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The map label for this gene is hmgA [H]

Identifier: 73537757

GI number: 73537757

Start: 554382

End: 555788

Strand: Direct

Name: hmgA [H]

Synonym: Reut_B3923

Alternate gene names: 73537757

Gene position: 554382-555788 (Clockwise)

Preceding gene: 73537756

Following gene: 73537758

Centisome position: 20.34

GC content: 63.54

Gene sequence:

>1407_bases
ATGCATTACGCAATTCGTAATTCGACATTCGTACTTCGCATTTCGTCATCCGATCGAAAGCTCCTGACCCCCGACGCTGA
TCCGACCATGAACCTTACGCACACCCAACTGGCCGAACATGGCTACATGTCCGGCTTTGCCAACGAGTTCGCCACTGAGG
CGCTTCCTGGCGCACTGCCGGTTGGCCAGAACTCACCGCAGCGCGCGCCGTACGGCCTGTACGCCGAGCAGTTGTCAGGC
ACGGCTTTCACCGCGCCGCGAGCCCACAACCGCCGTTCGTGGCTGTACCGCATCCGCCCGGGCGCCGTGCACAAGCCGTT
CACGCTGGTGGAGCAGTCGCGGTTCCTGAGCCGCTTCGACGAGGTGCCGCCATCGCCGAACCAGATGCGCTGGAGCCCGC
CGGCCATGCCCACTACGCCAACGGATTTCATCGACGGCATCGTCACCATGGCAGGCAACGGGGGTCCGGACGCCATGACC
GGTTGCGGTATCCATCTGTATCTGGCCAACCAGTCGATGCAGGACCGCTTCTTCTACAACGCCGACGGCGAAATGCTGAT
CGTGCCGCAACAGGGTCGCGTGCGTTTCGTGACGGAAATGGGCCGGCTCGACGTGGAGCCGCAGGAGATCGTGGTGATTC
CGCGCGGCGTGCGTTTCCGCGTGGAACTGCCTGATGGTGAGGCGCGTGGCTATATCTGCGAGAACTATGGTGCGCTGTTC
AAGCTGCCCGACCTCGGCGTGATCGGCTCCAATGGCCTGGCTAACCCGCGCGATTTCATGACCCCGGTTGCCGCGTACGA
GGACCGGGAAGGCGATTTCGAGCTGGTGGCCAAGTTCCAGGGCAATCTGTGGCGCGCCGATATCGGCCATTCGCCGCTCG
ATGTGGTGGCCTGGCACGGCAACTTCGCGCCGTACAAGTACGACCTGCGGCGCTTCAACACCATTGGCTCGATCAGCTTC
GACCACCCGGACCCGTCGATCTTCCTGGTACTGCAGTCGCCGTCGGACACGCCGGGCGTGGACACCATCGACTTCGTCAT
TTTCGGACCGCGCTGGCTGGCCATGGAAAACTCGTTCCGCCCGCCCTGGTTCCACCGCAATATCGCCAGCGAGTTCATGG
GCCTGATCACCGGCGTGTACGACGCTAAGGCCGACGGCTTCGCCCCGGGCGGCGCGAGCCTGCACAACTGCATGAGCGGC
CACGGTCCCGATGCCGATACGTTTGCCAAGGCGACCTCGGCCGACACATCGACGCCGCACCACATCACCGACACCATGGC
CTTCATGTTCGAGACGCCGGGCGTGATCCGGCCCACGCCGTACGCAGCGCGCTCGGCATCGCTGCAGCAGGACTACTACA
CCTGCTGGCAAGGGCTGAAGAAGCATTTCAACCCGAACGTGCGCTAA

Upstream 100 bases:

>100_bases
TTCCCTCGTTTCCCGCCTACAACGTCTGTGATGTGCGTTTTCCCGCGCGCGTCCCGGCAACGGTTTGACACGTCCATTGC
TGATGATTACGATATGGTAA

Downstream 100 bases:

>100_bases
GCACGGCAGACGCCACATAAAACAAACAAACGGCACGCGGCAATATCCGCGTGCCACAGACATTTTCCGGAGTCCCACAT
GACCGCCCCGATCACCAGCT

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MHYAIRNSTFVLRISSSDRKLLTPDADPTMNLTHTQLAEHGYMSGFANEFATEALPGALPVGQNSPQRAPYGLYAEQLSG
TAFTAPRAHNRRSWLYRIRPGAVHKPFTLVEQSRFLSRFDEVPPSPNQMRWSPPAMPTTPTDFIDGIVTMAGNGGPDAMT
GCGIHLYLANQSMQDRFFYNADGEMLIVPQQGRVRFVTEMGRLDVEPQEIVVIPRGVRFRVELPDGEARGYICENYGALF
KLPDLGVIGSNGLANPRDFMTPVAAYEDREGDFELVAKFQGNLWRADIGHSPLDVVAWHGNFAPYKYDLRRFNTIGSISF
DHPDPSIFLVLQSPSDTPGVDTIDFVIFGPRWLAMENSFRPPWFHRNIASEFMGLITGVYDAKADGFAPGGASLHNCMSG
HGPDADTFAKATSADTSTPHHITDTMAFMFETPGVIRPTPYAARSASLQQDYYTCWQGLKKHFNPNVR

Sequences:

