACAAGGAGTTTGA

Downstream 100 bases:

>100_bases
CCGGCGCGGCAATCGCGCGCCCCGATGGCGAACCTCGTGTGCTGGTTGTCTGCGGCATGGATTTCGAAGCCCGCATTGCC
GGCGGGCAGCATTCCGAAGT

Product: Terpene synthase:squalene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 673; Mature: 672

Protein sequence:

>673_residues
MSMNEAVLAAPRAAVATAAPALQAPIEALSPLDAGIGHAVDALLAQQNADGHWVYELEADATIPAEYVLMVHYLGETPDL
SLEARIARYLRRIQNADGGWPLFHEGRSDISASVKAYFALKMAGDDPQAAHMARAREVILAMGGAETSNVFTRTLLALYG
VMPWQAVPMMPVEIMLLPQWFPFHLSKVSYWARTVIVPLLVLNSLRPQARNPRKVGIDELFLGSRDAVRLPPRAPHQHKG
WHALFHGADVLLRTAEHVMPRGLRRRAIDAAKAFVRERLNGEDGLGAIFPAMANSVMMFDVLGVPPDDPDRAIARRSIDK
LLVVHGDEAYCQPCLSPVWDTALAAHALLEASEPRATAAVTRALDWLRPLQVLDVRGDWTVRRPDVRPGGWAFQYANPHY
PDVDDTAVVVAAMHRAARTDHSGRADPNAEATARAIEWIVGMQSANGGWGAFEPENTHLYLNNIPFADHGALLDPPTADV
SARCLSMLCQTGATPDKSEPAARALQYLLAEQLPDGSWFGRWGTNYIYGTWSALCALNAAGLGPDAPPLRRAAEWLVAIQ
NPDGGWGEDGDSYKLEYRGYETAPSVASQTAWALLALMAAGQAAHPAVTRGIDYLLRTQQADGLWHEPRFTAVGFPRVFY
LRYHGYARYFPLWALARYRNLERSGNRQVAWGL

Sequences:

>Translated_673_residues
MSMNEAVLAAPRAAVATAAPALQAPIEALSPLDAGIGHAVDALLAQQNADGHWVYELEADATIPAEYVLMVHYLGETPDL
SLEARIARYLRRIQNADGGWPLFHEGRSDISASVKAYFALKMAGDDPQAAHMARAREVILAMGGAETSNVFTRTLLALYG
VMPWQAVPMMPVEIMLLPQWFPFHLSKVSYWARTVIVPLLVLNSLRPQARNPRKVGIDELFLGSRDAVRLPPRAPHQHKG
WHALFHGADVLLRTAEHVMPRGLRRRAIDAAKAFVRERLNGEDGLGAIFPAMANSVMMFDVLGVPPDDPDRAIARRSIDK
LLVVHGDEAYCQPCLSPVWDTALAAHALLEASEPRATAAVTRALDWLRPLQVLDVRGDWTVRRPDVRPGGWAFQYANPHY
PDVDDTAVVVAAMHRAARTDHSGRADPNAEATARAIEWIVGMQSANGGWGAFEPENTHLYLNNIPFADHGALLDPPTADV
SARCLSMLCQTGATPDKSEPAARALQYLLAEQLPDGSWFGRWGTNYIYGTWSALCALNAAGLGPDAPPLRRAAEWLVAIQ
NPDGGWGEDGDSYKLEYRGYETAPSVASQTAWALLALMAAGQAAHPAVTRGIDYLLRTQQADGLWHEPRFTAVGFPRVFY
LRYHGYARYFPLWALARYRNLERSGNRQVAWGL
>Mature_672_residues
SMNEAVLAAPRAAVATAAPALQAPIEALSPLDAGIGHAVDALLAQQNADGHWVYELEADATIPAEYVLMVHYLGETPDLS
LEARIARYLRRIQNADGGWPLFHEGRSDISASVKAYFALKMAGDDPQAAHMARAREVILAMGGAETSNVFTRTLLALYGV
MPWQAVPMMPVEIMLLPQWFPFHLSKVSYWARTVIVPLLVLNSLRPQARNPRKVGIDELFLGSRDAVRLPPRAPHQHKGW
HALFHGADVLLRTAEHVMPRGLRRRAIDAAKAFVRERLNGEDGLGAIFPAMANSVMMFDVLGVPPDDPDRAIARRSIDKL
LVVHGDEAYCQPCLSPVWDTALAAHALLEASEPRATAAVTRALDWLRPLQVLDVRGDWTVRRPDVRPGGWAFQYANPHYP
DVDDTAVVVAAMHRAARTDHSGRADPNAEATARAIEWIVGMQSANGGWGAFEPENTHLYLNNIPFADHGALLDPPTADVS
ARCLSMLCQTGATPDKSEPAARALQYLLAEQLPDGSWFGRWGTNYIYGTWSALCALNAAGLGPDAPPLRRAAEWLVAIQN
PDGGWGEDGDSYKLEYRGYETAPSVASQTAWALLALMAAGQAAHPAVTRGIDYLLRTQQADGLWHEPRFTAVGFPRVFYL
RYHGYARYFPLWALARYRNLERSGNRQVAWGL

Specific function: Catalyzes the cyclization of squalene into hopene. Probably part of an operon y4aABCD involved in the synthesis of an isoprenoid compound [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI224177558, Length=647, Percent_Identity=27.3570324574961, Blast_Score=183, Evalue=6e-46,
Organism=Homo sapiens, GI47933395, Length=647, Percent_Identity=27.3570324574961, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI47933397, Length=647, Percent_Identity=27.3570324574961, Blast_Score=182, Evalue=7e-46,
Organism=Homo sapiens, GI224177556, Length=648, Percent_Identity=26.6975308641975, Blast_Score=166, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6321863, Length=609, Percent_Identity=22.9885057471264, Blast_Score=123, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 73924; Mature: 73793

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMNEAVLAAPRAAVATAAPALQAPIEALSPLDAGIGHAVDALLAQQNADGHWVYELEAD
CCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEECC
ATIPAEYVLMVHYLGETPDLSLEARIARYLRRIQNADGGWPLFHEGRSDISASVKAYFAL
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHCCCHHHHHHEEEEEEE
KMAGDDPQAAHMARAREVILAMGGAETSNVFTRTLLALYGVMPWQAVPMMPVEIMLLPQW
EECCCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCC
FPFHLSKVSYWARTVIVPLLVLNSLRPQARNPRKVGIDELFLGSRDAVRLPPRAPHQHKG
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCEECCCCCCCCCCC
WHALFHGADVLLRTAEHVMPRGLRRRAIDAAKAFVRERLNGEDGLGAIFPAMANSVMMFD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEE
VLGVPPDDPDRAIARRSIDKLLVVHGDEAYCQPCLSPVWDTALAAHALLEASEPRATAAV
EECCCCCCHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
TRALDWLRPLQVLDVRGDWTVRRPDVRPGGWAFQYANPHYPDVDDTAVVVAAMHRAARTD
HHHHHHHCCHHEEEECCCEEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
HSGRADPNAEATARAIEWIVGMQSANGGWGAFEPENTHLYLNNIPFADHGALLDPPTADV
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHH
SARCLSMLCQTGATPDKSEPAARALQYLLAEQLPDGSWFGRWGTNYIYGTWSALCALNAA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCEEEECHHHHHHHHCC
GLGPDAPPLRRAAEWLVAIQNPDGGWGEDGDSYKLEYRGYETAPSVASQTAWALLALMAA
CCCCCCCHHHHHHHHEEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHC
GQAAHPAVTRGIDYLLRTQQADGLWHEPRFTAVGFPRVFYLRYHGYARYFPLWALARYRN
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEEEEECCCHHHHHHHHHHHHHH
LERSGNRQVAWGL
HHHCCCCEEECCC
>Mature Secondary Structure 
SMNEAVLAAPRAAVATAAPALQAPIEALSPLDAGIGHAVDALLAQQNADGHWVYELEAD
CCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEEEEECC
ATIPAEYVLMVHYLGETPDLSLEARIARYLRRIQNADGGWPLFHEGRSDISASVKAYFAL
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHCCCHHHHHHEEEEEEE
KMAGDDPQAAHMARAREVILAMGGAETSNVFTRTLLALYGVMPWQAVPMMPVEIMLLPQW
EECCCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCC
FPFHLSKVSYWARTVIVPLLVLNSLRPQARNPRKVGIDELFLGSRDAVRLPPRAPHQHKG
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCEECCCCCCCCCCC
WHALFHGADVLLRTAEHVMPRGLRRRAIDAAKAFVRERLNGEDGLGAIFPAMANSVMMFD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCEEEEE
VLGVPPDDPDRAIARRSIDKLLVVHGDEAYCQPCLSPVWDTALAAHALLEASEPRATAAV
EECCCCCCHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
TRALDWLRPLQVLDVRGDWTVRRPDVRPGGWAFQYANPHYPDVDDTAVVVAAMHRAARTD
HHHHHHHCCHHEEEECCCEEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
HSGRADPNAEATARAIEWIVGMQSANGGWGAFEPENTHLYLNNIPFADHGALLDPPTADV
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHH
SARCLSMLCQTGATPDKSEPAARALQYLLAEQLPDGSWFGRWGTNYIYGTWSALCALNAA
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCEEEECHHHHHHHHCC
GLGPDAPPLRRAAEWLVAIQNPDGGWGEDGDSYKLEYRGYETAPSVASQTAWALLALMAA
CCCCCCCHHHHHHHHEEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHC
GQAAHPAVTRGIDYLLRTQQADGLWHEPRFTAVGFPRVFYLRYHGYARYFPLWALARYRN
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEEEEECCCHHHHHHHHHHHHHH
LERSGNRQVAWGL
HHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]