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The map label for this gene is arpR [H]

Identifier: 73543121

GI number: 73543121

Start: 3779303

End: 3780022

Strand: Reverse

Name: arpR [H]

Synonym: Reut_A3439

Alternate gene names: 73543121

Gene position: 3780022-3779303 (Counterclockwise)

Preceding gene: 73543125

Following gene: 73543119

Centisome position: 99.3

GC content: 65.83

Gene sequence:

>720_bases
ATGGTCAGACGCACCAAGGAAGAGGCGCTCGAAACGCGCCACCGGATTCTCGACGCAGCCGAAACCGTGTTTCACGCGCG
CGGCGTGGCGCGCCCGTCGCTGGCAGACATTGCCGAGGCGGCCGGCGTTACCCGCGGCGCCATCTACTGGCACTTCAAGA
ACAAGAGCGACGTGTTCGCCGCCATGTGCGACCGCGTGAACCTGCCCGTGGAAGCGCTATGCGACCCGGAGCGCATCGCG
CGCCAGGAAGACCCGCTGGGAGGCATACGCGACATCTGCGCCTTCGTCATGCGCCAGACCGTGGTCAATCCGCGCTGGCG
GCGGGTGTTCGAGATCATCTTCCACAAGTGCGAGATGGTGCAGGACAACGGGGCCATCTTCGAACGCCAGCGCCAGTCGC
ACCAGGAAGGCATGGTGAAGATCCGCGAGCACCTGCGCTTTGCGGTGGAGCGCGGCCAGCTTCCGGCCGATCTGGACCTG
GACCTGGCCGTGAACGCGTTCCATGCGGCGATTGGCGGCGTGCTCGCGCACTGGCTGTTCTCGCCACAGGACTTCGACCT
CGACGCCAATGCCGAGCGCCTGTCGGACGCCTTCATCGATACGCTCAGGTTTTCCCCGGCGCTGCGCCATGGCTATGTGC
CGCGCCCGATGGCGGAACTCGATCGCGAGCTGAGTACGCTTTGCGAGAAAGCCTGCCAGGAAGCCAACGGCGCGCCGTAA

Upstream 100 bases:

>100_bases
ACCAAAACGCTGGGCTGCTGCCGCAGTCACGCCAGGGGGAGGAAAACGGACCGGCCATTGACGCACTCATGCATCGTCAA
GGCCGGCACCAGAGATAGAA

Downstream 100 bases:

>100_bases
CGGCGCTGCCGAGCTAACCGCGCATGGCTTCGCGCCAGCGCTCCAGAAAGGCACGCTTGCGCAGCGTGTCCTGCGCCGCC
AGCAGGCCCGGGCCGACGCT

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: Antibiotic efflux pump ArpABC operon regulator [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MVRRTKEEALETRHRILDAAETVFHARGVARPSLADIAEAAGVTRGAIYWHFKNKSDVFAAMCDRVNLPVEALCDPERIA
RQEDPLGGIRDICAFVMRQTVVNPRWRRVFEIIFHKCEMVQDNGAIFERQRQSHQEGMVKIREHLRFAVERGQLPADLDL
DLAVNAFHAAIGGVLAHWLFSPQDFDLDANAERLSDAFIDTLRFSPALRHGYVPRPMAELDRELSTLCEKACQEANGAP

Sequences:

>Translated_239_residues
MVRRTKEEALETRHRILDAAETVFHARGVARPSLADIAEAAGVTRGAIYWHFKNKSDVFAAMCDRVNLPVEALCDPERIA
RQEDPLGGIRDICAFVMRQTVVNPRWRRVFEIIFHKCEMVQDNGAIFERQRQSHQEGMVKIREHLRFAVERGQLPADLDL
DLAVNAFHAAIGGVLAHWLFSPQDFDLDANAERLSDAFIDTLRFSPALRHGYVPRPMAELDRELSTLCEKACQEANGAP
>Mature_239_residues
MVRRTKEEALETRHRILDAAETVFHARGVARPSLADIAEAAGVTRGAIYWHFKNKSDVFAAMCDRVNLPVEALCDPERIA
RQEDPLGGIRDICAFVMRQTVVNPRWRRVFEIIFHKCEMVQDNGAIFERQRQSHQEGMVKIREHLRFAVERGQLPADLDL
DLAVNAFHAAIGGVLAHWLFSPQDFDLDANAERLSDAFIDTLRFSPALRHGYVPRPMAELDRELSTLCEKACQEANGAP

Specific function: Probable regulatory protein for the antibiotic efflux pump arpABC operon. May function as a repressor [H]

COG id: COG1309

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786669, Length=210, Percent_Identity=40, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1789664, Length=199, Percent_Identity=32.6633165829146, Blast_Score=108, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR013572
- InterPro:   IPR001647 [H]

Pfam domain/function: PF08361 TetR_C_2; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 27072; Mature: 27072

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRRTKEEALETRHRILDAAETVFHARGVARPSLADIAEAAGVTRGAIYWHFKNKSDVFA
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHH
AMCDRVNLPVEALCDPERIARQEDPLGGIRDICAFVMRQTVVNPRWRRVFEIIFHKCEMV
HHHHHCCCCHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
QDNGAIFERQRQSHQEGMVKIREHLRFAVERGQLPADLDLDLAVNAFHAAIGGVLAHWLF
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
SPQDFDLDANAERLSDAFIDTLRFSPALRHGYVPRPMAELDRELSTLCEKACQEANGAP
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MVRRTKEEALETRHRILDAAETVFHARGVARPSLADIAEAAGVTRGAIYWHFKNKSDVFA
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCCHHHH
AMCDRVNLPVEALCDPERIARQEDPLGGIRDICAFVMRQTVVNPRWRRVFEIIFHKCEMV
HHHHHCCCCHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
QDNGAIFERQRQSHQEGMVKIREHLRFAVERGQLPADLDLDLAVNAFHAAIGGVLAHWLF
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
SPQDFDLDANAERLSDAFIDTLRFSPALRHGYVPRPMAELDRELSTLCEKACQEANGAP
CCCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11160799 [H]