>Translated_468_residues
MHYAIRNSTFVLRISSSDRKLLTPDADPTMNLTHTQLAEHGYMSGFANEFATEALPGALPVGQNSPQRAPYGLYAEQLSG
TAFTAPRAHNRRSWLYRIRPGAVHKPFTLVEQSRFLSRFDEVPPSPNQMRWSPPAMPTTPTDFIDGIVTMAGNGGPDAMT
GCGIHLYLANQSMQDRFFYNADGEMLIVPQQGRVRFVTEMGRLDVEPQEIVVIPRGVRFRVELPDGEARGYICENYGALF
KLPDLGVIGSNGLANPRDFMTPVAAYEDREGDFELVAKFQGNLWRADIGHSPLDVVAWHGNFAPYKYDLRRFNTIGSISF
DHPDPSIFLVLQSPSDTPGVDTIDFVIFGPRWLAMENSFRPPWFHRNIASEFMGLITGVYDAKADGFAPGGASLHNCMSG
HGPDADTFAKATSADTSTPHHITDTMAFMFETPGVIRPTPYAARSASLQQDYYTCWQGLKKHFNPNVR
>Mature_468_residues
MHYAIRNSTFVLRISSSDRKLLTPDADPTMNLTHTQLAEHGYMSGFANEFATEALPGALPVGQNSPQRAPYGLYAEQLSG
TAFTAPRAHNRRSWLYRIRPGAVHKPFTLVEQSRFLSRFDEVPPSPNQMRWSPPAMPTTPTDFIDGIVTMAGNGGPDAMT
GCGIHLYLANQSMQDRFFYNADGEMLIVPQQGRVRFVTEMGRLDVEPQEIVVIPRGVRFRVELPDGEARGYICENYGALF
KLPDLGVIGSNGLANPRDFMTPVAAYEDREGDFELVAKFQGNLWRADIGHSPLDVVAWHGNFAPYKYDLRRFNTIGSISF
DHPDPSIFLVLQSPSDTPGVDTIDFVIFGPRWLAMENSFRPPWFHRNIASEFMGLITGVYDAKADGFAPGGASLHNCMSG
HGPDADTFAKATSADTSTPHHITDTMAFMFETPGVIRPTPYAARSASLQQDYYTCWQGLKKHFNPNVR

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=441, Percent_Identity=52.1541950113379, Blast_Score=466, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17507969, Length=434, Percent_Identity=52.7649769585253, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24583650, Length=435, Percent_Identity=51.7241379310345, Blast_Score=446, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 52020; Mature: 52020

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYAIRNSTFVLRISSSDRKLLTPDADPTMNLTHTQLAEHGYMSGFANEFATEALPGALP
CCEEEECCEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VGQNSPQRAPYGLYAEQLSGTAFTAPRAHNRRSWLYRIRPGAVHKPFTLVEQSRFLSRFD
CCCCCCCCCCCCHHHHHCCCCEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
EVPPSPNQMRWSPPAMPTTPTDFIDGIVTMAGNGGPDAMTGCGIHLYLANQSMQDRFFYN
CCCCCCCCEEECCCCCCCCCHHHHCCCEEECCCCCCCCCCCCCEEEEEECCCCCCCEEEC
ADGEMLIVPQQGRVRFVTEMGRLDVEPQEIVVIPRGVRFRVELPDGEARGYICENYGALF
CCCCEEEEECCCCEEEEEECCCCCCCCCEEEEEECCEEEEEECCCCCCCCEEEECCCCEE
KLPDLGVIGSNGLANPRDFMTPVAAYEDREGDFELVAKFQGNLWRADIGHSPLDVVAWHG
ECCCCCEECCCCCCCCHHHHCHHHHCCCCCCCEEEEEEECCCEEEECCCCCCCEEEEECC
NFAPYKYDLRRFNTIGSISFDHPDPSIFLVLQSPSDTPGVDTIDFVIFGPRWLAMENSFR
CCCCCCHHHHHHCCCCCEEECCCCCEEEEEEECCCCCCCCCEEEEEEECCEEEEECCCCC
PPWFHRNIASEFMGLITGVYDAKADGFAPGGASLHNCMSGHGPDADTFAKATSADTSTPH
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCCCCC
HITDTMAFMFETPGVIRPTPYAARSASLQQDYYTCWQGLKKHFNPNVR
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MHYAIRNSTFVLRISSSDRKLLTPDADPTMNLTHTQLAEHGYMSGFANEFATEALPGALP
CCEEEECCEEEEEECCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
VGQNSPQRAPYGLYAEQLSGTAFTAPRAHNRRSWLYRIRPGAVHKPFTLVEQSRFLSRFD
CCCCCCCCCCCCHHHHHCCCCEEECCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
EVPPSPNQMRWSPPAMPTTPTDFIDGIVTMAGNGGPDAMTGCGIHLYLANQSMQDRFFYN
CCCCCCCCEEECCCCCCCCCHHHHCCCEEECCCCCCCCCCCCCEEEEEECCCCCCCEEEC
ADGEMLIVPQQGRVRFVTEMGRLDVEPQEIVVIPRGVRFRVELPDGEARGYICENYGALF
CCCCEEEEECCCCEEEEEECCCCCCCCCEEEEEECCEEEEEECCCCCCCCEEEECCCCEE
KLPDLGVIGSNGLANPRDFMTPVAAYEDREGDFELVAKFQGNLWRADIGHSPLDVVAWHG
ECCCCCEECCCCCCCCHHHHCHHHHCCCCCCCEEEEEEECCCEEEECCCCCCCEEEEECC
NFAPYKYDLRRFNTIGSISFDHPDPSIFLVLQSPSDTPGVDTIDFVIFGPRWLAMENSFR
CCCCCCHHHHHHCCCCCEEECCCCCEEEEEEECCCCCCCCCEEEEEEECCEEEEECCCCC
PPWFHRNIASEFMGLITGVYDAKADGFAPGGASLHNCMSGHGPDADTFAKATSADTSTPH
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCCCCC
HITDTMAFMFETPGVIRPTPYAARSASLQQDYYTCWQGLKKHFNPNVR
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA