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The map label for this gene is phnW1

Identifier: 73537553

GI number: 73537553

Start: 307063

End: 308199

Strand: Reverse

Name: phnW1

Synonym: Reut_B3718

Alternate gene names: 73537553

Gene position: 308199-307063 (Counterclockwise)

Preceding gene: 73537558

Following gene: 73537552

Centisome position: 11.31

GC content: 66.23

Gene sequence:

>1137_bases
ATGATCCGCGGCAACGATCCGATCCTTCTCACCCCCGGCCCTCTCACCACATCGCTGGCCACCAAGCAGGCGATGCTGCG
CGACTGGGGATCGTGGGACGCCGCCTTCAACGCCATCACAGGAAGCCTGTGCGAGGACCTGGTGCGCATCGTCCATGGCG
AAGGCACGCACGTCTGCGTGCCGATGCAGGGCAGCGGCACCTTCTCCGTCGAAGCAGCCATTGCGAACGTGGTGCCGCGC
GACGGCAAGGTGCTGGTGCCGCAGAACGGCGCCTACTGCCAGCGCATTCTGAAGATCTGCAAGGTGCTGGGCCGCGCCCA
CGTGGAACTGCCGATTCCCGAGGACCGGCCCGCCACGGCGGCCGCGATCGAAGCGGCGCTCAAGAAGGACCCGTCGATCA
CGCACGTGGCGCAAGTCCACTGCGAGACCGGCGCGGGCGTGCTCAATCCGCTGCCCGAAATTGCGGCCGTGTGTGCGCGC
CTGGGCAAGGGACTGATCGTCGATGCCATGAGTTCGTTCGGCGCGATCGAGATCGATGCGCGCACGATGCCATTCGACGC
GCTGGTCGCGGCGACCGGCAAGTGCATCGAGGGCGTGCCGGGCATGGGTTTCGTGCTGGTGAAGAAGACCGTGCTGGAAG
GCAGCCAGGGCAACAGCCATTCGCTGGCGCTGGACCTGTACGACCAGTACACCTACATGCAGAAGACCACCCAGTGGCGT
TTCACGCCGCCCACGCACGTGGTCGCGGCCTTCCGCACGGCGCTGGACCAGTTCCTCGAGGAAGGCGGCCAGCCGGTGCG
CGGCGAGCGCTACCGCCGCAACTATGAAACGCTGGTGCAAGGCATGGCGGTGCTGGGCTTCCGTCCGTTTCTGTCGCCCG
ATGTGCAGGCGCCGATCATCGTGACGTTTCACGCGCCCGCCGACGCCCGCTATGACTTCAGGACGTTCTATGAAAAAGTG
CGCTCCCGCGGCTACATCCTGTACCCGGGCAAGCTGACGCAGGTGGAGACGTTCCGCGTCGGTTGCATCGGCGCGATCGA
CGACAACGAGATGCGCAATGTCGTCTCGGCGATCGGCGAGACGTTGCGCGAGATGGGCATCAGCATGCAGCCCGAAGGGC
GGGTGCGGGCCGCCTGA

Upstream 100 bases:

>100_bases
AGAACCGACTGCCAAAGCTTCGTCACGGACGCCCTGGCGGCATCGTCGGTCAGACACTGATCCGACAACCCTCTCTCCCT
CCCAACACCAGGAGCCCGAC

Downstream 100 bases:

>100_bases
CCCCGTCTGTTTCCAGCCCACGCCCTTTCCCGCCAGCGGTGGAAGGGCTCACCCTGCCAGCGCCACCAAGACCATATTGA
TGCCCCTTCCCGCCGACTTC

Product: 2-aminoethylphosphonate--pyruvate transaminase

Products: NA

Alternate protein names: 2-aminoethylphosphonate aminotransferase 1; AEP transaminase 1; AEPT 1

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MIRGNDPILLTPGPLTTSLATKQAMLRDWGSWDAAFNAITGSLCEDLVRIVHGEGTHVCVPMQGSGTFSVEAAIANVVPR
DGKVLVPQNGAYCQRILKICKVLGRAHVELPIPEDRPATAAAIEAALKKDPSITHVAQVHCETGAGVLNPLPEIAAVCAR
LGKGLIVDAMSSFGAIEIDARTMPFDALVAATGKCIEGVPGMGFVLVKKTVLEGSQGNSHSLALDLYDQYTYMQKTTQWR
FTPPTHVVAAFRTALDQFLEEGGQPVRGERYRRNYETLVQGMAVLGFRPFLSPDVQAPIIVTFHAPADARYDFRTFYEKV
RSRGYILYPGKLTQVETFRVGCIGAIDDNEMRNVVSAIGETLREMGISMQPEGRVRAA

Sequences:

>Translated_378_residues
MIRGNDPILLTPGPLTTSLATKQAMLRDWGSWDAAFNAITGSLCEDLVRIVHGEGTHVCVPMQGSGTFSVEAAIANVVPR
DGKVLVPQNGAYCQRILKICKVLGRAHVELPIPEDRPATAAAIEAALKKDPSITHVAQVHCETGAGVLNPLPEIAAVCAR
LGKGLIVDAMSSFGAIEIDARTMPFDALVAATGKCIEGVPGMGFVLVKKTVLEGSQGNSHSLALDLYDQYTYMQKTTQWR
FTPPTHVVAAFRTALDQFLEEGGQPVRGERYRRNYETLVQGMAVLGFRPFLSPDVQAPIIVTFHAPADARYDFRTFYEKV
RSRGYILYPGKLTQVETFRVGCIGAIDDNEMRNVVSAIGETLREMGISMQPEGRVRAA
>Mature_378_residues
MIRGNDPILLTPGPLTTSLATKQAMLRDWGSWDAAFNAITGSLCEDLVRIVHGEGTHVCVPMQGSGTFSVEAAIANVVPR
DGKVLVPQNGAYCQRILKICKVLGRAHVELPIPEDRPATAAAIEAALKKDPSITHVAQVHCETGAGVLNPLPEIAAVCAR
LGKGLIVDAMSSFGAIEIDARTMPFDALVAATGKCIEGVPGMGFVLVKKTVLEGSQGNSHSLALDLYDQYTYMQKTTQWR
FTPPTHVVAAFRTALDQFLEEGGQPVRGERYRRNYETLVQGMAVLGFRPFLSPDVQAPIIVTFHAPADARYDFRTFYEKV
RSRGYILYPGKLTQVETFRVGCIGAIDDNEMRNVVSAIGETLREMGISMQPEGRVRAA

Specific function: Involved in phosphonate degradation

COG id: COG0075

COG function: function code E; Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily

Homologues:

Organism=Homo sapiens, GI4557289, Length=346, Percent_Identity=24.5664739884393, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17536281, Length=314, Percent_Identity=22.6114649681529, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PHNW1_CUPPJ (Q46UV8)

Other databases:

- EMBL:   CP000091
- RefSeq:   YP_297920.1
- ProteinModelPortal:   Q46UV8
- SMR:   Q46UV8
- GeneID:   3614356
- GenomeReviews:   CP000091_GR
- KEGG:   reu:Reut_B3718
- NMPDR:   fig|264198.3.peg.4586
- HOGENOM:   HBG423997
- OMA:   ITHVAQV
- ProtClustDB:   PRK13479
- BioCyc:   REUT264198:REUT_B3718-MONOMER
- HAMAP:   MF_01376
- InterPro:   IPR017688
- InterPro:   IPR000192
- InterPro:   IPR012703
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR03301
- TIGRFAMs:   TIGR02326

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.37

Molecular weight: Translated: 41043; Mature: 41043

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRGNDPILLTPGPLTTSLATKQAMLRDWGSWDAAFNAITGSLCEDLVRIVHGEGTHVCV
CCCCCCCEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
PMQGSGTFSVEAAIANVVPRDGKVLVPQNGAYCQRILKICKVLGRAHVELPIPEDRPATA
EECCCCCEEHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCCCCHHH
AAIEAALKKDPSITHVAQVHCETGAGVLNPLPEIAAVCARLGKGLIVDAMSSFGAIEIDA
HHHHHHHHCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEHHHHCCEEEEEC
RTMPFDALVAATGKCIEGVPGMGFVLVKKTVLEGSQGNSHSLALDLYDQYTYMQKTTQWR
CCCCHHHHHHHCCHHHCCCCCCCHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHCCCEE
FTPPTHVVAAFRTALDQFLEEGGQPVRGERYRRNYETLVQGMAVLGFRPFLSPDVQAPII
ECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
VTFHAPADARYDFRTFYEKVRSRGYILYPGKLTQVETFRVGCIGAIDDNEMRNVVSAIGE
EEEECCCCCCCHHHHHHHHHHHCCEEEECCCCCEEEEEEEEEEECCCCHHHHHHHHHHHH
TLREMGISMQPEGRVRAA
HHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MIRGNDPILLTPGPLTTSLATKQAMLRDWGSWDAAFNAITGSLCEDLVRIVHGEGTHVCV
CCCCCCCEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
PMQGSGTFSVEAAIANVVPRDGKVLVPQNGAYCQRILKICKVLGRAHVELPIPEDRPATA
EECCCCCEEHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCCCCHHH
AAIEAALKKDPSITHVAQVHCETGAGVLNPLPEIAAVCARLGKGLIVDAMSSFGAIEIDA
HHHHHHHHCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEHHHHCCEEEEEC
RTMPFDALVAATGKCIEGVPGMGFVLVKKTVLEGSQGNSHSLALDLYDQYTYMQKTTQWR
CCCCHHHHHHHCCHHHCCCCCCCHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHCCCEE
FTPPTHVVAAFRTALDQFLEEGGQPVRGERYRRNYETLVQGMAVLGFRPFLSPDVQAPII
ECCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEE
VTFHAPADARYDFRTFYEKVRSRGYILYPGKLTQVETFRVGCIGAIDDNEMRNVVSAIGE
EEEECCCCCCCHHHHHHHHHHHCCEEEECCCCCEEEEEEEEEEECCCCHHHHHHHHHHHH
TLREMGISMQPEGRVRAA
HHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA