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The map label for this gene is 73537758

Identifier: 73537758

GI number: 73537758

Start: 555867

End: 557135

Strand: Direct

Name: 73537758

Synonym: Reut_B3924

Alternate gene names: NA

Gene position: 555867-557135 (Clockwise)

Preceding gene: 73537757

Following gene: 73537768

Centisome position: 20.39

GC content: 64.78

Gene sequence:

>1269_bases
ATGACCGCCCCGATCACCAGCTGGATTGAATCCGCCAACGACGGCAAGACCCATTTTCCCCTGCAGAACCTGCCGTACGG
CATCTTTTCCGTGAAGGGCCAGGCTGCACGCGTCGGCGTTGCGATCGGCAATGCTGTGCTCGATCTGGCTGCGCTCGATG
AAGCCGGCCTGCTGCCCGTGGCAGCGAAGGGCACGTTTGCCGCCGCCAGCCTCAACCGCTTCATCGCACTAGGCAAGCCG
GTGTGGTCCGAAACGCGCCAGCGCCTGACCGCGCTGCTGTCGGGCGCCGACGCCGCCCTGCGCGACAACGCCGCGCTGCG
TGACCGCGCACTCGTACCGATGGACCAGGTGATGCTGCATCTTCCCGTCGAGATTCCCGGCTACACCGACTTCTATTCGT
CGAAGGAACACGCCACAAACGTCGGCCGCATGTTCCGCGATCCGGACAACGCGCTGCTGCCGAACTGGCTGGAAATCCCG
ATCGGCTACAACGGCCGTGCGAGCTCGGTGGTGGTGAGCGGTACCGACCTGCGCCGCCCGAACGGGCAGATCAAGCTGCC
CAACGAAGCGCGCCCGATTTTCAGCGCATGCCGCAAGCTCGACTTCGAGCTTGAGGTCGGCTTTATCGTCGGCAAGGAAT
CGGCACTGGGCGAACCGGTCAGCACGGCTGATGCACCGAACTATATGTTTGGCATGGTGCTGCTCAACGACTGGAGCGCG
CGTGACATCCAGCAGTGGGAATATGTGCCGCTCGGGCCGTTCAATTCCAAGGGCTTCGGTACCTCGATTTCGCCGTGGAT
CGTGACTATGGAAGCGCTGGAGCCGTTCCGCCGCGACAACCCCGAGCAGTCGCCGCAGCCGCTGCCGTACCTGCAGCAGC
AAAGCAAGAACGCCTACGACATCGCGCTCGAAGTCGCGCTGCGCCCGCAAGGCGCCGCGGCGGCCACCACGATCTGCCGC
ACCAACTTCAAGGCGATGTACTGGACCATGGCGCAGCAACTCGCGCATCACACGGTGTCGGGTTGCAACGTGCGCGTGGG
CGACCTGATGGGCTCGGGCACGATCAGCGGCACCACGCCGGATTCCTACGGCAGCCTGCTCGAACTCACGCGCAACGGTG
CCGAGCCGTTGAAGCTCGCCGACGGCAGCAGCCGCGCGTTCCTCGAGGACGGCGATGAAGTCGTGATGAGCGGTTTCGCT
GCGGGCGACGGATACGTCGTCGGCTTTGGCGCAGTGTCCGGCAAGATCCTGCCGGCGCCCAAAGCGTAA

Upstream 100 bases:

>100_bases
TTTCAACCCGAACGTGCGCTAAGCACGGCAGACGCCACATAAAACAAACAAACGGCACGCGGCAATATCCGCGTGCCACA
GACATTTTCCGGAGTCCCAC

Downstream 100 bases:

>100_bases
GCGCGTTCAGGCGGCGCCGGGTGGCGCCACGTCAAGGATCACCGCCGCCCGGCCGGAAAGCAGCCGCTTGCCGCCACCGC
TGACCTCGAACGCATAGAGC

Product: fumarylacetoacetate hydrolase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Hydroxylase; Fumarylacetoacetate Hydrolase Family Protein; 2-Hydroxyhepta-2 4-Diene-1 7-Dioate Isomerase; Fumarylacetoacetase Hydrolase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MTAPITSWIESANDGKTHFPLQNLPYGIFSVKGQAARVGVAIGNAVLDLAALDEAGLLPVAAKGTFAAASLNRFIALGKP
VWSETRQRLTALLSGADAALRDNAALRDRALVPMDQVMLHLPVEIPGYTDFYSSKEHATNVGRMFRDPDNALLPNWLEIP
IGYNGRASSVVVSGTDLRRPNGQIKLPNEARPIFSACRKLDFELEVGFIVGKESALGEPVSTADAPNYMFGMVLLNDWSA
RDIQQWEYVPLGPFNSKGFGTSISPWIVTMEALEPFRRDNPEQSPQPLPYLQQQSKNAYDIALEVALRPQGAAAATTICR
TNFKAMYWTMAQQLAHHTVSGCNVRVGDLMGSGTISGTTPDSYGSLLELTRNGAEPLKLADGSSRAFLEDGDEVVMSGFA
AGDGYVVGFGAVSGKILPAPKA

Sequences:

