Click here to switch to the map view.

The map label for this gene is pip [H]

Identifier: 73537327

GI number: 73537327

Start: 28231

End: 29184

Strand: Reverse

Name: pip [H]

Synonym: Reut_B3492

Alternate gene names: 73537327

Gene position: 29184-28231 (Counterclockwise)

Preceding gene: 73537334

Following gene: 73537321

Centisome position: 1.07

GC content: 65.09

Gene sequence:

>954_bases
ATGCCAACCCTTCGCACCCTCTACCCTGCCATCGAACCGTATGCCACGGGCACGCTCGATGTCGGCGACGGCCACGTGAT
CCATTACGAGCGCGTCGGCACGCCTGGCGCCAAGCCTGCAGTTTTCCTGCATGGCGGACCCGGCGGCGGCATCAGTGCCG
ATCATCGCCGGCTGTTCGATCCCGCGCACTACGACGTGCTGCTGTTCGACCAGCGTGGCTGCGGCCGCTCCAGGCCGCAT
GCAGGACTAGAGGCAAACACCACGTGGCATCTCGTCGACGATATCGAGCGCTTGCGCGAACTCGCGGGTGTCGAGCGCTG
GCTCGTGTTCGGCGGCTCATGGGGCTCGACGCTGGCGCTCGCCTACGCGCAGAAGCATCCGCAGCGCGCGAGCGAACTCG
TGCTGCGCGGCGTCTATACGGTGTCGCAAGCGGAGTTGGACTGGTACTACCAGTTCGGCGTGTCGGAGATGTTCCCCGAG
AAGTGGGCGCGCTTTCAGGCGCCGGTGCCGGAAGCGGAACGCGGCAACATGATGGCCGCCTATCGCAAGCTGCTGACCGG
CGACGACGAGGCAAAACAACTGCAAGCGGCGCGCGCGTGGAGCGTCTGGGAAGGGGAAACCATCACCCTGCTGCCGGACG
CGGACAACAGCGCGAAGCACGATGATGCGCATTTCGCGCTGGCCTTCGCACGGCTCGAGAACCACTACTTCACGCACCGC
GCGTGGCTTGAAGACGGGCAACTGCTGCGCGACGCGCATCGCCTGGCTGGGATTCCCGGCGTAATCGTGCACGGCCGCTA
CGATATGCCTTGCCCTGCGCGCTACGCGTTCGCGTTACACAACGCATGGCCTGACGCAGACTTCCATCTGATCGAAGGTG
CGGGACATGCGTGGACCGAGCCGGGTATCCTGGATCAGTTGATTCGGGCCACAGACCGGTTCGCGCAGCAGTAA

Upstream 100 bases:

>100_bases
GCGACTGCTTCGCCTTTCACAAAGATCGACGCAACGGTGGCCGCGTGATCGCGCACGCCCAGCGCTACACTGAACCATGA
CGCACCCGGAGCCCAACCCC

Downstream 100 bases:

>100_bases
CGTCGCCCCGATTTGTGCGGAACCTTAGTCCCGGTCCGGCGCGCCGGGTGGAAACAGCTTGCGGTACGGGCGCGCCTCGT
CTACCGCCCGCGCAAATGCG

Product: prolyl aminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MPTLRTLYPAIEPYATGTLDVGDGHVIHYERVGTPGAKPAVFLHGGPGGGISADHRRLFDPAHYDVLLFDQRGCGRSRPH
AGLEANTTWHLVDDIERLRELAGVERWLVFGGSWGSTLALAYAQKHPQRASELVLRGVYTVSQAELDWYYQFGVSEMFPE
KWARFQAPVPEAERGNMMAAYRKLLTGDDEAKQLQAARAWSVWEGETITLLPDADNSAKHDDAHFALAFARLENHYFTHR
AWLEDGQLLRDAHRLAGIPGVIVHGRYDMPCPARYAFALHNAWPDADFHLIEGAGHAWTEPGILDQLIRATDRFAQQ

Sequences:

>Translated_317_residues
MPTLRTLYPAIEPYATGTLDVGDGHVIHYERVGTPGAKPAVFLHGGPGGGISADHRRLFDPAHYDVLLFDQRGCGRSRPH
AGLEANTTWHLVDDIERLRELAGVERWLVFGGSWGSTLALAYAQKHPQRASELVLRGVYTVSQAELDWYYQFGVSEMFPE
KWARFQAPVPEAERGNMMAAYRKLLTGDDEAKQLQAARAWSVWEGETITLLPDADNSAKHDDAHFALAFARLENHYFTHR
AWLEDGQLLRDAHRLAGIPGVIVHGRYDMPCPARYAFALHNAWPDADFHLIEGAGHAWTEPGILDQLIRATDRFAQQ
>Mature_316_residues
PTLRTLYPAIEPYATGTLDVGDGHVIHYERVGTPGAKPAVFLHGGPGGGISADHRRLFDPAHYDVLLFDQRGCGRSRPHA
GLEANTTWHLVDDIERLRELAGVERWLVFGGSWGSTLALAYAQKHPQRASELVLRGVYTVSQAELDWYYQFGVSEMFPEK
WARFQAPVPEAERGNMMAAYRKLLTGDDEAKQLQAARAWSVWEGETITLLPDADNSAKHDDAHFALAFARLENHYFTHRA
WLEDGQLLRDAHRLAGIPGVIVHGRYDMPCPARYAFALHNAWPDADFHLIEGAGHAWTEPGILDQLIRATDRFAQQ

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 35512; Mature: 35381

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTLRTLYPAIEPYATGTLDVGDGHVIHYERVGTPGAKPAVFLHGGPGGGISADHRRLFD
CCCHHHHHHCCCCCCCCEEECCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCHHHHCC
PAHYDVLLFDQRGCGRSRPHAGLEANTTWHLVDDIERLRELAGVERWLVFGGSWGSTLAL
CCCCEEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCEEEEEECCCCCHHHHH
AYAQKHPQRASELVLRGVYTVSQAELDWYYQFGVSEMFPEKWARFQAPVPEAERGNMMAA
HHHHHCHHHHHHHHHHHHHHHHHHCEEEEEECCHHHHCHHHHHHHCCCCCCCCCCCHHHH
YRKLLTGDDEAKQLQAARAWSVWEGETITLLPDADNSAKHDDAHFALAFARLENHYFTHR
HHHHHCCCHHHHHHHHHHHCEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHH
AWLEDGQLLRDAHRLAGIPGVIVHGRYDMPCPARYAFALHNAWPDADFHLIEGAGHAWTE
HHHHCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCC
PGILDQLIRATDRFAQQ
CHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PTLRTLYPAIEPYATGTLDVGDGHVIHYERVGTPGAKPAVFLHGGPGGGISADHRRLFD
CCHHHHHHCCCCCCCCEEECCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCHHHHCC
PAHYDVLLFDQRGCGRSRPHAGLEANTTWHLVDDIERLRELAGVERWLVFGGSWGSTLAL
CCCCEEEEEECCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHCCEEEEEECCCCCHHHHH
AYAQKHPQRASELVLRGVYTVSQAELDWYYQFGVSEMFPEKWARFQAPVPEAERGNMMAA
HHHHHCHHHHHHHHHHHHHHHHHHCEEEEEECCHHHHCHHHHHHHCCCCCCCCCCCHHHH
YRKLLTGDDEAKQLQAARAWSVWEGETITLLPDADNSAKHDDAHFALAFARLENHYFTHR
HHHHHCCCHHHHHHHHHHHCEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHH
AWLEDGQLLRDAHRLAGIPGVIVHGRYDMPCPARYAFALHNAWPDADFHLIEGAGHAWTE
HHHHCCHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCC
PGILDQLIRATDRFAQQ
CHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9348090; 11011150; 10467172 [H]