>Translated_422_residues
MTAPITSWIESANDGKTHFPLQNLPYGIFSVKGQAARVGVAIGNAVLDLAALDEAGLLPVAAKGTFAAASLNRFIALGKP
VWSETRQRLTALLSGADAALRDNAALRDRALVPMDQVMLHLPVEIPGYTDFYSSKEHATNVGRMFRDPDNALLPNWLEIP
IGYNGRASSVVVSGTDLRRPNGQIKLPNEARPIFSACRKLDFELEVGFIVGKESALGEPVSTADAPNYMFGMVLLNDWSA
RDIQQWEYVPLGPFNSKGFGTSISPWIVTMEALEPFRRDNPEQSPQPLPYLQQQSKNAYDIALEVALRPQGAAAATTICR
TNFKAMYWTMAQQLAHHTVSGCNVRVGDLMGSGTISGTTPDSYGSLLELTRNGAEPLKLADGSSRAFLEDGDEVVMSGFA
AGDGYVVGFGAVSGKILPAPKA
>Mature_421_residues
TAPITSWIESANDGKTHFPLQNLPYGIFSVKGQAARVGVAIGNAVLDLAALDEAGLLPVAAKGTFAAASLNRFIALGKPV
WSETRQRLTALLSGADAALRDNAALRDRALVPMDQVMLHLPVEIPGYTDFYSSKEHATNVGRMFRDPDNALLPNWLEIPI
GYNGRASSVVVSGTDLRRPNGQIKLPNEARPIFSACRKLDFELEVGFIVGKESALGEPVSTADAPNYMFGMVLLNDWSAR
DIQQWEYVPLGPFNSKGFGTSISPWIVTMEALEPFRRDNPEQSPQPLPYLQQQSKNAYDIALEVALRPQGAAAATTICRT
NFKAMYWTMAQQLAHHTVSGCNVRVGDLMGSGTISGTTPDSYGSLLELTRNGAEPLKLADGSSRAFLEDGDEVVMSGFAA
GDGYVVGFGAVSGKILPAPKA

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=416, Percent_Identity=53.6057692307692, Blast_Score=471, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI17568863, Length=407, Percent_Identity=52.5798525798526, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24657182, Length=403, Percent_Identity=51.8610421836228, Blast_Score=419, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 45359; Mature: 45228

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPITSWIESANDGKTHFPLQNLPYGIFSVKGQAARVGVAIGNAVLDLAALDEAGLLPV
CCCCHHHHHHCCCCCCEECCHHHCCCCEEEECCCCEEEEEEHHHHHHHHHHCCCCCCCEE
AAKGTFAAASLNRFIALGKPVWSETRQRLTALLSGADAALRDNAALRDRALVPMDQVMLH
ECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHCCCHHHCCCCCCHHHHHEE
LPVEIPGYTDFYSSKEHATNVGRMFRDPDNALLPNWLEIPIGYNGRASSVVVSGTDLRRP
ECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCC
NGQIKLPNEARPIFSACRKLDFELEVGFIVGKESALGEPVSTADAPNYMFGMVLLNDWSA
CCCEECCCCCCHHHHHHHHCCCEEEEEEEEECCHHCCCCCCCCCCCCEEEEEEEEECCCC
RDIQQWEYVPLGPFNSKGFGTSISPWIVTMEALEPFRRDNPEQSPQPLPYLQQQSKNAYD
CCCCCCCEEECCCCCCCCCCCCCCHHEEEHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEE
IALEVALRPQGAAAATTICRTNFKAMYWTMAQQLAHHTVSGCNVRVGDLMGSGTISGTTP
EEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEECCEECCCCCCCCCC
DSYGSLLELTRNGAEPLKLADGSSRAFLEDGDEVVMSGFAAGDGYVVGFGAVSGKILPAP
HHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEECCC
KA
CC
>Mature Secondary Structure 
TAPITSWIESANDGKTHFPLQNLPYGIFSVKGQAARVGVAIGNAVLDLAALDEAGLLPV
CCCHHHHHHCCCCCCEECCHHHCCCCEEEECCCCEEEEEEHHHHHHHHHHCCCCCCCEE
AAKGTFAAASLNRFIALGKPVWSETRQRLTALLSGADAALRDNAALRDRALVPMDQVMLH
ECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHCCCHHHCCCCCCHHHHHEE
LPVEIPGYTDFYSSKEHATNVGRMFRDPDNALLPNWLEIPIGYNGRASSVVVSGTDLRRP
ECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCEEEEECCCCCCC
NGQIKLPNEARPIFSACRKLDFELEVGFIVGKESALGEPVSTADAPNYMFGMVLLNDWSA
CCCEECCCCCCHHHHHHHHCCCEEEEEEEEECCHHCCCCCCCCCCCCEEEEEEEEECCCC
RDIQQWEYVPLGPFNSKGFGTSISPWIVTMEALEPFRRDNPEQSPQPLPYLQQQSKNAYD
CCCCCCCEEECCCCCCCCCCCCCCHHEEEHHHHHHHHHCCCCCCCCCCCHHHHHCCCCEE
IALEVALRPQGAAAATTICRTNFKAMYWTMAQQLAHHTVSGCNVRVGDLMGSGTISGTTP
EEEEEEECCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEECCEECCCCCCCCCC
DSYGSLLELTRNGAEPLKLADGSSRAFLEDGDEVVMSGFAAGDGYVVGFGAVSGKILPAP
HHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEECCC
KA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA